The activities of the catalytic hydrolysis of phosphate diester （BNPP） [bis（p-nitrophenyl）phosphate diester] and plasmid DNA （pUC 18） by mononuclear macrocyclic polyamine metal complexes have been investigated i...The activities of the catalytic hydrolysis of phosphate diester （BNPP） [bis（p-nitrophenyl）phosphate diester] and plasmid DNA （pUC 18） by mononuclear macrocyclic polyamine metal complexes have been investigated in this paper. The results showed that the highest activity in hydrolysis of BNPP was obtained with le--Zn（II） complex （composed of lipophilic group） as catalyst. The hydrolysis rate enhancement is up to 3.64 × 10^4 fold. These metal complexes could effectively promote the cleavage of plasmid DNA （pUC18） at physiological conditions.展开更多
Efficient catalysis of functinnatized β-cyctodextrins bearing aninoatkytimino groups for atdot condensations of nitrobenzatdehydes and acetone has been effected and substantiated by preparative experiments
A series of novel bis-squaramidoacid ligands were prepared. Prochiral ketone and diketones were direct reduced by borane in the presence of these ligands giving secondary alcohol products with enantiomeric excesses u...A series of novel bis-squaramidoacid ligands were prepared. Prochiral ketone and diketones were direct reduced by borane in the presence of these ligands giving secondary alcohol products with enantiomeric excesses up to 64.2% for w-bromoacetophenone and 90.0% for 1, 6-diphenyl-1, 6-hexanedione.展开更多
Reaction of 6-deoxy-6-(N-imidazolyl)-β-cyclodextrin 2 with α, α'-dibromoxylene afforded cyclodextrin dimer 3 with two imidazolium residues as catalytic site and two cyclodextrin cavities as binding site.
A novel one-pot synthesis of 4,5-bis(hydroxymethyl) imidazoles 2a-b, new ethers 3a-b and a new type of imidazolophane 4b by the bis-hydroxymethylation of imidazole or 2-methyl imidazole with formaldehyde and potassium...A novel one-pot synthesis of 4,5-bis(hydroxymethyl) imidazoles 2a-b, new ethers 3a-b and a new type of imidazolophane 4b by the bis-hydroxymethylation of imidazole or 2-methyl imidazole with formaldehyde and potassium hydroxide is reported. The structures of these compounds have been established by MS, (1)HNMR IR and elemental analyses.展开更多
A series of tyrosinase model ligands and complexes containing polyimidazoles wereprepared. 2, 4-Di-tert-butyl-phenol was ortho-hydroxylated by the binuclear copper (?) complex[Cu2(6a)(CH3CN)2](ClO4)2 8a and molecular ...A series of tyrosinase model ligands and complexes containing polyimidazoles wereprepared. 2, 4-Di-tert-butyl-phenol was ortho-hydroxylated by the binuclear copper (?) complex[Cu2(6a)(CH3CN)2](ClO4)2 8a and molecular dioxygen under mild conditions with up to 80.4%yield, 91.4% selectivity and 92.0% conversion.展开更多
A new efficient synthesis of bisphenol A diether bis-imidazoles and bis-benzimidazoles by bromoalkylation and imidazolylation or benzimidazolylation two-step reactions from commercial bisphenol A, imidazole, 2-methyli...A new efficient synthesis of bisphenol A diether bis-imidazoles and bis-benzimidazoles by bromoalkylation and imidazolylation or benzimidazolylation two-step reactions from commercial bisphenol A, imidazole, 2-methylimidazole and benzimidazole is reported.展开更多
A facile and efficient synthesis for a series of bis(N-imidazolylethyl) ethers from oligo-ethyleneglycols and imidazole has been studied. All these compounds obtained were characterized by MS,(HNMR)-H-1, and elemental...A facile and efficient synthesis for a series of bis(N-imidazolylethyl) ethers from oligo-ethyleneglycols and imidazole has been studied. All these compounds obtained were characterized by MS,(HNMR)-H-1, and elemental analysis.展开更多
A new type of cyclodextrin dimers (2a-c) bridged with multidentate coordination units has been synthesized by treatment of 6-deoxy-6-hydroxyethylamino-beta-cyclodextrin 1 with corresponding dibromides in the presence ...A new type of cyclodextrin dimers (2a-c) bridged with multidentate coordination units has been synthesized by treatment of 6-deoxy-6-hydroxyethylamino-beta-cyclodextrin 1 with corresponding dibromides in the presence of base.展开更多
基金supported by the Science and Technology Department(No.04JY029-018)Education Department of Sichuan Province(No.2006ZD049).
文摘The activities of the catalytic hydrolysis of phosphate diester （BNPP） [bis（p-nitrophenyl）phosphate diester] and plasmid DNA （pUC 18） by mononuclear macrocyclic polyamine metal complexes have been investigated in this paper. The results showed that the highest activity in hydrolysis of BNPP was obtained with le--Zn（II） complex （composed of lipophilic group） as catalyst. The hydrolysis rate enhancement is up to 3.64 × 10^4 fold. These metal complexes could effectively promote the cleavage of plasmid DNA （pUC18） at physiological conditions.
文摘Efficient catalysis of functinnatized β-cyctodextrins bearing aninoatkytimino groups for atdot condensations of nitrobenzatdehydes and acetone has been effected and substantiated by preparative experiments
文摘A series of novel bis-squaramidoacid ligands were prepared. Prochiral ketone and diketones were direct reduced by borane in the presence of these ligands giving secondary alcohol products with enantiomeric excesses up to 64.2% for w-bromoacetophenone and 90.0% for 1, 6-diphenyl-1, 6-hexanedione.
文摘Reaction of 6-deoxy-6-(N-imidazolyl)-β-cyclodextrin 2 with α, α'-dibromoxylene afforded cyclodextrin dimer 3 with two imidazolium residues as catalytic site and two cyclodextrin cavities as binding site.
文摘A novel one-pot synthesis of 4,5-bis(hydroxymethyl) imidazoles 2a-b, new ethers 3a-b and a new type of imidazolophane 4b by the bis-hydroxymethylation of imidazole or 2-methyl imidazole with formaldehyde and potassium hydroxide is reported. The structures of these compounds have been established by MS, (1)HNMR IR and elemental analyses.
基金supported by the National Natural Science Foundation of China.(No.20172038)
文摘A series of tyrosinase model ligands and complexes containing polyimidazoles wereprepared. 2, 4-Di-tert-butyl-phenol was ortho-hydroxylated by the binuclear copper (?) complex[Cu2(6a)(CH3CN)2](ClO4)2 8a and molecular dioxygen under mild conditions with up to 80.4%yield, 91.4% selectivity and 92.0% conversion.
文摘A new efficient synthesis of bisphenol A diether bis-imidazoles and bis-benzimidazoles by bromoalkylation and imidazolylation or benzimidazolylation two-step reactions from commercial bisphenol A, imidazole, 2-methylimidazole and benzimidazole is reported.
文摘A facile and efficient synthesis for a series of bis(N-imidazolylethyl) ethers from oligo-ethyleneglycols and imidazole has been studied. All these compounds obtained were characterized by MS,(HNMR)-H-1, and elemental analysis.
文摘A new type of cyclodextrin dimers (2a-c) bridged with multidentate coordination units has been synthesized by treatment of 6-deoxy-6-hydroxyethylamino-beta-cyclodextrin 1 with corresponding dibromides in the presence of base.
