Background:To summarize the rules of the use of traditional Chinese medicine against influenza virus in the high-quality literatures of core journals,and to provide guidance for the prevention and treatment of influen...Background:To summarize the rules of the use of traditional Chinese medicine against influenza virus in the high-quality literatures of core journals,and to provide guidance for the prevention and treatment of influenza.Methods:Excel 2010 and ancient and modern medical case cloud platform(2.5V)were used to summarize the categories,nature,flavour and channel tropism of drugs.The cluster analysis of high-frequency drugs was carried out by SPSS 22.0,and the association rules of high-frequency drugs were analyzed by Apriori algorithm provided by SPSS modeler 18.0.Results:One thousand one hundred and thirty-one articles from core journals were retrieved and 135 articles were screened out,including 109 prescriptions and 170 drugs,with a total frequency of 1,655 times.The 3 most frequently appeared herbs were Gancao(Glycyrrhizae radix et rhizoma),Jinyinhua(Lonicerae japonicae flos)and Lianqiao(Forsythiae fructus).The top 3 efficacy were“Heat-Clearing(remove heat from the body surface and inside)”drugs,drugs for“Relieving Exterior Disorder(treat fever,chills and headaches caused by pathogenic substances in the air)”,and“Phlegm Relieving Cough Antiasthmatic Medicine(relieves respiratory cough and sputum symptoms)”drugs.The top 3 nature of drugs were cold,warm and flat.The top 3 flavour of drugs were bitter,spicy and sweet.The top 5 channel tropism of drugs were“Lung”,“Stomach”,“Heart”,“Spleen”,“Liver”.Association rule yields 20 drug pairs,Jingjie(Schizonepetae herba),Forsythiae fructus,Lonicerae japonicae flos,Niubangzi(Arctii fructus),Mahuang(Ephedrae herba)and Glycyrrhizae radix et rhizoma were commonly used concerted application;four new methods were obtained by cluster analysis.Conclusion:The use of traditional Chinese medicine against influenza virus has a certain regularity,which provides an important reference value for the prevention and treatment of influenza.展开更多
To analyze the medication rule of Chinese patent medicine compound for constipation by data mining,and to provide reference for the treatment of constipation.Methods:The Chinese patent medicines for constipation in th...To analyze the medication rule of Chinese patent medicine compound for constipation by data mining,and to provide reference for the treatment of constipation.Methods:The Chinese patent medicines for constipation in the Pharmacopoeia of the People’s Republic of China(2020)and Chinese patent medicine prescription database of yaozhi.com(https://db.yaozh.com/chufang)were collected and sorted.The prescriptions and drug composition were input into Excel2010.ategories,nature,flavour and channel tropism of drugs were analyzed by using ancient and modern medical case cloud platform(V2.3.5).The cluster analysis of high-frequency drugs was carried out by SPSS 22.0,and rules of high-frequency drugs were analyzed by Apriori algorithm provided by SPSS modeler 18.0.Results:Two hundred and thirty-six Chinese patent medicine prescriptions that met the requirements were collected,containing 349 Chinese medicines in total,with a total frequency of 2,277.The drugs with frequency≥25 times were high-frequency drugs,with a total of 24 flavours,and the top 5 were Dahuang(Rhei radix et rhizoma),Huangqin(Scutellariae radix),Gancao(Glycyrrhizae radix et rhizoma),Huanglian(Coptidis rhizoma)and Bohe(Menthae haplocalycis herba).The top 3 frequency of efficacy of high-frequency drugs were“Heat-Clearing(remove heat from the body surface and inside)”drugs,“Purgating(to promote excretion of stools)”drugs and“Reinforcing”(to supplement the body’s lack of“Qi,Blood,Yin and Yang”)drugs.The nature of high-frequency drugs were cold,warm and flat.The top 3 flavour of the high frequency drugs were bitter,spicy and sweet.The top 4 channel tropism of high-frequency drugs were“Spleen”,“Stomach”,“Lung”,“Large intestine”.According to the association rule,11 drug pairs were obtained,and the core drug pairs were Zhizi(Gardeniae fructus)-Rhei radix et rhizoma,Huangbo(Phellodendri chinensis cortex)-Rhei radix et rhizoma.Four new methods were obtained based on cluster analysis.Conclusion:Chinese patent medicine has a certain regularity in the treatment of constipation.This paper can provide some references for the clinical treatment of constipation with Chinese medicine.展开更多
Hirudin is an active ingredient extracted from leeches(Hirudo).At present,there are many hirudin preparations on the market,which are roughly divided into three categories,the first is natural hirudin,the second is hi...Hirudin is an active ingredient extracted from leeches(Hirudo).At present,there are many hirudin preparations on the market,which are roughly divided into three categories,the first is natural hirudin,the second is hirudin derivatives such as lepirudin,desirudin and bivalirudin,and the third is new hirudin preparations such as hirudin-bovine serum albumin(BSA)nanoparticles,polydopamine fitted titanium dioxide nanoparticles systems and recombinant hirudins-2(rhv2)-loaded picmice.The pharmacological effects and adverse reactions of hirudin were reviewed to evaluate its safety,efficacy and quality control.Hirudin has obvious pharmacological effects on cardio-cerebrovascular diseases(coronary atherosclerotic heart disease,myocardial infarction,hyperlipidemia,cerebral infarction,arteriosclerosis obliterans of lower extremities),angiogenesis(fracture,skinflaptransplantation),tissue fibrosis,tumor,ophthalmopathy,hyperuricemia and female infertility.However,attention should be paid to clinical adverse reactions(bleeding,allergic reaction,infection,cutaneous pseudolymphoma).展开更多
基金the Discipline Innovation Team Construction Project of the Second Affiliated Hospital of Shaanxi University of Chinese Medicine(2020XKTD-A02).
文摘Background:To summarize the rules of the use of traditional Chinese medicine against influenza virus in the high-quality literatures of core journals,and to provide guidance for the prevention and treatment of influenza.Methods:Excel 2010 and ancient and modern medical case cloud platform(2.5V)were used to summarize the categories,nature,flavour and channel tropism of drugs.The cluster analysis of high-frequency drugs was carried out by SPSS 22.0,and the association rules of high-frequency drugs were analyzed by Apriori algorithm provided by SPSS modeler 18.0.Results:One thousand one hundred and thirty-one articles from core journals were retrieved and 135 articles were screened out,including 109 prescriptions and 170 drugs,with a total frequency of 1,655 times.The 3 most frequently appeared herbs were Gancao(Glycyrrhizae radix et rhizoma),Jinyinhua(Lonicerae japonicae flos)and Lianqiao(Forsythiae fructus).The top 3 efficacy were“Heat-Clearing(remove heat from the body surface and inside)”drugs,drugs for“Relieving Exterior Disorder(treat fever,chills and headaches caused by pathogenic substances in the air)”,and“Phlegm Relieving Cough Antiasthmatic Medicine(relieves respiratory cough and sputum symptoms)”drugs.The top 3 nature of drugs were cold,warm and flat.The top 3 flavour of drugs were bitter,spicy and sweet.The top 5 channel tropism of drugs were“Lung”,“Stomach”,“Heart”,“Spleen”,“Liver”.Association rule yields 20 drug pairs,Jingjie(Schizonepetae herba),Forsythiae fructus,Lonicerae japonicae flos,Niubangzi(Arctii fructus),Mahuang(Ephedrae herba)and Glycyrrhizae radix et rhizoma were commonly used concerted application;four new methods were obtained by cluster analysis.Conclusion:The use of traditional Chinese medicine against influenza virus has a certain regularity,which provides an important reference value for the prevention and treatment of influenza.
基金This study was supported by the Discipline Innovation Team Construction Project of the Second Affiliated Hospital of Shaanxi University of Chinese Medicine(2020XKTD-A02).
文摘To analyze the medication rule of Chinese patent medicine compound for constipation by data mining,and to provide reference for the treatment of constipation.Methods:The Chinese patent medicines for constipation in the Pharmacopoeia of the People’s Republic of China(2020)and Chinese patent medicine prescription database of yaozhi.com(https://db.yaozh.com/chufang)were collected and sorted.The prescriptions and drug composition were input into Excel2010.ategories,nature,flavour and channel tropism of drugs were analyzed by using ancient and modern medical case cloud platform(V2.3.5).The cluster analysis of high-frequency drugs was carried out by SPSS 22.0,and rules of high-frequency drugs were analyzed by Apriori algorithm provided by SPSS modeler 18.0.Results:Two hundred and thirty-six Chinese patent medicine prescriptions that met the requirements were collected,containing 349 Chinese medicines in total,with a total frequency of 2,277.The drugs with frequency≥25 times were high-frequency drugs,with a total of 24 flavours,and the top 5 were Dahuang(Rhei radix et rhizoma),Huangqin(Scutellariae radix),Gancao(Glycyrrhizae radix et rhizoma),Huanglian(Coptidis rhizoma)and Bohe(Menthae haplocalycis herba).The top 3 frequency of efficacy of high-frequency drugs were“Heat-Clearing(remove heat from the body surface and inside)”drugs,“Purgating(to promote excretion of stools)”drugs and“Reinforcing”(to supplement the body’s lack of“Qi,Blood,Yin and Yang”)drugs.The nature of high-frequency drugs were cold,warm and flat.The top 3 flavour of the high frequency drugs were bitter,spicy and sweet.The top 4 channel tropism of high-frequency drugs were“Spleen”,“Stomach”,“Lung”,“Large intestine”.According to the association rule,11 drug pairs were obtained,and the core drug pairs were Zhizi(Gardeniae fructus)-Rhei radix et rhizoma,Huangbo(Phellodendri chinensis cortex)-Rhei radix et rhizoma.Four new methods were obtained based on cluster analysis.Conclusion:Chinese patent medicine has a certain regularity in the treatment of constipation.This paper can provide some references for the clinical treatment of constipation with Chinese medicine.
文摘Hirudin is an active ingredient extracted from leeches(Hirudo).At present,there are many hirudin preparations on the market,which are roughly divided into three categories,the first is natural hirudin,the second is hirudin derivatives such as lepirudin,desirudin and bivalirudin,and the third is new hirudin preparations such as hirudin-bovine serum albumin(BSA)nanoparticles,polydopamine fitted titanium dioxide nanoparticles systems and recombinant hirudins-2(rhv2)-loaded picmice.The pharmacological effects and adverse reactions of hirudin were reviewed to evaluate its safety,efficacy and quality control.Hirudin has obvious pharmacological effects on cardio-cerebrovascular diseases(coronary atherosclerotic heart disease,myocardial infarction,hyperlipidemia,cerebral infarction,arteriosclerosis obliterans of lower extremities),angiogenesis(fracture,skinflaptransplantation),tissue fibrosis,tumor,ophthalmopathy,hyperuricemia and female infertility.However,attention should be paid to clinical adverse reactions(bleeding,allergic reaction,infection,cutaneous pseudolymphoma).
