Future wireless communication systemembraces physical-layer signal detection with highsensitivity, especially in the microwave photon level.Currently, the receiver primarily adopts the signal detection based on semi-c...Future wireless communication systemembraces physical-layer signal detection with highsensitivity, especially in the microwave photon level.Currently, the receiver primarily adopts the signal detection based on semi-conductor devices for signal detection, while this paper introduces high-sensitivityphoton-level microwave detection based on superconducting structure. We first overview existing works onthe photon-level communication in the optical spectrum as well as the microwave photon-level sensingbased on superconducting structure in both theoreticaland experimental perspectives, including microwavedetection circuit model based on Josephson junction,microwave photon counter based on Josephson junction, and two reconstruction approaches under background noise. In addition, we characterize channelmodeling based on two different microwave photondetection approaches, including the absorption barrierand the dual-path Handury Brown-Twiss (HBT) experiments, and predict the corresponding achievablerates. According to the performance prediction, it isseen that the microwave photon-level signal detectioncan increase the receiver sensitivity compared withthe state-of-the-art standardized communication system with waveform signal reception, with gain over 10dB.展开更多
Objective:To analyze the visual functions of the elder people in China by Useful Field of View (UFOV) to verify performances in Chinese elders.Methods:A total of 90 participants aged 60 years or above were recruited f...Objective:To analyze the visual functions of the elder people in China by Useful Field of View (UFOV) to verify performances in Chinese elders.Methods:A total of 90 participants aged 60 years or above were recruited from residents in the Jiade Senior Apartment and the Fuchengmen Public Health Community in Beijing.Participants completed three tests,Mini Mental State Examination (NMSE),Digit Span test and UFOV.We also tested the digit span and UFOV the following year.Results:The correlation between age and MMSE score was significant (r =-0.422,P <.001).Digit Span scores showed significant negative relationships for all three subtests (P <.01) between ages.The scores of UFOV test 1 showed a non-significant correlation with age,r =0.147,P >.1,while UFOV test 2 and UFOV test 3 showed significant positive relationships with ages,(both P <.01).Thirty-nine participants (out of 90) finished the digit span and UFOV the following year.Only UFOV test 3 has a significant differential performance between two years (t =-2.95,P <.01).We found UFOV tests showed the visual response capacity and had a strong correlation with ages (statistically significant).Conclusion:UFOV could be an effective way to evaluate cognitive ability in Chinese elderly people and the selective-attention test of UFOV may be a more sensitive measurement.展开更多
AIM: To explore hemodynamics and vasoactive substance levels during renal vein congestion that occurs in the anhepatic phase of liver transplantation.METHODS: New Zealand rabbits received ligation of the hepatic pedic...AIM: To explore hemodynamics and vasoactive substance levels during renal vein congestion that occurs in the anhepatic phase of liver transplantation.METHODS: New Zealand rabbits received ligation of the hepatic pedicle, supra-hepatic vena cava and infrahepatic vena cava [anhepatic phase group(APH); n = 8], the renal veins(RVL; n = 8), renal veins and hepatic pedicle [with the inferior vena cava left open)(RVHP; n = 8)], or a sham operation(SOP; n = 8). Hemodynamic parameters(systolic, diastolic, and mean arterial blood pressures) and the levels of serum bradykinin(BK) and angiotensin Ⅱ(ANGII) were measured at baseline(0 min), and 10 min, 20 min, 30 min, and 45 min after the surgery. Correlation analyses were performed to evaluate the associations between hemodynamic parameters and levels of vasoactive substances.RESULTS:All experimental groups(APH,RVL,and RVHP)showed significant decreases in hemodynamic parameters(systolic,diastolic,and mean arterial blood pressures)compared to baseline levels,as well as compared to the SOP controls(P<0.05 for all).In contrast,BK levels were significantly increased compared to baseline in the APH,RVL,and RVHP groups at all time points measured(P<0.05 for all),whereas no change was observed in the SOP controls.There were no significant differences among the experimental groups for any measure at any time point.Further analyses revealed that systolic,diastolic,and mean arterial blood pressures were all negatively correlated with BK levels,and positively correlated with ANGII levels in the APH,RVL,and RVHP groups(P<0.05 for all).CONCLUSION:In the anhepatic phase of orthotopic liver transplantation,renal vein congestion significantly impacts hemodynamic parameters,which correlate with serum BK and ANGII levels.展开更多
We provide an overview of the recent progresses on the system architecture design and performance prediction for microwave signal detection under weak signal intensity regime,up to quantumized level.The technique road...We provide an overview of the recent progresses on the system architecture design and performance prediction for microwave signal detection under weak signal intensity regime,up to quantumized level.The technique roadmap includes two perspectives,the opto-electro-mechanical(OEM)and superconducting devices.For the former one,we first overview the concept of OEM,and then introduce the signal detection based on capacitive-opto-electro-mechanical systems and piezoopto-electro-mechanical systems.For the latter one,we first overview the concept and architecture of Josephson junction,and then introduce the signal detection based on superconducting Hanbury Brown-Twiss(HBT)experiments andΛenergy-level splitting system.Besides,we review the microwave detection based on Rydberg atom system.We believe that this overview can provide a guidance for future transmission limit,signal processing,detection device fabrication and real experiments.展开更多
In this work, we propose a new scheme to generate frequency-doubled vortex beams from a radially poled Li Nb O3 micro-ring resonator based on nonlinear Cherenkov radiation. The near-infrared fundamental wave is resona...In this work, we propose a new scheme to generate frequency-doubled vortex beams from a radially poled Li Nb O3 micro-ring resonator based on nonlinear Cherenkov radiation. The near-infrared fundamental wave is resonant in the micro-ring, while the second harmonic is emitted from the resonator along the Cherenkov phase-matching direction. The topological charge of the emitted second-harmonic vortex beam is determined by both the azimuthal order of the whispering galley modes and the number of nonlinear grating elements. The field distribution and the conversion efficiency of the emitted vortex beam are investigated.展开更多
Transgenesis, which inserts exogenous DNA into animal genomes, is a widely used technique. Traditionally, the constructs for transgenesis are generated by step-by-step subcloning of DNA fragments, which requires multi...Transgenesis, which inserts exogenous DNA into animal genomes, is a widely used technique. Traditionally, the constructs for transgenesis are generated by step-by-step subcloning of DNA fragments, which requires multiple steps depending on the construct complexity. To overcome the limitation, advanced tools such as Gateway cloning (Hartley et al., 2000;Kwan et al., 2007), In-Fusion cloning (Sleight et al., 2010), and Gibson assembly (Gibson et al., 2009) have been developed. However, due to their ligation characteristics, no systematic method for transgenesis has been developed. ‘Golden Gate’ cloning first appeared in 2008, which is a widely used DNA assembly method (Engler et al., 2008, 2009). Here, we take zebrafish transgenesis as an example and develop a standardized system called GoldenFish, which is based on Golden Gate cloning. It can customize transgenic constructs in one step and can be applied to multiple types of transgenesis such as one gene driven by one promoter, multiple genes driven by one promoter, and multiple genes respectively driven by multiple promoters, significantly reducing working time.展开更多
基金National Key Research and Development Program of China(Grant No.2018YFB1801904)Key Program of National Natural Science Foundation of China(Grant No.61631018)Key Research Program of Frontier Sciences of CAS(Grant No.QYZDY-SSW-JSC003).
文摘Future wireless communication systemembraces physical-layer signal detection with highsensitivity, especially in the microwave photon level.Currently, the receiver primarily adopts the signal detection based on semi-conductor devices for signal detection, while this paper introduces high-sensitivityphoton-level microwave detection based on superconducting structure. We first overview existing works onthe photon-level communication in the optical spectrum as well as the microwave photon-level sensingbased on superconducting structure in both theoreticaland experimental perspectives, including microwavedetection circuit model based on Josephson junction,microwave photon counter based on Josephson junction, and two reconstruction approaches under background noise. In addition, we characterize channelmodeling based on two different microwave photondetection approaches, including the absorption barrierand the dual-path Handury Brown-Twiss (HBT) experiments, and predict the corresponding achievablerates. According to the performance prediction, it isseen that the microwave photon-level signal detectioncan increase the receiver sensitivity compared withthe state-of-the-art standardized communication system with waveform signal reception, with gain over 10dB.
文摘Objective:To analyze the visual functions of the elder people in China by Useful Field of View (UFOV) to verify performances in Chinese elders.Methods:A total of 90 participants aged 60 years or above were recruited from residents in the Jiade Senior Apartment and the Fuchengmen Public Health Community in Beijing.Participants completed three tests,Mini Mental State Examination (NMSE),Digit Span test and UFOV.We also tested the digit span and UFOV the following year.Results:The correlation between age and MMSE score was significant (r =-0.422,P <.001).Digit Span scores showed significant negative relationships for all three subtests (P <.01) between ages.The scores of UFOV test 1 showed a non-significant correlation with age,r =0.147,P >.1,while UFOV test 2 and UFOV test 3 showed significant positive relationships with ages,(both P <.01).Thirty-nine participants (out of 90) finished the digit span and UFOV the following year.Only UFOV test 3 has a significant differential performance between two years (t =-2.95,P <.01).We found UFOV tests showed the visual response capacity and had a strong correlation with ages (statistically significant).Conclusion:UFOV could be an effective way to evaluate cognitive ability in Chinese elderly people and the selective-attention test of UFOV may be a more sensitive measurement.
基金Supported by Natural Science Foundation of Gansu Province,China,No.3ZS051-A25-104Clinical Medicine Research Special Funds of Chinese Medical Association,China,No.14040360573
文摘AIM: To explore hemodynamics and vasoactive substance levels during renal vein congestion that occurs in the anhepatic phase of liver transplantation.METHODS: New Zealand rabbits received ligation of the hepatic pedicle, supra-hepatic vena cava and infrahepatic vena cava [anhepatic phase group(APH); n = 8], the renal veins(RVL; n = 8), renal veins and hepatic pedicle [with the inferior vena cava left open)(RVHP; n = 8)], or a sham operation(SOP; n = 8). Hemodynamic parameters(systolic, diastolic, and mean arterial blood pressures) and the levels of serum bradykinin(BK) and angiotensin Ⅱ(ANGII) were measured at baseline(0 min), and 10 min, 20 min, 30 min, and 45 min after the surgery. Correlation analyses were performed to evaluate the associations between hemodynamic parameters and levels of vasoactive substances.RESULTS:All experimental groups(APH,RVL,and RVHP)showed significant decreases in hemodynamic parameters(systolic,diastolic,and mean arterial blood pressures)compared to baseline levels,as well as compared to the SOP controls(P<0.05 for all).In contrast,BK levels were significantly increased compared to baseline in the APH,RVL,and RVHP groups at all time points measured(P<0.05 for all),whereas no change was observed in the SOP controls.There were no significant differences among the experimental groups for any measure at any time point.Further analyses revealed that systolic,diastolic,and mean arterial blood pressures were all negatively correlated with BK levels,and positively correlated with ANGII levels in the APH,RVL,and RVHP groups(P<0.05 for all).CONCLUSION:In the anhepatic phase of orthotopic liver transplantation,renal vein congestion significantly impacts hemodynamic parameters,which correlate with serum BK and ANGII levels.
基金National Key Research and Development Program of China(2018YFB1801904)Key Program of National Natural Science Foundation of China(61631018)+1 种基金Key Research Program of Frontier Sciences of CAS(QYZDY-SSWJSC003)Huawei Innovation Project。
文摘We provide an overview of the recent progresses on the system architecture design and performance prediction for microwave signal detection under weak signal intensity regime,up to quantumized level.The technique roadmap includes two perspectives,the opto-electro-mechanical(OEM)and superconducting devices.For the former one,we first overview the concept of OEM,and then introduce the signal detection based on capacitive-opto-electro-mechanical systems and piezoopto-electro-mechanical systems.For the latter one,we first overview the concept and architecture of Josephson junction,and then introduce the signal detection based on superconducting Hanbury Brown-Twiss(HBT)experiments andΛenergy-level splitting system.Besides,we review the microwave detection based on Rydberg atom system.We believe that this overview can provide a guidance for future transmission limit,signal processing,detection device fabrication and real experiments.
基金supported by the National Key R&D Program of China(Nos.2019YFA0705000,2017YFA0303700 and 2017YFB0405204)the National Natural Science Foundation of China(NSFC)(Nos.11674171,91950206,51890861 and 11627810)+1 种基金the Leading-edge Technology Program of Jiangsu Natural Science Foundation(No.BK20192001)the Key R&D Program of Guangdong Province(No.2018B030329001)
文摘In this work, we propose a new scheme to generate frequency-doubled vortex beams from a radially poled Li Nb O3 micro-ring resonator based on nonlinear Cherenkov radiation. The near-infrared fundamental wave is resonant in the micro-ring, while the second harmonic is emitted from the resonator along the Cherenkov phase-matching direction. The topological charge of the emitted second-harmonic vortex beam is determined by both the azimuthal order of the whispering galley modes and the number of nonlinear grating elements. The field distribution and the conversion efficiency of the emitted vortex beam are investigated.
基金supported by the National Natural Science Foundation of China(32270859,32000576,and32192400)the National Key R&D Program of China(2021YFA0805000)the Natural ScienceeFoundationofChongqing(cstc2020jcyj-msxmX0882).
文摘Transgenesis, which inserts exogenous DNA into animal genomes, is a widely used technique. Traditionally, the constructs for transgenesis are generated by step-by-step subcloning of DNA fragments, which requires multiple steps depending on the construct complexity. To overcome the limitation, advanced tools such as Gateway cloning (Hartley et al., 2000;Kwan et al., 2007), In-Fusion cloning (Sleight et al., 2010), and Gibson assembly (Gibson et al., 2009) have been developed. However, due to their ligation characteristics, no systematic method for transgenesis has been developed. ‘Golden Gate’ cloning first appeared in 2008, which is a widely used DNA assembly method (Engler et al., 2008, 2009). Here, we take zebrafish transgenesis as an example and develop a standardized system called GoldenFish, which is based on Golden Gate cloning. It can customize transgenic constructs in one step and can be applied to multiple types of transgenesis such as one gene driven by one promoter, multiple genes driven by one promoter, and multiple genes respectively driven by multiple promoters, significantly reducing working time.
