This article explores the geographical factors of polycystic ovary syndrome(PCOS)based on the prevalence of PCOS in selected regions of the world and the associated data and thus proposes a proposal for the establishm...This article explores the geographical factors of polycystic ovary syndrome(PCOS)based on the prevalence of PCOS in selected regions of the world and the associated data and thus proposes a proposal for the establishment of a regionally differentiated PCOS survey and awareness program.As a common infertility problem in women of reproductive age,PCOS shows significant geographical differences around the world,and its prevalence is associated with ethnicity and genetic factors.At the same time,PCOS does not have a fully actual pathogen,a definitive diagnostic name,or associated physiological changes.Its prevalence depends on the epidemiological design and criteria used to study the disease.Thus,a single ESHRE/ASRM diagnosis should be avoided as far as possible in mass prevalence surveys and promotion of PCOS,incorporating local high prevalence signs,reducing the cost of PCOS diagnosis,providing more accurate diagnostic criteria,establishing differential PCOS survey protocols to improve the efficiency of mass self-testing as well as social prevalence,making early diagnosis and treatment,and predicting the direction of local PCOS trends for provide a timely response.It may improve women's health,reduce infertility,and increase local fertility rates.展开更多
This paper presents a novel design method for discrete-time repetitive control systems （RCS） based on two-dimensional （2D） discrete-time model. Firstly, the 2D model of an RCS is established by considering both th...This paper presents a novel design method for discrete-time repetitive control systems （RCS） based on two-dimensional （2D） discrete-time model. Firstly, the 2D model of an RCS is established by considering both the control action and the learning action in RCS. Then, through constructing a 2D state feedback controller, the design problem of the RCS is converted to the design problem of a 2D system. Then, using 2D system theory and linear matrix inequality （LMI） method, stability criterion is derived for the system without and with uncertainties, respectively. Parameters of the system can be determined by solving the LMI of the stability criterion. Finally, numerical simulations validate the effectiveness of the proposed method.展开更多
Delimiting species requires multiple sources of evidence.Here,we delimited two varieties of Halenia elliptica(Gentianaceae)using several lines of evidence,including morphological traits and mating system in a sympatri...Delimiting species requires multiple sources of evidence.Here,we delimited two varieties of Halenia elliptica(Gentianaceae)using several lines of evidence,including morphological traits and mating system in a sympatric population,phylogenetic relationships based on nrITS and cpDNA(rpl16)data,and complete chloroplast genome sequences.Comparative analysis of 21 morphological traits clearly separates the two varieties of H.elliptica.Examination of the flowering process and pollination treatments indicate that H.elliptica var.grandiflora produces seeds via outcrossing,whereas H.elliptica var.elliptica produces seeds via mixed mating.Furthermore,hand-pollinated hybridization of the two varieties produced no seeds.Observations of pollinators showed that when bees began a pollination bout on H.elliptica var.grandiflora they preferred to continue pollinating this variety;however,when they began a pollination bout on H.elliptica var.elliptica,they showed no preference for either variety.Phylogenetic analysis confirmed the monophyly of H.elliptica,which was further divided into two monophyletic clades corresponding to the two varieties.A large number of variants from the chloroplast genomes reflected remarkable genetic dissimilarities between the two varieties of H.elliptica.We recommend that the two varieties of H.elliptica should be revised as two species(H.elliptica and H.grandiflora).Our findings indicate that H.elliptica varieties may have split into two separate species due to a shift in mating system,changes in flowering phenology and/or post-pollination reproductive isolation.展开更多
Optical nanofiber(ONF) is a special tool for effectively controlling coupling of light and atoms. In this paper, we study the ladder-type electromagnetically induced transparent(EIT) under ultralow power level in a wa...Optical nanofiber(ONF) is a special tool for effectively controlling coupling of light and atoms. In this paper, we study the ladder-type electromagnetically induced transparent(EIT) under ultralow power level in a warm cesium vapor by observing the transmission of ONF that couples the 6 S → 6 P Cs atoms in the presence of a 6 P → 8 S control beam through the same fiber. The linewidth and transmission of the EIT signal are investigated at different intensities of the control laser. In addition, we theoretically study the nonlinear interaction at the ONF interface using the multi-level density matrix equations, and obtain good agreements between theory and experiments. The results may have great significance for further study of optical nonlinear effect at low power level.展开更多
Objective： To review the prevalence and prognostic significance of fibroblast growth factor receptor 1 （FGFRI） amplification and to establish an association between FGFRI amplification and the clinical characterist...Objective： To review the prevalence and prognostic significance of fibroblast growth factor receptor 1 （FGFRI） amplification and to establish an association between FGFRI amplification and the clinical characteristics of nonsmall cell lung cancer （NSCLC）. Data Sources： We searched PubMed for English-language studies published between January 2010 and May 2016. Study Selection： We included all relevant articles, with no limitation of study design. Results： FGFRI amplification was reported in 8.7-20.0% of NSCLC cases and was significantly more frequent in squamous cell carcinomas （SCCs） （9.7-28.3%） than in adenocarcinomas （ADCs） （0-15.0%）. The rates of FGFRI amplification were as follows： males, 13.9-22.1%; females, 0-20.1%; Stage 1 NSCLC, 9.3-24.1%; Stage II NSCLC, 12.9-25.0%; Stage 111 NSCLC, 8.2-19.5%： Stage IV NSCLC, 0-12.5%; current smokers, 13.3-29.0%; former smokers, 2.5-23.0%; and nonsmokers, 0-22.2%. Overall survival was 43.9-70.8 months in patients with FGFRI amplification and 42.4-115.0 months in patients with no FGFRI amplification; disease-free survival was 22.5-58.5 months and 52.4-94.6 months, respectively. Conclusions： FGFR1 amplification is more frequent in SCCs than in ADCs. The association between FGFRI amplification and clinical characteristics （gender, smoking status, and disease stage） and the prognostic significance of FGFRI amplification in NSCLC remain controversial.展开更多
In this paper, a new analysis and design method for proportional-integrative-derivative （PID） tuning is proposed based on controller scaling analysis. Integral of time absolute error （ITAE） index is minimized for ...In this paper, a new analysis and design method for proportional-integrative-derivative （PID） tuning is proposed based on controller scaling analysis. Integral of time absolute error （ITAE） index is minimized for specified gain and phase margins （GPM） constraints, so that the transient performance and robustness are both satisfied. The requirements on gain and phase margins are ingeniously formulated by real part constraints （RPC） and imaginary part constraints （IPC）. This set of new constraints is simply related with three parameters and decoupling of the remaining four unknowns, including three controller parameters and the gain margin, in the nonlinear and coupled characteristic equation simultaneously. The formulas of the optimal GPM-PID are derived based on controller scaling analysis. Finally, this method is applied to liquid level control of coke fractionation tower, which demonstrate that the proposed method provides better disturbance rejection and robust tracking performance than some commonly used PID tuning methods.展开更多
文摘This article explores the geographical factors of polycystic ovary syndrome(PCOS)based on the prevalence of PCOS in selected regions of the world and the associated data and thus proposes a proposal for the establishment of a regionally differentiated PCOS survey and awareness program.As a common infertility problem in women of reproductive age,PCOS shows significant geographical differences around the world,and its prevalence is associated with ethnicity and genetic factors.At the same time,PCOS does not have a fully actual pathogen,a definitive diagnostic name,or associated physiological changes.Its prevalence depends on the epidemiological design and criteria used to study the disease.Thus,a single ESHRE/ASRM diagnosis should be avoided as far as possible in mass prevalence surveys and promotion of PCOS,incorporating local high prevalence signs,reducing the cost of PCOS diagnosis,providing more accurate diagnostic criteria,establishing differential PCOS survey protocols to improve the efficiency of mass self-testing as well as social prevalence,making early diagnosis and treatment,and predicting the direction of local PCOS trends for provide a timely response.It may improve women's health,reduce infertility,and increase local fertility rates.
基金supported by National Natural Science Foundation of China (Nos. 60974045 and 60674016)the Research Foundation of Education Bureau of Hunan Province, China (No. 08C090)
文摘This paper presents a novel design method for discrete-time repetitive control systems （RCS） based on two-dimensional （2D） discrete-time model. Firstly, the 2D model of an RCS is established by considering both the control action and the learning action in RCS. Then, through constructing a 2D state feedback controller, the design problem of the RCS is converted to the design problem of a 2D system. Then, using 2D system theory and linear matrix inequality （LMI） method, stability criterion is derived for the system without and with uncertainties, respectively. Parameters of the system can be determined by solving the LMI of the stability criterion. Finally, numerical simulations validate the effectiveness of the proposed method.
基金the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(2019QZKK0502)National Key R&D Program of China(2017YFC0505200)+1 种基金National Natural Science Foundation of China(31460096 and 31590823)State Key Laboratory of Phytochemistry and Plant Resources in West China(P2020-KF04).
文摘Delimiting species requires multiple sources of evidence.Here,we delimited two varieties of Halenia elliptica(Gentianaceae)using several lines of evidence,including morphological traits and mating system in a sympatric population,phylogenetic relationships based on nrITS and cpDNA(rpl16)data,and complete chloroplast genome sequences.Comparative analysis of 21 morphological traits clearly separates the two varieties of H.elliptica.Examination of the flowering process and pollination treatments indicate that H.elliptica var.grandiflora produces seeds via outcrossing,whereas H.elliptica var.elliptica produces seeds via mixed mating.Furthermore,hand-pollinated hybridization of the two varieties produced no seeds.Observations of pollinators showed that when bees began a pollination bout on H.elliptica var.grandiflora they preferred to continue pollinating this variety;however,when they began a pollination bout on H.elliptica var.elliptica,they showed no preference for either variety.Phylogenetic analysis confirmed the monophyly of H.elliptica,which was further divided into two monophyletic clades corresponding to the two varieties.A large number of variants from the chloroplast genomes reflected remarkable genetic dissimilarities between the two varieties of H.elliptica.We recommend that the two varieties of H.elliptica should be revised as two species(H.elliptica and H.grandiflora).Our findings indicate that H.elliptica varieties may have split into two separate species due to a shift in mating system,changes in flowering phenology and/or post-pollination reproductive isolation.
基金Project supported by the National Key Research and Development Program of China(Grant No.2017YFA0304203)the National Natural Science Foundation of China(Grant Nos.61675120,11434007,and 61875110)+2 种基金Project of the National Natural Science Foundation of China for Excellent Research Team(Grant No.61121064)the Shanxi “1331 Project” Key Subjects Construction,PCSIRT,China(Grant No.IRT_17R70)the 111 Project,China(Grant No.D18001)
文摘Optical nanofiber(ONF) is a special tool for effectively controlling coupling of light and atoms. In this paper, we study the ladder-type electromagnetically induced transparent(EIT) under ultralow power level in a warm cesium vapor by observing the transmission of ONF that couples the 6 S → 6 P Cs atoms in the presence of a 6 P → 8 S control beam through the same fiber. The linewidth and transmission of the EIT signal are investigated at different intensities of the control laser. In addition, we theoretically study the nonlinear interaction at the ONF interface using the multi-level density matrix equations, and obtain good agreements between theory and experiments. The results may have great significance for further study of optical nonlinear effect at low power level.
文摘Objective： To review the prevalence and prognostic significance of fibroblast growth factor receptor 1 （FGFRI） amplification and to establish an association between FGFRI amplification and the clinical characteristics of nonsmall cell lung cancer （NSCLC）. Data Sources： We searched PubMed for English-language studies published between January 2010 and May 2016. Study Selection： We included all relevant articles, with no limitation of study design. Results： FGFRI amplification was reported in 8.7-20.0% of NSCLC cases and was significantly more frequent in squamous cell carcinomas （SCCs） （9.7-28.3%） than in adenocarcinomas （ADCs） （0-15.0%）. The rates of FGFRI amplification were as follows： males, 13.9-22.1%; females, 0-20.1%; Stage 1 NSCLC, 9.3-24.1%; Stage II NSCLC, 12.9-25.0%; Stage 111 NSCLC, 8.2-19.5%： Stage IV NSCLC, 0-12.5%; current smokers, 13.3-29.0%; former smokers, 2.5-23.0%; and nonsmokers, 0-22.2%. Overall survival was 43.9-70.8 months in patients with FGFRI amplification and 42.4-115.0 months in patients with no FGFRI amplification; disease-free survival was 22.5-58.5 months and 52.4-94.6 months, respectively. Conclusions： FGFR1 amplification is more frequent in SCCs than in ADCs. The association between FGFRI amplification and clinical characteristics （gender, smoking status, and disease stage） and the prognostic significance of FGFRI amplification in NSCLC remain controversial.
基金supported by National Natural Science Foundation of China(Nos.61403149 and 61273069)Natural Science Foundation of Fujian Province(No.2015J01261)the Scientific Research Foundation of National Huaqiao University
文摘In this paper, a new analysis and design method for proportional-integrative-derivative （PID） tuning is proposed based on controller scaling analysis. Integral of time absolute error （ITAE） index is minimized for specified gain and phase margins （GPM） constraints, so that the transient performance and robustness are both satisfied. The requirements on gain and phase margins are ingeniously formulated by real part constraints （RPC） and imaginary part constraints （IPC）. This set of new constraints is simply related with three parameters and decoupling of the remaining four unknowns, including three controller parameters and the gain margin, in the nonlinear and coupled characteristic equation simultaneously. The formulas of the optimal GPM-PID are derived based on controller scaling analysis. Finally, this method is applied to liquid level control of coke fractionation tower, which demonstrate that the proposed method provides better disturbance rejection and robust tracking performance than some commonly used PID tuning methods.
