BACKGROUND By comprehensively analyzing the blood flow parameters of the umbilical and middle cerebral arteries,doctors can more accurately identify fetal intrauterine distress,as well as assess its severity,so that t...BACKGROUND By comprehensively analyzing the blood flow parameters of the umbilical and middle cerebral arteries,doctors can more accurately identify fetal intrauterine distress,as well as assess its severity,so that timely interventions can be implemented to safeguard the health and safety of the fetus.AIM To identify the relationship between ultrasound parameters of the umbilical and middle cerebral arteries and intrauterine distress.METHODS Clinical data of pregnant women admitted between January 2021 and January 2023 were collected and divided into the observation and control groups(n=50 each),according to the presence or absence of intrauterine distress.The ultrasound hemodynamic parameters of the uterine artery(UtA),fetal middle cerebral artery(MCA),and umbilical artery(UmA)were compared with neonatal outcomes and occurrence of intrauterine distress in the two groups.RESULTS Comparison of ultrasonic hemodynamic parameters,resistance index(RI),pulsatility index(PI),and systolic maximal blood flow velocity of UmA compared to diastolic blood flow velocity(S/D),revealed higher values of fetal MCA,PI,and S/D of UmA in pregnant women with UtA compared to controls(P<0.05),while there was no difference between the two groups in terms of RI(P<0.05)The incidence of a neonatal Apgar score of 8-10 points was lower in the observation group(66.7%)than in the control group(90.0%),and neonatal weight(2675.5±27.6 g)was lower than in the control group(3117.5±31.2 g).Further,cesarean section rate was higher in the observation group(70.0%)than in the control group(11.7%),and preterm labor rate was higher in the observation group(40.0%)than in the control group(10.0%).The incidence of fetal distress,neonatal growth restriction and neonatal asphyxia were also higher in the observation group(all P<0.05).CONCLUSION Fetal MCA,UmA,and maternal UtA hemodynamic abnormalities all develop in pregnant women with intrauterine distress during late pregnancy,which suggests that clinical attention should be paid to them,and monitoring should be strengthened to provide guidance for clinical intervention.展开更多
Objective:To investigate the effects of pre-eclampsia (PE) on blood biochemical parameters and pregnancy outcomes in patients with intrahepatic cholestasis of pregnancy (ICP). Methods: The study subjects selected 180 ...Objective:To investigate the effects of pre-eclampsia (PE) on blood biochemical parameters and pregnancy outcomes in patients with intrahepatic cholestasis of pregnancy (ICP). Methods: The study subjects selected 180 patients with ICP who were admitted to our hospital from January 2016 to January 2018. Among them, 45 patients with PE were marked as observation group, and the remaining 135 patients with ICP were labeled as control group. The liver function indicators, serum inflammatory factor index levels, and differences between pregnancy outcomes and neonatal outcomes were compared between the two groups.Results:The liver function indexes (ALT, AST, GGT, TBA, TBIL) in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P<0.01). The levels of serum IL-12, TNF-α and SOCS-3 in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P<0.01). The gestational weeks (36.89±0.55) of the observation group were significantly shorter than the control group (38.68±0.59), and the difference was statistically significant (t=18.56,P=0.00). The cesarean section rate and amniotic fluid rate in the observation group were observed. They were significantly higher than the control group, and the differences were statistically significant (P<0.01). The neonatal weight of the observation group (3.05±0.32) was significantly lower than that of the control group (3.39±0.45), and the difference was statistically significant (t=5.53,P=0.00). The premature birth rate, fetal distress rate, neonate in the observation group. The asphyxiation rate was significantly higher than that of the control group, and the difference was statistically significant (P<0.05).Conclusion:Preeclampsia can aggravate liver function damage and serum inflammatory factor levels in patients with intrahepatic cholestasis of pregnancy. It is an important risk factor for pregnancy outcome and neonatal outcome, and it is worthy of attention in clinical diagnosis and treatment.展开更多
文摘BACKGROUND By comprehensively analyzing the blood flow parameters of the umbilical and middle cerebral arteries,doctors can more accurately identify fetal intrauterine distress,as well as assess its severity,so that timely interventions can be implemented to safeguard the health and safety of the fetus.AIM To identify the relationship between ultrasound parameters of the umbilical and middle cerebral arteries and intrauterine distress.METHODS Clinical data of pregnant women admitted between January 2021 and January 2023 were collected and divided into the observation and control groups(n=50 each),according to the presence or absence of intrauterine distress.The ultrasound hemodynamic parameters of the uterine artery(UtA),fetal middle cerebral artery(MCA),and umbilical artery(UmA)were compared with neonatal outcomes and occurrence of intrauterine distress in the two groups.RESULTS Comparison of ultrasonic hemodynamic parameters,resistance index(RI),pulsatility index(PI),and systolic maximal blood flow velocity of UmA compared to diastolic blood flow velocity(S/D),revealed higher values of fetal MCA,PI,and S/D of UmA in pregnant women with UtA compared to controls(P<0.05),while there was no difference between the two groups in terms of RI(P<0.05)The incidence of a neonatal Apgar score of 8-10 points was lower in the observation group(66.7%)than in the control group(90.0%),and neonatal weight(2675.5±27.6 g)was lower than in the control group(3117.5±31.2 g).Further,cesarean section rate was higher in the observation group(70.0%)than in the control group(11.7%),and preterm labor rate was higher in the observation group(40.0%)than in the control group(10.0%).The incidence of fetal distress,neonatal growth restriction and neonatal asphyxia were also higher in the observation group(all P<0.05).CONCLUSION Fetal MCA,UmA,and maternal UtA hemodynamic abnormalities all develop in pregnant women with intrauterine distress during late pregnancy,which suggests that clinical attention should be paid to them,and monitoring should be strengthened to provide guidance for clinical intervention.
文摘Objective:To investigate the effects of pre-eclampsia (PE) on blood biochemical parameters and pregnancy outcomes in patients with intrahepatic cholestasis of pregnancy (ICP). Methods: The study subjects selected 180 patients with ICP who were admitted to our hospital from January 2016 to January 2018. Among them, 45 patients with PE were marked as observation group, and the remaining 135 patients with ICP were labeled as control group. The liver function indicators, serum inflammatory factor index levels, and differences between pregnancy outcomes and neonatal outcomes were compared between the two groups.Results:The liver function indexes (ALT, AST, GGT, TBA, TBIL) in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P<0.01). The levels of serum IL-12, TNF-α and SOCS-3 in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P<0.01). The gestational weeks (36.89±0.55) of the observation group were significantly shorter than the control group (38.68±0.59), and the difference was statistically significant (t=18.56,P=0.00). The cesarean section rate and amniotic fluid rate in the observation group were observed. They were significantly higher than the control group, and the differences were statistically significant (P<0.01). The neonatal weight of the observation group (3.05±0.32) was significantly lower than that of the control group (3.39±0.45), and the difference was statistically significant (t=5.53,P=0.00). The premature birth rate, fetal distress rate, neonate in the observation group. The asphyxiation rate was significantly higher than that of the control group, and the difference was statistically significant (P<0.05).Conclusion:Preeclampsia can aggravate liver function damage and serum inflammatory factor levels in patients with intrahepatic cholestasis of pregnancy. It is an important risk factor for pregnancy outcome and neonatal outcome, and it is worthy of attention in clinical diagnosis and treatment.
