Objective:To investigate the effect of vascular endothelial growth factor(VEGF),P53 and telomerase on angiogenesis in gastric carcinoma tissue.Methods:A total of 95 surgical resection samples of gastric cancer tissue ...Objective:To investigate the effect of vascular endothelial growth factor(VEGF),P53 and telomerase on angiogenesis in gastric carcinoma tissue.Methods:A total of 95 surgical resection samples of gastric cancer tissue after pathological diagnosis are collected to observe the VEGF,P53 and telomerase expression using immunohistochemical methods.Relationship between their expression and its influence on angiogenesis in gastric carcinoma tissue were analyzed.Results:Microvascular density(MVD)and the expression of VEGF,P53 and telomerase were positively correlated.Expression of VEGF and P53 protein were related to tumor type and lymph metastasis,and also a correlation was observed between P53 and VEGF.The telomerase expression had no correlation with VEGF,and P53.Conclusions:VEGF angiogenesis has a angiogenesis promoting effect on gastric cancer tissue development and plays an important role in tumor generation and metastasis.Mutant P53 promotes the tumor angiogenesis generation by adjusting VEGF.Telomerase has a certain role in promoting activity of angiogenesis through different way rather than P53.展开更多
An Al2O3P/Al composite was successfully synthesized using a displacement reaction between 80 wt% Al and20 wt% Cu O powders at a heating rate of 5 °C/min. Two different sizes Cu O particles were used, and all the ...An Al2O3P/Al composite was successfully synthesized using a displacement reaction between 80 wt% Al and20 wt% Cu O powders at a heating rate of 5 °C/min. Two different sizes Cu O particles were used, and all the experiments were conducted under an argon atmosphere. To analyze the microstructural evolution during synthesis, the Al–20 wt%Cu O samples were heated to the temperatures selected according to the differential scanning calorimetry curve and then immediately quenched with water. The phase composites and microstructure of the water-quenching samples were investigated using X-ray diffraction, optical microscopy, scanning electron microscopy and energy-dispersive spectrometry.The results indicate that the Cu O particle size has a significant effect on the microstructural evolution of the samples during the heating stage and on the microstructure of synthesized composites. Smaller Cu O particles can decrease the reaction temperature, narrow the reaction temperature range at the different reaction stages during the heating stage and make the size and distribution of in situ Al2O3 particles more uniform. The reaction between Al and Cu O can be complete as the temperature rises to 900 °C. The size of the in situ Al2O3 particles is approximately 5 lm when the size of the Cu O particles is less than 6 lm. This sample has a relatively high Rockwell hardness of 60 HRB.展开更多
Hot compression behavior of TiC–Al2O3/Al composites was studied using the Gleeble-1500 system at a temperature range of 300–550 °C and at strain rate range of 0.01–10.00 s-1. The associated structural changes ...Hot compression behavior of TiC–Al2O3/Al composites was studied using the Gleeble-1500 system at a temperature range of 300–550 °C and at strain rate range of 0.01–10.00 s-1. The associated structural changes were studied by TEM observations. The results show that stress level decreases with deformation temperature increasing and strain rate decreasing, which can be represented by a Zener–Hollomon parameter in an exponent-type equation with hot deformation activation energy Q of 172.56 kJ·mol-1.Dynamic recovery occurs easily when strain rates are less than 10.00 s-1. Dynamic recrystallization can occur at strain rate of 10.00 s-1.展开更多
An efficient synthesis of 3-(diarylallylidene)oxindoles from 3-(1 H-indol-3-yl)-1,1-diarylpropan-1-ol under metal-free conditions is described.NBS serves as a critical medium leading to a facile oxygenmigration in the...An efficient synthesis of 3-(diarylallylidene)oxindoles from 3-(1 H-indol-3-yl)-1,1-diarylpropan-1-ol under metal-free conditions is described.NBS serves as a critical medium leading to a facile oxygenmigration in the transformation.The protocol has advantages of high efficiency,simple opreation,mild reaction conditions,good atom-economy,wide substrate scope and good yields of products.A detailed mechanism is proposed after careful investigation.展开更多
基金supported by Handan City Technology Bureau Scientific Research Project(No 1023108101-8)
文摘Objective:To investigate the effect of vascular endothelial growth factor(VEGF),P53 and telomerase on angiogenesis in gastric carcinoma tissue.Methods:A total of 95 surgical resection samples of gastric cancer tissue after pathological diagnosis are collected to observe the VEGF,P53 and telomerase expression using immunohistochemical methods.Relationship between their expression and its influence on angiogenesis in gastric carcinoma tissue were analyzed.Results:Microvascular density(MVD)and the expression of VEGF,P53 and telomerase were positively correlated.Expression of VEGF and P53 protein were related to tumor type and lymph metastasis,and also a correlation was observed between P53 and VEGF.The telomerase expression had no correlation with VEGF,and P53.Conclusions:VEGF angiogenesis has a angiogenesis promoting effect on gastric cancer tissue development and plays an important role in tumor generation and metastasis.Mutant P53 promotes the tumor angiogenesis generation by adjusting VEGF.Telomerase has a certain role in promoting activity of angiogenesis through different way rather than P53.
基金financially supported by the Inner Mongolia Natural Science Foundation of China (Nos. 2012MS0801 and 2013MS0804)
文摘An Al2O3P/Al composite was successfully synthesized using a displacement reaction between 80 wt% Al and20 wt% Cu O powders at a heating rate of 5 °C/min. Two different sizes Cu O particles were used, and all the experiments were conducted under an argon atmosphere. To analyze the microstructural evolution during synthesis, the Al–20 wt%Cu O samples were heated to the temperatures selected according to the differential scanning calorimetry curve and then immediately quenched with water. The phase composites and microstructure of the water-quenching samples were investigated using X-ray diffraction, optical microscopy, scanning electron microscopy and energy-dispersive spectrometry.The results indicate that the Cu O particle size has a significant effect on the microstructural evolution of the samples during the heating stage and on the microstructure of synthesized composites. Smaller Cu O particles can decrease the reaction temperature, narrow the reaction temperature range at the different reaction stages during the heating stage and make the size and distribution of in situ Al2O3 particles more uniform. The reaction between Al and Cu O can be complete as the temperature rises to 900 °C. The size of the in situ Al2O3 particles is approximately 5 lm when the size of the Cu O particles is less than 6 lm. This sample has a relatively high Rockwell hardness of 60 HRB.
基金financially supported by the Inner Mongolia Science and Technology Reward Foundation(No.20101707)the Inner Mongolia Natural Science Foundation(No.2013MS0804)+1 种基金the Inner Mongolia High School Scientific Research Foundation(No.NJZZ14056)the Inner Mongolia University of Technology Foundation(No.ZD20120015)
文摘Hot compression behavior of TiC–Al2O3/Al composites was studied using the Gleeble-1500 system at a temperature range of 300–550 °C and at strain rate range of 0.01–10.00 s-1. The associated structural changes were studied by TEM observations. The results show that stress level decreases with deformation temperature increasing and strain rate decreasing, which can be represented by a Zener–Hollomon parameter in an exponent-type equation with hot deformation activation energy Q of 172.56 kJ·mol-1.Dynamic recovery occurs easily when strain rates are less than 10.00 s-1. Dynamic recrystallization can occur at strain rate of 10.00 s-1.
基金the National Natural Science Foundation of China(Nos.21772138 and 21672157)PAPD,the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX19_1899)+1 种基金the Project of Scientific and Technologic Infrastructute of Suzhou(No.SZS201708)State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials for financial support。
文摘An efficient synthesis of 3-(diarylallylidene)oxindoles from 3-(1 H-indol-3-yl)-1,1-diarylpropan-1-ol under metal-free conditions is described.NBS serves as a critical medium leading to a facile oxygenmigration in the transformation.The protocol has advantages of high efficiency,simple opreation,mild reaction conditions,good atom-economy,wide substrate scope and good yields of products.A detailed mechanism is proposed after careful investigation.
