RNAs are involved in the crucial processes of disease progression and have emerged as powerful therapeutic targets and diagnostic biomarkers.However,efficient delivery of therapeutic RNA to the targeted location and p...RNAs are involved in the crucial processes of disease progression and have emerged as powerful therapeutic targets and diagnostic biomarkers.However,efficient delivery of therapeutic RNA to the targeted location and precise detection of RNA markers remains challenging.Recently,more and more attention has been paid to applying nucleic acid nanoassemblies in diagnosing and treating.Due to the flexibility and deformability of nucleic acids,the nanoassemblies could be fabricated with different shapes and structures.With hybridization,nucleic acid nanoassemblies,including DNA and RNA nanostructures,can be applied to enhance RNA therapeutics and diagnosis.This review briefly introduces the construction and properties of different nucleic acid nanoassemblies and their applications for RNA therapy and diagnosis and makes further prospects for their development.展开更多
Renewable energy dominated future power grids require enhanced system flexibility,in particular,activating the participation from various distributed en-ergy resources(DERs).A coordinated two-stage flexibility trading...Renewable energy dominated future power grids require enhanced system flexibility,in particular,activating the participation from various distributed en-ergy resources(DERs).A coordinated two-stage flexibility trading framework for distribution system with mi-crogrids(MGs)is proposed in this paper.At day-ahead stage,a peer to peer(P2P)trading mechanism and the associate leasing strategy of shared energy storage system are performed to solve the power variations caused by the wide spread integration of renewable resources,where asymmetric Nash bargaining is used to realize the fair revenue allocation according to the contribution of each MG in P2P trading.At intra-day stage,given the power imbalances from unexpected uncertainties,MGs exploit the adjustability of the DERs in responding to rapid flexibility requirements issued by distribution system operator.In particular,the average consensus based de-centralized Newton method with super linear convergence is utilized to meet the requirements of flexibility while maintaining the information security.The feasibility,effectiveness and equity of the proposed trading strategies are verified through various simulation studies.展开更多
基金supported by the National Science Foundation of China(No.82003689,to Mengnan Zhao,China)the Outstanding Young Scientific Talent Foundation of Sichuan Province(No.2022JDJQ0052,to Sanjun Shi,China)+3 种基金the China Postdoctoral Science Foundation(No.2021M690489,to Mengnan Zhao,China)the Project of High-Level Talents in Sichuan Province(No.003113014003,to Sanjun Shi,China)the International Postdoctoral Exchange Fellowship Program(No.YJ20200040,to Mengnan Zhao,China)the Xinglin Scholar Research Promotion Project of Chengdu University of Traditional Chinese Medicine(No.BSH2020006,to Mengnan Zhao,China).
文摘RNAs are involved in the crucial processes of disease progression and have emerged as powerful therapeutic targets and diagnostic biomarkers.However,efficient delivery of therapeutic RNA to the targeted location and precise detection of RNA markers remains challenging.Recently,more and more attention has been paid to applying nucleic acid nanoassemblies in diagnosing and treating.Due to the flexibility and deformability of nucleic acids,the nanoassemblies could be fabricated with different shapes and structures.With hybridization,nucleic acid nanoassemblies,including DNA and RNA nanostructures,can be applied to enhance RNA therapeutics and diagnosis.This review briefly introduces the construction and properties of different nucleic acid nanoassemblies and their applications for RNA therapy and diagnosis and makes further prospects for their development.
基金supported by the National Key Research&Development Program(No.2021YFB2401204)the National Natural Science Foundation of China(No.52277119)the Natural Science Foundation of Tianjin Municipal(No.22JCZDJC00690).
文摘Renewable energy dominated future power grids require enhanced system flexibility,in particular,activating the participation from various distributed en-ergy resources(DERs).A coordinated two-stage flexibility trading framework for distribution system with mi-crogrids(MGs)is proposed in this paper.At day-ahead stage,a peer to peer(P2P)trading mechanism and the associate leasing strategy of shared energy storage system are performed to solve the power variations caused by the wide spread integration of renewable resources,where asymmetric Nash bargaining is used to realize the fair revenue allocation according to the contribution of each MG in P2P trading.At intra-day stage,given the power imbalances from unexpected uncertainties,MGs exploit the adjustability of the DERs in responding to rapid flexibility requirements issued by distribution system operator.In particular,the average consensus based de-centralized Newton method with super linear convergence is utilized to meet the requirements of flexibility while maintaining the information security.The feasibility,effectiveness and equity of the proposed trading strategies are verified through various simulation studies.
