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Liver cirrhosis induced by long-term administration of a daily low dose of amiodarone: A case report 被引量:5
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作者 Hiroki Oikawa Chihaya Maesawa +8 位作者 ryo sato Kanta Oikawa Hiroyuki Yamada Seizo Oriso Sadahide Ono Akiko Yashima-Abo Koji Kotani Kazuyuki Suzuki Tomoyuki Masuda 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第34期5394-5397,共4页
The anti-arrhythmic agent amiodarone (AD) is associated with numerous adverse effects, but serious liver disease is rare. The improved safety of administration of daily low doses of AD has already been established a... The anti-arrhythmic agent amiodarone (AD) is associated with numerous adverse effects, but serious liver disease is rare. The improved safety of administration of daily low doses of AD has already been established and this regimen is used for long-term medication. Nevertheless, asymptomatic continuous liver injury by AD may increase the risk of step-wise progression of non-alcoholic fatty liver disease. We present an autopsy case of AD-induced liver cirrhosis in a patient who had been treated with a low dose of AD (200 rag/d) daily for 84 too. The patient was a 85-year-old male with a history of ischemic heart disease. Seven years after initiation of treatment with AD, he was admitted with cardiac congestion. The total dose of AD was 528 g. Mild elevation of serum aminotransferase and hepatomegaly were present. Liver biopsy specimens revealed cirrhosis, and under electron microscopy numerous lysosomes with electron-dense, whorled, lamellar inclusions characteristic of a secondary phospholipidosis were observed. Initially, withdrawal of AD led to a slight improvement of serum aminotransferase levels, but unfortunately his general condition deteriorated and he died from complications of pneumonia and renal failure. Long-term administration of daily low doses of AD carries the risk of progression to irreversible liver injury. Therefore, periodic examination of liver function and/or liver biopsy is required for the management of patients receiving long-term treatment with AD. 展开更多
关键词 AMIODARONE Liver cirrhosis NASH NAFLD Liver biopsy
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Angle Measurement Based on Second Harmonic Generation Using Artificial Neural Network 被引量:1
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作者 Kuangyi Li Zhiyang Zhang +3 位作者 Jiahui Lin ryo sato Hiraku Matsukuma Wei Gao 《Nanomanufacturing and Metrology》 EI 2023年第4期1-15,共15页
This article proposed an angle measurement method based on second harmonic generation(SHG)using an artifcial neural network(ANN).The method comprises three sequential parts:SHG spectrum collection,data preprocessing,a... This article proposed an angle measurement method based on second harmonic generation(SHG)using an artifcial neural network(ANN).The method comprises three sequential parts:SHG spectrum collection,data preprocessing,and neural network training.First,the referenced angles and SHG spectrums are collected by the autocollimator and SHG-based angle sensor,respectively,for training.The mapping is learned by the trained ANN after completing the training process,which solves the inverse problem of obtaining the angle from the SHG spectrum.Then,the feasibility of the proposed method is verifed in multiple-peak Maker fringe and single-peak phase-matching areas,with an overall angle measurement range exceeding 20,000 arcseconds.The predicted angles by ANN are compared with the autocollimator to evaluate the measure-ment performance in all the angular ranges.Particularly,a sub-arcsecond level of accuracy and resolution is achieved in the phase-matching area. 展开更多
关键词 Angle measurement Second harmonic generation Artifcial neural network Femtosecond laser
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