Bioactive bone cements based on a paste-paste system for orthopaedic applications were developed consisting of hydroxyapatite （ HA ） filler panicles in a methacrylate matrix comprising urethane dimethacrylate （ UD...Bioactive bone cements based on a paste-paste system for orthopaedic applications were developed consisting of hydroxyapatite （ HA ） filler panicles in a methacrylate matrix comprising urethane dimethacrylate （ UDMA ） and triethylene glycol dimethacrylate （ TEGDMA ）. To improve the interface between inorganic filler and organic matrix the HA panicles were subjected to two different surface treatment methods, using polyacrylic acid （PAA） and γ-methacryloxy propyl trimethoxy silane （γMPS）. The aim of the present study was to determine the influence of surface treatment and the inclusion of multifunctional methacrylates on the mechanical properties, namely 3-point flexural strength （FS） and fracture toughness of the cements and the effect of ageing in simulated body fluid. Comparing the mechanical properties of the two cements, the γMPS- HA cement showed that the fracture toughness of the experimental bone cements were significantly greater （ p 〈 0.001） compared to that of the PMMA cement, whereas PAA-HA containing cement had strength vollues around 20% lower. Interestingly, PAA was found to be more effective in improving the interface as the PAA treated HA cement （ UTHAPPA ） maintained its strength on immersion in SBF, suggesting that PAA provided a coupling, which was less sensitive to moisture, a similar trend was also observed with the inclusion of the carboxyl containing multifunctional methacrylates.展开更多
文摘Bioactive bone cements based on a paste-paste system for orthopaedic applications were developed consisting of hydroxyapatite （ HA ） filler panicles in a methacrylate matrix comprising urethane dimethacrylate （ UDMA ） and triethylene glycol dimethacrylate （ TEGDMA ）. To improve the interface between inorganic filler and organic matrix the HA panicles were subjected to two different surface treatment methods, using polyacrylic acid （PAA） and γ-methacryloxy propyl trimethoxy silane （γMPS）. The aim of the present study was to determine the influence of surface treatment and the inclusion of multifunctional methacrylates on the mechanical properties, namely 3-point flexural strength （FS） and fracture toughness of the cements and the effect of ageing in simulated body fluid. Comparing the mechanical properties of the two cements, the γMPS- HA cement showed that the fracture toughness of the experimental bone cements were significantly greater （ p 〈 0.001） compared to that of the PMMA cement, whereas PAA-HA containing cement had strength vollues around 20% lower. Interestingly, PAA was found to be more effective in improving the interface as the PAA treated HA cement （ UTHAPPA ） maintained its strength on immersion in SBF, suggesting that PAA provided a coupling, which was less sensitive to moisture, a similar trend was also observed with the inclusion of the carboxyl containing multifunctional methacrylates.
