目的观察补肾健脾通络方治疗老年衰弱综合征临床疗效及安全性。方法研究纳入2021年1月—2022年6月收治的老年衰弱综合征患者共计102例,以随机数字表法将患者分为对照组与观察组,每组51例,对照组患者采取临床常规治疗,观察组患者采取常...目的观察补肾健脾通络方治疗老年衰弱综合征临床疗效及安全性。方法研究纳入2021年1月—2022年6月收治的老年衰弱综合征患者共计102例,以随机数字表法将患者分为对照组与观察组,每组51例,对照组患者采取临床常规治疗,观察组患者采取常规治疗结合补肾健脾通络方治疗。观察各组数据:治疗总有效率、治疗前后患者中医证候总积分变化及Fried表型衰弱量表(frailty phenotype,FP)评分变化及白介素-6(interleukin 6,IL-6)、超敏C反应蛋白(C-ReactiveProtein,hs-CRP)水平变化、握力变化及起立-行走计时测试(Timed Up and Go test,TUG)变化、5次坐立试验(five-times-sit-to-stand test,FTSST)变化、步速变化、体质指数(Body Mass Index,BMI)变化及四肢骨骼肌质量指数(appendicular skeletal muscle mass index,ASMI)变化、简易精神状态评分(Mini-mental State Examination,MMSE)变化、匹兹堡睡眠指数(Pittsburgh sleep quality index,PSQI)评分变化、日常生活能力(Activity of Daily Living,ADL)评分变化、微型营养评估(mini nutritionaal assessment,MNA)评分变化、患者治疗满意度、不良反应。结果观察组患者治疗总有效率比对照组高[96.08%(49/51)vs84.31%(43/51)],P<0.05;治疗前,各组患者中医证候总积分、FP评分、IL-6、hs-CRP水平、握力、TUG测试结果及FTSST测试结果、步速、BMI、ASMI、MMSE评分、PSQI评分、ADL评分、MNA评分比较,P>0.05,治疗后各组患者中医证候总积分、FP评分、IL-6、hs-CRP水平、握力、TUG测试结果及FTSST测试结果、步速、BMI、ASMI、MMSE评分、PSQI评分、ADL评分、MNA评分均改善,观察组患者治疗后中医证候总积分、FP评分、IL-6、hs-CRP水平、握力、TUG测试结果及FTSST测试结果、步速、BMI、ASMI、MMSE评分、PSQI评分、ADL评分、MNA评分均优于对照组患者,P<0.05;观察组患者治疗满意度高于对照组[98.04%(50/51)vs84.31%(43/51)],P<0.05;观察组与对照组不良反应率均较低,且可自行缓解,P>0.05。结论补肾健脾通络方治疗老年衰弱综合征临床疗效显著,能缓解衰弱综合征患者的临床症状,抑制患者机体炎性反应,增加肌肉质量,改善睡眠,提高生活质量,且无不良反应,较为安全可靠,值得应用。展开更多
The Permian is one of the most important periods during which the vegetative earth witnessed the transition from icehouse to greenhouse climate and the global environment changes.Organisms on the planet encountered gr...The Permian is one of the most important periods during which the vegetative earth witnessed the transition from icehouse to greenhouse climate and the global environment changes.Organisms on the planet encountered great challenge and the demise of swamp caused the extinction of arborescent lycopods and the rising of Mesophytic plants accomplished the floral transition from the Paleophytic to Mesophytic vegetation.In order to depict the climatic changes and floral succession in the middle and high latitudes of the North Hemisphere,palynological investigation was engaged,and 40 samples collected from the uppermost of Taerlang Formation,Hongyanchi Formation and Quanzijie Formation in the Tianshan Town,Turpan-Hami Basin,eastern Xinjiang,China.The result shows that the palynoflora in the studied area is composed of 50 species of 33 genera,dominated by disaccites and striatiti gymnosperm pollen,and characterized by diverse Protohaploxypinus,Hamia-pollenites,Alisporites and Klausipollenites.It is quite similar to those Middle and Late Permian palynological assemblages reported in the Dalongkou section and other localities in southern margin of Junggar Basin,and aged at Middle and Late Permian.The diversity of typical Angara and sub-Angara pollen,such as Falcisporites,Alisporites,Protohaploxypinus,Vittatina,Lunatisporites,Hamiapollenites,etc.indicates that the studied palynoflora belonged to the sub-Angara phytoprovince,while the presence of Lueckisporites virkkiae implied Euramerica pollen intruded northward sometimes.The paleoclimate of the studied area might be warm and humid with fluctuated dry seasons during the late Guadalupian and early Lopingian time.展开更多
文摘目的观察补肾健脾通络方治疗老年衰弱综合征临床疗效及安全性。方法研究纳入2021年1月—2022年6月收治的老年衰弱综合征患者共计102例,以随机数字表法将患者分为对照组与观察组,每组51例,对照组患者采取临床常规治疗,观察组患者采取常规治疗结合补肾健脾通络方治疗。观察各组数据:治疗总有效率、治疗前后患者中医证候总积分变化及Fried表型衰弱量表(frailty phenotype,FP)评分变化及白介素-6(interleukin 6,IL-6)、超敏C反应蛋白(C-ReactiveProtein,hs-CRP)水平变化、握力变化及起立-行走计时测试(Timed Up and Go test,TUG)变化、5次坐立试验(five-times-sit-to-stand test,FTSST)变化、步速变化、体质指数(Body Mass Index,BMI)变化及四肢骨骼肌质量指数(appendicular skeletal muscle mass index,ASMI)变化、简易精神状态评分(Mini-mental State Examination,MMSE)变化、匹兹堡睡眠指数(Pittsburgh sleep quality index,PSQI)评分变化、日常生活能力(Activity of Daily Living,ADL)评分变化、微型营养评估(mini nutritionaal assessment,MNA)评分变化、患者治疗满意度、不良反应。结果观察组患者治疗总有效率比对照组高[96.08%(49/51)vs84.31%(43/51)],P<0.05;治疗前,各组患者中医证候总积分、FP评分、IL-6、hs-CRP水平、握力、TUG测试结果及FTSST测试结果、步速、BMI、ASMI、MMSE评分、PSQI评分、ADL评分、MNA评分比较,P>0.05,治疗后各组患者中医证候总积分、FP评分、IL-6、hs-CRP水平、握力、TUG测试结果及FTSST测试结果、步速、BMI、ASMI、MMSE评分、PSQI评分、ADL评分、MNA评分均改善,观察组患者治疗后中医证候总积分、FP评分、IL-6、hs-CRP水平、握力、TUG测试结果及FTSST测试结果、步速、BMI、ASMI、MMSE评分、PSQI评分、ADL评分、MNA评分均优于对照组患者,P<0.05;观察组患者治疗满意度高于对照组[98.04%(50/51)vs84.31%(43/51)],P<0.05;观察组与对照组不良反应率均较低,且可自行缓解,P>0.05。结论补肾健脾通络方治疗老年衰弱综合征临床疗效显著,能缓解衰弱综合征患者的临床症状,抑制患者机体炎性反应,增加肌肉质量,改善睡眠,提高生活质量,且无不良反应,较为安全可靠,值得应用。
基金Supported by National Natural Science Foundation of China(No.31670215).
文摘The Permian is one of the most important periods during which the vegetative earth witnessed the transition from icehouse to greenhouse climate and the global environment changes.Organisms on the planet encountered great challenge and the demise of swamp caused the extinction of arborescent lycopods and the rising of Mesophytic plants accomplished the floral transition from the Paleophytic to Mesophytic vegetation.In order to depict the climatic changes and floral succession in the middle and high latitudes of the North Hemisphere,palynological investigation was engaged,and 40 samples collected from the uppermost of Taerlang Formation,Hongyanchi Formation and Quanzijie Formation in the Tianshan Town,Turpan-Hami Basin,eastern Xinjiang,China.The result shows that the palynoflora in the studied area is composed of 50 species of 33 genera,dominated by disaccites and striatiti gymnosperm pollen,and characterized by diverse Protohaploxypinus,Hamia-pollenites,Alisporites and Klausipollenites.It is quite similar to those Middle and Late Permian palynological assemblages reported in the Dalongkou section and other localities in southern margin of Junggar Basin,and aged at Middle and Late Permian.The diversity of typical Angara and sub-Angara pollen,such as Falcisporites,Alisporites,Protohaploxypinus,Vittatina,Lunatisporites,Hamiapollenites,etc.indicates that the studied palynoflora belonged to the sub-Angara phytoprovince,while the presence of Lueckisporites virkkiae implied Euramerica pollen intruded northward sometimes.The paleoclimate of the studied area might be warm and humid with fluctuated dry seasons during the late Guadalupian and early Lopingian time.
