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Endoscopic ultrasound-guided biliary drainage with placement of a fully covered metal stent for malignant biliary obstruction 被引量:16
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作者 Tae Hyeon kim seong hun kim +2 位作者 Hyo Jeong Oh Young Woo Sohn Seung Ok Lee 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第20期2526-2532,共7页
AIM:To determine the utility of endoscopic ultrasoundguided biliary drainage(EUS-BD)with a fully covered self-expandable metal stent for managing malignant biliary stricture. METHODS:We collected data from 13 patients... AIM:To determine the utility of endoscopic ultrasoundguided biliary drainage(EUS-BD)with a fully covered self-expandable metal stent for managing malignant biliary stricture. METHODS:We collected data from 13 patients who presented with malignant biliary obstruction and underwent EUS-BD with a nitinol fully covered selfexpandable metal stent when endoscopic retrograde cholangiopancreatography(ERCP)fails.EUS-guided choledochoduodenostomy(EUS-CD)and EUS-guided hepaticogastrostomy(EUS-HG)was performed in 9 patients and 4 patients,respectively. RESULTS:The technical and functional success rate was 92.3%(12/13)and 91.7%(11/12),respectively. Using an intrahepatic approach(EUS-HG,n=4),there was mild peritonitis(n=1)and migration of the metal stent to the stomach(n=1).With an extrahepatic approach(EUS-CD,n=10),there was pneumoperitoneum(n=2),migration(n=2),and mild peritonitis (n=1).All patients were managed conservatively with antibiotics.During follow-up(range,1-12 mo),there was re-intervention(4/13 cases,30.7%)necessitated by stent migration(n=2)and stent occlusion(n=2). CONCLUSION:EUS-BD with a nitinol fully covered self-expandable metal stent may be a feasible and effective treatment option in patients with malignant biliary obstruction when ERCP fails. 展开更多
关键词 Endoscopic ultrasound-guided Biliary drainage Metal stent Biliary obstruction
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3-Dimensional liver volume assessment in patients with hepatitis B virus-related liver cirrhosis during long-term oral nucleos(t)ide analogues therapy 被引量:6
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作者 Chang hun Lee In Hee kim +8 位作者 Jin Chang Moon Seung Young Seo seong hun kim Sang Wook kim Seung Ok Lee Soo Teik Lee Dae Ghon kim Jae Do Yang Hee Chul Yu 《World Journal of Gastroenterology》 SCIE CAS 2017年第2期297-305,共9页
AIMTo assess the effect of long-term oral nucleos(t)ide analogues (NUCs) therapy on liver volume change in patients with suppress hepatitis B virus (HBV)-related liver cirrhosis.METHODSWe reviewed the data of na&#... AIMTo assess the effect of long-term oral nucleos(t)ide analogues (NUCs) therapy on liver volume change in patients with suppress hepatitis B virus (HBV)-related liver cirrhosis.METHODSWe reviewed the data of na&#x000ef;ve patients with HBV-related liver cirrhosis, who had taken oral NUCs therapy, between 2003 and 2007 at Chonbuk University Hospital. We analyzed two consecutive sets of abdominal computerized tomography scans-one at the time of treatment initiation and another at the second-year follow-up. Liver volume was calculated by 3-dimensional liver extraction volumetry program.RESULTSA total of 55 patients (34 males) were included. There was 114.3 mL &#x000b1; 167.8 mL (12.9% &#x000b1; 17.9%) of increase in liver volume during the two years of NUCs therapy (993.8 mL &#x000b1; 242.8 mL at baseline vs 1108.1 mL &#x000b1; 263.3 mL at two-year follow-up, P &#x0003c; 0.001). The ratio of the measured baseline liver volume to the estimated standard liver volume was improved from 70.8% to 78.0%. An increase in liver volume was shown not only in patients with compensated cirrhosis (P = 0.046) but also in those with decompensated cirrhosis (P &#x0003c; 0.001). Significant factors for volume increases were Child-Turcotte-Pugh grade and model for end-stage liver disease score improvement without virological breakthrough. In multiple linear regression analysis, delta albumin and delta alanine aminotransferase levels showed a significant association with the increase in liver volume (P = 0.002 and 0.005, respectively).CONCLUSIONLong-term oral NUCs therapy in patients with HBV-related liver cirrhosis lead to significant increase in liver volume assessed with 3-dimensional liver extraction volumetry program. 展开更多
关键词 Antiviral agents Liver cirrhosis Liver regeneration Image processing COMPUTER-ASSISTED
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Repetitive response to gemcitabine that led to curative resection in cholangiocarcinoma 被引量:1
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作者 seong hun kim In Hee kim +1 位作者 Sang Wook kim Seung-Ok Lee 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第36期4593-4595,共3页
This study reports a case of unresectable intrahepatic mass-forming cholangiocarcinoma which showed a dramatic response to gemcitabine that led to curative resection and a long-term survival of more than five years.Si... This study reports a case of unresectable intrahepatic mass-forming cholangiocarcinoma which showed a dramatic response to gemcitabine that led to curative resection and a long-term survival of more than five years.Six and five cycles of gemcitabine monotherapy were administered separately over a three-year period and a radical excision was performed at 4.5 years after diagnosis.This case indicates the role of gemcitabine as a neoadjuvant chemotherapeutic agent for cholangiocarcinoma and guarantees a randomized controlled prospective study. 展开更多
关键词 CHOLANGIOCARCINOMA GEMCITABINE Neoadjuvant chemotherapy
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