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Percutaneous coronary intervention for unprotected left main coronary artery stenosis 被引量:13
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作者 seung-jung park Young-Hak Kim 《World Journal of Cardiology》 CAS 2010年第4期78-88,共11页
Hemodynamically significant left main coronary artery stenosis(LMCA) is found in around 4% of diagnostic coronary angiograms and is known as unprotected LMCA stenosis if the left coronary artery and left cir-cumflex a... Hemodynamically significant left main coronary artery stenosis(LMCA) is found in around 4% of diagnostic coronary angiograms and is known as unprotected LMCA stenosis if the left coronary artery and left cir-cumflex artery has no previous patent grafts.Previous randomized studies have demonstrated a significant re-duction in mortality when revascularization by coronary artery bypass graft(CABG) surgery was undertaken compared with medical treatment.Therefore,current practice guidelines do not recommend percutaneous coronary intervention(PCI) for such a lesion because of the proven benefit of surgery and high rates of reste-nosis with the use of bare metal stents.However,with the advent of drug-eluting stents(DES),the long term outcomes of PCI with DES to treat unprotected LMCA stenoses have been acceptable.Therefore,apart from the current guidelines,PCI for treatment of unprotected LMCA stenosis is often undertaken in individuals who are at a very high risk of CABG or refuse to undergo a sternotomy.Future randomized studies comparing CABG vs PCI using DES for treatment of unprotected LMCA stenosis would be a great advance in clinical knowledge for the adoption of appropriate treatment. 展开更多
关键词 BYPASS surgery LEFT main PROGNOSIS Re-stenosis STENT
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Hyperpolarization caused by serotonin contributes to endothelium-dependent relaxations in the porcine coronary artery
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作者 seung-jung park Mikio NAKASHIMA +1 位作者 Tetsuhiko NAGAO Paul M VANHOUTTE 《中国药理学报》 CSCD 1999年第12期1093-1096,共4页
AIM:The present study was designed to investigate the contribution of membrane hyperpolarization to endothelium-dependent relaxations induced by serotonin in the porcine coronary artery.METHODS:Rings with and without ... AIM:The present study was designed to investigate the contribution of membrane hyperpolarization to endothelium-dependent relaxations induced by serotonin in the porcine coronary artery.METHODS:Rings with and without endothelium of porcine coronary arteries were suspended in conventional organ chambers for the measurement of isometric force.The cell membrane potential of the vascular smooth muscle cells was measured using glass microelectrodes,in the presence of indometacin,ketanserin,and/or N^(ω)-nitro-L-arginine.RESULTS:Serotonin induced a transient endothelium-,and concentration-dependent relaxation in rings contracted with prostaglandin F_(2α)in the presence of N^(ω)-nitro-L-arginine(maximal relaxation;19%).The N^(ω)-nitro-L-arginine resistant relaxation was abolished by high K^(+)and tetrabutylammonium chloride.Serotonin also caused an endothelium-,concentration-dependent membrane hyperpolarizations with a maximal amplitude of-8.8mV.The nitro-L-arginine resistant relaxations and hyperpolarizations were abolished by methiothepin,but not by glibenclamide.The time course of the endothelium-dependent relaxations and hyperpolarizations was similar.CONCLUSION:These results suggest a contribution of cell membrane hyperpolarization to theendothelium-dependent relaxations induced by serotonin in the porcine coronary artery. 展开更多
关键词 INDOMETHACIN KETANSERIN membrane potentials methiothepin nitric oxide potassium channels SEROTONIN vascular endothelium
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内皮素-1促进猪冠状动脉再生内皮释放内皮衍生内过氧化物和血栓素A_2(英文)
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作者 seung-jung park John J LEE Paul M VANHOUTTE 《中国药理学报》 CSCD 1999年第10期872-878,共7页
AIM: To determine the role of endothelium-derivedcontracting factor (EDCF) in the response toendothelin-1 in arteries with regenerated endothelium.METHODS: Rings of porcine coronary arteries, withand without endotheli... AIM: To determine the role of endothelium-derivedcontracting factor (EDCF) in the response toendothelin-1 in arteries with regenerated endothelium.METHODS: Rings of porcine coronary arteries, withand without endothelium of previously deendothelializedleft anterior descending coronary arteries and native leftcircumflex coronary arteries, were suspended inconventional organ chambers for the measurement ofisometric force. RESULTS: In quiescent rings of thepreviously deendothelialized left anterior 展开更多
关键词 血管内皮 药理 冠状血管 内皮素-1 吲哚美辛
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