Metabolic dysfunction-associated steatotic liver disease(MASLD)is a widespread global disease with significant health burden.Unhealthy lifestyle,obesity,diabetes mellitus(DM),insulin resistance,and genetics have been ...Metabolic dysfunction-associated steatotic liver disease(MASLD)is a widespread global disease with significant health burden.Unhealthy lifestyle,obesity,diabetes mellitus(DM),insulin resistance,and genetics have been implicated in the pathogenesis of MASLD.A significant degree of heterogeneity exists among each of above-mentioned risk factors.Heterogeneity of these risk factors translates into the heterogeneity of MASLD.On the other hand,MASLD can itself lead to insulin resistance and DM.Such heterogeneity makes it difficult to assess the natural course of an individual with MASLD in clinical practice.At present MASLD is considered as one disease despite the variability of etiopathogenic processes,and we lack the consensus definitions of unique subtypes of MASLD.In this review,pathogenic processes of MASLD are discussed and a need of subtyping is recommended.展开更多
Nutrient metabolism is regulated by several factors.Social determinants of health with or without genetics are the primary regulator of metabolism,and an unhealthy lifestyle affects all modulators and mediators,leadin...Nutrient metabolism is regulated by several factors.Social determinants of health with or without genetics are the primary regulator of metabolism,and an unhealthy lifestyle affects all modulators and mediators,leading to the adaptation and finally to the exhaustion of cellular functions.Hepatic steatosis is defined by presence of fat in more than 5%of hepatocytes.In hepatocytes,fat is stored as triglycerides in lipid droplet.Hepatic steatosis results from a combination of multiple intracellular processes.In a healthy individual nutrient metabolism is regulated at several steps.It ranges from the selection of nutrients in a grocery store to the last step of consumption of ATP as an energy or as a building block of a cell as structural component.Several hormones,peptides,and genes have been described that participate in nutrient metabolism.Several enzymes participate in each nutrient metabolism as described above from ingestion to generation of ATP.As of now several publications have revealed very intricate regulation of nutrient metabolism,where most of the regulatory factors are tied to each other bidirectionally,making it difficult to comprehend chronological sequence of events.Insulin hormone is the primary regulator of all nutrients’metabolism both in prandial and fasting states.Insulin exerts its effects directly and indirectly on enzymes involved in the three main cellular function processes;metabolic,inflammation and repair,and cell growth and regeneration.Final regulators that control the enzymatic functions through stimulation or suppression of a cell are nuclear receptors in especially farnesoid X receptor and peroxisome proliferator-activated receptor/RXR ligands,adiponectin,leptin,and adiponutrin.Insulin hormone has direct effect on these final modulators.Whereas blood glucose level,serum lipids,incretin hormones,bile acids in conjunction with microbiota are intermediary modulators which are controlled by lifestyle.The purpose of this review is to overview the key players in the pathogenesis of metabolic dysfunction-associated steatotic liver disease(MASLD)that help us understand the disease natural course,risk stratification,role of lifestyle and pharmacotherapy in each individual patient with MASLD to achieve personalized care and target the practice of precision medicine.PubMed and Google Scholar databases were used to identify publication related to metabolism of carbohydrate and fat in states of health and disease states;MASLD,cardiovascular disease and cancer.More than 1000 publications including original research and review papers were reviewed.展开更多
A low-profile ultra-wideband(UWB)band-stop frequency selective surface(FSS)is designed for S-,C-,X-and Ku-bands communication applications.The FSS is constructed by using square and circular loop elements printed on t...A low-profile ultra-wideband(UWB)band-stop frequency selective surface(FSS)is designed for S-,C-,X-and Ku-bands communication applications.The FSS is constructed by using square and circular loop elements printed on the top and bottom sides of the RO3210 substrate.The FSS has been designed to reduce the electromagnetic interference(EMI)as well as to mitigate the harmful effects of electromagnetic radiation on the human body caused by different radio devices.The dimension and size of the UWB FSS have been reduced to 0.12λ×0.12λand 90%,respectively,as compared to the reported literature.The other advantages of the proposed FSS are that it is low profile,it has a simplified geometry and it ensures better angular and polarization stability of up to 85◦.The-10 and-20 dB bandwidths of the proposed FSS are 146%(2.0-13.0 GHz)and 80%(4.87-11.42 GHz),respectively.Theoretical results have been obtained using ANSYS HFSS and verified through measured results.展开更多
In this Letter, we have proposed a generalized Gaussian probability density function（GGPDF）-based method to estimate the symbol error ratio（SER） for pulse amplitude modulation（PAM-4） in an intensity modulation/d...In this Letter, we have proposed a generalized Gaussian probability density function（GGPDF）-based method to estimate the symbol error ratio（SER） for pulse amplitude modulation（PAM-4） in an intensity modulation/direct detection（IM/DD） system. Furthermore, a closed form expression of SERGGDfor PAM-4 has been derived. The performance of the proposed method is evaluated through simulation as well as experimental work.The fitting of probability density functions of the received signal is applied via GGPDF and shape parameters P1 and P2 associated with different PAM-4 levels are determined. The optimum single value of shape parameter P is then calculated to estimate the SER. The mathematical relationship of P with different received optical powers and receiver bandwidths has been determined and verified. The proposed method is a fast and accurate method to estimate SER of a PAM-4 system, which is more reliable and in agreement with the error counting method.展开更多
文摘Metabolic dysfunction-associated steatotic liver disease(MASLD)is a widespread global disease with significant health burden.Unhealthy lifestyle,obesity,diabetes mellitus(DM),insulin resistance,and genetics have been implicated in the pathogenesis of MASLD.A significant degree of heterogeneity exists among each of above-mentioned risk factors.Heterogeneity of these risk factors translates into the heterogeneity of MASLD.On the other hand,MASLD can itself lead to insulin resistance and DM.Such heterogeneity makes it difficult to assess the natural course of an individual with MASLD in clinical practice.At present MASLD is considered as one disease despite the variability of etiopathogenic processes,and we lack the consensus definitions of unique subtypes of MASLD.In this review,pathogenic processes of MASLD are discussed and a need of subtyping is recommended.
文摘Nutrient metabolism is regulated by several factors.Social determinants of health with or without genetics are the primary regulator of metabolism,and an unhealthy lifestyle affects all modulators and mediators,leading to the adaptation and finally to the exhaustion of cellular functions.Hepatic steatosis is defined by presence of fat in more than 5%of hepatocytes.In hepatocytes,fat is stored as triglycerides in lipid droplet.Hepatic steatosis results from a combination of multiple intracellular processes.In a healthy individual nutrient metabolism is regulated at several steps.It ranges from the selection of nutrients in a grocery store to the last step of consumption of ATP as an energy or as a building block of a cell as structural component.Several hormones,peptides,and genes have been described that participate in nutrient metabolism.Several enzymes participate in each nutrient metabolism as described above from ingestion to generation of ATP.As of now several publications have revealed very intricate regulation of nutrient metabolism,where most of the regulatory factors are tied to each other bidirectionally,making it difficult to comprehend chronological sequence of events.Insulin hormone is the primary regulator of all nutrients’metabolism both in prandial and fasting states.Insulin exerts its effects directly and indirectly on enzymes involved in the three main cellular function processes;metabolic,inflammation and repair,and cell growth and regeneration.Final regulators that control the enzymatic functions through stimulation or suppression of a cell are nuclear receptors in especially farnesoid X receptor and peroxisome proliferator-activated receptor/RXR ligands,adiponectin,leptin,and adiponutrin.Insulin hormone has direct effect on these final modulators.Whereas blood glucose level,serum lipids,incretin hormones,bile acids in conjunction with microbiota are intermediary modulators which are controlled by lifestyle.The purpose of this review is to overview the key players in the pathogenesis of metabolic dysfunction-associated steatotic liver disease(MASLD)that help us understand the disease natural course,risk stratification,role of lifestyle and pharmacotherapy in each individual patient with MASLD to achieve personalized care and target the practice of precision medicine.PubMed and Google Scholar databases were used to identify publication related to metabolism of carbohydrate and fat in states of health and disease states;MASLD,cardiovascular disease and cancer.More than 1000 publications including original research and review papers were reviewed.
基金The work was supported by King Abdulaziz University,Jeddah,Kingdom of Saudi Arabia.M.F.U.Butt would like to gratefully acknowledge the Higher Education Commission(HEC),Government of Pakistan’s financial support through its Post-Doctoral Fellowship Program(PDFP)Grant.
文摘A low-profile ultra-wideband(UWB)band-stop frequency selective surface(FSS)is designed for S-,C-,X-and Ku-bands communication applications.The FSS is constructed by using square and circular loop elements printed on the top and bottom sides of the RO3210 substrate.The FSS has been designed to reduce the electromagnetic interference(EMI)as well as to mitigate the harmful effects of electromagnetic radiation on the human body caused by different radio devices.The dimension and size of the UWB FSS have been reduced to 0.12λ×0.12λand 90%,respectively,as compared to the reported literature.The other advantages of the proposed FSS are that it is low profile,it has a simplified geometry and it ensures better angular and polarization stability of up to 85◦.The-10 and-20 dB bandwidths of the proposed FSS are 146%(2.0-13.0 GHz)and 80%(4.87-11.42 GHz),respectively.Theoretical results have been obtained using ANSYS HFSS and verified through measured results.
文摘In this Letter, we have proposed a generalized Gaussian probability density function（GGPDF）-based method to estimate the symbol error ratio（SER） for pulse amplitude modulation（PAM-4） in an intensity modulation/direct detection（IM/DD） system. Furthermore, a closed form expression of SERGGDfor PAM-4 has been derived. The performance of the proposed method is evaluated through simulation as well as experimental work.The fitting of probability density functions of the received signal is applied via GGPDF and shape parameters P1 and P2 associated with different PAM-4 levels are determined. The optimum single value of shape parameter P is then calculated to estimate the SER. The mathematical relationship of P with different received optical powers and receiver bandwidths has been determined and verified. The proposed method is a fast and accurate method to estimate SER of a PAM-4 system, which is more reliable and in agreement with the error counting method.
