Silicon nanowires(Si NWs)have been widely researched as the best alternative to graphite anodes for the next-generation of high-performance lithium-ion batteries(LIBs)owing to their high capacity and low discharge pot...Silicon nanowires(Si NWs)have been widely researched as the best alternative to graphite anodes for the next-generation of high-performance lithium-ion batteries(LIBs)owing to their high capacity and low discharge potential.However,growing binder-free Si NW anodes with adequate mass loading and stable capacity is severely limited by the low surface area of planar current collectors(CCs),and is particularly challenging to achieve on standard pure-Cu substrates due to the ubiquitous formation of Li+inactive silicide phases.Here,the growth of densely-interwoven In-seeded Si NWs is facilitated by a thin-film of copper-silicide(CS)network in situ grown on a Cu-foil,allowing for a thin active NW layer(<10μm thick)and high areal loading(≈1.04 mg/cm^(2))binder-free electrode architecture.The electrode exhibits an average Coulombic efficiency(CE)of>99.6%and stable performance for>900 cycles with≈88.7%capacity retention.More significantly,it delivers a volumetric capacity of≈1086.1 m A h/cm^(3)at 5C.The full-cell versus lithium manganese oxide(LMO)cathode delivers a capacity of≈1177.1 m A h/g at 1C with a stable rate capability.This electrode architecture represents significant advances toward the development of binder-free Si NW electrodes for LIB application.展开更多
Type 2 diabetes mellitus(T2DM) is a silent progressive polygenic metabolic disorder resulting from ineffective insulin cascading in the body. World-wide, about 415 million people are suffering from T2DM with a project...Type 2 diabetes mellitus(T2DM) is a silent progressive polygenic metabolic disorder resulting from ineffective insulin cascading in the body. World-wide, about 415 million people are suffering from T2DM with a projected rise to 642 million in 2040. T2DM is treated with several classes of oral antidiabetic drugs(OADs) viz. biguanides, sulfonylureas, thiazolidinediones, meglitinides, etc. Treatment strategies for T2DM are to minimize long-term micro and macro vascular complications by achieving an optimized glycemic control. Genetic variations in the human genome not only disclose the risk of T2DM development but also predict the personalized response to drug therapy. Inter-individual variability in response to OADs is due to polymorphisms in genes encoding drug receptors, transporters, and metabolizing enzymes for example, genetic variants in solute carrier transporters(SLC22A1, SLC22A2, SLC22A3, SLC47A1 and SLC47A2) are actively involved in glycemic/HbA1c management of metformin. In addition, CYP gene encoding Cytochrome P450 enzymes also play a crucial role with respect to metabolism of drugs. Pharmacogenetic studies provide insights on the relationship between individual genetic variants and variable therapeutic outcomes of various OADs. Clinical utility of pharmacogenetic study is to predict the therapeutic dose of various OADs on individual basis. Pharmacogenetics therefore, is a step towards personalized medicine which will greatly improve the efficacy of diabetes treatment.展开更多
Nanotechnology is defined as the study and application of 1 - 100 nm sized structures. Nanomaterials have opened avenues for the industries and scientific endeavors. These recognized for unique size, dependant physica...Nanotechnology is defined as the study and application of 1 - 100 nm sized structures. Nanomaterials have opened avenues for the industries and scientific endeavors. These recognized for unique size, dependant physical and chemical properties (optical, magnetic, catalytic, thermodynamic, electrochemical) [1]. Most significant properties of nanoparticles is their carbon strength. It is said to be so tough that recently with a nano-sized particles i.e. carbon nanotube—a bullet proof T-shirt/vests was manufactured. Nanotechnology were firstly proposed/initiated by Nobel Prize winner Richard Feynman in 1959 [2]. This science is credited to have applications ranging from electronics, biomedicals, food, fuel cells to biosensors and even fabrics. Though every field of science progressing but still faces some lacunae and that result in development of a new technology. The thriving biomedical techniques for disorders like cancers etc. is still in developmental stage where researchers and doctors are working hard for concrete therapeutic results from such nano-techniques. On Cancers, the harmful side effects of its treatment like chemotherapy can’t be left aside which is result of one of its drug delivery methods that don’t pinpoint their intended target cells accurately rather affects whole area. Researchers in universities like Harvard and MIT have been able to attach special RNA strands, measuring about 10nm in diameter, to nanoparticles and fill the nanoparticles with a chemotherapy drug. The RNA strands get attracted to cancer cells. When the nanoparticle encounters a cancer cell it adheres to it and releases the drug into the cancer cell. This directed method of drug delivery has great potential for treating cancer patients while producing less side harmful effects than those produced by conventional chemotherapy [3]. This paper provides valuable information to the researchers, knowledge experts and policy makers regarding the application of nanotechnology and its values in science and technology. Biomedical is one of the major issues which were catered by nanotechnology.展开更多
The mobile ad hoc network (MANET) with infrastructure networks (hybrid networks) has several practical uses. The utility of hybrid network is increased in real time applications by providing some suitable quality of s...The mobile ad hoc network (MANET) with infrastructure networks (hybrid networks) has several practical uses. The utility of hybrid network is increased in real time applications by providing some suitable quality of service. The quality thresholds are imposed on parameters like end-to-end delay (EED), jitter, packet delivery ratio (PDR) and throughput. This paper utilizes the extended ad hoc on-demand distance vector (AODV) routing protocol for communication between ad hoc network and fixed wired network. This paper also uses the IEEE 802.11e medium access control (MAC) function HCF Controlled Channel Access (HCCA) to support quality of service (QoS) in hybrid network. In this paper two simulation scenarios are analyzed for hybrid networks. The nodes in wireless ad hoc networks are mobile in one scenario and static in the other scenario. Both simulation scenarios are used to compare the performance of extended AODV with HCCA (IEEE 802.11e) and without HCCA (IEEE802.11) for real time voice over IP (VoIP) traffic. The extensive set of simulations results show that the performance of extended AODV with HCCA (IEEE 802.11e) improves QoS in hybrid network and it is unaffected whether the nodes in wireless ad hoc networks are mobile or static.展开更多
Quantitative Structure-Activity Relationship (2D-QSAR) models for binding affinity constants (log Ki) of 78 flavanoid ligands towards the benzodiazepine site of GABA (A) receptor complex were estimated using the PRECL...Quantitative Structure-Activity Relationship (2D-QSAR) models for binding affinity constants (log Ki) of 78 flavanoid ligands towards the benzodiazepine site of GABA (A) receptor complex were estimated using the PRECLAV (Property-Evaluation by Class Variables) program. The best MLR equation with nine PRECLAV descriptors has R2 = 0.843 and R2C = 0.782. Attempt is also made for obtaining 2D-QSAR model using NCSS software. The comparison of the results indicated that the PRECLAV method is very efficient in detecting structure-activity correlation with good predictive power.展开更多
Phosphoinositide-dependent protein kinase-1 (PDK1), the class of serine threonine kinase, is a master regulator of the AGC family of kinases. It is a main component of the PI3K pathway. As it is reported that this pat...Phosphoinositide-dependent protein kinase-1 (PDK1), the class of serine threonine kinase, is a master regulator of the AGC family of kinases. It is a main component of the PI3K pathway. As it is reported that this pathway is most commonly, and this pathway is the most commonly deregulated among many cancers. So designing a selective inhibitor of PDK1 may have the efficacy as an anticancer agent. Herein, we describe our work focused on the structure based on screening of 95% similar analogues of Myricetin deposited in PubChem database as earlier studies have been suggested that myricetin acts as an anti cancer agent. Further molecular docking as well as the in silico ADMET studies are incorporated on these compounds to evaluate the binding and pharmacokinetic properties of these compounds. Due to low oral bioavailability, clinical use of myricetin is limited. Therefore this study is an attempt towards screening of structurally similar better compounds as compare with myricetin which can act as better inhibitor against PDK-1.展开更多
Background:Betel nut/areca nut/Areca catechu is one of the most commonly used psychoactive substance,and is also a major preventable cause of cancer.Unlike other psychoactive substances,such as nicotine,the mechanisms...Background:Betel nut/areca nut/Areca catechu is one of the most commonly used psychoactive substance,and is also a major preventable cause of cancer.Unlike other psychoactive substances,such as nicotine,the mechanisms underlying addiction to areca nuts and related oncogenesis remain elusive.Recent reports suggest a possible overlap in the mechanisms of action of nicotine and areca nuts in the human body.Thus,this study aimed to investigate the interactome of human proteins associated with areca nut exposure and the intricate similarities and differences in the effects of the two psychoactive substances on humans.Methods:A list of proteins associated with areca nut use was obtained from the available literature using terms from Medical Subject Headings(MeSH).Protein-protein interaction(PPI)networks and functional enrichment were analyzed.The results obtained for both psychoactive substances were compared.Results:Given the limited number of common proteins(36/226,16%)in the two sets,a substantial overlap(612/1176 nodes,52%)was observed in the PPI networks,as well as in Gene Ontology.Areca nuts mainly affect signaling pathways through three hub proteins(alpha serine/threonine-protein kinase,tumor protein 53,and interleukin-6),which are common to both psychoactive substances,as well as two unique hub proteins(epidermal growth factor receptor and master regulator of cell cycle entry and proliferative metabolism).Areca nut-related proteins are associated with unique pathways,such as extracellular matrix organization,lipid storage,and metabolism,which are not found in nicotine-associated proteins.Conclusions:Areca nuts affect regulatory mechanisms,leading to systemic toxicity and oncogenesis.Areca nuts also affect unique pathways that can be studied as potential markers of exposure,as well as targets for anticancer therapeutic agents.展开更多
Three ethylene diurea （EDU） concentrations （0, 150 and 300 mg/L） were used to evaluate the negative impact of ozone （O3） on two cultivars of Trifoliurn repens L. cv. Vardan and Bundel grown under natural field c...Three ethylene diurea （EDU） concentrations （0, 150 and 300 mg/L） were used to evaluate the negative impact of ozone （O3） on two cultivars of Trifoliurn repens L. cv. Vardan and Bundel grown under natural field conditions in a suburban area of Varanasi, India. Mean O3 concentrations varied from 30.3 to 46.6 μg/L during the experimental period. Higher photosynthetic pigments and ascorhic acid concentrations were noticed in both EDU-treated cultivars over non-EDU-treated ones, but a reverse trend was found for lipid peroxidation. Growth parameters and biomass also showed increments under EDU treatment of both cultivars. The ratio of variable fluorescence to maximum fluorescence increased significantly in Vardan but not in Bundel upon EDU treatment. Results revealed that EDU concentration of 300 mg/L was more effective to combat the oxidative stress as well as protecting plants from O3 injury symptoms. The test cultivar Vardan is relatively sensitive to O3, thereby can be used as a bioindicator of O3 pollution in areas having higher O3 concentrations. Results also indicated that Bundel has more efficient antioxidant defense system than Vardan and hence was more tolerant to O3 stress.展开更多
2D materials are considered for applications that require strong light-matter interaction because of the apparently giant oscillator strength of the exciton transitions in the absorbance spectrum.Nevertheless,the effe...2D materials are considered for applications that require strong light-matter interaction because of the apparently giant oscillator strength of the exciton transitions in the absorbance spectrum.Nevertheless,the effective oscillator strengths of these transitions have bee n scarcely reported,nor is there a con sistent interpretati on of the obtained values.Here,we analyse the transition dipole moment and the ensuing oscillator strength of the exciton transition in 2D CdSe nanoplatelets by means of the optically induced Stark effect(OSE).Intriguingly,we find that the exciton absorption line reacts to a high intensity optical field as a transition with an oscillator strength FStark that is 50 times smaller than expected based on the linear absorption coefficient.We propose that the pronounced exciton absorption line should be seen as the sum of multiple,low oscillator strength transitions,rather than a single high oscillator strength one,a feat we assign to strong exciton center-of-mass localization.Within the quantum mechanical description of excitons,this 50-fold difference between both oscillator strengths corresponds to the ratio between the cohere nee area of the exciton's center of mass and the total area,which yields a coherence area of a mere 6.1 nm2.Since we find that the coherence area in creases with reducing temperature,we conclude that thermal effects,related to lattice vibrations,contribute to exciton localization.In further support of this localization model,we show that FStark is in dependent of the n anoplatelet area,correctly predicts the radiative lifetime,and lines up for strongly confined quantum dot systems.展开更多
基金funded by the Science Foundation Ireland (SFI)under the Principal Investigator Program under contract No.11PI-1148,16/IA/4629 and SFI 16/M-ERA/3419funding under the European Union’s Horizon 2020 Research and Innovation Program+7 种基金grant agreement No.814464 (Si-DRIVE project)IRCLA/2017/285 and SFI Research Centres AMBER,Ma REI and CONFIRM 12/RC/2302_P2,12/RC/2278_P2,and 16/RC/3918SFI for SIRG grant No.18/SIRG/5484support from the Sustainable Energy Authority of Ireland through the Research Development and Demonstration Funding Program (Grant No.19/RDD/548)Enterprise Ireland through the Innovation Partnership Program (Grant No.IP 20190910)support from the SFI Research Centre Ma REI (award reference No.12/RC/2302_P2)support from the SFI Industry RD&I Fellowship Program (21/IRDIF/9876)the EU Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Individual Fellowship Grant (843621)。
文摘Silicon nanowires(Si NWs)have been widely researched as the best alternative to graphite anodes for the next-generation of high-performance lithium-ion batteries(LIBs)owing to their high capacity and low discharge potential.However,growing binder-free Si NW anodes with adequate mass loading and stable capacity is severely limited by the low surface area of planar current collectors(CCs),and is particularly challenging to achieve on standard pure-Cu substrates due to the ubiquitous formation of Li+inactive silicide phases.Here,the growth of densely-interwoven In-seeded Si NWs is facilitated by a thin-film of copper-silicide(CS)network in situ grown on a Cu-foil,allowing for a thin active NW layer(<10μm thick)and high areal loading(≈1.04 mg/cm^(2))binder-free electrode architecture.The electrode exhibits an average Coulombic efficiency(CE)of>99.6%and stable performance for>900 cycles with≈88.7%capacity retention.More significantly,it delivers a volumetric capacity of≈1086.1 m A h/cm^(3)at 5C.The full-cell versus lithium manganese oxide(LMO)cathode delivers a capacity of≈1177.1 m A h/g at 1C with a stable rate capability.This electrode architecture represents significant advances toward the development of binder-free Si NW electrodes for LIB application.
文摘Type 2 diabetes mellitus(T2DM) is a silent progressive polygenic metabolic disorder resulting from ineffective insulin cascading in the body. World-wide, about 415 million people are suffering from T2DM with a projected rise to 642 million in 2040. T2DM is treated with several classes of oral antidiabetic drugs(OADs) viz. biguanides, sulfonylureas, thiazolidinediones, meglitinides, etc. Treatment strategies for T2DM are to minimize long-term micro and macro vascular complications by achieving an optimized glycemic control. Genetic variations in the human genome not only disclose the risk of T2DM development but also predict the personalized response to drug therapy. Inter-individual variability in response to OADs is due to polymorphisms in genes encoding drug receptors, transporters, and metabolizing enzymes for example, genetic variants in solute carrier transporters(SLC22A1, SLC22A2, SLC22A3, SLC47A1 and SLC47A2) are actively involved in glycemic/HbA1c management of metformin. In addition, CYP gene encoding Cytochrome P450 enzymes also play a crucial role with respect to metabolism of drugs. Pharmacogenetic studies provide insights on the relationship between individual genetic variants and variable therapeutic outcomes of various OADs. Clinical utility of pharmacogenetic study is to predict the therapeutic dose of various OADs on individual basis. Pharmacogenetics therefore, is a step towards personalized medicine which will greatly improve the efficacy of diabetes treatment.
文摘Nanotechnology is defined as the study and application of 1 - 100 nm sized structures. Nanomaterials have opened avenues for the industries and scientific endeavors. These recognized for unique size, dependant physical and chemical properties (optical, magnetic, catalytic, thermodynamic, electrochemical) [1]. Most significant properties of nanoparticles is their carbon strength. It is said to be so tough that recently with a nano-sized particles i.e. carbon nanotube—a bullet proof T-shirt/vests was manufactured. Nanotechnology were firstly proposed/initiated by Nobel Prize winner Richard Feynman in 1959 [2]. This science is credited to have applications ranging from electronics, biomedicals, food, fuel cells to biosensors and even fabrics. Though every field of science progressing but still faces some lacunae and that result in development of a new technology. The thriving biomedical techniques for disorders like cancers etc. is still in developmental stage where researchers and doctors are working hard for concrete therapeutic results from such nano-techniques. On Cancers, the harmful side effects of its treatment like chemotherapy can’t be left aside which is result of one of its drug delivery methods that don’t pinpoint their intended target cells accurately rather affects whole area. Researchers in universities like Harvard and MIT have been able to attach special RNA strands, measuring about 10nm in diameter, to nanoparticles and fill the nanoparticles with a chemotherapy drug. The RNA strands get attracted to cancer cells. When the nanoparticle encounters a cancer cell it adheres to it and releases the drug into the cancer cell. This directed method of drug delivery has great potential for treating cancer patients while producing less side harmful effects than those produced by conventional chemotherapy [3]. This paper provides valuable information to the researchers, knowledge experts and policy makers regarding the application of nanotechnology and its values in science and technology. Biomedical is one of the major issues which were catered by nanotechnology.
文摘The mobile ad hoc network (MANET) with infrastructure networks (hybrid networks) has several practical uses. The utility of hybrid network is increased in real time applications by providing some suitable quality of service. The quality thresholds are imposed on parameters like end-to-end delay (EED), jitter, packet delivery ratio (PDR) and throughput. This paper utilizes the extended ad hoc on-demand distance vector (AODV) routing protocol for communication between ad hoc network and fixed wired network. This paper also uses the IEEE 802.11e medium access control (MAC) function HCF Controlled Channel Access (HCCA) to support quality of service (QoS) in hybrid network. In this paper two simulation scenarios are analyzed for hybrid networks. The nodes in wireless ad hoc networks are mobile in one scenario and static in the other scenario. Both simulation scenarios are used to compare the performance of extended AODV with HCCA (IEEE 802.11e) and without HCCA (IEEE802.11) for real time voice over IP (VoIP) traffic. The extensive set of simulations results show that the performance of extended AODV with HCCA (IEEE 802.11e) improves QoS in hybrid network and it is unaffected whether the nodes in wireless ad hoc networks are mobile or static.
文摘Quantitative Structure-Activity Relationship (2D-QSAR) models for binding affinity constants (log Ki) of 78 flavanoid ligands towards the benzodiazepine site of GABA (A) receptor complex were estimated using the PRECLAV (Property-Evaluation by Class Variables) program. The best MLR equation with nine PRECLAV descriptors has R2 = 0.843 and R2C = 0.782. Attempt is also made for obtaining 2D-QSAR model using NCSS software. The comparison of the results indicated that the PRECLAV method is very efficient in detecting structure-activity correlation with good predictive power.
文摘Phosphoinositide-dependent protein kinase-1 (PDK1), the class of serine threonine kinase, is a master regulator of the AGC family of kinases. It is a main component of the PI3K pathway. As it is reported that this pathway is most commonly, and this pathway is the most commonly deregulated among many cancers. So designing a selective inhibitor of PDK1 may have the efficacy as an anticancer agent. Herein, we describe our work focused on the structure based on screening of 95% similar analogues of Myricetin deposited in PubChem database as earlier studies have been suggested that myricetin acts as an anti cancer agent. Further molecular docking as well as the in silico ADMET studies are incorporated on these compounds to evaluate the binding and pharmacokinetic properties of these compounds. Due to low oral bioavailability, clinical use of myricetin is limited. Therefore this study is an attempt towards screening of structurally similar better compounds as compare with myricetin which can act as better inhibitor against PDK-1.
基金supported by intramural funding from the National Institute of Cancer Prevention and Research,Indian Council of Medical Research(No.NICPR/Anuj/intramural/2021/1).
文摘Background:Betel nut/areca nut/Areca catechu is one of the most commonly used psychoactive substance,and is also a major preventable cause of cancer.Unlike other psychoactive substances,such as nicotine,the mechanisms underlying addiction to areca nuts and related oncogenesis remain elusive.Recent reports suggest a possible overlap in the mechanisms of action of nicotine and areca nuts in the human body.Thus,this study aimed to investigate the interactome of human proteins associated with areca nut exposure and the intricate similarities and differences in the effects of the two psychoactive substances on humans.Methods:A list of proteins associated with areca nut use was obtained from the available literature using terms from Medical Subject Headings(MeSH).Protein-protein interaction(PPI)networks and functional enrichment were analyzed.The results obtained for both psychoactive substances were compared.Results:Given the limited number of common proteins(36/226,16%)in the two sets,a substantial overlap(612/1176 nodes,52%)was observed in the PPI networks,as well as in Gene Ontology.Areca nuts mainly affect signaling pathways through three hub proteins(alpha serine/threonine-protein kinase,tumor protein 53,and interleukin-6),which are common to both psychoactive substances,as well as two unique hub proteins(epidermal growth factor receptor and master regulator of cell cycle entry and proliferative metabolism).Areca nut-related proteins are associated with unique pathways,such as extracellular matrix organization,lipid storage,and metabolism,which are not found in nicotine-associated proteins.Conclusions:Areca nuts affect regulatory mechanisms,leading to systemic toxicity and oncogenesis.Areca nuts also affect unique pathways that can be studied as potential markers of exposure,as well as targets for anticancer therapeutic agents.
文摘Three ethylene diurea （EDU） concentrations （0, 150 and 300 mg/L） were used to evaluate the negative impact of ozone （O3） on two cultivars of Trifoliurn repens L. cv. Vardan and Bundel grown under natural field conditions in a suburban area of Varanasi, India. Mean O3 concentrations varied from 30.3 to 46.6 μg/L during the experimental period. Higher photosynthetic pigments and ascorhic acid concentrations were noticed in both EDU-treated cultivars over non-EDU-treated ones, but a reverse trend was found for lipid peroxidation. Growth parameters and biomass also showed increments under EDU treatment of both cultivars. The ratio of variable fluorescence to maximum fluorescence increased significantly in Vardan but not in Bundel upon EDU treatment. Results revealed that EDU concentration of 300 mg/L was more effective to combat the oxidative stress as well as protecting plants from O3 injury symptoms. The test cultivar Vardan is relatively sensitive to O3, thereby can be used as a bioindicator of O3 pollution in areas having higher O3 concentrations. Results also indicated that Bundel has more efficient antioxidant defense system than Vardan and hence was more tolerant to O3 stress.
基金from FWO-Vlaanderen(12K8216N)Z.H.ack no wledges the Research Foundation Flanders(research projects 17006602 and G0F0920N)+1 种基金Ghent University(GOA no.01G01513)for funding.AJ.H acknowledges the ERC and NWO-TTW.S.Bisschop is acknowledged for SEM imaging of the platelet layers and K.De Nolf for help with the CdSe QD/platelet synthesis respectively.This project has received fun ding from the European Research Council(ERC)under the European Union's Horizon 2020 research and innovation program(grant agreement no.714876 PHOCONA).
文摘2D materials are considered for applications that require strong light-matter interaction because of the apparently giant oscillator strength of the exciton transitions in the absorbance spectrum.Nevertheless,the effective oscillator strengths of these transitions have bee n scarcely reported,nor is there a con sistent interpretati on of the obtained values.Here,we analyse the transition dipole moment and the ensuing oscillator strength of the exciton transition in 2D CdSe nanoplatelets by means of the optically induced Stark effect(OSE).Intriguingly,we find that the exciton absorption line reacts to a high intensity optical field as a transition with an oscillator strength FStark that is 50 times smaller than expected based on the linear absorption coefficient.We propose that the pronounced exciton absorption line should be seen as the sum of multiple,low oscillator strength transitions,rather than a single high oscillator strength one,a feat we assign to strong exciton center-of-mass localization.Within the quantum mechanical description of excitons,this 50-fold difference between both oscillator strengths corresponds to the ratio between the cohere nee area of the exciton's center of mass and the total area,which yields a coherence area of a mere 6.1 nm2.Since we find that the coherence area in creases with reducing temperature,we conclude that thermal effects,related to lattice vibrations,contribute to exciton localization.In further support of this localization model,we show that FStark is in dependent of the n anoplatelet area,correctly predicts the radiative lifetime,and lines up for strongly confined quantum dot systems.
