The model of“post-course competition certificate”can be the basic model of Building Information Modeling(BIM)course teaching in vocational colleges in the new era,and many vocational colleges have also made attempts...The model of“post-course competition certificate”can be the basic model of Building Information Modeling(BIM)course teaching in vocational colleges in the new era,and many vocational colleges have also made attempts to construct and apply this model in BIM courses and other professional courses.Based on the application of methods such as literature review and observation,it can be found that it is highly feasible in theory and practice to promote the innovation and reform of BIM curriculum based on this model.However,there are more influencing factors at the practical level,which can easily lead to some problems.In this paper,we will analyze the corresponding problems and put forward a more effective reform strategy of BIM course education innovation in combination with reality.展开更多
In this paper,the intelligent construction of prefabricated components is analyzed based on building information modeling(BIM).It includes an overview of BIM-based prefabricated components and intelligent construction...In this paper,the intelligent construction of prefabricated components is analyzed based on building information modeling(BIM).It includes an overview of BIM-based prefabricated components and intelligent construction,intelligent production lines in BIM-based intelligent construction systems,and analysis of the application of intelligent manufacturing in BIM-based prefabricated components.It was found that the determination of construction goals,the establishment of intelligent construction systems,and the application of intelligent construction systems are all areas that need to be emphasized in producing prefabricated building components through intelligent construction.It is hoped that this analysis can provide some reference for the application of intelligent construction and the improvement of the quality of prefabricated building components.展开更多
The trade situation about China’s export of toy products to the EU was introduced. The recall characteristics of China’s toy products by the EU “Safety Gate” in terms of recall frequency, notified countries, taken...The trade situation about China’s export of toy products to the EU was introduced. The recall characteristics of China’s toy products by the EU “Safety Gate” in terms of recall frequency, notified countries, taken measures, and reasons for recall were analyzed in this paper, and the risk factors of human health of unqualified products in terms of chemical hazards were studied in this paper. It is found that phthalate, boron, plumbum and cadmium were the main factors. Assessment of risk for boron in toys was conducted. It is suggested to limit the boron element in Slime: the limit of migration of boron in Slime toys for 3- to 6-year-old children shall be less than 704 mg/kg, and the limitation of migration of boron in Slime toys for 7- to 12-year-old children shall be less than 1268 mg/kg.展开更多
Helicobacter pylori(H.pylori)is one of the most common pathogenic bacterial infections and is found in the stomachs of approximately half of the world’s population.It is the primary known cause of gastritis,gastroduo...Helicobacter pylori(H.pylori)is one of the most common pathogenic bacterial infections and is found in the stomachs of approximately half of the world’s population.It is the primary known cause of gastritis,gastroduodenal ulcer disease and gastric cancer.However,combined drug therapy as the general treatment in the clinic,the rise of antibiotic-resistant bacteria,adverse reactions and poor patient compliance are major obstacles to the eradication of H.pylori.Oral site-specific drug delivery systems that could increase the longevity of the treatment agent at the target site might improve the therapeutic effect and avoid side effects.Gastroretentive drug delivery systems potentially prolong the gastric retention time and controlled/sustained release of a drug,thereby increasing the concentration of the drug at the application site,potentially improving its bioavailability and reducing the necessary dosage.Recommended gastroretentive drug delivery systems for enhancing local drug delivery include floating systems,bioadhesive systems and expandable systems.In this review,we summarize the important physiological parameters of the gastrointestinal tract that affect the gastric residence time.We then focus on various aspects useful in the development of gastroretentive drug delivery systems,including current trends and the progress of novel forms,especially with respect to their application for the treatment of H.pylori infections.展开更多
Gastrointestinal(GI)cancer is one of the leading causes of cancer-related deaths worldwide.According to the Global Cancer Statistics,colorectal cancer is the second leading cause of cancer-related mortality,closely fo...Gastrointestinal(GI)cancer is one of the leading causes of cancer-related deaths worldwide.According to the Global Cancer Statistics,colorectal cancer is the second leading cause of cancer-related mortality,closely followed by gastric cancer(GC).Environmental,dietary,and lifestyle factors including cigarette smoking,alcohol intake,and genetics are the most important risk factors for GI cancer.Furthermore,infections caused by Helicobacter pylori are a major cause of GC initiation.Despite improvements in conventional therapies,including surgery,chemotherapy,and radiotherapy,the length or quality of life of patients with advanced GI cancer is still poor because of delayed diagnosis,recurrence and side effect.Resveratrol(3,4,5-trihydroxy-trans-stilbene;Res),a natural polyphenolic compound,reportedly has various pharmacologic functions including anti-oxidant,anti-inflammatory,anti-cancer,and cardioprotective functions.Many studies have demonstrated that Res also exerts a chemopreventive effect on GI cancer.Research investigating the anti-cancer mechanism of Res for the prevention and treatment of GI cancer has implicated multiple pathways including oxidative stress,cell proliferation,and apoptosis.Therefore,this paper provides a review of the function and molecular mechanisms of Res in the prevention and treatment of GI cancer.展开更多
By efficiently and accurately predicting the adoptability of pets,shelters and rescuers can be positively guided on improving attraction of pet profiles,reducing animal suffering and euthanization.Previous prediction ...By efficiently and accurately predicting the adoptability of pets,shelters and rescuers can be positively guided on improving attraction of pet profiles,reducing animal suffering and euthanization.Previous prediction methods usually only used a single type of content for training.However,many pets contain not only textual content,but also images.To make full use of textual and visual information,this paper proposed a novel method to process pets that contain multimodal information.We employed several CNN(Convolutional Neural Network)based models and other methods to extract features from images and texts to obtain the initial multimodal representation,then reduce the dimensions and fuse them.Finally,we trained the fused features with two GBDT(Gradient Boosting Decision Tree)based models and a Neural Network(NN)and compare the performance of them and their ensemble.The evaluation result demonstrates that the proposed ensemble learning can improve the accuracy of prediction.展开更多
With the continuous development of e-commerce,consumers show increasing interest in posting comments on consumption experience and quality of commodities.Meanwhile,people make purchasing decisions relying on other com...With the continuous development of e-commerce,consumers show increasing interest in posting comments on consumption experience and quality of commodities.Meanwhile,people make purchasing decisions relying on other comments much more than ever before.So the reliability of commodity comments has a significant impact on ensuring consumers’equity and building a fair internet-trade-environment.However,some unscrupulous online-sellers write fake praiseful reviews for themselves and malicious comments for their business counterparts to maximize their profits.Those improper ways of self-profiting have severely ruined the entire online shopping industry.Aiming to detect and prevent these deceptive comments effectively,we construct a model of Multi-Filters Convolutional Neural Network(MFCNN)for opinion spam detection.MFCNN is designed with a fixed-length sequence input and an improved activation function to avoid the gradient vanishing problem in spam opinion detection.Moreover,convolution filters with different widths are used in MFCNN to represent the sentences and documents.Our experimental results show that MFCNN outperforms current state-of-the-art methods on standard spam detection benchmarks.展开更多
Edge storage stores the data directly at the data collection point,and does not need to transmit the collected data to the storage central server through the network.It is a critical technology that supports applicati...Edge storage stores the data directly at the data collection point,and does not need to transmit the collected data to the storage central server through the network.It is a critical technology that supports applications such as edge computing and 5G network applications,with lower network communication overhead,lower interaction delay and lower bandwidth cost.However,with the explosion of data and higher real-time requirements,the traditional Internet of Things(IoT)storage architecture cannot meet the requirements of low latency and large capacity.Non-volatile memory(NVM)presents new possibilities regarding this aspect.This paper classifies the different storage architectures based on NVM and compares the system goals,architectures,features,and limitations to explore new research opportunities.Moreover,the existing solutions to reduce the write latency and energy consumption and increase the lifetime of NVM IoT storage devices are analyzed.Furthermore,we discuss the security and privacy issues of IoT devices and compare the mainstream solutions.Finally,we present the opportunities and challenges of building IoT storage systems based on NVM.展开更多
In this paper, a hybrid method (hybrid PMM-MoM method) is presented for the effective and accurate analysis of finite periodic structures. This method divides a finite periodic structure into two parts. The inner part...In this paper, a hybrid method (hybrid PMM-MoM method) is presented for the effective and accurate analysis of finite periodic structures. This method divides a finite periodic structure into two parts. The inner part of an approximate infinite periodic structure is analyzed by periodic method of moment (PMM);the outer part is then analyzed by method of moments (MoM). For the finite periodic structures, the accuracy of the new method is much better than that of the pure PMM, and is almost the same as that of pure MoM. Because pure PMM uses the periodic boundary conditions, it takes much less memory resources and computation time. For hybrid PMM-MoM method, because the inner part is calculated by PMM, the calculation work concentrates on the outer part. Consequently, compared with the exact MoM, the new method saves much more memory resources and computation time, which provides a drastic reduction of unknowns.展开更多
Building information modeling(BIM)technology simulates visual information data by integrating the information data of construction projects.The presentation of information parameters allows better collaborative manage...Building information modeling(BIM)technology simulates visual information data by integrating the information data of construction projects.The presentation of information parameters allows better collaborative management of the construction process.BIM technology is applied to integrate information data during the construction of prefabricated structures,analyze the source of information data of construction projects,and build a digital information model.BIM technology consists of information integration function,information data simulation,cross-region coordination and more.Therefore,this paper applies it to the process of prefabricated structure design,puts forward relevant technical research strategies,establishes relevant models,ensures the accuracy of drawing,and simulates the final construction effect according to the combination of arranged relevant parameters.展开更多
Pyrite is widely distributed in estuarine sediments as an inexpensive natural Fenton-like reagent,however,the mechanism on the hydroxyl radical(HO^(·))production by pyrite under estuarine environmental conditions...Pyrite is widely distributed in estuarine sediments as an inexpensive natural Fenton-like reagent,however,the mechanism on the hydroxyl radical(HO^(·))production by pyrite under estuarine environmental conditions is still poorly understood.The batch experiments were performed to investigate the effects of estuarine conditions including aging(in air,in water),seawater anions(Cl^(-),Br^(-)and HCO_(3)^(-))and light on the HO^(·)production by pyrite oxidation.The one-electron transfer dominated the process from O_(2) to HO^(·)induced by oxidation of pyrite.The Fe(oxyhydr)oxide coatings on the surface of pyrite aged in air and water consumed hydrogen peroxide while mediating the electron transfer,and the combined effect of the two resulted in a suppression of HO^(·)production in the early stage of aging and a promotion of HO^(·)production in the later stage of aging.Corrosion of the surface oxide layers by aggressive anions was the main reason for the inhibition of HO^(·)production by Cl^(-)and Br^(-),and the generation of Cl^(·)and Br^(·)may also play a role in the scavenging of HO^(·).HCO_(3)^(-)increased the average rate of HO^(·)production through surface-CO_(2) complexes formed by adsorption on the surface of pyrite.The significant enhancement of HO^(·)production under light was attributed to the formation of photoelectrons induced by photochemical reactions on pyrite and its surface oxide layers.These findings provide new insights into the environmental chemical behavior of pyrite in the estuary and enrich the understanding of natural remediation of estuarine environments.展开更多
m^(6)A methylation is the most frequent modification of mRNA in eukaryotes and plays a crucial role in cancer progression by regulating biological functions.Insulin-like growth factor 2 mRNA-binding proteins(IGF2BP)ar...m^(6)A methylation is the most frequent modification of mRNA in eukaryotes and plays a crucial role in cancer progression by regulating biological functions.Insulin-like growth factor 2 mRNA-binding proteins(IGF2BP)are newly identified m^(6)A‘readers’.They belong to a family of RNA-binding proteins,which bind to the m^(6)A sites on different RNA sequences and stabilize them to promote cancer progression.In this review,we summarize the mechanisms by which different upstream factors regulate IGF2BP in cancer.The current literature analyzed here reveals that the IGF2BP family proteins promote cancer cell proliferation,survival,and chemoresistance,inhibit apoptosis,and are also associated with cancer glycolysis,angiogenesis,and the immune response in the tumor microenvironment.Therefore,with the discovery of their role as‘readers’of m^(6)A and the characteristic re-expression of IGF2BPs in cancers,it is important to elucidate their mechanism of action in the immunosuppressive tumor microenvironment.We also describe in detail the regulatory and interaction network of the IGF2BP family in downstream target RNAs and discuss their potential clinical applications as diagnostic and prognostic markers,as well as recent advances in IGF2BP biology and associated therapeutic value.展开更多
As an important fruit pest of global significance,Drosophila suzukii occupies a special ecological niche,with the characteristics of high sugar and low protein contents.This niche differs from those occupied by other ...As an important fruit pest of global significance,Drosophila suzukii occupies a special ecological niche,with the characteristics of high sugar and low protein contents.This niche differs from those occupied by other fruit-damaging Drosophila species.Gut bacteria substantially impact the physiology and ecology of insects.However,the contribution of gut microbes to the fitness of D.suzukii in their special ecological niche remains unclear.In this study,the effect of Klebsiella oxytoca on the development of D.suzukii was examined at physiological and molecular levels.The results showed that,after the removal of gut microbiota,the survival rate and longevity of axenic D.suzukii decreased significantly.Reintroduction of K.oxytoca to the midgut of D.suzukii advanced the development level of D.suzukii.The differentially expressed genes and metabolites between axenic and K.oxytoca-reintroduced D.suzukii were enriched in the pathways of carbohydrate metabolism.This advancement was achieved through an increased glycolysis rate and the regulation of the transcript level of key genes in the glycolysis/gluconeogenesis pathway.Klebsiella oxytoca is likely to play an important role in increasing host fitness in their high-sugar ecological niche by stimulating the glycolysis/gluconeogenesis pathway.As a protein source,bacteria can also provide direct nutrition for D.suzukii,which depends on the quantity or biomass of K.oxytoca.This result may provide a new target for controlling D.suzukii by inhibiting sugar metabolism through eliminating the effect of K.oxytoca and thus disrupting the balance of gut microbial communities.展开更多
基金Chongqing Municipal Education Science Planning Project+Educational Reform Special Project+Practice Research on Integrated Teaching Reform of“Post-Course Competition Certificate”for BIM Intelligent Construction Major in Vocational Schools(Project number:K23ZG3250169)。
文摘The model of“post-course competition certificate”can be the basic model of Building Information Modeling(BIM)course teaching in vocational colleges in the new era,and many vocational colleges have also made attempts to construct and apply this model in BIM courses and other professional courses.Based on the application of methods such as literature review and observation,it can be found that it is highly feasible in theory and practice to promote the innovation and reform of BIM curriculum based on this model.However,there are more influencing factors at the practical level,which can easily lead to some problems.In this paper,we will analyze the corresponding problems and put forward a more effective reform strategy of BIM course education innovation in combination with reality.
文摘In this paper,the intelligent construction of prefabricated components is analyzed based on building information modeling(BIM).It includes an overview of BIM-based prefabricated components and intelligent construction,intelligent production lines in BIM-based intelligent construction systems,and analysis of the application of intelligent manufacturing in BIM-based prefabricated components.It was found that the determination of construction goals,the establishment of intelligent construction systems,and the application of intelligent construction systems are all areas that need to be emphasized in producing prefabricated building components through intelligent construction.It is hoped that this analysis can provide some reference for the application of intelligent construction and the improvement of the quality of prefabricated building components.
文摘The trade situation about China’s export of toy products to the EU was introduced. The recall characteristics of China’s toy products by the EU “Safety Gate” in terms of recall frequency, notified countries, taken measures, and reasons for recall were analyzed in this paper, and the risk factors of human health of unqualified products in terms of chemical hazards were studied in this paper. It is found that phthalate, boron, plumbum and cadmium were the main factors. Assessment of risk for boron in toys was conducted. It is suggested to limit the boron element in Slime: the limit of migration of boron in Slime toys for 3- to 6-year-old children shall be less than 704 mg/kg, and the limitation of migration of boron in Slime toys for 7- to 12-year-old children shall be less than 1268 mg/kg.
文摘Helicobacter pylori(H.pylori)is one of the most common pathogenic bacterial infections and is found in the stomachs of approximately half of the world’s population.It is the primary known cause of gastritis,gastroduodenal ulcer disease and gastric cancer.However,combined drug therapy as the general treatment in the clinic,the rise of antibiotic-resistant bacteria,adverse reactions and poor patient compliance are major obstacles to the eradication of H.pylori.Oral site-specific drug delivery systems that could increase the longevity of the treatment agent at the target site might improve the therapeutic effect and avoid side effects.Gastroretentive drug delivery systems potentially prolong the gastric retention time and controlled/sustained release of a drug,thereby increasing the concentration of the drug at the application site,potentially improving its bioavailability and reducing the necessary dosage.Recommended gastroretentive drug delivery systems for enhancing local drug delivery include floating systems,bioadhesive systems and expandable systems.In this review,we summarize the important physiological parameters of the gastrointestinal tract that affect the gastric residence time.We then focus on various aspects useful in the development of gastroretentive drug delivery systems,including current trends and the progress of novel forms,especially with respect to their application for the treatment of H.pylori infections.
基金Supported by National Natural Science Foundation of China,No.21576254National Natural Science Foundation of China,No.81903560Dalian Young Star of Science and Technology Project,No.2018RQ81.
文摘Gastrointestinal(GI)cancer is one of the leading causes of cancer-related deaths worldwide.According to the Global Cancer Statistics,colorectal cancer is the second leading cause of cancer-related mortality,closely followed by gastric cancer(GC).Environmental,dietary,and lifestyle factors including cigarette smoking,alcohol intake,and genetics are the most important risk factors for GI cancer.Furthermore,infections caused by Helicobacter pylori are a major cause of GC initiation.Despite improvements in conventional therapies,including surgery,chemotherapy,and radiotherapy,the length or quality of life of patients with advanced GI cancer is still poor because of delayed diagnosis,recurrence and side effect.Resveratrol(3,4,5-trihydroxy-trans-stilbene;Res),a natural polyphenolic compound,reportedly has various pharmacologic functions including anti-oxidant,anti-inflammatory,anti-cancer,and cardioprotective functions.Many studies have demonstrated that Res also exerts a chemopreventive effect on GI cancer.Research investigating the anti-cancer mechanism of Res for the prevention and treatment of GI cancer has implicated multiple pathways including oxidative stress,cell proliferation,and apoptosis.Therefore,this paper provides a review of the function and molecular mechanisms of Res in the prevention and treatment of GI cancer.
基金This work is supported by The National Key Research and Development Program of China(2018YFB1800202,2016YFB1000302,SQ2019ZD090149,2018YFB0204301).
文摘By efficiently and accurately predicting the adoptability of pets,shelters and rescuers can be positively guided on improving attraction of pet profiles,reducing animal suffering and euthanization.Previous prediction methods usually only used a single type of content for training.However,many pets contain not only textual content,but also images.To make full use of textual and visual information,this paper proposed a novel method to process pets that contain multimodal information.We employed several CNN(Convolutional Neural Network)based models and other methods to extract features from images and texts to obtain the initial multimodal representation,then reduce the dimensions and fuse them.Finally,we trained the fused features with two GBDT(Gradient Boosting Decision Tree)based models and a Neural Network(NN)and compare the performance of them and their ensemble.The evaluation result demonstrates that the proposed ensemble learning can improve the accuracy of prediction.
基金This work is supported by The National Key Research and Development Program of China(2018YFB1800202,2016YFB1000302,SQ2019ZD090149,2018YFB0204301).
文摘With the continuous development of e-commerce,consumers show increasing interest in posting comments on consumption experience and quality of commodities.Meanwhile,people make purchasing decisions relying on other comments much more than ever before.So the reliability of commodity comments has a significant impact on ensuring consumers’equity and building a fair internet-trade-environment.However,some unscrupulous online-sellers write fake praiseful reviews for themselves and malicious comments for their business counterparts to maximize their profits.Those improper ways of self-profiting have severely ruined the entire online shopping industry.Aiming to detect and prevent these deceptive comments effectively,we construct a model of Multi-Filters Convolutional Neural Network(MFCNN)for opinion spam detection.MFCNN is designed with a fixed-length sequence input and an improved activation function to avoid the gradient vanishing problem in spam opinion detection.Moreover,convolution filters with different widths are used in MFCNN to represent the sentences and documents.Our experimental results show that MFCNN outperforms current state-of-the-art methods on standard spam detection benchmarks.
基金This work is supported by National Key Research and Development Program of China NO.2018YFB0203904National Natural Science Foundation of China(61832020,61872392,U1611261,U1811461,61702569)the Pearl River S&T Nova Program of Guangzhou Province(201906010008)+1 种基金Natural Science Foundation of Guangdong Province(2018B030312002)Key Area Research and Development Program of Guang Dong Province(2019B010107001).
文摘Edge storage stores the data directly at the data collection point,and does not need to transmit the collected data to the storage central server through the network.It is a critical technology that supports applications such as edge computing and 5G network applications,with lower network communication overhead,lower interaction delay and lower bandwidth cost.However,with the explosion of data and higher real-time requirements,the traditional Internet of Things(IoT)storage architecture cannot meet the requirements of low latency and large capacity.Non-volatile memory(NVM)presents new possibilities regarding this aspect.This paper classifies the different storage architectures based on NVM and compares the system goals,architectures,features,and limitations to explore new research opportunities.Moreover,the existing solutions to reduce the write latency and energy consumption and increase the lifetime of NVM IoT storage devices are analyzed.Furthermore,we discuss the security and privacy issues of IoT devices and compare the mainstream solutions.Finally,we present the opportunities and challenges of building IoT storage systems based on NVM.
文摘In this paper, a hybrid method (hybrid PMM-MoM method) is presented for the effective and accurate analysis of finite periodic structures. This method divides a finite periodic structure into two parts. The inner part of an approximate infinite periodic structure is analyzed by periodic method of moment (PMM);the outer part is then analyzed by method of moments (MoM). For the finite periodic structures, the accuracy of the new method is much better than that of the pure PMM, and is almost the same as that of pure MoM. Because pure PMM uses the periodic boundary conditions, it takes much less memory resources and computation time. For hybrid PMM-MoM method, because the inner part is calculated by PMM, the calculation work concentrates on the outer part. Consequently, compared with the exact MoM, the new method saves much more memory resources and computation time, which provides a drastic reduction of unknowns.
文摘Building information modeling(BIM)technology simulates visual information data by integrating the information data of construction projects.The presentation of information parameters allows better collaborative management of the construction process.BIM technology is applied to integrate information data during the construction of prefabricated structures,analyze the source of information data of construction projects,and build a digital information model.BIM technology consists of information integration function,information data simulation,cross-region coordination and more.Therefore,this paper applies it to the process of prefabricated structure design,puts forward relevant technical research strategies,establishes relevant models,ensures the accuracy of drawing,and simulates the final construction effect according to the combination of arranged relevant parameters.
基金supported by the National Natural Science Foundation of China (No.51709157)the Youth Interdisciplinary Science and Innovative Research Groups of Shandong University (No.2020QNQT014)。
文摘Pyrite is widely distributed in estuarine sediments as an inexpensive natural Fenton-like reagent,however,the mechanism on the hydroxyl radical(HO^(·))production by pyrite under estuarine environmental conditions is still poorly understood.The batch experiments were performed to investigate the effects of estuarine conditions including aging(in air,in water),seawater anions(Cl^(-),Br^(-)and HCO_(3)^(-))and light on the HO^(·)production by pyrite oxidation.The one-electron transfer dominated the process from O_(2) to HO^(·)induced by oxidation of pyrite.The Fe(oxyhydr)oxide coatings on the surface of pyrite aged in air and water consumed hydrogen peroxide while mediating the electron transfer,and the combined effect of the two resulted in a suppression of HO^(·)production in the early stage of aging and a promotion of HO^(·)production in the later stage of aging.Corrosion of the surface oxide layers by aggressive anions was the main reason for the inhibition of HO^(·)production by Cl^(-)and Br^(-),and the generation of Cl^(·)and Br^(·)may also play a role in the scavenging of HO^(·).HCO_(3)^(-)increased the average rate of HO^(·)production through surface-CO_(2) complexes formed by adsorption on the surface of pyrite.The significant enhancement of HO^(·)production under light was attributed to the formation of photoelectrons induced by photochemical reactions on pyrite and its surface oxide layers.These findings provide new insights into the environmental chemical behavior of pyrite in the estuary and enrich the understanding of natural remediation of estuarine environments.
基金supported by grants from the Liaoning Nature Science Foundationof China(No.2022JH2/101300042)The National Natural Science Foundation of China(No.82173194,81672877)+1 种基金the Key Research Project of Liaoning Provincial Department of Education of China(No.ZD2020004)2018 Youth Backbone Support Program of China Medical University(No.QGZ2018063).
文摘m^(6)A methylation is the most frequent modification of mRNA in eukaryotes and plays a crucial role in cancer progression by regulating biological functions.Insulin-like growth factor 2 mRNA-binding proteins(IGF2BP)are newly identified m^(6)A‘readers’.They belong to a family of RNA-binding proteins,which bind to the m^(6)A sites on different RNA sequences and stabilize them to promote cancer progression.In this review,we summarize the mechanisms by which different upstream factors regulate IGF2BP in cancer.The current literature analyzed here reveals that the IGF2BP family proteins promote cancer cell proliferation,survival,and chemoresistance,inhibit apoptosis,and are also associated with cancer glycolysis,angiogenesis,and the immune response in the tumor microenvironment.Therefore,with the discovery of their role as‘readers’of m^(6)A and the characteristic re-expression of IGF2BPs in cancers,it is important to elucidate their mechanism of action in the immunosuppressive tumor microenvironment.We also describe in detail the regulatory and interaction network of the IGF2BP family in downstream target RNAs and discuss their potential clinical applications as diagnostic and prognostic markers,as well as recent advances in IGF2BP biology and associated therapeutic value.
基金supported financially through grants from the National Natural Science Foundation of China(31801750,31972273)Science and Technology In-novation Project of Shandong Academy of Agricul-tural Sciences(CXG2023A24,CXG2023A47)National.Natural Science Foundation of Shandong province(ZR2021YQ21,ZR2021QC218).
文摘As an important fruit pest of global significance,Drosophila suzukii occupies a special ecological niche,with the characteristics of high sugar and low protein contents.This niche differs from those occupied by other fruit-damaging Drosophila species.Gut bacteria substantially impact the physiology and ecology of insects.However,the contribution of gut microbes to the fitness of D.suzukii in their special ecological niche remains unclear.In this study,the effect of Klebsiella oxytoca on the development of D.suzukii was examined at physiological and molecular levels.The results showed that,after the removal of gut microbiota,the survival rate and longevity of axenic D.suzukii decreased significantly.Reintroduction of K.oxytoca to the midgut of D.suzukii advanced the development level of D.suzukii.The differentially expressed genes and metabolites between axenic and K.oxytoca-reintroduced D.suzukii were enriched in the pathways of carbohydrate metabolism.This advancement was achieved through an increased glycolysis rate and the regulation of the transcript level of key genes in the glycolysis/gluconeogenesis pathway.Klebsiella oxytoca is likely to play an important role in increasing host fitness in their high-sugar ecological niche by stimulating the glycolysis/gluconeogenesis pathway.As a protein source,bacteria can also provide direct nutrition for D.suzukii,which depends on the quantity or biomass of K.oxytoca.This result may provide a new target for controlling D.suzukii by inhibiting sugar metabolism through eliminating the effect of K.oxytoca and thus disrupting the balance of gut microbial communities.
