Prostate cancer(PCa)risk calculators(RCs)with prostate-specific antigen(PSA)and other risk factors can greatly improve the accurate prediction of potential risk of PCa compared to PSA.The European Randomized Study of ...Prostate cancer(PCa)risk calculators(RCs)with prostate-specific antigen(PSA)and other risk factors can greatly improve the accurate prediction of potential risk of PCa compared to PSA.The European Randomized Study of Screening for PCa Risk Calculator(ERSPC-RC)and the Prostate Cancer Prevention Trial Risk Calculator(PCPT-RC)are developed on the Western population.However,the Western RCs showed limited diagnostic efficacy in the Eastern Asian population,mainly due to racial differences between the two populations.We aimed to review the application of Western RCs and Eastern Asian RCs in Eastern Asian cohorts and to identify the characteristics and efficacy of these RCs.展开更多
The surgical spectrum for radical prostatectomy(RP)has evolved from open surgery to novel minimally invasive approaches during the past few decades,with roboticassisted radical prostatectomy(RARP)being collectively re...The surgical spectrum for radical prostatectomy(RP)has evolved from open surgery to novel minimally invasive approaches during the past few decades,with roboticassisted radical prostatectomy(RARP)being collectively reckoned as an increasingly popular option for prostate cancer(PCa).A previous study has demonstrated the safety and effectiveness of radical-assisted Laparoscopic radical Prostatectomy(RALP).[1]While the transperitoneal route is the most popular surgical access option,alternative propositions include extraperitoneal,perineal,or transvesical access.Since the advent of the next-generation da Vinci Xi and single-port(SP)platforms,robotic laparoendoscopic single-site surgery(R-LESS)has emerged as an intriguing concept in various general or gynecological procedures and in partial nephrectomy.The first single-port robotic-assisted radical prostatectomy(spRARP)was reported in 2008,[2]but has not seen much improvement in surgical techniques and popularity thereafter,with less than 60 total cases reported globally.[3]A previous report[4]demonstrated that the adoption of transumbilical incision in spRARP surgery may cause reduced flexibility,limited working space,and frequent instrument clashing,potentially leading to longer surgeries and increased difficulty.Extraperitoneal RARP has been widely reported in the literature with similar trifecta outcomes and shows more rapid recovery and reduced peri-operative complication rates.[5]The current study aims to investigate the feasibility of extraperitoneal single-port RARP(espRARP)with the use of the da Vinci Si HD model.展开更多
基金This study was supported by the National Basic Research Program of China （No. 2012CB518306）, the National Natural Science Foundation of China （No. 81101946）, the Prostate Cancer Foundation Young Investigator Award and the Shanghai Pujiang Program （No. 12PID008）.
基金This study was supported by the National Basic Research Program of China （No. 2012CB518300）, the National Natural Science Foundation of China（No. 81101946）, the Prostate Cancer Foundation Young Investigator Award, the Shanghai Pujiang Program （No. 12PID008） and the Key Project of Science and Technology Commission of Shanghai Municipality （No. 09DJ 1400400）.
基金This study is supported by the Fund for National Natural Science Foundation Youth Project(No.81702514 to RC).
文摘Prostate cancer(PCa)risk calculators(RCs)with prostate-specific antigen(PSA)and other risk factors can greatly improve the accurate prediction of potential risk of PCa compared to PSA.The European Randomized Study of Screening for PCa Risk Calculator(ERSPC-RC)and the Prostate Cancer Prevention Trial Risk Calculator(PCPT-RC)are developed on the Western population.However,the Western RCs showed limited diagnostic efficacy in the Eastern Asian population,mainly due to racial differences between the two populations.We aimed to review the application of Western RCs and Eastern Asian RCs in Eastern Asian cohorts and to identify the characteristics and efficacy of these RCs.
基金We would like to thank all the study participants, urologists, and study coordinators for participating in the study. This work was partially funded by the National Key Basic Research Program Grant 973 （2012CB518301）, the Key Project of the National Natural Science Foundation of China （81130047）, National Natural Science Foundation of China （81202001, 81272835）, China Scholarship Council （CSC）, intramural grants from Fudan University and Huashan Hospital, and a research grant from Beckman Coulter, Inc.
基金partially funded by the National Natural Science Foundation of China(No.81872105)the National Major R&D Program of China(No.2017YFC0908002)Shanghai Changhai Hospital(No.2019YXK058)。
文摘The surgical spectrum for radical prostatectomy(RP)has evolved from open surgery to novel minimally invasive approaches during the past few decades,with roboticassisted radical prostatectomy(RARP)being collectively reckoned as an increasingly popular option for prostate cancer(PCa).A previous study has demonstrated the safety and effectiveness of radical-assisted Laparoscopic radical Prostatectomy(RALP).[1]While the transperitoneal route is the most popular surgical access option,alternative propositions include extraperitoneal,perineal,or transvesical access.Since the advent of the next-generation da Vinci Xi and single-port(SP)platforms,robotic laparoendoscopic single-site surgery(R-LESS)has emerged as an intriguing concept in various general or gynecological procedures and in partial nephrectomy.The first single-port robotic-assisted radical prostatectomy(spRARP)was reported in 2008,[2]but has not seen much improvement in surgical techniques and popularity thereafter,with less than 60 total cases reported globally.[3]A previous report[4]demonstrated that the adoption of transumbilical incision in spRARP surgery may cause reduced flexibility,limited working space,and frequent instrument clashing,potentially leading to longer surgeries and increased difficulty.Extraperitoneal RARP has been widely reported in the literature with similar trifecta outcomes and shows more rapid recovery and reduced peri-operative complication rates.[5]The current study aims to investigate the feasibility of extraperitoneal single-port RARP(espRARP)with the use of the da Vinci Si HD model.
