Flexible electrochromic energy storage devices(FECESDs)for powering flexible electronics have attracted considerable attention.Silver nanowires(AgNWs)are one kind of the most promising flexible transparent electrodes(...Flexible electrochromic energy storage devices(FECESDs)for powering flexible electronics have attracted considerable attention.Silver nanowires(AgNWs)are one kind of the most promising flexible transparent electrodes(FTEs)materials for the emerging flexible devices.Currently,fabricating FECESD based on AgNWs FTEs is still hindered by their intrinsic poor electrochemical stability.To address this issue,a hybrid AgNWs/Co(OH)_(2)/PEDOT:PSS electrode is proposed.The PEDOT:PSS could not only improve the resistance against electrochemical corrosion of AgNWs,but also work as functional layer to realize the color-changing and energy storage properties.Moreover,the Co(OH)_(2)interlayer further improved the color-changing and energy storage performance.Based on the improvement,we assembled the symmetrical FECESDs.Under the same condition,the areal capacitance(0.8 mF cm^(−2))and coloration efficiency(269.80 cm^(2)C−1)of AgNWs/Co(OH)_(2)/PEDOT:PSS FECESDs were obviously higher than AgNWs/PEDOT:PSS FECESDs.Furthermore,the obtained FECESDs exhibited excellent stability against the mechanical deformation.The areal capacitance remained stable during 1000 times cyclic bending with a 25 mm curvature radius.These results demonstrated the broad application potential of the AgNWs/Co(OH)_(2)/PEDOT:PSS FECESD for the emerging portable and multifunctional electronics.展开更多
Prolactin(PRL)is a polypeptide hormone that is mainly synthesized and secreted by the lactotroph cells of the pituitary.There are two main isoforms of PRL:23-kDa PRL(named full-l ength PRL)and vasoinhibins(including ...Prolactin(PRL)is a polypeptide hormone that is mainly synthesized and secreted by the lactotroph cells of the pituitary.There are two main isoforms of PRL:23-kDa PRL(named full-l ength PRL)and vasoinhibins(including 5.6–18 kDa fragments).Both act as circulating hormones and cytokines to stimulate or inhibit vascular formation at different stages and neovascularization,including endothelial cell proliferation and migration,protease production,and apoptosis.However,their effects on vascular function and cardiovascular diseases are different or even contrary.In addition to the structure,secretion regulation,and signal transduction of PRL/vasoinhibins,this review focuses on the pathological mechanism and clinical significance of PRL/vasoinhibins in cardiovascular diseases.展开更多
To address the problem of conventional approaches for mechanical property determination requiring destructive sampling, which may be unsuitable for in-service structures, the authors proposed a method for determining ...To address the problem of conventional approaches for mechanical property determination requiring destructive sampling, which may be unsuitable for in-service structures, the authors proposed a method for determining the quasi-static fracture toughness and impact absorbed energy of ductile metals from spherical indentation tests (SITs). The stress status and damage mechanism of SIT, mode I fracture, Charpy impact tests, and related tests were frst investigated through fnite element (FE) calculations and scanning electron microscopy (SEM) observations, respectively. It was found that the damage mechanism of SITs is diferent from that of mode I fractures, while mode I fractures and Charpy impact tests share the same damage mechanism. Considering the diference between SIT and mode I fractures, uniaxial tension and pure shear were introduced to correlate SIT with mode I fractures. Based on this, the widely used critical indentation energy (CIE) model for fracture toughness determination using SITs was modifed. The quasi-static fracture toughness determined from the modifed CIE model was used to evaluate the impact absorbed energy using the dynamic fracture toughness and energy for crack initiation. The efectiveness of the newly proposed method was verifed through experiments on four types of steels: Q345R, SA508-3, 18MnMoNbR, and S30408.展开更多
Pericytes are the main cellular components of tiny arteries and capillaries.Studies have found that pericytes can undergo morphological contraction or relaxation under stimulation by cytokines,thus affecting the contr...Pericytes are the main cellular components of tiny arteries and capillaries.Studies have found that pericytes can undergo morphological contraction or relaxation under stimulation by cytokines,thus affecting the contraction and relaxation of microvessels and playing an essential role in regulating vascular microcirculation.Moreover,due to the characteristics of stem cells,pericytes can differentiate into a variety of inflammatory cell phenotypes,which then affect the immune function.Additionally,pericytes can also participate in angiogenesis and wound healing by interacting with endothelial cells in vascular microcirculation disorders.Here we review the origin,biological phenotype and function of pericytes,and discuss the potential mechanisms of pericytes in vascular microcirculation disorders,especially in pulmonary hypertension,so as to provide a sound basis and direction for the prevention and treatment of vascular microcirculation diseases.展开更多
Skilled talents are the main support for the strategic development of science and technology in China.The quality of talents is an important guarantee for the transformation and upgrading of national industries.By ana...Skilled talents are the main support for the strategic development of science and technology in China.The quality of talents is an important guarantee for the transformation and upgrading of national industries.By analyzing and studying Huang Yanpei’s thought on vocational education,this paper focuses on the cultivation of students’craftsmanship in vocational schools.First,we analyze the results of previous research and then elaborate on the connotations of Huang Yanpei’s education thought and craftsmanship spirit.Lastly,we propose five suggestions for the cultivation of craftsmanship.Our research work carries certain reference value to the study of craftsmanship cultivation in Huang Yanpei’s education thought.展开更多
The quality of the teaching staff is crucial to the development of vocational education.Skilled and knowledgeable teachers can provide students with specialized technical knowledge and practical skills.In addition to ...The quality of the teaching staff is crucial to the development of vocational education.Skilled and knowledgeable teachers can provide students with specialized technical knowledge and practical skills.In addition to teaching,teachers also act as mentors in providing guidance and support in all areas to students.However,the development of young teachers faces many problems,such as unclear career plans and a lack of attention to operational skills.This paper analyzes the research findings of past scholars and uses a questionnaire to analyze the problems faced by young teachers in their career development.Based on this,this paper puts forward some targeted suggestions,which can provide guidelines for the career development of young teachers.展开更多
Vocational education is an important part of the overall education system.The development of higher vocational education is one of the guiding principles of education in China.The development of teachers is an importa...Vocational education is an important part of the overall education system.The development of higher vocational education is one of the guiding principles of education in China.The development of teachers is an important support for the development of vocational education.Teachers who can teach theoretically and guide students in practical work are known as“double-qualified”teachers.Building a highly qualified and professional double-qualified teaching team is the fundamental task in modernizing vocational education.Firstly,this paper discusses the importance of“double-qualified”teachers by describing the relevant policies of the Ministry of Education in China.Secondly,it reviews the research works of early scholars.Thirdly,it analyzes the main problems of teacher training in higher education institutions.Fourthly,it proposes five suggestions for the development of a“double-qualified”teaching team in higher education institutions.A high level and professional teaching team is an important support for the high-quality development of vocational institutions.School leaders must attach great importance to the construction of a“double-qualified”teaching team and increase the support in terms of policies,institutional protection,and financial investment.展开更多
This study investigates the challenges encountered by vocational colleges when preparing for innovative skills competitions and proposes effective countermeasures.It highlights issues concerning students’motivation,l...This study investigates the challenges encountered by vocational colleges when preparing for innovative skills competitions and proposes effective countermeasures.It highlights issues concerning students’motivation,limited financial resources and hardware,teacher capacity limitations,inadequate reward systems,and curriculum misalignment.Through meticulous research and analysis,this paper presents practical recommendations to mitigate these challenges.Suggestions encompass strategies to enhance students’motivation,increase financial support,provide professional development opportunities for teachers,revamp the reward system,and align the curriculum with competition requirements.By implementing these measures,vocational colleges can cultivate active student participation,elevate teaching quality,bridge the gap between education and industry demands,and equip students for success in innovative skills competitions.展开更多
The spirit of craftsmanship is gaining increasing attention from both society and the education community.Along with professional knowledge,continuous research,and innovation have become decisive factors in determinin...The spirit of craftsmanship is gaining increasing attention from both society and the education community.Along with professional knowledge,continuous research,and innovation have become decisive factors in determining the quality of products.In this context,vocational colleges strive to cultivate high-quality skilled talents,making the cultivation of craftsmanship spirit a crucial component of vocational education.This study explores the cultivation path of craftsmanship spirit through the lens of skills competitions,with a special emphasis on developing students’perseverance.The research conclusions of this article hold significant reference value for the implementation of vocational education policies.展开更多
Vocational education and general education are two different types of education that are equally important.The orientation of talent training in vocational education is to nurture skilled talents to serve the society....Vocational education and general education are two different types of education that are equally important.The orientation of talent training in vocational education is to nurture skilled talents to serve the society.The practical ability of students is both the focus of teaching in vocational colleges and the requirement of enterprise posts.The various types of skills competitions provide a“stage”for students to showcase their abilities.First,this paper explores students’problem-solving ability while preparing for these competitions,expounding the importance of vocational education and skills competitions.Second,this paper summarizes the views of different scholars.Third,based on a specific case,this paper describes the improvement in students’ability while preparing for these competitions.Fourth,this paper analyzes the results of the questionnaire survey conducted to investigate the improvement in students’ability.Lastly,this paper puts forward several suggestions that appeal for vocational colleges to pay more attention to skills competitions.展开更多
Engineering mechanics is as a basic course,and the learning effect of this course directly affects the learning of subsequent professional courses.However,the teaching quality of engineering mechanics in vocational co...Engineering mechanics is as a basic course,and the learning effect of this course directly affects the learning of subsequent professional courses.However,the teaching quality of engineering mechanics in vocational colleges has been subpar for a long time.In this study,we explored the teaching situation of engineering mechanics by using questionnaires,pointing out the challenges faced in the teaching of engineering mechanics and putting forward four targeted suggestions,which include stimulating students’interest and increasing the investment in laboratory equipment,to improve the teaching quality.The findings of this study may provide some reference for the teaching reform of engineering mechanics.展开更多
With the continuous progress of science and technology,the speed of technology iteration in enterprise production line and the demand for comprehensive quality among workers are increasing.Companies not only require t...With the continuous progress of science and technology,the speed of technology iteration in enterprise production line and the demand for comprehensive quality among workers are increasing.Companies not only require their employees to have excellent skills,but also require them to be rigorous and meticulous,possess excellence,and carry out continuous innovation of the craftsman spirit.The talent training goal in vocational colleges is to supply high-quality skilled talents to the society.Vocational colleges have an important duty to cultivate the spirit of craftsmanship in students through multiple paths.Through in-depth analysis of previous research results,we carried out a study on the cultivation path of craftsmanship spirit.The results of this study may provide reference for the development of moral education in vocational colleges.展开更多
Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the bone microarchitecture,leading to an increased risk of fractures.Recently,circular RNAs(circ RNAs)have been demonst...Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the bone microarchitecture,leading to an increased risk of fractures.Recently,circular RNAs(circ RNAs)have been demonstrated to play pivotal roles in regulating bone metabolism.However,the underlying functions of circ RNAs in bone metabolism in postmenopausal osteoporosis remain obscure.Here,we report that circ Stag1 is a critical osteoporosis-related circ RNA that shows significantly downregulated expression in osteoporotic bone marrow mesenchymal stem cells(BMSCs)and clinical bone tissue samples from patients with osteoporosis.Overexpression of circ Stag1 significantly promoted the osteogenic capability of BMSCs.Mechanistically,we found that circ Stag1 interacts with human antigen R(Hu R),an RNA-binding protein,and promotes the translocation of Hu R into the cytoplasm.A high cytoplasmic level of Hu R led to the activation of the Wnt signaling pathway by stabilizing and enhancing low-density lipoprotein receptor-related protein 5/6(Lrp5/6)andβ-catenin expression,thereby stimulating the osteogenic differentiation of BMSCs.Furthermore,overexpression of circ Stag1 in vivo by circ Stag1-loaded adeno-associated virus(circ Stag1-AAV)promoted new bone formation,thereby preventing bone loss in ovariectomized rats.Collectively,we show that circ Stag1 plays a pivotal role in promoting the regeneration of bone tissue via Hu R/Wnt signaling,which may provide new strategies to prevent bone metabolic disorders such as postmenopausal osteoporosis.展开更多
Objective:Hematogenous metastasis is essential for the progression of ovarian cancer(OC),and circulating tumor cells(CTCs)are part of the metastatic cascade.However,the detection rate of CTC is low due to the use of l...Objective:Hematogenous metastasis is essential for the progression of ovarian cancer(OC),and circulating tumor cells(CTCs)are part of the metastatic cascade.However,the detection rate of CTC is low due to the use of less sensitive detection methods.Therefore,this study aimed to detect CTCs and circulating tumorigenic endothelial cells(CTECs)in patients with OC using subtraction enrichment and immunostaining and fluorescence in situ hybridization(SE-iFISH).Methods:We enrolled a total of 56 subjects,including 20 OC patients and 36 ovarian benign tumor patients.CTCs and CTECs were captured by subtraction enrichment(SE)and counted and classified according to immunofluorescence staining of tumor markers(TMs)carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)combined with fluorescence in situ hybridization(iFISH)of chromosome 8(Chr8)aneuploidy.The diagnostic value and subtype characteristics of CTCs and CTECs were investigated.Results:The detection rate of CTCs by SE-iFISH was high.Compared with CA125 and HE4,Chr8 aneuploidy was the major identification feature of CTC.CTC counts in OC were statistically higher than those in benign groups.CTC and CTEC with≥pentaploidy were detected in both groups,illustrating the poor diagnostic value of CTC or CTEC.Distributions of triploid and tetraploid CTC subtypes were significantly different,and combined detection of triploid and tetraploid CTCs showed the best diagnostic value.In contrast,the distribution of CTECs in the OC and benign groups had no statistically significant difference.Small CTCs accounted for over 1/3 of the total CTC count.We also found that small CTCs and CTECs primarily comprised triploid cells,while large CTCs and CTECs mainly comprised pentaploidy and beyond.Conclusions:The application of SE-iFISH offered a more comprehensive understanding of heterogeneous CTCs and CTECs in OC.Analysis of subclass characteristics of the CTCs and CTECs according to Chr8 aneuploidy and cell size may broaden their potential clinical utility and deepen mechanistic studies in OC.展开更多
Copper nanowires(Cu NWs)are considered an excellent alternative to indium tin oxide(ITO)in flexible transparency electrodes(FTEs).However,the mixed particles and surface oxidation of Cu NWs degrade the transmittance a...Copper nanowires(Cu NWs)are considered an excellent alternative to indium tin oxide(ITO)in flexible transparency electrodes(FTEs).However,the mixed particles and surface oxidation of Cu NWs degrade the transmittance and conductivity of the electrodes.Therefore,highly purified Cu NWs without oxidation are vital for high-performance FTEs.Herein,a facile and effective purification process is introduced to purify Cu NWs in a water and n-hexane system,which takes advantage of the differences in hydrophilicity between Cu NWs and Cu NPs caused by their different adsorption affinities to octadecylamine(ODA).At the same sheet resistance,the transmittance of the purified Cu NW-based FTEs improved approximately 2%compared to that of non-purified Cu NW-based FTEs.Immersion of the electrode in glacial acetic acid removed the surface organics and oxides.After only 40 s of treatment,the sheet resistance dramatically decreased from 10^5 Ohm/sq to 31 Ohm/sq with a transmittance of 85%.In addition,the Cu NW-based FTE conductors showed excellent flexibility(remaining stable after 1000 bending cycles).The Cu NW-based FTEs were further applied to fabricate a flexible transparent heater.At a voltage of 10 V,the temperature of the heater reached 73℃,demonstrating the potential applications of this material in various fields.展开更多
A methodology(HPLC)proposed in this paper for simultaneously quantitative determination of ilaprazole and its related impurities in commercial tablets was developed and validated.The chromatographic separation was car...A methodology(HPLC)proposed in this paper for simultaneously quantitative determination of ilaprazole and its related impurities in commercial tablets was developed and validated.The chromatographic separation was carried out by gradient elution using an Agilent C8 column(4.6 mm×250 mm,5 mm)which was maintained at 25℃.The mobile phase composed of solvent A(methanol)and solvent B(solution consisting 0.02 mmol/l monopotassium phosphate and 0.025 mmol/l sodium hydroxide)was at a flow rate of 1.0 ml/min.The samples were detected and quantified at 237 nm using an ultraviolet absorbance detector.Calibration curves of all analytes from 0.5 to 3.5 mg/ml were good linearity(r≥0.9990)and recovery was greater than 99.5% for each analyte.The lower limit of detection(LLOD)and quantification(LOQ)of this analytical method were 10 ng/ml and 25 ng/ml for all impurities,respectively.The stress studies indicated that the degradation products could not interfere with the detection of ilaprazole and its related impurities and the assay can thus be considered stability-indicating.The method precisions were in the range of 0.41-1.21 while the instrument precisions were in the range of 0.38-0.95 in terms of peak area RSD% for all impurities,respectively.This method is considered stabilityindicating and is applicable for accurate and simultaneous measuring of the ilaprazole and its related impurities in commercial enteric-coated tablets.展开更多
A biodegradable poly(lactic-co-glycolic acid) loading atorvastatin calcium(AC) nanoparticles(AC-PLGA-NPs) were prepared by probe ultrasonication and evaporation method aiming at improving the oral bioavailability of A...A biodegradable poly(lactic-co-glycolic acid) loading atorvastatin calcium(AC) nanoparticles(AC-PLGA-NPs) were prepared by probe ultrasonication and evaporation method aiming at improving the oral bioavailability of AC. The effects of experimental parameters, including stabilizer species, stabilizer concentration and pH of aqueous phase, on particle size were also evaluated. The resultant nanoparticles were in spherical shape with an average diameter of 174.7 nm and a narrow particle size distribution. And the drug loading and encapsulation efficiency were about 8% and 71%, respectively. The particle size and polydispersion were almost unchanged in 10 days. The release curves of AC-PLGA-NPs in vitro displaying sustained release characteristics indicated that its release mechanisms were matrix erosion and diffusion. The pharmacokinetic study in vivo revealed that the Cmax and AUC0-∞ of AC-PLGA-NPs in rats were nearly 3.7-fold and 4.7-fold higher than that of pure atorvastatin calcium suspension. Our results demonstrated that the delivery of AC-PLGANPs could be a promising approach for the oral delivery of AC for enhanced bioavailability.展开更多
The association between blood eosinophil(EOS)counts and arterial/venous throm-bosis is unclear.We aim to explore whether EOS count is a risk factor for throm-bosis.We searched several databases and preprint platforms ...The association between blood eosinophil(EOS)counts and arterial/venous throm-bosis is unclear.We aim to explore whether EOS count is a risk factor for throm-bosis.We searched several databases and preprint platforms using core terms‘eosinophil’,‘myocardial infarction’,‘ischemic stroke’,and‘venous thromboembo-lism’(VTE),among others.Studies comparing the odds ratios(ORs)or risk ratios(RRs)of EOSs with the abovementioned diseases were eligible.Overall,22 studies were included.A high EOS count was associated with acute coronary artery throm-bosis events(OR:1.23,95%CI:1.15-1.32),short-term cerebral infarction and mor-tality(RR:2.87,95%CI:1.49-5.51).The short-term risk of VTE was more common in patients with EOS-related diseases(RR:6.52,95%CI:2.42-17.54).For coronary artery disease,a high EOS count was a protective factor against 6-month to 1-year mortality(RR:0.56,95%CI:0.45-0.69)but was associated with long-term mortal-ity(RR:1.64,95%CI:1.25-2.14).Therefore,we conclude that for coronary artery thrombosis,EOS count is not associated with AMI events in general population.It may be associated with NSTEMI and STEMI in CAD patients,but more studies are needed to confirm this.In addition,EOS count is associated with an increased risk of both short-and long-term mortality but is not predictive of the composite end-points.For cerebral artery thrombosis,EOS count may be associated with cerebral infarction and could lead to an increased risk of poor short-term prognosis.For VTEs,EOS count was a risk factor for some patients,especially those with acute-phase EOS-related diseases.展开更多
Raman spectroscopy is a type of inelastic scattering spectroscopy that is widely used in determining and analyzing molecular structure.It also has a number of practical applications in evaluating food safety,medicine,...Raman spectroscopy is a type of inelastic scattering spectroscopy that is widely used in determining and analyzing molecular structure.It also has a number of practical applications in evaluating food safety,medicine,and forensics.The Raman spectral signal is weak,but the development of the surface-enhanced Raman scattering(SERS)technique has overcome this problem and led to further developments in Raman spectroscopy.This paper describes a fundamental study of the use of focused ion beam(FIB)direct writing for preparing gold substrates for SERS.Molecular dynamics and Monte Carlo simulation methods are used to investigate the damage induced by gallium ion implantation of a gold substrate.Based on characterization by x-ray photoelectron spectroscopy(XPS)and scanning electron microscopy,the mechanism by which ion implantation and annealing influence the damage induced by a gallium FIB is analyzed.After annealing at 350 XC,a mixture of metallic gallium,its oxide Ga2O3 conforming to the stoichiometric ratio,and its sub-stable oxide(Ga2Ox)in sub-stoichiometric ratio precipitated on the surface are detected by XPS.Annealing treatment can effectively reduce the effect of gallium ion implantation on a SERS substrate fabricated by FIB direct writing.展开更多
基金supports from the National Natural Science Foundation of China (Grant No. 52175300)Fundamental Research Funds for the Central Universities (2022FRFK060008)+2 种基金Heilongjiang Touyan Innovation Team Program (HITTY-20190013)Shenzhen Fundamental Research Programs (JCYJ20200925160843002)Start-up fund of SUSTech (Y01256114)
文摘Flexible electrochromic energy storage devices(FECESDs)for powering flexible electronics have attracted considerable attention.Silver nanowires(AgNWs)are one kind of the most promising flexible transparent electrodes(FTEs)materials for the emerging flexible devices.Currently,fabricating FECESD based on AgNWs FTEs is still hindered by their intrinsic poor electrochemical stability.To address this issue,a hybrid AgNWs/Co(OH)_(2)/PEDOT:PSS electrode is proposed.The PEDOT:PSS could not only improve the resistance against electrochemical corrosion of AgNWs,but also work as functional layer to realize the color-changing and energy storage properties.Moreover,the Co(OH)_(2)interlayer further improved the color-changing and energy storage performance.Based on the improvement,we assembled the symmetrical FECESDs.Under the same condition,the areal capacitance(0.8 mF cm^(−2))and coloration efficiency(269.80 cm^(2)C−1)of AgNWs/Co(OH)_(2)/PEDOT:PSS FECESDs were obviously higher than AgNWs/PEDOT:PSS FECESDs.Furthermore,the obtained FECESDs exhibited excellent stability against the mechanical deformation.The areal capacitance remained stable during 1000 times cyclic bending with a 25 mm curvature radius.These results demonstrated the broad application potential of the AgNWs/Co(OH)_(2)/PEDOT:PSS FECESD for the emerging portable and multifunctional electronics.
基金National Natural Science Foundation of China,Grant/Award Number:81700045,81870042 and 81900050Natural Science Foundation of Shanghai,Grant/Award Number:22ZR1452400+1 种基金Shanghai Municipal Commission of Health,Grant/Award Number:20204Y0384Shanghai Pulmonary Hospital,Grant/Award Number:fk18003 and fkyq1605。
文摘Prolactin(PRL)is a polypeptide hormone that is mainly synthesized and secreted by the lactotroph cells of the pituitary.There are two main isoforms of PRL:23-kDa PRL(named full-l ength PRL)and vasoinhibins(including 5.6–18 kDa fragments).Both act as circulating hormones and cytokines to stimulate or inhibit vascular formation at different stages and neovascularization,including endothelial cell proliferation and migration,protease production,and apoptosis.However,their effects on vascular function and cardiovascular diseases are different or even contrary.In addition to the structure,secretion regulation,and signal transduction of PRL/vasoinhibins,this review focuses on the pathological mechanism and clinical significance of PRL/vasoinhibins in cardiovascular diseases.
基金Supported by National Natural Science Foundation of China(Grant No.52275154)National Key Research and Development Project of China(Grant No.2016YFF0203005).
文摘To address the problem of conventional approaches for mechanical property determination requiring destructive sampling, which may be unsuitable for in-service structures, the authors proposed a method for determining the quasi-static fracture toughness and impact absorbed energy of ductile metals from spherical indentation tests (SITs). The stress status and damage mechanism of SIT, mode I fracture, Charpy impact tests, and related tests were frst investigated through fnite element (FE) calculations and scanning electron microscopy (SEM) observations, respectively. It was found that the damage mechanism of SITs is diferent from that of mode I fractures, while mode I fractures and Charpy impact tests share the same damage mechanism. Considering the diference between SIT and mode I fractures, uniaxial tension and pure shear were introduced to correlate SIT with mode I fractures. Based on this, the widely used critical indentation energy (CIE) model for fracture toughness determination using SITs was modifed. The quasi-static fracture toughness determined from the modifed CIE model was used to evaluate the impact absorbed energy using the dynamic fracture toughness and energy for crack initiation. The efectiveness of the newly proposed method was verifed through experiments on four types of steels: Q345R, SA508-3, 18MnMoNbR, and S30408.
基金Program of Fundamental Research Funds for the Central Universities,Grant/Award Number:22120220562Program of Natural Science Foundation of Shanghai,Grant/Award Number:201409004100 and 21ZR1453800+1 种基金Three Year Action Plan to Promote Clinical Skills and Clinical Innovation in Municipal Hospitals,Grant/Award Number:SHDC2020CR6016-002 and SHDC2020CR4021Program of Shanghai Pulmonary Hospital,Grant/Award Number:fkzr2320 and FKLY20005。
文摘Pericytes are the main cellular components of tiny arteries and capillaries.Studies have found that pericytes can undergo morphological contraction or relaxation under stimulation by cytokines,thus affecting the contraction and relaxation of microvessels and playing an essential role in regulating vascular microcirculation.Moreover,due to the characteristics of stem cells,pericytes can differentiate into a variety of inflammatory cell phenotypes,which then affect the immune function.Additionally,pericytes can also participate in angiogenesis and wound healing by interacting with endothelial cells in vascular microcirculation disorders.Here we review the origin,biological phenotype and function of pericytes,and discuss the potential mechanisms of pericytes in vascular microcirculation disorders,especially in pulmonary hypertension,so as to provide a sound basis and direction for the prevention and treatment of vascular microcirculation diseases.
基金The Project of China Vocational Education Association(Project Number:ZJS2022YB024)The Project of Innovation and Development Center of Ideological and Political Work(Beijing Polytechnic),Ministry of Education(Project Number:2022X305-SXZC).
文摘Skilled talents are the main support for the strategic development of science and technology in China.The quality of talents is an important guarantee for the transformation and upgrading of national industries.By analyzing and studying Huang Yanpei’s thought on vocational education,this paper focuses on the cultivation of students’craftsmanship in vocational schools.First,we analyze the results of previous research and then elaborate on the connotations of Huang Yanpei’s education thought and craftsmanship spirit.Lastly,we propose five suggestions for the cultivation of craftsmanship.Our research work carries certain reference value to the study of craftsmanship cultivation in Huang Yanpei’s education thought.
文摘The quality of the teaching staff is crucial to the development of vocational education.Skilled and knowledgeable teachers can provide students with specialized technical knowledge and practical skills.In addition to teaching,teachers also act as mentors in providing guidance and support in all areas to students.However,the development of young teachers faces many problems,such as unclear career plans and a lack of attention to operational skills.This paper analyzes the research findings of past scholars and uses a questionnaire to analyze the problems faced by young teachers in their career development.Based on this,this paper puts forward some targeted suggestions,which can provide guidelines for the career development of young teachers.
基金This work was supported by the Project of Beijing Office for Education Sciences Planning(Project Number:AFDB21206).
文摘Vocational education is an important part of the overall education system.The development of higher vocational education is one of the guiding principles of education in China.The development of teachers is an important support for the development of vocational education.Teachers who can teach theoretically and guide students in practical work are known as“double-qualified”teachers.Building a highly qualified and professional double-qualified teaching team is the fundamental task in modernizing vocational education.Firstly,this paper discusses the importance of“double-qualified”teachers by describing the relevant policies of the Ministry of Education in China.Secondly,it reviews the research works of early scholars.Thirdly,it analyzes the main problems of teacher training in higher education institutions.Fourthly,it proposes five suggestions for the development of a“double-qualified”teaching team in higher education institutions.A high level and professional teaching team is an important support for the high-quality development of vocational institutions.School leaders must attach great importance to the construction of a“double-qualified”teaching team and increase the support in terms of policies,institutional protection,and financial investment.
基金The Project of China Vocational Education Association(Project number:ZJS2022YB024)the Project of Innovation and Development Center of Ideological and Political Work(Beijing Polytechnic),Ministry of Education(Project number:2022X305-SXZC).
文摘This study investigates the challenges encountered by vocational colleges when preparing for innovative skills competitions and proposes effective countermeasures.It highlights issues concerning students’motivation,limited financial resources and hardware,teacher capacity limitations,inadequate reward systems,and curriculum misalignment.Through meticulous research and analysis,this paper presents practical recommendations to mitigate these challenges.Suggestions encompass strategies to enhance students’motivation,increase financial support,provide professional development opportunities for teachers,revamp the reward system,and align the curriculum with competition requirements.By implementing these measures,vocational colleges can cultivate active student participation,elevate teaching quality,bridge the gap between education and industry demands,and equip students for success in innovative skills competitions.
基金The Project of China Vocational Education Association(Project number:ZJS2022YB024)the Project of Innovation and Development Center of Ideological and Political Work(Beijing Polytechnic),Ministry of Education(Project number:2022X305-SXZC).
文摘The spirit of craftsmanship is gaining increasing attention from both society and the education community.Along with professional knowledge,continuous research,and innovation have become decisive factors in determining the quality of products.In this context,vocational colleges strive to cultivate high-quality skilled talents,making the cultivation of craftsmanship spirit a crucial component of vocational education.This study explores the cultivation path of craftsmanship spirit through the lens of skills competitions,with a special emphasis on developing students’perseverance.The research conclusions of this article hold significant reference value for the implementation of vocational education policies.
基金This work was supported by the Project of China Vocational Education Association(Project Number:ZJS2022YB024)the Project of Innovation and Development Center of Ideological and Political Work(Beijing Polytechnic),Ministry of Education(Project Number:2022X305-SXZC).
文摘Vocational education and general education are two different types of education that are equally important.The orientation of talent training in vocational education is to nurture skilled talents to serve the society.The practical ability of students is both the focus of teaching in vocational colleges and the requirement of enterprise posts.The various types of skills competitions provide a“stage”for students to showcase their abilities.First,this paper explores students’problem-solving ability while preparing for these competitions,expounding the importance of vocational education and skills competitions.Second,this paper summarizes the views of different scholars.Third,based on a specific case,this paper describes the improvement in students’ability while preparing for these competitions.Fourth,this paper analyzes the results of the questionnaire survey conducted to investigate the improvement in students’ability.Lastly,this paper puts forward several suggestions that appeal for vocational colleges to pay more attention to skills competitions.
基金supported by the Project of China Vocational Education Association(Project number:ZJS2022YB024)the Project of Innovation and Development Center of Ideological and Political Work(Beijing Polytechnic),Ministry of Education(Project number:2022X305-SXZC)+1 种基金the Project of Beijing Municipal Social Science Foundation(Project number:22XCC015)the Project of Key Program of Beijing Polytechnic(Project number:2023X018-SXZ).
文摘Engineering mechanics is as a basic course,and the learning effect of this course directly affects the learning of subsequent professional courses.However,the teaching quality of engineering mechanics in vocational colleges has been subpar for a long time.In this study,we explored the teaching situation of engineering mechanics by using questionnaires,pointing out the challenges faced in the teaching of engineering mechanics and putting forward four targeted suggestions,which include stimulating students’interest and increasing the investment in laboratory equipment,to improve the teaching quality.The findings of this study may provide some reference for the teaching reform of engineering mechanics.
基金The Project of China Vocational Education Association(Project number:ZJS2022YB024)The Project of Innovation and Development Center of Ideological and Political Work(Beijing Polytechnic),Ministry of Education(Project number:2022X305-SXZC).
文摘With the continuous progress of science and technology,the speed of technology iteration in enterprise production line and the demand for comprehensive quality among workers are increasing.Companies not only require their employees to have excellent skills,but also require them to be rigorous and meticulous,possess excellence,and carry out continuous innovation of the craftsman spirit.The talent training goal in vocational colleges is to supply high-quality skilled talents to the society.Vocational colleges have an important duty to cultivate the spirit of craftsmanship in students through multiple paths.Through in-depth analysis of previous research results,we carried out a study on the cultivation path of craftsmanship spirit.The results of this study may provide reference for the development of moral education in vocational colleges.
基金The Shenzhen Municipal Science and Technology Innovation Committee Project(JCYJ20190806160407178,JCYJ20180305164544288,JSGG20180504170427135,SGLH20180625141602256,JCYJ20180305164659637)the Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration(ZDSYS20200811143752005)supported this work。
文摘Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the bone microarchitecture,leading to an increased risk of fractures.Recently,circular RNAs(circ RNAs)have been demonstrated to play pivotal roles in regulating bone metabolism.However,the underlying functions of circ RNAs in bone metabolism in postmenopausal osteoporosis remain obscure.Here,we report that circ Stag1 is a critical osteoporosis-related circ RNA that shows significantly downregulated expression in osteoporotic bone marrow mesenchymal stem cells(BMSCs)and clinical bone tissue samples from patients with osteoporosis.Overexpression of circ Stag1 significantly promoted the osteogenic capability of BMSCs.Mechanistically,we found that circ Stag1 interacts with human antigen R(Hu R),an RNA-binding protein,and promotes the translocation of Hu R into the cytoplasm.A high cytoplasmic level of Hu R led to the activation of the Wnt signaling pathway by stabilizing and enhancing low-density lipoprotein receptor-related protein 5/6(Lrp5/6)andβ-catenin expression,thereby stimulating the osteogenic differentiation of BMSCs.Furthermore,overexpression of circ Stag1 in vivo by circ Stag1-loaded adeno-associated virus(circ Stag1-AAV)promoted new bone formation,thereby preventing bone loss in ovariectomized rats.Collectively,we show that circ Stag1 plays a pivotal role in promoting the regeneration of bone tissue via Hu R/Wnt signaling,which may provide new strategies to prevent bone metabolic disorders such as postmenopausal osteoporosis.
基金supported by grants from National Science Foundation of China(Grant Nos.41030211 and 41002123)the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Edncation Ministry,Research Fund for the Doctoral Program of Higher Education of China(Grant No. 20100022120009)+1 种基金the Fundamental Research Funds for the Central Universities(Grant Nos.2010ZY16 and 2011YXL03)the Teaching Laboratory Funds from China University of Geosciences,Beijing
基金financially supported by the National Key Research and Development Program of China(No.2016YFA0201404)National Natural Science Foundation of China(No.81971360)the National Key Technology R&D Program of China(No.2015BAI 13B06)。
文摘Objective:Hematogenous metastasis is essential for the progression of ovarian cancer(OC),and circulating tumor cells(CTCs)are part of the metastatic cascade.However,the detection rate of CTC is low due to the use of less sensitive detection methods.Therefore,this study aimed to detect CTCs and circulating tumorigenic endothelial cells(CTECs)in patients with OC using subtraction enrichment and immunostaining and fluorescence in situ hybridization(SE-iFISH).Methods:We enrolled a total of 56 subjects,including 20 OC patients and 36 ovarian benign tumor patients.CTCs and CTECs were captured by subtraction enrichment(SE)and counted and classified according to immunofluorescence staining of tumor markers(TMs)carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)combined with fluorescence in situ hybridization(iFISH)of chromosome 8(Chr8)aneuploidy.The diagnostic value and subtype characteristics of CTCs and CTECs were investigated.Results:The detection rate of CTCs by SE-iFISH was high.Compared with CA125 and HE4,Chr8 aneuploidy was the major identification feature of CTC.CTC counts in OC were statistically higher than those in benign groups.CTC and CTEC with≥pentaploidy were detected in both groups,illustrating the poor diagnostic value of CTC or CTEC.Distributions of triploid and tetraploid CTC subtypes were significantly different,and combined detection of triploid and tetraploid CTCs showed the best diagnostic value.In contrast,the distribution of CTECs in the OC and benign groups had no statistically significant difference.Small CTCs accounted for over 1/3 of the total CTC count.We also found that small CTCs and CTECs primarily comprised triploid cells,while large CTCs and CTECs mainly comprised pentaploidy and beyond.Conclusions:The application of SE-iFISH offered a more comprehensive understanding of heterogeneous CTCs and CTECs in OC.Analysis of subclass characteristics of the CTCs and CTECs according to Chr8 aneuploidy and cell size may broaden their potential clinical utility and deepen mechanistic studies in OC.
基金the National Natural Science Foundation of China(Grant No.51522503)the Program for New Century Excellent Talents in University(NCET-13-0175).
文摘Copper nanowires(Cu NWs)are considered an excellent alternative to indium tin oxide(ITO)in flexible transparency electrodes(FTEs).However,the mixed particles and surface oxidation of Cu NWs degrade the transmittance and conductivity of the electrodes.Therefore,highly purified Cu NWs without oxidation are vital for high-performance FTEs.Herein,a facile and effective purification process is introduced to purify Cu NWs in a water and n-hexane system,which takes advantage of the differences in hydrophilicity between Cu NWs and Cu NPs caused by their different adsorption affinities to octadecylamine(ODA).At the same sheet resistance,the transmittance of the purified Cu NW-based FTEs improved approximately 2%compared to that of non-purified Cu NW-based FTEs.Immersion of the electrode in glacial acetic acid removed the surface organics and oxides.After only 40 s of treatment,the sheet resistance dramatically decreased from 10^5 Ohm/sq to 31 Ohm/sq with a transmittance of 85%.In addition,the Cu NW-based FTE conductors showed excellent flexibility(remaining stable after 1000 bending cycles).The Cu NW-based FTEs were further applied to fabricate a flexible transparent heater.At a voltage of 10 V,the temperature of the heater reached 73℃,demonstrating the potential applications of this material in various fields.
文摘A methodology(HPLC)proposed in this paper for simultaneously quantitative determination of ilaprazole and its related impurities in commercial tablets was developed and validated.The chromatographic separation was carried out by gradient elution using an Agilent C8 column(4.6 mm×250 mm,5 mm)which was maintained at 25℃.The mobile phase composed of solvent A(methanol)and solvent B(solution consisting 0.02 mmol/l monopotassium phosphate and 0.025 mmol/l sodium hydroxide)was at a flow rate of 1.0 ml/min.The samples were detected and quantified at 237 nm using an ultraviolet absorbance detector.Calibration curves of all analytes from 0.5 to 3.5 mg/ml were good linearity(r≥0.9990)and recovery was greater than 99.5% for each analyte.The lower limit of detection(LLOD)and quantification(LOQ)of this analytical method were 10 ng/ml and 25 ng/ml for all impurities,respectively.The stress studies indicated that the degradation products could not interfere with the detection of ilaprazole and its related impurities and the assay can thus be considered stability-indicating.The method precisions were in the range of 0.41-1.21 while the instrument precisions were in the range of 0.38-0.95 in terms of peak area RSD% for all impurities,respectively.This method is considered stabilityindicating and is applicable for accurate and simultaneous measuring of the ilaprazole and its related impurities in commercial enteric-coated tablets.
基金financially supported by the Science and Technology Research Project of Liaoning Provincial Education Department L2013390
文摘A biodegradable poly(lactic-co-glycolic acid) loading atorvastatin calcium(AC) nanoparticles(AC-PLGA-NPs) were prepared by probe ultrasonication and evaporation method aiming at improving the oral bioavailability of AC. The effects of experimental parameters, including stabilizer species, stabilizer concentration and pH of aqueous phase, on particle size were also evaluated. The resultant nanoparticles were in spherical shape with an average diameter of 174.7 nm and a narrow particle size distribution. And the drug loading and encapsulation efficiency were about 8% and 71%, respectively. The particle size and polydispersion were almost unchanged in 10 days. The release curves of AC-PLGA-NPs in vitro displaying sustained release characteristics indicated that its release mechanisms were matrix erosion and diffusion. The pharmacokinetic study in vivo revealed that the Cmax and AUC0-∞ of AC-PLGA-NPs in rats were nearly 3.7-fold and 4.7-fold higher than that of pure atorvastatin calcium suspension. Our results demonstrated that the delivery of AC-PLGANPs could be a promising approach for the oral delivery of AC for enhanced bioavailability.
基金National Natural Science Foundation of China,Grant/Award Number:81700045 and 82000059Program of Shanghai Pulmonary Hospital,Grant/Award Number:FKLY20005Three-year Action Plan to Promote Clinical Skills and Clinical Innovation in Municipal Hospitals,Grant/Award Number:SHDC2020CR4021。
文摘The association between blood eosinophil(EOS)counts and arterial/venous throm-bosis is unclear.We aim to explore whether EOS count is a risk factor for throm-bosis.We searched several databases and preprint platforms using core terms‘eosinophil’,‘myocardial infarction’,‘ischemic stroke’,and‘venous thromboembo-lism’(VTE),among others.Studies comparing the odds ratios(ORs)or risk ratios(RRs)of EOSs with the abovementioned diseases were eligible.Overall,22 studies were included.A high EOS count was associated with acute coronary artery throm-bosis events(OR:1.23,95%CI:1.15-1.32),short-term cerebral infarction and mor-tality(RR:2.87,95%CI:1.49-5.51).The short-term risk of VTE was more common in patients with EOS-related diseases(RR:6.52,95%CI:2.42-17.54).For coronary artery disease,a high EOS count was a protective factor against 6-month to 1-year mortality(RR:0.56,95%CI:0.45-0.69)but was associated with long-term mortal-ity(RR:1.64,95%CI:1.25-2.14).Therefore,we conclude that for coronary artery thrombosis,EOS count is not associated with AMI events in general population.It may be associated with NSTEMI and STEMI in CAD patients,but more studies are needed to confirm this.In addition,EOS count is associated with an increased risk of both short-and long-term mortality but is not predictive of the composite end-points.For cerebral artery thrombosis,EOS count may be associated with cerebral infarction and could lead to an increased risk of poor short-term prognosis.For VTEs,EOS count was a risk factor for some patients,especially those with acute-phase EOS-related diseases.
基金The study is supported by the National Natural Science Foundation of China(Grant No.51575389)the State Key Laboratory of Precision Measurement Technology and Instruments(Pilt1705)。
文摘Raman spectroscopy is a type of inelastic scattering spectroscopy that is widely used in determining and analyzing molecular structure.It also has a number of practical applications in evaluating food safety,medicine,and forensics.The Raman spectral signal is weak,but the development of the surface-enhanced Raman scattering(SERS)technique has overcome this problem and led to further developments in Raman spectroscopy.This paper describes a fundamental study of the use of focused ion beam(FIB)direct writing for preparing gold substrates for SERS.Molecular dynamics and Monte Carlo simulation methods are used to investigate the damage induced by gallium ion implantation of a gold substrate.Based on characterization by x-ray photoelectron spectroscopy(XPS)and scanning electron microscopy,the mechanism by which ion implantation and annealing influence the damage induced by a gallium FIB is analyzed.After annealing at 350 XC,a mixture of metallic gallium,its oxide Ga2O3 conforming to the stoichiometric ratio,and its sub-stable oxide(Ga2Ox)in sub-stoichiometric ratio precipitated on the surface are detected by XPS.Annealing treatment can effectively reduce the effect of gallium ion implantation on a SERS substrate fabricated by FIB direct writing.
