BACKGROUND Rapid regeneration of the residual liver is one of the key determinants of successful partial hepatectomy(PHx).At present,there is a lack of recognized safe,effective,and stable drugs to promote liver regen...BACKGROUND Rapid regeneration of the residual liver is one of the key determinants of successful partial hepatectomy(PHx).At present,there is a lack of recognized safe,effective,and stable drugs to promote liver regeneration.It has been reported that vagus nerve signaling is beneficial to liver regeneration,but the potential mechanism at play here is not fully understood.AIM To explore the effect and mechanism of hepatic vagus nerve in liver regeneration after PHx.METHODS A PHx plus hepatic vagotomy(Hv)mouse model was established.The effect of Hv on liver regeneration after PHx was determined by comparing the liver regeneration levels of the PHx-Hv group and the PHx-sham group mice.In order to further investigate the role of interleukin(IL)-22 in liver regeneration inhibition mediated by Hv,the levels of IL-22 in the PHx-Hv group and the PHx-sham group was measured.The degree of liver injury in the PHx-Hv group and the PHx-sham group mice was detected to determine the role of the hepatic vagus nerve in liver injury after PHx.RESULTS Compared to control-group mice,Hv mice showed severe liver injury and weakened liver regeneration after PHx.Further research found that Hv downregulates the production of IL-22 induced by PHx and blocks activation of the signal transducer and activator of transcription 3(STAT3)pathway then reduces the expression of various mitogenic and anti-apoptotic proteins after PHx.Exogenous IL-22 reverses the inhibition of liver regeneration induced by Hv and alleviates liver injury,while treatment with IL-22 binding protein(an inhibitor of IL-22 signaling)reduce the concentration of IL-22 induced by PHx,inhibits the activation of the STAT3 signaling pathway in the liver after PHx,thereby hindering liver regeneration and aggravating liver injury in PHx-sham mice.CONCLUSION Hv attenuates liver regeneration after hepatectomy,and the mechanism may be related to the fact that Hv downregulates the production of IL-22,then blocks activation of the STAT3 pathway.展开更多
Objective:Medical images have been increased rapidly in digital medicine era,presenting an opportunity for the intervention of artificial intelligence(AI).In order to explore the value of convolutional neural network(...Objective:Medical images have been increased rapidly in digital medicine era,presenting an opportunity for the intervention of artificial intelligence(AI).In order to explore the value of convolutional neural network(CNN)algorithms in endoscopic images,we developed an AI-assisted comprehensive analysis system for endoscopic images and explored its performance in clinical real scenarios.Methods:A total of 6,270 white light endoscopic images from 516 cases were used to train 14 different CNN models.The images were divided into training set,validation set and test set according to 7:1:2 for exploring the possibility of discrimination of gastric cancer(GC)and benign lesions(nGC),gastric ulcer(GU)and ulcerated cancer(UCa),early gastric cancer(EGC)and nGC,infection of Helicobacter pylori(Hp)and no infection of Hp(noHp),as well as metastasis and no-metastasis at perigastric lymph nodes.Results:Among the 14 CNN models,EfficientNetB7 revealed the best performance on two-category of GC and nGC[accuracy:96.40%and area under the curve(AUC)=0.9959],GU and UCa(accuracy:90.84%and AUC=0.8155),EGC and nGC(accuracy:97.88%and AUC=0.9943),and Hp and noHp(accuracy:83.33%and AUC=0.9096).Whereas,InceptionV3 model showed better performance on predicting metastasis and nometastasis of perigastric lymph nodes for EGC(accuracy:79.44%and AUC=0.7181).In addition,the integrated analysis of endoscopic images and gross images of gastrectomy specimens was performed on 95 cases by EfficientNetB7 and RFB-SSD object detection model,resulting in 100%of predictive accuracy in EGC.Conclusions:Taken together,this study integrated image sources from endoscopic examination and gastrectomy of gastric tumors and incorporated the advantages of different CNN models.The AI-assisted diagnostic system will play an important role in the therapeutic decision-making of EGC.展开更多
In recent years, the use of Schwann cell transplantation to repair peripheral nerve injury has attracted much attention. Animal-based studies show that the transplantation of Schwann cells in combination with nerve sc...In recent years, the use of Schwann cell transplantation to repair peripheral nerve injury has attracted much attention. Animal-based studies show that the transplantation of Schwann cells in combination with nerve scaffolds promotes the repair of injured peripheral nerves. Autologous Schwann cell transplantation in humans has been reported recently. This article reviews current methods for removing the extracellular matrix and analyzes its composition and function. The development and secretory products of Schwann cells are also reviewed. The methods for the repair of peripheral nerve injuries that use myelin and Schwann cell transplantation are assessed. This survey of the literature data shows that using a decellularized nerve conduit combined with Schwann cells represents an effective strategy for the treatment of peripheral nerve injury. This analysis provides a comprehensive basis on which to make clinical decisions for the repair of peripheral nerve injury.展开更多
Micro-arc oxidation(MAO)coatings of ZK60 magnesium alloys were formed in a self-developed dual electrolyte composed of sodium silicate and phosphate at the high constant current of 1.8 A(15 A/dm^(2)).The MAO process a...Micro-arc oxidation(MAO)coatings of ZK60 magnesium alloys were formed in a self-developed dual electrolyte composed of sodium silicate and phosphate at the high constant current of 1.8 A(15 A/dm^(2)).The MAO process and growth mechanism were investigated by scanning electron microscopy(SEM)coupled with an energy dispersive spectrometer(EDS),confocal laser scanning microscopy and X-ray diffraction(XRD).The results indicate that the growth process of MAO coating mainly goes through“forming→puncturing→rapid growth of micro-arc oxidation→large arc discharge→self-repairing”.The coating grows inward and outward at the same time in the initial stage,but outward growth of the coating is dominant later.Mg,Mg_(2)SiO_(4) and MgO are the main phases of ceramic coating.展开更多
Micro-arc oxidation （MAO） process was cartied out in an optimized dual electrolyte system to fabricate a compact, smooth, and corrosion resistant coating on ZK60 Mg alloy. The microstructural characteristics of coat...Micro-arc oxidation （MAO） process was cartied out in an optimized dual electrolyte system to fabricate a compact, smooth, and corrosion resistant coating on ZK60 Mg alloy. The microstructural characteristics of coating were investigated by scanning electron microscopy （SEM） coupled with an energy dispersive spectrometer （EDS） and X-ray diffraction （XRD）. Test of mass loss was conducted at a 3.5 % NaCl solution to assess the resistance to corrosion. The bonding strength between the coating and ZK60 substrate was evaluated using scratch experiment. The results reveal that MgA1204 and MgO are the main phases of ceramic coating obtained in the dual electrolyte system. The corrosion rate of coating prepared in the optimized dual electrolyte is only 0.0061 g.m-2.h-1, which demonstrates excellent corrosion resistance. This is mainly due to the compact, uniform coating with high bonding strength.展开更多
Single nucleotide polymorphism(SNP)armays are a powerful genotyping tool used in genetic research and genomic breeding programs.Japanese flounder(Paralichthys olivaceus)is an economically-important aquaculture flatfis...Single nucleotide polymorphism(SNP)armays are a powerful genotyping tool used in genetic research and genomic breeding programs.Japanese flounder(Paralichthys olivaceus)is an economically-important aquaculture flatfish in many countries.However,the lack of high-efficient genotyping tools has impeded the genomic breeding programs for Japanese flounder.We developed a 50K Japanese flounder SNP array,"Yuxin No.1,"and report its utility in genomic selection(GS)for disease resistance to bacterial pathogens.We screened more than 42,.2 million SNPs from the whole-genome resequencing data of 1099 individuals and selected 48697 SNPs that were evenly distributed across the genome to anchor the array with Affymetrix Axiom genotyping technology.Evaluation of the array performance with 168 fishs howed that 74.7%of the loci were successfully genotyped with high call rates(>98%)and that the poly-morphic SNPs had good cluster separations.More than 85%of the SNPs were concordant with SNPs obtained from the whole-genome resequencing data.To validate"Yuxin No.1"for GS,the arrayed geno-typing data of 27 individuals from a candidate population and 931 individuals from a reference popula-tion were used to calculate the genomic estimated breeding values(GEBVs)for disease resistance toEdwardsiella tarda.There was a 21.2%relative increase in the accuracy of GEBV using the weighted geno-mic best linear unpiased prediction(wGBLUJP),compared to traditional pedigree-based best linear unbi-ased prediction(ABLUP),suggesting good performance of the'Yuxin No.1"SNP array for GS.In summary,we developed the"Yuxin No.1"50K SNP array,which provides a useful platform for high-quality geno-typing that may be beneficial to the genomic selective breeding of Japanese flounder.展开更多
Objective:Intraperitoneal(IP)chemotherapy through subcutaneous port is an effective treatment for gastric cancer(GC)patients with peritoneal metastasis(PM).The objective of this study is to assess the port complicatio...Objective:Intraperitoneal(IP)chemotherapy through subcutaneous port is an effective treatment for gastric cancer(GC)patients with peritoneal metastasis(PM).The objective of this study is to assess the port complications and risk factors for complications in GC patients with PM.Methods:In retrospective screening of 301 patients with subcutaneous ports implantation,249 GC patients with PM who received IP chemotherapy were screened out for analysis.Port complications and risk factors for complications were analyzed.Results:Of the 249 analyzed patients,57(22.9%)experienced port complications.Subcutaneous liquid accumulation(42.1%)and infection(28.1%)were the main complications,and other complications included port rotation(14.1%),wound dehiscence(12.3%),inflow obstruction(1.7%)and subcutaneous metastasis(1.7%).The median interval between port implantation and occurrence of complications was 3.0 months.Eastern Cooperative Oncology Group(ECOG)performance status[odds ratio(OR),1.74;95%confidence interval(95%CI),1.12-2.69],albumin(OR,3.67;95%CI,1.96-6.86),implantation procedure optimization(OR,0.33;95%CI,0.18-0.61)and implantation groups(OR,0.37;95%CI,0.20-0.69)were independent risk factors for port complications(P<0.05).ECOG performance status was the only factor that related to the grades of port complications(P=0.016).Conclusions:Port complications in GC patients who received IP chemotherapy are manageable.ECOG performance status,albumin,implantation procedure and implantation group are independent risk factors for port complications in GC patients with PM.展开更多
Objective: Postoperative complications adversely affected the prognosis in patients with gastric cancer. This study intends to investigate the feasibility of using machine-learning model to predict surgical outcomes i...Objective: Postoperative complications adversely affected the prognosis in patients with gastric cancer. This study intends to investigate the feasibility of using machine-learning model to predict surgical outcomes in patients undergoing gastrectomy.Methods: In this study, cancer patients who underwent gastrectomy at Shanghai Rui Jin Hospital in 2017 were randomly assigned to a development or validation cohort in a 9:1 ratio. A support vector classification(SVC) model to predict surgical outcomes in patients undergoing gastrectomy was developed and further validated.Results: A total of 321 patients with 32 features were collected. The positive and negative outcomes of postoperative complication after gastrectomy appeared in 100(31.2%) and 221(68.8%) patients, respectively. The SVC model was constructed to predict surgical outcomes in patients undergoing gastrectomy. The accuracy of 10-fold cross validation and external verification was 78.17% and 78.12%, respectively. Further, an online web server has been developed to share the SVC model for machine-learning-assisted prediction of surgical outcomes in patients undergoing gastrectomy in the future procedures, which is accessible at the web address:http://47.100.47.97:5005/r_model_prediction.Conclusions: The SVC model was a useful predictor for measuring the risk of postoperative complications after gastrectomy, which may help stratify patients with different overall status for choice of surgical procedure or other treatments. It can be expected that machine-learning models in cancer informatics research are possibly shareable and accessible via web address all over the world.展开更多
We design and fabricateλ/2 coplanar waveguide NbN resonators,the thickness and length of which are only several nanometers and hundred microns,respectively.The quality factor of such compact resonators can reach up t...We design and fabricateλ/2 coplanar waveguide NbN resonators,the thickness and length of which are only several nanometers and hundred microns,respectively.The quality factor of such compact resonators can reach up to 7.5×10~4 at single photon power level at 30 m K with the resonance frequency around 6.835 GHz.In order to tune the resonant frequency,the resonator is terminated to the ground with a dc-SQUID.By tuning the magnetic flux in the dc-SQUID,the effective inductance of the dc-SQUID is varied,which leads to the change in the resonant frequency of the resonator.The tunability range is more than 30 MHz and the quality factor is about 3×10~3.These compact and tunable NbN resonators have potential applications in the quantum information processing,such as in the precision measurement,coupling and/or reading out the quantum states of qubits.展开更多
Using the diluted S1813 UV photoresist as a sacrificial layer, we successfully fabricate a superconducting suspended parallel-plate capacitor, in which the top layer of aluminum film acts as a membrane mechanical reso...Using the diluted S1813 UV photoresist as a sacrificial layer, we successfully fabricate a superconducting suspended parallel-plate capacitor, in which the top layer of aluminum film acts as a membrane mechanical resonator. Together with a superconducting octagonal spiral inductor, this parallel-plate capacitor constitutes a superconducting microwave resonator. At m K temperature, the transmission characteristic and spectrum of the microwave resonator are measured.Sideband frequencies caused by the vibration of the membrane mechanical resonator are clearly demonstrated. By downconverting with a mixer, the dependence of fundamental frequency and its harmonics on the input microwave power are clearly demonstrated, which is consistent with the numerical simulation.展开更多
基金supported by the Jiangsu Province Industry–University–Research Project,China(No.BY20221160)the Postgraduate Research and Practice Innovation Program of Jiangsu Province,China(No.KYCX22_3798)+2 种基金the National Natural Science Foundation of China(No.52275339)the Key Research and Development Plan of the Ministry of Science and Technology,China(No.2023YFE0200400)the Science and Technology Project of Jiangsu Province,China(No.BZ2021053)。
基金Supported by the Natural Science Foundation of Zhejiang Province,No.LQ20H310002the Scientific Technology Projects of Health and Medicine of Zhejiang Province,No.2020KY308and the Huzhou Science and Technology Fund,No.2020GY39.
文摘BACKGROUND Rapid regeneration of the residual liver is one of the key determinants of successful partial hepatectomy(PHx).At present,there is a lack of recognized safe,effective,and stable drugs to promote liver regeneration.It has been reported that vagus nerve signaling is beneficial to liver regeneration,but the potential mechanism at play here is not fully understood.AIM To explore the effect and mechanism of hepatic vagus nerve in liver regeneration after PHx.METHODS A PHx plus hepatic vagotomy(Hv)mouse model was established.The effect of Hv on liver regeneration after PHx was determined by comparing the liver regeneration levels of the PHx-Hv group and the PHx-sham group mice.In order to further investigate the role of interleukin(IL)-22 in liver regeneration inhibition mediated by Hv,the levels of IL-22 in the PHx-Hv group and the PHx-sham group was measured.The degree of liver injury in the PHx-Hv group and the PHx-sham group mice was detected to determine the role of the hepatic vagus nerve in liver injury after PHx.RESULTS Compared to control-group mice,Hv mice showed severe liver injury and weakened liver regeneration after PHx.Further research found that Hv downregulates the production of IL-22 induced by PHx and blocks activation of the signal transducer and activator of transcription 3(STAT3)pathway then reduces the expression of various mitogenic and anti-apoptotic proteins after PHx.Exogenous IL-22 reverses the inhibition of liver regeneration induced by Hv and alleviates liver injury,while treatment with IL-22 binding protein(an inhibitor of IL-22 signaling)reduce the concentration of IL-22 induced by PHx,inhibits the activation of the STAT3 signaling pathway in the liver after PHx,thereby hindering liver regeneration and aggravating liver injury in PHx-sham mice.CONCLUSION Hv attenuates liver regeneration after hepatectomy,and the mechanism may be related to the fact that Hv downregulates the production of IL-22,then blocks activation of the STAT3 pathway.
基金supported by the National Natural Science Foundation of China(No.82473013,82072602,82270575 and 82070558)the Shanghai Science and Technology Committee(No.20DZ2201900)+1 种基金the Innovation Foundation of Translational Medicine of Shanghai Jiao Tong University School of Medicine(No.TM202001)the Collaborative Innovation Center for Clinical and Translational Science by Chinese Ministry of Education&Shanghai Municipal Government(No.CCTS-2022202 and CCTS-202302)。
文摘Objective:Medical images have been increased rapidly in digital medicine era,presenting an opportunity for the intervention of artificial intelligence(AI).In order to explore the value of convolutional neural network(CNN)algorithms in endoscopic images,we developed an AI-assisted comprehensive analysis system for endoscopic images and explored its performance in clinical real scenarios.Methods:A total of 6,270 white light endoscopic images from 516 cases were used to train 14 different CNN models.The images were divided into training set,validation set and test set according to 7:1:2 for exploring the possibility of discrimination of gastric cancer(GC)and benign lesions(nGC),gastric ulcer(GU)and ulcerated cancer(UCa),early gastric cancer(EGC)and nGC,infection of Helicobacter pylori(Hp)and no infection of Hp(noHp),as well as metastasis and no-metastasis at perigastric lymph nodes.Results:Among the 14 CNN models,EfficientNetB7 revealed the best performance on two-category of GC and nGC[accuracy:96.40%and area under the curve(AUC)=0.9959],GU and UCa(accuracy:90.84%and AUC=0.8155),EGC and nGC(accuracy:97.88%and AUC=0.9943),and Hp and noHp(accuracy:83.33%and AUC=0.9096).Whereas,InceptionV3 model showed better performance on predicting metastasis and nometastasis of perigastric lymph nodes for EGC(accuracy:79.44%and AUC=0.7181).In addition,the integrated analysis of endoscopic images and gross images of gastrectomy specimens was performed on 95 cases by EfficientNetB7 and RFB-SSD object detection model,resulting in 100%of predictive accuracy in EGC.Conclusions:Taken together,this study integrated image sources from endoscopic examination and gastrectomy of gastric tumors and incorporated the advantages of different CNN models.The AI-assisted diagnostic system will play an important role in the therapeutic decision-making of EGC.
基金supported by the National Key R&D Program of China,No.2017YFA0104701(to YW)the National Natural Science Foundation of China,No.31771052(to YW)+1 种基金the Natural Science Foundation of Beijing of China,No.7172202(to YW)the PLA Youth Training Project for Medical Science of China,No.16QNP144(to YW)
文摘In recent years, the use of Schwann cell transplantation to repair peripheral nerve injury has attracted much attention. Animal-based studies show that the transplantation of Schwann cells in combination with nerve scaffolds promotes the repair of injured peripheral nerves. Autologous Schwann cell transplantation in humans has been reported recently. This article reviews current methods for removing the extracellular matrix and analyzes its composition and function. The development and secretory products of Schwann cells are also reviewed. The methods for the repair of peripheral nerve injuries that use myelin and Schwann cell transplantation are assessed. This survey of the literature data shows that using a decellularized nerve conduit combined with Schwann cells represents an effective strategy for the treatment of peripheral nerve injury. This analysis provides a comprehensive basis on which to make clinical decisions for the repair of peripheral nerve injury.
文摘Micro-arc oxidation(MAO)coatings of ZK60 magnesium alloys were formed in a self-developed dual electrolyte composed of sodium silicate and phosphate at the high constant current of 1.8 A(15 A/dm^(2)).The MAO process and growth mechanism were investigated by scanning electron microscopy(SEM)coupled with an energy dispersive spectrometer(EDS),confocal laser scanning microscopy and X-ray diffraction(XRD).The results indicate that the growth process of MAO coating mainly goes through“forming→puncturing→rapid growth of micro-arc oxidation→large arc discharge→self-repairing”.The coating grows inward and outward at the same time in the initial stage,but outward growth of the coating is dominant later.Mg,Mg_(2)SiO_(4) and MgO are the main phases of ceramic coating.
基金supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions and the Key Laboratory of Advanced Welding Technology of Jiangsu Province, China (No. JSAWT-11)
文摘Micro-arc oxidation （MAO） process was cartied out in an optimized dual electrolyte system to fabricate a compact, smooth, and corrosion resistant coating on ZK60 Mg alloy. The microstructural characteristics of coating were investigated by scanning electron microscopy （SEM） coupled with an energy dispersive spectrometer （EDS） and X-ray diffraction （XRD）. Test of mass loss was conducted at a 3.5 % NaCl solution to assess the resistance to corrosion. The bonding strength between the coating and ZK60 substrate was evaluated using scratch experiment. The results reveal that MgA1204 and MgO are the main phases of ceramic coating obtained in the dual electrolyte system. The corrosion rate of coating prepared in the optimized dual electrolyte is only 0.0061 g.m-2.h-1, which demonstrates excellent corrosion resistance. This is mainly due to the compact, uniform coating with high bonding strength.
文摘Single nucleotide polymorphism(SNP)armays are a powerful genotyping tool used in genetic research and genomic breeding programs.Japanese flounder(Paralichthys olivaceus)is an economically-important aquaculture flatfish in many countries.However,the lack of high-efficient genotyping tools has impeded the genomic breeding programs for Japanese flounder.We developed a 50K Japanese flounder SNP array,"Yuxin No.1,"and report its utility in genomic selection(GS)for disease resistance to bacterial pathogens.We screened more than 42,.2 million SNPs from the whole-genome resequencing data of 1099 individuals and selected 48697 SNPs that were evenly distributed across the genome to anchor the array with Affymetrix Axiom genotyping technology.Evaluation of the array performance with 168 fishs howed that 74.7%of the loci were successfully genotyped with high call rates(>98%)and that the poly-morphic SNPs had good cluster separations.More than 85%of the SNPs were concordant with SNPs obtained from the whole-genome resequencing data.To validate"Yuxin No.1"for GS,the arrayed geno-typing data of 27 individuals from a candidate population and 931 individuals from a reference popula-tion were used to calculate the genomic estimated breeding values(GEBVs)for disease resistance toEdwardsiella tarda.There was a 21.2%relative increase in the accuracy of GEBV using the weighted geno-mic best linear unpiased prediction(wGBLUJP),compared to traditional pedigree-based best linear unbi-ased prediction(ABLUP),suggesting good performance of the'Yuxin No.1"SNP array for GS.In summary,we developed the"Yuxin No.1"50K SNP array,which provides a useful platform for high-quality geno-typing that may be beneficial to the genomic selective breeding of Japanese flounder.
基金This work was supported by National Natural Science Foundation of China(No.81772518)Multicenter Clinical Trial of Shanghai Jiao Tong University School of Medicine(No.DLY201602).
文摘Objective:Intraperitoneal(IP)chemotherapy through subcutaneous port is an effective treatment for gastric cancer(GC)patients with peritoneal metastasis(PM).The objective of this study is to assess the port complications and risk factors for complications in GC patients with PM.Methods:In retrospective screening of 301 patients with subcutaneous ports implantation,249 GC patients with PM who received IP chemotherapy were screened out for analysis.Port complications and risk factors for complications were analyzed.Results:Of the 249 analyzed patients,57(22.9%)experienced port complications.Subcutaneous liquid accumulation(42.1%)and infection(28.1%)were the main complications,and other complications included port rotation(14.1%),wound dehiscence(12.3%),inflow obstruction(1.7%)and subcutaneous metastasis(1.7%).The median interval between port implantation and occurrence of complications was 3.0 months.Eastern Cooperative Oncology Group(ECOG)performance status[odds ratio(OR),1.74;95%confidence interval(95%CI),1.12-2.69],albumin(OR,3.67;95%CI,1.96-6.86),implantation procedure optimization(OR,0.33;95%CI,0.18-0.61)and implantation groups(OR,0.37;95%CI,0.20-0.69)were independent risk factors for port complications(P<0.05).ECOG performance status was the only factor that related to the grades of port complications(P=0.016).Conclusions:Port complications in GC patients who received IP chemotherapy are manageable.ECOG performance status,albumin,implantation procedure and implantation group are independent risk factors for port complications in GC patients with PM.
文摘Objective: Postoperative complications adversely affected the prognosis in patients with gastric cancer. This study intends to investigate the feasibility of using machine-learning model to predict surgical outcomes in patients undergoing gastrectomy.Methods: In this study, cancer patients who underwent gastrectomy at Shanghai Rui Jin Hospital in 2017 were randomly assigned to a development or validation cohort in a 9:1 ratio. A support vector classification(SVC) model to predict surgical outcomes in patients undergoing gastrectomy was developed and further validated.Results: A total of 321 patients with 32 features were collected. The positive and negative outcomes of postoperative complication after gastrectomy appeared in 100(31.2%) and 221(68.8%) patients, respectively. The SVC model was constructed to predict surgical outcomes in patients undergoing gastrectomy. The accuracy of 10-fold cross validation and external verification was 78.17% and 78.12%, respectively. Further, an online web server has been developed to share the SVC model for machine-learning-assisted prediction of surgical outcomes in patients undergoing gastrectomy in the future procedures, which is accessible at the web address:http://47.100.47.97:5005/r_model_prediction.Conclusions: The SVC model was a useful predictor for measuring the risk of postoperative complications after gastrectomy, which may help stratify patients with different overall status for choice of surgical procedure or other treatments. It can be expected that machine-learning models in cancer informatics research are possibly shareable and accessible via web address all over the world.
基金Project partially supported by the National Key R&D Program of China(Grant No.2016YFA0301801)the National Natural Science Foundation of China(Grant Nos.11474154 and 61521001)+1 种基金PAPD,Dengfeng Project B of Nanjing Universitythe Fundamental Research Funds for the Central Universities,China(Grant No.14380134)。
文摘We design and fabricateλ/2 coplanar waveguide NbN resonators,the thickness and length of which are only several nanometers and hundred microns,respectively.The quality factor of such compact resonators can reach up to 7.5×10~4 at single photon power level at 30 m K with the resonance frequency around 6.835 GHz.In order to tune the resonant frequency,the resonator is terminated to the ground with a dc-SQUID.By tuning the magnetic flux in the dc-SQUID,the effective inductance of the dc-SQUID is varied,which leads to the change in the resonant frequency of the resonator.The tunability range is more than 30 MHz and the quality factor is about 3×10~3.These compact and tunable NbN resonators have potential applications in the quantum information processing,such as in the precision measurement,coupling and/or reading out the quantum states of qubits.
基金supported by the National Key Research and Development Program of China(Grant No.2016YFA0301801)the National Natural Science Foundation of China(Grant Nos.11474154 and 61521001)the Priority Academic Development Program of Jiangsu Higher Education Institutions and Dengfeng Project B of Nanjing University,China
文摘Using the diluted S1813 UV photoresist as a sacrificial layer, we successfully fabricate a superconducting suspended parallel-plate capacitor, in which the top layer of aluminum film acts as a membrane mechanical resonator. Together with a superconducting octagonal spiral inductor, this parallel-plate capacitor constitutes a superconducting microwave resonator. At m K temperature, the transmission characteristic and spectrum of the microwave resonator are measured.Sideband frequencies caused by the vibration of the membrane mechanical resonator are clearly demonstrated. By downconverting with a mixer, the dependence of fundamental frequency and its harmonics on the input microwave power are clearly demonstrated, which is consistent with the numerical simulation.
