We propose a method of reliable tracking orientation and flexible step size fiber tracking. A new directional strategy was defined to select one optimal tracking orientation from each directional set, which was based ...We propose a method of reliable tracking orientation and flexible step size fiber tracking. A new directional strategy was defined to select one optimal tracking orientation from each directional set, which was based on the single-tensor model and the two-tensor model. The directional set of planar voxels contained three tracking directions： two from the two-tensor model and one from the single- tensor model. The directional set of linear voxels contained only one principal vector. In addition, a flexible step size, rather than fixable step sizes, was implemented to improve the accuracy of fiber tracking. We used two sets of human data to assess the performance of our method; one was from a healthy volunteer and the other from a patient with low-grade glioma. Results verified that our method was superior to the single-tensor Fiber Assignment by Continuous Tracking and the two-tensor eXtended Streamline Tractography for showing detailed images of fiber bundles.展开更多
To overcome the computational burden of processing three-dimensional(3 D)medical scans and the lack of spatial information in two-dimensional(2 D)medical scans,a novel segmentation method was proposed that integrates ...To overcome the computational burden of processing three-dimensional(3 D)medical scans and the lack of spatial information in two-dimensional(2 D)medical scans,a novel segmentation method was proposed that integrates the segmentation results of three densely connected 2 D convolutional neural networks(2 D-CNNs).In order to combine the lowlevel features and high-level features,we added densely connected blocks in the network structure design so that the low-level features will not be missed as the network layer increases during the learning process.Further,in order to resolve the problems of the blurred boundary of the glioma edema area,we superimposed and fused the T2-weighted fluid-attenuated inversion recovery(FLAIR)modal image and the T2-weighted(T2)modal image to enhance the edema section.For the loss function of network training,we improved the cross-entropy loss function to effectively avoid network over-fitting.On the Multimodal Brain Tumor Image Segmentation Challenge(BraTS)datasets,our method achieves dice similarity coefficient values of 0.84,0.82,and 0.83 on the BraTS2018 training;0.82,0.85,and 0.83 on the BraTS2018 validation;and 0.81,0.78,and 0.83 on the BraTS2013 testing in terms of whole tumors,tumor cores,and enhancing cores,respectively.Experimental results showed that the proposed method achieved promising accuracy and fast processing,demonstrating good potential for clinical medicine.展开更多
In the USA,there were about 1806590 new cancer cases in 2020,and 606520 cancer deaths are expected to have occurred in 2021.Lung cancer has become the leading cause of death from cancer in both men and women(Siegel et...In the USA,there were about 1806590 new cancer cases in 2020,and 606520 cancer deaths are expected to have occurred in 2021.Lung cancer has become the leading cause of death from cancer in both men and women(Siegel et al.,2020).Clinical studies show that the five-year survival rate of lung cancer patients after early diagnosis and treatment intervention can reach 80%,compared with that of patients having advanced lung cancer.Thus,the early diagnosis of lung cancer is a key factorto reduce mortality.展开更多
基金supported by the Science and Technology Commission of the Shanghai Municipality of China,No.10dz2211800,No.10XD1421400the National High Technology Research and Development Program,No.2009AA02Z415the Innovation Program of Shanghai Municipal Education Commission,No.11yz292
文摘We propose a method of reliable tracking orientation and flexible step size fiber tracking. A new directional strategy was defined to select one optimal tracking orientation from each directional set, which was based on the single-tensor model and the two-tensor model. The directional set of planar voxels contained three tracking directions： two from the two-tensor model and one from the single- tensor model. The directional set of linear voxels contained only one principal vector. In addition, a flexible step size, rather than fixable step sizes, was implemented to improve the accuracy of fiber tracking. We used two sets of human data to assess the performance of our method; one was from a healthy volunteer and the other from a patient with low-grade glioma. Results verified that our method was superior to the single-tensor Fiber Assignment by Continuous Tracking and the two-tensor eXtended Streamline Tractography for showing detailed images of fiber bundles.
基金the National Natural Science Foundation of China(No.81830052)the Shanghai Natural Science Foundation of China(No.20ZR1438300)the Shanghai Science and Technology Support Project(No.18441900500),China。
文摘To overcome the computational burden of processing three-dimensional(3 D)medical scans and the lack of spatial information in two-dimensional(2 D)medical scans,a novel segmentation method was proposed that integrates the segmentation results of three densely connected 2 D convolutional neural networks(2 D-CNNs).In order to combine the lowlevel features and high-level features,we added densely connected blocks in the network structure design so that the low-level features will not be missed as the network layer increases during the learning process.Further,in order to resolve the problems of the blurred boundary of the glioma edema area,we superimposed and fused the T2-weighted fluid-attenuated inversion recovery(FLAIR)modal image and the T2-weighted(T2)modal image to enhance the edema section.For the loss function of network training,we improved the cross-entropy loss function to effectively avoid network over-fitting.On the Multimodal Brain Tumor Image Segmentation Challenge(BraTS)datasets,our method achieves dice similarity coefficient values of 0.84,0.82,and 0.83 on the BraTS2018 training;0.82,0.85,and 0.83 on the BraTS2018 validation;and 0.81,0.78,and 0.83 on the BraTS2013 testing in terms of whole tumors,tumor cores,and enhancing cores,respectively.Experimental results showed that the proposed method achieved promising accuracy and fast processing,demonstrating good potential for clinical medicine.
基金the National Natural Science Foundation of China(No.81830052)the Science and Technology Innovation Action Plan of Shanghai(No.18441900500)the Shanghai Natural Science Foundation of China(No.20ZR1438300)。
文摘In the USA,there were about 1806590 new cancer cases in 2020,and 606520 cancer deaths are expected to have occurred in 2021.Lung cancer has become the leading cause of death from cancer in both men and women(Siegel et al.,2020).Clinical studies show that the five-year survival rate of lung cancer patients after early diagnosis and treatment intervention can reach 80%,compared with that of patients having advanced lung cancer.Thus,the early diagnosis of lung cancer is a key factorto reduce mortality.
