Colorectal cancer(CRC),a multifactorial disease,is usually induced and developed through complex mechanisms,including impact of diet and lifestyle,genomic abnormalities,change of signaling pathways,inflammatory respon...Colorectal cancer(CRC),a multifactorial disease,is usually induced and developed through complex mechanisms,including impact of diet and lifestyle,genomic abnormalities,change of signaling pathways,inflammatory response,oxidation stress,dysbiosis,and so on.As natural polyphenolic phytochemicals that exist primarily in tea,tea polyphenols(TPs)have been shown to have many clinical applications,especially as anticancer agents.Most animal studies and epidemiological studies have demonstrated that TPs can prevent and treat CRC.TPs can inhibit the growth and metastasis of CRC by exerting the antiinflammatory,anti-oxidative or pro-oxidative,and pro-apoptotic effects,which are achieved by modulations at multiple levels.Many experiments have demonstrated that TPs can modulate several signaling pathways in cancer cells,including the mitogen-activated protein kinase pathway,phosphatidylinositol-3 kinase/Akt pathway,Wnt/β-catenin pathway,and 67 kDa laminin receptor pathway,to inhibit proliferation and promote cell apoptosis.In addition,novel studies have also suggested that TPs can prevent the growth and metastasis of CRC by modulating the composition of gut microbiota to improve immune system and decrease inflammatory responses.Molecular pathological epidemiology,a novel multidisciplinary investigation,has made great progress on CRC,and the further molecular pathological epidemiology research should be developed in the field of TPs and CRC.This review summarizes the existing in vitro and in vivo animal and human studies and potential mechanisms to examine the effects of tea polyphenols on CRC.展开更多
Caffeine is a purine alkaloid and is widely consumed in coffee,soda,tea,chocolate and energy drinks.To date,a growing number of studies have indicated that caffeine is associated with many diseases including colorecta...Caffeine is a purine alkaloid and is widely consumed in coffee,soda,tea,chocolate and energy drinks.To date,a growing number of studies have indicated that caffeine is associated with many diseases including colorectal cancer.Caffeine exerts its biological activity through binding to adenosine receptors,inhibiting phosphodiesterases,sensitizing calcium channels,antagonizing gamma-aminobutyric acid receptors and stimulating adrenal hormones.Some studies have indicated that caffeine can interact with signaling pathways such as transforming growth factorβ,phosphoinositide-3-kinase/AKT/mammalian target of rapamycin and mitogen-activated protein kinase pathways through which caffeine can play an important role in colorectal cancer pathogenesis,metastasis and prognosis.Moreover,caffeine can act as a general antioxidant that protects cells from oxidative stress and also as a regulatory factor of the cell cycle that modulates the DNA repair system.Additionally,as for intestinal homeostasis,through the interaction with receptors and cytokines,caffeine can modulate the immune system mediating its effects on T lymphocytes,B lymphocytes,natural killer cells and macrophages.Furthermore,caffeine can not only directly inhibit species in the gut microbiome,such as Escherichia coli and Candida albicans but also can indirectly exert inhibition by increasing the effects of other antimicrobial drugs.This review summarizes the association between colorectal cancer and caffeine that is being currently studied.展开更多
The prediction accuracy and generalization of fermentation process modeling on exopolysaccharide (EPS) production from Lactobacillus are often deteriorated by noise existing in the corresponding experimental data. In ...The prediction accuracy and generalization of fermentation process modeling on exopolysaccharide (EPS) production from Lactobacillus are often deteriorated by noise existing in the corresponding experimental data. In order to circumvent this problem, a novel entropy-based criterion is proposed as the objective function of several commonly used modeling methods, i.e. Multi-Layer Perceptron (MLP) network, Radial Basis Function (RBF) neural network, Takagi-Sugeno-Kang (TSK) fuzzy system, for fermentation process model in this study. Quite different from the traditional Mean Square Error (MSE) based criterion, the novel entropy-based criterion can be used to train the parameters of the adopted modeling methods from the whole distribution structure of the training data set, which results in the fact that the adopted modeling methods can have global approximation capability. Compared with the MSE- criterion, the advantage of this novel criterion exists in that the parameter learning can effectively avoid the over-fitting phenomenon, therefore the proposed criterion based modeling methods have much better generalization ability and robustness. Our experimental results confirm the above virtues of the proposed entropy-criterion based modeling methods.展开更多
基金Supported by the Innovative Talents Support Program of Institution of Higher Learning of Liaoning Province,No.2018-478Innovative Talents of Science and Technology Support Program of Young and Middle Aged People of Shenyang,No.RC170446
文摘Colorectal cancer(CRC),a multifactorial disease,is usually induced and developed through complex mechanisms,including impact of diet and lifestyle,genomic abnormalities,change of signaling pathways,inflammatory response,oxidation stress,dysbiosis,and so on.As natural polyphenolic phytochemicals that exist primarily in tea,tea polyphenols(TPs)have been shown to have many clinical applications,especially as anticancer agents.Most animal studies and epidemiological studies have demonstrated that TPs can prevent and treat CRC.TPs can inhibit the growth and metastasis of CRC by exerting the antiinflammatory,anti-oxidative or pro-oxidative,and pro-apoptotic effects,which are achieved by modulations at multiple levels.Many experiments have demonstrated that TPs can modulate several signaling pathways in cancer cells,including the mitogen-activated protein kinase pathway,phosphatidylinositol-3 kinase/Akt pathway,Wnt/β-catenin pathway,and 67 kDa laminin receptor pathway,to inhibit proliferation and promote cell apoptosis.In addition,novel studies have also suggested that TPs can prevent the growth and metastasis of CRC by modulating the composition of gut microbiota to improve immune system and decrease inflammatory responses.Molecular pathological epidemiology,a novel multidisciplinary investigation,has made great progress on CRC,and the further molecular pathological epidemiology research should be developed in the field of TPs and CRC.This review summarizes the existing in vitro and in vivo animal and human studies and potential mechanisms to examine the effects of tea polyphenols on CRC.
基金Supported by the innovative talents support program of institution of higher learning of Liao Ning province,No.2018-478The innovative talents of science and technology support program of young and middle-aged people of Shenyang,No.RC170446
文摘Caffeine is a purine alkaloid and is widely consumed in coffee,soda,tea,chocolate and energy drinks.To date,a growing number of studies have indicated that caffeine is associated with many diseases including colorectal cancer.Caffeine exerts its biological activity through binding to adenosine receptors,inhibiting phosphodiesterases,sensitizing calcium channels,antagonizing gamma-aminobutyric acid receptors and stimulating adrenal hormones.Some studies have indicated that caffeine can interact with signaling pathways such as transforming growth factorβ,phosphoinositide-3-kinase/AKT/mammalian target of rapamycin and mitogen-activated protein kinase pathways through which caffeine can play an important role in colorectal cancer pathogenesis,metastasis and prognosis.Moreover,caffeine can act as a general antioxidant that protects cells from oxidative stress and also as a regulatory factor of the cell cycle that modulates the DNA repair system.Additionally,as for intestinal homeostasis,through the interaction with receptors and cytokines,caffeine can modulate the immune system mediating its effects on T lymphocytes,B lymphocytes,natural killer cells and macrophages.Furthermore,caffeine can not only directly inhibit species in the gut microbiome,such as Escherichia coli and Candida albicans but also can indirectly exert inhibition by increasing the effects of other antimicrobial drugs.This review summarizes the association between colorectal cancer and caffeine that is being currently studied.
文摘The prediction accuracy and generalization of fermentation process modeling on exopolysaccharide (EPS) production from Lactobacillus are often deteriorated by noise existing in the corresponding experimental data. In order to circumvent this problem, a novel entropy-based criterion is proposed as the objective function of several commonly used modeling methods, i.e. Multi-Layer Perceptron (MLP) network, Radial Basis Function (RBF) neural network, Takagi-Sugeno-Kang (TSK) fuzzy system, for fermentation process model in this study. Quite different from the traditional Mean Square Error (MSE) based criterion, the novel entropy-based criterion can be used to train the parameters of the adopted modeling methods from the whole distribution structure of the training data set, which results in the fact that the adopted modeling methods can have global approximation capability. Compared with the MSE- criterion, the advantage of this novel criterion exists in that the parameter learning can effectively avoid the over-fitting phenomenon, therefore the proposed criterion based modeling methods have much better generalization ability and robustness. Our experimental results confirm the above virtues of the proposed entropy-criterion based modeling methods.
