In the present study,we propose to integrate the bilateral filter into the Shepard-interpolation-based method for the optimization of composite structures.The bilateral filter is used to avoid defects in the structure...In the present study,we propose to integrate the bilateral filter into the Shepard-interpolation-based method for the optimization of composite structures.The bilateral filter is used to avoid defects in the structure that may arise due to the gap/overlap of adjacent fiber tows or excessive curvature of fiber tows.According to the bilateral filter,sensitivities at design points in the filter area are smoothed by both domain filtering and range filtering.Then,the filtered sensitivities are used to update the design variables.Through several numerical examples,the effectiveness of the method was verified.展开更多
CRISPR base editor(BE)techniques are a promising tool for precise cytosine(C)to thymine(T),adenine(A)to guanine(G),and C to G base editing(CBE,ABE,and GBE,respectively)without the use of a donor DNA template conversio...CRISPR base editor(BE)techniques are a promising tool for precise cytosine(C)to thymine(T),adenine(A)to guanine(G),and C to G base editing(CBE,ABE,and GBE,respectively)without the use of a donor DNA template conversion(Komor et al.,2016;Nishida et al.,2016;Gaudelli et al.,2017;Kurt et al.,2021;Zhao et al.,2021).展开更多
基金This research work was supported by the National Natural Science Foundation of China(Grant No.51975227)the Natural Science Foundation for Distinguished Young Scholars of Hubei Province,China(Grant No.2017CFA044).
文摘In the present study,we propose to integrate the bilateral filter into the Shepard-interpolation-based method for the optimization of composite structures.The bilateral filter is used to avoid defects in the structure that may arise due to the gap/overlap of adjacent fiber tows or excessive curvature of fiber tows.According to the bilateral filter,sensitivities at design points in the filter area are smoothed by both domain filtering and range filtering.Then,the filtered sensitivities are used to update the design variables.Through several numerical examples,the effectiveness of the method was verified.
基金This work was financially supported by the National Key Research and Development Program of China(2018YFA0904900)the National Natural Science Foundation of China(32225031,32171449,81903776)+2 种基金the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(TSBICIP-KJGG-017)the Tianjin Natural Science Foundation(20JCYBJC00310)the Youth Innovation Promotion Association CAS(2022177).
文摘CRISPR base editor(BE)techniques are a promising tool for precise cytosine(C)to thymine(T),adenine(A)to guanine(G),and C to G base editing(CBE,ABE,and GBE,respectively)without the use of a donor DNA template conversion(Komor et al.,2016;Nishida et al.,2016;Gaudelli et al.,2017;Kurt et al.,2021;Zhao et al.,2021).
