Preclinical and clinical studies have shown that microglia and macrophages participate in a multiphasic brain damage repair process following intracerebral hemorrhage.The E26 transformation-specific sequence-related t...Preclinical and clinical studies have shown that microglia and macrophages participate in a multiphasic brain damage repair process following intracerebral hemorrhage.The E26 transformation-specific sequence-related transcription factor Spi1 regulates microglial/macrophage commitment and maturation.However,the effect of Spi1 on intracerebral hemorrhage remains unclear.In this study,we found that Spi1 may regulate recovery from the neuroinflammation and neurofunctional damage caused by intracerebral hemorrhage by modulating the microglial/macrophage transcriptome.We showed that high Spi1expression in microglia/macrophages after intracerebral hemorrhage is associated with the activation of many pathways that promote phagocytosis,glycolysis,and autophagy,as well as debris clearance and sustained remyelination.Notably,microglia with higher levels of Soil expression were chara cterized by activation of pathways associated with a variety of hemorrhage-related cellular processes,such as complement activation,angiogenesis,and coagulation.In conclusion,our results suggest that Spi1 plays a vital role in the microglial/macrophage inflammatory response following intracerebral hemorrhage.This new insight into the regulation of Spi1 and its target genes may advance our understanding of neuroinflammation in intracerebral hemorrhage and provide therapeutic targets for patients with intracerebral hemorrhage.展开更多
Core-shell structured magnetic wrinkled organosilica-based metal-enzyme integrated catalysts were synthesized,and their catalytic performances were studied in the chemoenzymatic dynamic kinetic resolution of chiral am...Core-shell structured magnetic wrinkled organosilica-based metal-enzyme integrated catalysts were synthesized,and their catalytic performances were studied in the chemoenzymatic dynamic kinetic resolution of chiral amines in an organic solvent,as well as in the chemoenzymatic synthesis of chiral alcohols in water.Structureperformance studies revealed the important influence of their tunable structure and composition on the optimization of activity,stability,and recyclability in chemoenzymatic catalysis.展开更多
Histone acetylation is involved in chromatin structural remodeling and the regulation of gene expression, and it is important for the activation of defense-related gene expression in eukaryotes[1]. The silent informat...Histone acetylation is involved in chromatin structural remodeling and the regulation of gene expression, and it is important for the activation of defense-related gene expression in eukaryotes[1]. The silent information regulator 2(SIR2) family of proteins were initially described as nuclear proteins with histone deacetylase activity that causes chromatin compaction and gene silencing[2].展开更多
Current research shows that the traditional shock control bump（SCB） can weaken the intensity of shock and better the transonic buffet performance. The author finds that when SCB is placed downstream of the shock, it...Current research shows that the traditional shock control bump（SCB） can weaken the intensity of shock and better the transonic buffet performance. The author finds that when SCB is placed downstream of the shock, it can decrease the adverse pressure gradient. This may prevent the shock foot separation bubble to merge with the trailing edge separation and finally improve the buffet performance. Based on RAE2822 airfoil, two types of SCB are designed according to the two different mechanisms. By using Reynolds-averaged Navier-Stokes（RANS） and unsteady Reynolds-averaged Navier-Stokes（URANS） methods to analyze the properties of RAE2822 airfoil with and without SCB, the results show that the downstream SCB can better the buffet performance under a wide range of freestream Mach number and the steady aerodynamics characteristic is similar to that of RAE2822 airfoil. The traditional SCB can only weaken the intensity of the shock under the design condition. Under the off-design conditions, the SCB does not do much to or even worsen the buffet performance. Indeed, the use of backward bump can flatten the leeward side of the airfoil, and this is similar to the mechanism that supercritical airfoil can weaken the recompression of shock wave.展开更多
基金supported by the National Natural Science Foundation of China,No.81971097(to JY)。
文摘Preclinical and clinical studies have shown that microglia and macrophages participate in a multiphasic brain damage repair process following intracerebral hemorrhage.The E26 transformation-specific sequence-related transcription factor Spi1 regulates microglial/macrophage commitment and maturation.However,the effect of Spi1 on intracerebral hemorrhage remains unclear.In this study,we found that Spi1 may regulate recovery from the neuroinflammation and neurofunctional damage caused by intracerebral hemorrhage by modulating the microglial/macrophage transcriptome.We showed that high Spi1expression in microglia/macrophages after intracerebral hemorrhage is associated with the activation of many pathways that promote phagocytosis,glycolysis,and autophagy,as well as debris clearance and sustained remyelination.Notably,microglia with higher levels of Soil expression were chara cterized by activation of pathways associated with a variety of hemorrhage-related cellular processes,such as complement activation,angiogenesis,and coagulation.In conclusion,our results suggest that Spi1 plays a vital role in the microglial/macrophage inflammatory response following intracerebral hemorrhage.This new insight into the regulation of Spi1 and its target genes may advance our understanding of neuroinflammation in intracerebral hemorrhage and provide therapeutic targets for patients with intracerebral hemorrhage.
基金financially supported by the National Key Research and Development Program of China(No.2021YFC2104100)the National Natural Science Foundation of China(Nos.21901058,22178083 and 22078081)+2 种基金the S&T program of Hebei(Nos.21372805D,21372804D and 20372802D)the Natural Science Foundation of Tianjin City(No.20JCYBJC00530)the Natural Science Foundation of Hebei Province(No.B2022202014).
文摘Core-shell structured magnetic wrinkled organosilica-based metal-enzyme integrated catalysts were synthesized,and their catalytic performances were studied in the chemoenzymatic dynamic kinetic resolution of chiral amines in an organic solvent,as well as in the chemoenzymatic synthesis of chiral alcohols in water.Structureperformance studies revealed the important influence of their tunable structure and composition on the optimization of activity,stability,and recyclability in chemoenzymatic catalysis.
基金supported by the National Key Research and Development Program of China(2023YFD1400300)Zhejiang Provincial Natural Science Foundation of China(LY23C140006)+2 种基金National Natural Science Foundation of China(31901954)Ningbo Natural Science Foundation(2021J126,2023J382)China Agriculture Research System of MOF and MARA(CARS-03)。
文摘Histone acetylation is involved in chromatin structural remodeling and the regulation of gene expression, and it is important for the activation of defense-related gene expression in eukaryotes[1]. The silent information regulator 2(SIR2) family of proteins were initially described as nuclear proteins with histone deacetylase activity that causes chromatin compaction and gene silencing[2].
文摘Current research shows that the traditional shock control bump（SCB） can weaken the intensity of shock and better the transonic buffet performance. The author finds that when SCB is placed downstream of the shock, it can decrease the adverse pressure gradient. This may prevent the shock foot separation bubble to merge with the trailing edge separation and finally improve the buffet performance. Based on RAE2822 airfoil, two types of SCB are designed according to the two different mechanisms. By using Reynolds-averaged Navier-Stokes（RANS） and unsteady Reynolds-averaged Navier-Stokes（URANS） methods to analyze the properties of RAE2822 airfoil with and without SCB, the results show that the downstream SCB can better the buffet performance under a wide range of freestream Mach number and the steady aerodynamics characteristic is similar to that of RAE2822 airfoil. The traditional SCB can only weaken the intensity of the shock under the design condition. Under the off-design conditions, the SCB does not do much to or even worsen the buffet performance. Indeed, the use of backward bump can flatten the leeward side of the airfoil, and this is similar to the mechanism that supercritical airfoil can weaken the recompression of shock wave.
