As one of the micro-blocks dispersed in the South China Sea(SCS), the basement of the Xisha Islands has rarely been drilled because of the thick overlying Cenozoic sediments, which has led to a confused understanding ...As one of the micro-blocks dispersed in the South China Sea(SCS), the basement of the Xisha Islands has rarely been drilled because of the thick overlying Cenozoic sediments, which has led to a confused understanding of the pre-Cenozoic basement of the Xisha Islands. Well CK-1, a kilometer-scale major scientific drill in the Xisha Islands in the northwestern SCS, penetrated thick reefal limestone(0–888.4 m) and the underlying basement rocks(888.4–901.4 m). In this study, we present the zircon U-Pb ages of basement basaltic pyroclastic rocks from Well CK-1 in the Xisha Islands of the northwestern SCS to investigate the basement nature of the Xisha microblock. The basement of Well CK-1 consists of basaltic pyroclastic rocks on the seamount. The zircon grains yielded apparent ages ranging from ca. 2 138.9 Ma to ca. 36 Ma. The old group of zircon grains from Well CK-1 was considered to be inherited zircons. Two Cenozoic zircons gave a weighted mean 206Pb/238U age of(36.3 ± 1.1) Ma,Mean Squared Weighted Deviations(MSWD) = 1.2, which may represent the maximum age of the volcano eruption. The Yanshanian inherited zircons(116.9–105.7 Ma and 146.1–130.2 Ma) from Well CK-1 are consistent with the zircons from Well XK-1, indicating that the basement of Chenhang Island may be similar to that of Well XK-1. We propose that the Xisha micro-block may have developed on a uniform Late Jurassic metamorphic crystalline basement, intruded by Cretaceous granitic magma.展开更多
Sodium(Na)metal batteries with a high volumetric energy density that can be operated at high rates are highly desirable.However,an uneven Na-ion migration in bulk Na anodes leads to localized deposition/dissolution of...Sodium(Na)metal batteries with a high volumetric energy density that can be operated at high rates are highly desirable.However,an uneven Na-ion migration in bulk Na anodes leads to localized deposition/dissolution of sodium during high-rate plating/stripping behaviors,followed by severe dendrite growth and loose stacking.Herein,we engineer the Na hybrid anode with sodiophilic Na_(3)Bi-penetration to develop the abundant phase-boundary ionic transport channels.Compared to intrinsic Na,the reduced adsorption energy and ion-diffusion barrier on Na_(3)Bi ensure even Na^(+)nucleation and rapid Na^(+)migration within the hybrid electrode,leading to uniform deposition and dissolution at high current densities.Furthermore,the bismuthide enables compact Na deposition within the sodiophilic framework during cycling,thus favoring a high volumetric capacity.Consequently,the obtained anode was endowed with a high current density(up to 5 mA∙cm^(−2)),high areal capacity(up to 5 mA∙h∙cm^(−2)),and long-term cycling stability(up to 2800 h at 2 mA∙cm^(−2)).展开更多
We investigated the role of the Wnt signaling pathway in cerebral ischemia/reperfusion injury by examining β-catenin and glycogen synthase kinase-3β protein expression in the rat hippocampal CA1 region following acu...We investigated the role of the Wnt signaling pathway in cerebral ischemia/reperfusion injury by examining β-catenin and glycogen synthase kinase-3β protein expression in the rat hippocampal CA1 region following acute cerebral ischemia/reperfusion. Our results demonstrate that cell apoptosis increases in the CA1 region following ischemia/reperfusion. In addition, β-catenin and glycogen synthase kinase-3β protein expression gradually increases, peaking at 48 hours following reperfusion. Dickkopf-1 administration, after cerebral ischemia/reperfusion injury, results in decreased cell apoptosis, and β-catenin and glycogen synthase kinase-3β expression, in the CA1 region. This suggests that β-catenin and glycogen synthase kinase-3β, both components of the Wnt signaling pathway, participate in cell apoptosis following cerebral ischemia/reperfusion injury.展开更多
Tissue engineering is a relatively new but rapidly developing field in the medical sciences. Noncoding RNAs(ncRNAs) are functional RNA molecules without a protein-coding function; they can regulate cellular behavior a...Tissue engineering is a relatively new but rapidly developing field in the medical sciences. Noncoding RNAs(ncRNAs) are functional RNA molecules without a protein-coding function; they can regulate cellular behavior and change the biological milieu of the tissue. The application of ncRNAs in tissue engineering is starting to attract increasing attention as a means of resolving a large number of unmet healthcare needs, although ncRNA-based approaches have not yet entered clinical practice. In-depth research on the regulation and delivery of ncRNAs may improve their application in tissue engineering.The aim of this review is: to outline essential ncRNAs that are related to tissue engineering for the repair and regeneration of nerve, skin, liver, vascular system, and muscle tissue; to discuss their regulation and delivery; and to anticipate their potential therapeutic applications.展开更多
Photodynamic therapy(PDT)is applied as a robust therapeutic option for tumor,which exhibits some advantages of unique selectivity and irreversible damage to tumor cells.Among which,photosensitizer(PS),appropriate lase...Photodynamic therapy(PDT)is applied as a robust therapeutic option for tumor,which exhibits some advantages of unique selectivity and irreversible damage to tumor cells.Among which,photosensitizer(PS),appropriate laser irradiation and oxygen(O_(2))are three essential components for PDT,but the hypoxic tumor microenvironment(TME)restricts the O_(2) supply in tumor tissues.Even worse,tumor metastasis and drug resistance frequently happen under hypoxic condition,which further deteriorate the antitumor effect of PDT.To enhance the PDT efficiency,critical attention has been received by relieving tumor hypoxia,and innovative strategies on this topic continue to emerge.Traditionally,the O_(2) supplement strategy is considered as a direct and effective strategy to relieve TME,whereas it is confronted with great challenges for continuous O_(2) supply.Recently,O_(2)-independent PDT provides a brand new strategy to enhance the antitumor efficiency,which can avoid the influence of TME.In addition,PDT can synergize with other antitumor strategies,such as chemotherapy,immunotherapy,photothermal therapy(PTT)and starvation therapy,to remedy the inadequate PDT effect under hypoxia conditions.In this paper,we summarized the latest progresses in the development of innovative strategies to improve PDT efficacy against hypoxic tumor,which were classified into O_(2)-dependent PDT,O_(2)-independent PDT and synergistic therapy.Furthermore,the advantages and deficiencies of various strategies were also discussed to envisage the prospects and challenges in future study.展开更多
Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species(ROS)levels at focal sites and the evolvement of antioxidant defense systems.Herein,we develop an albumin-based...Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species(ROS)levels at focal sites and the evolvement of antioxidant defense systems.Herein,we develop an albumin-based nanomedicine to co-deliver chlorin e6(Ce6)and COH-SR4(CS),which can simultaneously enhance the yield and lethality of intracellular ROS for amplified photodynamic therapy(PDT).In which,CS acts as both an activator of AMP-activated protein kinase(AMPK)and an inhibitor of glutathione S-transferases(GSTs).Benefiting from it,the prepared HSA-Ce6@COH-SR4(HCCS)enables positive feed-back uptake by promoting AMPK phosphorylation,leading to rapid and extensive tumor accumulation of drugs.As a result,HCCS obviously increases the ROS production to elevate intracellular oxidative stress.Furthermore,HCCS can inhibit GSTs to disturb the antioxidant defense system of tumor cells,intensifying the oxidative damage of ROS.Ultimately,the PDT of HCCS is significantly strengthened by improving the ROS yield and lethality,which greatly declines the proliferation of breast cancer in vivo.This study may open a window in the development of drug co-delivery system for enhanced oxidative therapy of tumors.展开更多
It remains unclear whether autophagy affects hippocampal neuronal injury in vascular dementia. In the present study, we investigated the effects of autophagy blockade on hippocampal neuro- nal injury in a rat model of...It remains unclear whether autophagy affects hippocampal neuronal injury in vascular dementia. In the present study, we investigated the effects of autophagy blockade on hippocampal neuro- nal injury in a rat model of vascular dementia. In model rats, hippocampal CA1 neurons were severely damaged, and expression of the autophagy-related proteins beclin-1, cathepsin B and microtubule-associated protein 1 light chain 3 was elevated compared with that in sham-operated animals. These responses were suppressed in animals that received a single intraperitoneal injection of wortmannin, an autophagy inhibitor, prior to model establishment. The present results confirm that autophagy and autophagy-related proteins are involved in the pathological changes of vascular dementia, and that inhibition of autophagy has neuroprotective effects.展开更多
High-quality and high-resolution precipitation data are the basis for mesoscale numerical weather forecasting,model verification,and hydrological monitoring,which play an important role in meteorological and hydrologi...High-quality and high-resolution precipitation data are the basis for mesoscale numerical weather forecasting,model verification,and hydrological monitoring,which play an important role in meteorological and hydrological disaster prevention and mitigation.In this study,high-density rain gauge data are used to evaluate the fusion accuracy of the China Meteorological Administration Multisource Precipitation Analysis System(CMPAS),and four CMPAS products with different spatial and temporal resolution and different data sources are compared,to derive the applicability of CMPAS.Results show that all the CMPAS products show high accuracy in the Sichuan Basin,followed by Panxi Area and the western Sichuan Plateau.The errors of the four products all rise with the increase in precipitation.CMPAS overestimates precipitation in summer and autumn and underestimates it in spring and winter.Overall,the applicability of these fused data in the Sichuan Basin is quite good.Due to the lack of observations and the influence of the terrain and meteorological conditions,the evaluation of CMPAS in the plateau area needs further analysis.展开更多
In our retrospective cohort study,we aim to explore whether Azvudine modifies the risk of death in COVID-19 patients.It was conducted on the medical records of patients,consecutively admitted for COVID-19 pneumonia to...In our retrospective cohort study,we aim to explore whether Azvudine modifies the risk of death in COVID-19 patients.It was conducted on the medical records of patients,consecutively admitted for COVID-19 pneumonia to two hospitals in Chongqing,China.Based on Azvudine treatment exposure,the patients were divided into Azvudine group and non-Azvudine group.We used 1:2 ratio propensity score matching(PSM)in our study to adjust for confounding factors and differences between Azvudine and non-Azvudine groups.There were 1072 patients included in our original cohort.With 1:2 ratio PSM,the Azvudine group included 195 patients and non-Azvudine group included 390 patients.The results showed that Azvudine treatment was associated with improved in-hospital mortality in overall population(OR 0.375,95%CI 0.225-0.623,P<0.001),severe subgroup(OR 0.239,95%CI 0.107-0.535,P=0.001),critical subgroup(OR 0.091,95%CI 0.011-0.769,P=0.028)in matched cohort with univariate analysis.And there was a significantly lower in-hospital mortality in overall population(11%vs.24%,P<0.001),severe sub-group(10%vs.32%,P<0.001)and critical sub-group(5%vs.34%,P=0.017)in matched cohort.These results suggest Azvudine can reduce in-hospital mortality in overall COVID-19 patients,severe,and critical subgroup population.展开更多
The immunosuppressive phenotype of tumor cells extensively attenuates the immune activation effects of traditional treatments.In this work,a transferrin receptor(TfR)targeted immunostimulant(PTI)is fabricated for phot...The immunosuppressive phenotype of tumor cells extensively attenuates the immune activation effects of traditional treatments.In this work,a transferrin receptor(TfR)targeted immunostimulant(PTI)is fabricated for photodynamic immunotherapy against metastatic tumors by interrupting β-catenin signal pathway.To synthesize PTI,the photosensitizer conjugated TfR targeting peptide moiety(Palmitic-K(PpIX)-HAIYPRH)is unitized to encapsulate the transcription interrupter of ICG-001.On the one hand,the recognition of PTI and TfR can promote drug delivery into tumor cells to destruct primary tumors through photodynamic therapy and initiate an immunogenic cell death with the release of tumorassociated antigens.On the other hand,PTI will interrupt the binding between b-catenin andcAMP response element-binding protein(CREB),regulating the gene transcription to downregulate programmed death ligand 1(PD-L1)while upregulating CeC motif chemokine ligand 4(CCL4).Furthermore,the elevated CCL4 can recruit the dendritic cells to present tumor-specific antigens and promote T cells activation and infiltration,and the downregulated PD-L1 can avoid the immune evasion of tumor cells and activate systemic anti-tumor immunity to eradicate lung metastasis.This work may inspire the development of antibody antibody-free strategy to activate systemic immune response in consideration of immunosuppressive conditions.展开更多
This paper presents a system of autonomous intelligent software agents,based on a cognitive architecture,capable of automated instantiation,visualisation and analysis of multifaceted City Information Models in dynamic...This paper presents a system of autonomous intelligent software agents,based on a cognitive architecture,capable of automated instantiation,visualisation and analysis of multifaceted City Information Models in dynamic geospatial knowledge graphs.Design of JPS Agent Framework and Routed Knowledge Graph Access components was required in order to provide backbone infrastructure for an intelligent agent system as well as technology agnostic knowledge graph access enabling automation of multi-domain data interoperability.Development of CityImportAgent,CityExportAgent and DistanceAgent showcased intelligent automation capa-bilities of the Cities Knowledge Graph.The agents successfully created a semantic model of Berlin in LOD 2,compliant with CityGML 2.0 standard and consisting of 419909661 triples described using OntoCityGML.The system of agents also visualised and analysed the model by autonomously tracking interactions with a web interface as well as enriched the model by adding new information to the knowledge graph.This way it was possible to design a geospatial information system able to meet demands imposed by the Industry 4.0 and link it with the other multi-domain knowledge representations of The World Avatar.展开更多
With the rapid development of interdisciplinary studies in recent decades,science and technology has achieved both greater breadth and greater spe-cialization,and the number of manuscripts pub-lished annually has incr...With the rapid development of interdisciplinary studies in recent decades,science and technology has achieved both greater breadth and greater spe-cialization,and the number of manuscripts pub-lished annually has increased year on year[1].展开更多
Loh-Seng Tsai(蔡乐生,1901–1992)(Fig.1),the worldrenowned Chinese animal psychologist and psychopharmacologist,was born to a merchant family in Chaoan County,Guangdong Province on February 6th,1901.He was nominated fo...Loh-Seng Tsai(蔡乐生,1901–1992)(Fig.1),the worldrenowned Chinese animal psychologist and psychopharmacologist,was born to a merchant family in Chaoan County,Guangdong Province on February 6th,1901.He was nominated for the Nobel Peace Prize in 1951 and U.S.President Nixon praised his“exemplary academic achievements”in 1973.Tsai’s research in experimental psychology can be divided into two stages.During the first stage(1919–1949),Tsai embarked on the path of psychology as a student under the guidance of Clarence Herbert Hamilton.Subsequently,Tsai expanded and popularized the experimental research conducted by comparative psychologist Zing-Yang Kuo(郭任远,1898–1970)and Harvey Carr,both of whom were Tsai’s supervisors at different times.展开更多
This paper presents a dynamic geospatial knowledge graph as part of The World Avatar project,with an underlying ontology based on CityGML 2.0 for three-dimensional geometrical city objects.We comprehensively evaluated...This paper presents a dynamic geospatial knowledge graph as part of The World Avatar project,with an underlying ontology based on CityGML 2.0 for three-dimensional geometrical city objects.We comprehensively evaluated,repaired and refined an existing CityGML ontology to produce an improved version that could pass the necessary tests and complete unit test development.A corresponding data transformation tool,originally designed to work alongside CityGML,was extended.This allowed for the transformation of original data into a form of semantic triples.We compared various scalable technologies for this semantic data storage and chose Blazegraph™as it provided the required geospatial search functionality.We also evaluated scalable hardware data solutions and file systems using the publicly available CityGML 2.0 data of Charlottenburg in Berlin,Germany as a working example.The structural isomorphism of the CityGML schemas and the OntoCityGML Tbox allowed the data to be transformed without loss of information.Efficient geospatial search algorithms allowed us to retrieve building data from any point in a city using coordinates.The use of named graphs and namespaces for data partitioning ensured the system performance stayed well below its capacity limits.This was achieved by evaluating scalable and dedicated data storage hardware capable of hosting expansible file systems,which strengthened the architectural foundations of the target system.展开更多
Yu-Chuan Tsang(臧玉洤,1901-1964),styled Botan(伯潭),was an outstanding Chinese physiological psychologist,a comparative neuroscientist,and a neuroanatomist(Fig.1).He was a member of the First Council of the Chinese So...Yu-Chuan Tsang(臧玉洤,1901-1964),styled Botan(伯潭),was an outstanding Chinese physiological psychologist,a comparative neuroscientist,and a neuroanatomist(Fig.1).He was a member of the First Council of the Chinese Society for Anatomical Sciences,an executive member of the sec-ond,third,fourth and fifth councils,and the Chairman of the Third Council.He was one of the founders of neuroanatomy in modem China and the Beijing Medical College(now the Department of Medicine at Peking University).Neu-roanatomy is a discipline that consists of making observa-tions and making recordings.Moreover,there are different interdisciplinary subjects based on neuroscience,including cognitive science,neurobehavioral science,neuroengineer-ing,and psychology.Tsang's academic career followed an opposite direction,starting from psychology and turning to neuroanatomy,where he made remarkable achievements.展开更多
基金The National Natural Science Foundation of China under contract Nos 42030502, 42090041 and 42166003the Guangxi Scientific Projects under contract Nos AD17129063 and AA17204074+1 种基金the Guangxi Youth Science Fund Project under contract 2019GXNSFBA185016the Ph.D. Research Start-up Foundation of Guangxi University under contract No. XBZ170339。
文摘As one of the micro-blocks dispersed in the South China Sea(SCS), the basement of the Xisha Islands has rarely been drilled because of the thick overlying Cenozoic sediments, which has led to a confused understanding of the pre-Cenozoic basement of the Xisha Islands. Well CK-1, a kilometer-scale major scientific drill in the Xisha Islands in the northwestern SCS, penetrated thick reefal limestone(0–888.4 m) and the underlying basement rocks(888.4–901.4 m). In this study, we present the zircon U-Pb ages of basement basaltic pyroclastic rocks from Well CK-1 in the Xisha Islands of the northwestern SCS to investigate the basement nature of the Xisha microblock. The basement of Well CK-1 consists of basaltic pyroclastic rocks on the seamount. The zircon grains yielded apparent ages ranging from ca. 2 138.9 Ma to ca. 36 Ma. The old group of zircon grains from Well CK-1 was considered to be inherited zircons. Two Cenozoic zircons gave a weighted mean 206Pb/238U age of(36.3 ± 1.1) Ma,Mean Squared Weighted Deviations(MSWD) = 1.2, which may represent the maximum age of the volcano eruption. The Yanshanian inherited zircons(116.9–105.7 Ma and 146.1–130.2 Ma) from Well CK-1 are consistent with the zircons from Well XK-1, indicating that the basement of Chenhang Island may be similar to that of Well XK-1. We propose that the Xisha micro-block may have developed on a uniform Late Jurassic metamorphic crystalline basement, intruded by Cretaceous granitic magma.
基金supported by the National Natural Science Foundation of China (21938005 and 21776197)Key Laboratory of Coal Science and Technology, Education Ministry and Shanxi Province, Taiyuan University of Technology
文摘Sodium(Na)metal batteries with a high volumetric energy density that can be operated at high rates are highly desirable.However,an uneven Na-ion migration in bulk Na anodes leads to localized deposition/dissolution of sodium during high-rate plating/stripping behaviors,followed by severe dendrite growth and loose stacking.Herein,we engineer the Na hybrid anode with sodiophilic Na_(3)Bi-penetration to develop the abundant phase-boundary ionic transport channels.Compared to intrinsic Na,the reduced adsorption energy and ion-diffusion barrier on Na_(3)Bi ensure even Na^(+)nucleation and rapid Na^(+)migration within the hybrid electrode,leading to uniform deposition and dissolution at high current densities.Furthermore,the bismuthide enables compact Na deposition within the sodiophilic framework during cycling,thus favoring a high volumetric capacity.Consequently,the obtained anode was endowed with a high current density(up to 5 mA∙cm^(−2)),high areal capacity(up to 5 mA∙h∙cm^(−2)),and long-term cycling stability(up to 2800 h at 2 mA∙cm^(−2)).
基金supported by the Medical Research Key Program of Hebei Province,No.20110531
文摘We investigated the role of the Wnt signaling pathway in cerebral ischemia/reperfusion injury by examining β-catenin and glycogen synthase kinase-3β protein expression in the rat hippocampal CA1 region following acute cerebral ischemia/reperfusion. Our results demonstrate that cell apoptosis increases in the CA1 region following ischemia/reperfusion. In addition, β-catenin and glycogen synthase kinase-3β protein expression gradually increases, peaking at 48 hours following reperfusion. Dickkopf-1 administration, after cerebral ischemia/reperfusion injury, results in decreased cell apoptosis, and β-catenin and glycogen synthase kinase-3β expression, in the CA1 region. This suggests that β-catenin and glycogen synthase kinase-3β, both components of the Wnt signaling pathway, participate in cell apoptosis following cerebral ischemia/reperfusion injury.
基金This work was supported by the National Basic Research Program of China （973 Program, 2014CB542202）, the National HiTech Research and Development Program of China （863 Program, 2012AA020502）, the National Natural Science Foundation of China （81130080 and 31300879）, and the Key University Science Research Project of Jiangsu Province （16KJA310005）. It was also a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions （PAPD）.
文摘Tissue engineering is a relatively new but rapidly developing field in the medical sciences. Noncoding RNAs(ncRNAs) are functional RNA molecules without a protein-coding function; they can regulate cellular behavior and change the biological milieu of the tissue. The application of ncRNAs in tissue engineering is starting to attract increasing attention as a means of resolving a large number of unmet healthcare needs, although ncRNA-based approaches have not yet entered clinical practice. In-depth research on the regulation and delivery of ncRNAs may improve their application in tissue engineering.The aim of this review is: to outline essential ncRNAs that are related to tissue engineering for the repair and regeneration of nerve, skin, liver, vascular system, and muscle tissue; to discuss their regulation and delivery; and to anticipate their potential therapeutic applications.
文摘Photodynamic therapy(PDT)is applied as a robust therapeutic option for tumor,which exhibits some advantages of unique selectivity and irreversible damage to tumor cells.Among which,photosensitizer(PS),appropriate laser irradiation and oxygen(O_(2))are three essential components for PDT,but the hypoxic tumor microenvironment(TME)restricts the O_(2) supply in tumor tissues.Even worse,tumor metastasis and drug resistance frequently happen under hypoxic condition,which further deteriorate the antitumor effect of PDT.To enhance the PDT efficiency,critical attention has been received by relieving tumor hypoxia,and innovative strategies on this topic continue to emerge.Traditionally,the O_(2) supplement strategy is considered as a direct and effective strategy to relieve TME,whereas it is confronted with great challenges for continuous O_(2) supply.Recently,O_(2)-independent PDT provides a brand new strategy to enhance the antitumor efficiency,which can avoid the influence of TME.In addition,PDT can synergize with other antitumor strategies,such as chemotherapy,immunotherapy,photothermal therapy(PTT)and starvation therapy,to remedy the inadequate PDT effect under hypoxia conditions.In this paper,we summarized the latest progresses in the development of innovative strategies to improve PDT efficacy against hypoxic tumor,which were classified into O_(2)-dependent PDT,O_(2)-independent PDT and synergistic therapy.Furthermore,the advantages and deficiencies of various strategies were also discussed to envisage the prospects and challenges in future study.
基金support of National Natural Science Foundation of China(No.52073140)the Guangdong Basic and Applied Basic Research Foundation(No.2022B1515020095).
文摘Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species(ROS)levels at focal sites and the evolvement of antioxidant defense systems.Herein,we develop an albumin-based nanomedicine to co-deliver chlorin e6(Ce6)and COH-SR4(CS),which can simultaneously enhance the yield and lethality of intracellular ROS for amplified photodynamic therapy(PDT).In which,CS acts as both an activator of AMP-activated protein kinase(AMPK)and an inhibitor of glutathione S-transferases(GSTs).Benefiting from it,the prepared HSA-Ce6@COH-SR4(HCCS)enables positive feed-back uptake by promoting AMPK phosphorylation,leading to rapid and extensive tumor accumulation of drugs.As a result,HCCS obviously increases the ROS production to elevate intracellular oxidative stress.Furthermore,HCCS can inhibit GSTs to disturb the antioxidant defense system of tumor cells,intensifying the oxidative damage of ROS.Ultimately,the PDT of HCCS is significantly strengthened by improving the ROS yield and lethality,which greatly declines the proliferation of breast cancer in vivo.This study may open a window in the development of drug co-delivery system for enhanced oxidative therapy of tumors.
基金supported by the Scientific Technology Research Project of Hebei Provincial Higher Learning Schools in China,No.ZH2012046the Major Medical Research Program of Hebei Province in China,No.ZD2013087
文摘It remains unclear whether autophagy affects hippocampal neuronal injury in vascular dementia. In the present study, we investigated the effects of autophagy blockade on hippocampal neuro- nal injury in a rat model of vascular dementia. In model rats, hippocampal CA1 neurons were severely damaged, and expression of the autophagy-related proteins beclin-1, cathepsin B and microtubule-associated protein 1 light chain 3 was elevated compared with that in sham-operated animals. These responses were suppressed in animals that received a single intraperitoneal injection of wortmannin, an autophagy inhibitor, prior to model establishment. The present results confirm that autophagy and autophagy-related proteins are involved in the pathological changes of vascular dementia, and that inhibition of autophagy has neuroprotective effects.
基金supported by the Sichuan Meteorological Bureau,the Sichuan Meteorological Observation and Data Centerthe Heavy Rain and Drought-Flood Disasters in Plateau and Basin Key Laboratory of Sichuan Province[grant number SCQXKJQN202121]+1 种基金the Key Technology Development Project of Weather Forecasting[grant number YBGJXM(2020)1A-08]the Innovative Development Project of the China Meteorological Administration[grant number CXFZ2021Z007]。
文摘High-quality and high-resolution precipitation data are the basis for mesoscale numerical weather forecasting,model verification,and hydrological monitoring,which play an important role in meteorological and hydrological disaster prevention and mitigation.In this study,high-density rain gauge data are used to evaluate the fusion accuracy of the China Meteorological Administration Multisource Precipitation Analysis System(CMPAS),and four CMPAS products with different spatial and temporal resolution and different data sources are compared,to derive the applicability of CMPAS.Results show that all the CMPAS products show high accuracy in the Sichuan Basin,followed by Panxi Area and the western Sichuan Plateau.The errors of the four products all rise with the increase in precipitation.CMPAS overestimates precipitation in summer and autumn and underestimates it in spring and winter.Overall,the applicability of these fused data in the Sichuan Basin is quite good.Due to the lack of observations and the influence of the terrain and meteorological conditions,the evaluation of CMPAS in the plateau area needs further analysis.
基金supported by the General Program of Chongqing Natural Science Foundation (CSTB2022NSCQ-MSX0901,China)Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University (kryc-yq-2204,China)。
文摘In our retrospective cohort study,we aim to explore whether Azvudine modifies the risk of death in COVID-19 patients.It was conducted on the medical records of patients,consecutively admitted for COVID-19 pneumonia to two hospitals in Chongqing,China.Based on Azvudine treatment exposure,the patients were divided into Azvudine group and non-Azvudine group.We used 1:2 ratio propensity score matching(PSM)in our study to adjust for confounding factors and differences between Azvudine and non-Azvudine groups.There were 1072 patients included in our original cohort.With 1:2 ratio PSM,the Azvudine group included 195 patients and non-Azvudine group included 390 patients.The results showed that Azvudine treatment was associated with improved in-hospital mortality in overall population(OR 0.375,95%CI 0.225-0.623,P<0.001),severe subgroup(OR 0.239,95%CI 0.107-0.535,P=0.001),critical subgroup(OR 0.091,95%CI 0.011-0.769,P=0.028)in matched cohort with univariate analysis.And there was a significantly lower in-hospital mortality in overall population(11%vs.24%,P<0.001),severe sub-group(10%vs.32%,P<0.001)and critical sub-group(5%vs.34%,P=0.017)in matched cohort.These results suggest Azvudine can reduce in-hospital mortality in overall COVID-19 patients,severe,and critical subgroup population.
基金the financial support of National Key R&D Program of China(No.2021YFD1800600)the National Natural Science Foundation of China(No.32371394)+2 种基金the Guangdong Basic and Applied Basic Research Foundation(No.2021B1515020043,China)the Special Projects in Key Areas of Colleges and Universities in Guangdong Province(No.2022ZDZX2046,China)Open Research Foundation of State Key Laboratory of Respiratory Diseases(No.SKLRD-OP-202204,China).
文摘The immunosuppressive phenotype of tumor cells extensively attenuates the immune activation effects of traditional treatments.In this work,a transferrin receptor(TfR)targeted immunostimulant(PTI)is fabricated for photodynamic immunotherapy against metastatic tumors by interrupting β-catenin signal pathway.To synthesize PTI,the photosensitizer conjugated TfR targeting peptide moiety(Palmitic-K(PpIX)-HAIYPRH)is unitized to encapsulate the transcription interrupter of ICG-001.On the one hand,the recognition of PTI and TfR can promote drug delivery into tumor cells to destruct primary tumors through photodynamic therapy and initiate an immunogenic cell death with the release of tumorassociated antigens.On the other hand,PTI will interrupt the binding between b-catenin andcAMP response element-binding protein(CREB),regulating the gene transcription to downregulate programmed death ligand 1(PD-L1)while upregulating CeC motif chemokine ligand 4(CCL4).Furthermore,the elevated CCL4 can recruit the dendritic cells to present tumor-specific antigens and promote T cells activation and infiltration,and the downregulated PD-L1 can avoid the immune evasion of tumor cells and activate systemic anti-tumor immunity to eradicate lung metastasis.This work may inspire the development of antibody antibody-free strategy to activate systemic immune response in consideration of immunosuppressive conditions.
文摘This paper presents a system of autonomous intelligent software agents,based on a cognitive architecture,capable of automated instantiation,visualisation and analysis of multifaceted City Information Models in dynamic geospatial knowledge graphs.Design of JPS Agent Framework and Routed Knowledge Graph Access components was required in order to provide backbone infrastructure for an intelligent agent system as well as technology agnostic knowledge graph access enabling automation of multi-domain data interoperability.Development of CityImportAgent,CityExportAgent and DistanceAgent showcased intelligent automation capa-bilities of the Cities Knowledge Graph.The agents successfully created a semantic model of Berlin in LOD 2,compliant with CityGML 2.0 standard and consisting of 419909661 triples described using OntoCityGML.The system of agents also visualised and analysed the model by autonomously tracking interactions with a web interface as well as enriched the model by adding new information to the knowledge graph.This way it was possible to design a geospatial information system able to meet demands imposed by the Industry 4.0 and link it with the other multi-domain knowledge representations of The World Avatar.
基金This study was supported by grants from Central Public-interest Scientific Institution Basal Research Fund[grant number GY2019G-5]the National Key R&D Program of China[2016YFC0800701]the Science and Technology Committee of Shanghai Municipality[17DZ2273200/19DZ2290900]。
文摘With the rapid development of interdisciplinary studies in recent decades,science and technology has achieved both greater breadth and greater spe-cialization,and the number of manuscripts pub-lished annually has increased year on year[1].
基金the Major Support Project for the Emerging Cross-Discipline of the Philosophical Social Science Foundation of Zhejiang Province“Neurophilosophical Basis and Experimental Research of the Direct Perception of Other Minds”(21XXJC05ZD).
文摘Loh-Seng Tsai(蔡乐生,1901–1992)(Fig.1),the worldrenowned Chinese animal psychologist and psychopharmacologist,was born to a merchant family in Chaoan County,Guangdong Province on February 6th,1901.He was nominated for the Nobel Peace Prize in 1951 and U.S.President Nixon praised his“exemplary academic achievements”in 1973.Tsai’s research in experimental psychology can be divided into two stages.During the first stage(1919–1949),Tsai embarked on the path of psychology as a student under the guidance of Clarence Herbert Hamilton.Subsequently,Tsai expanded and popularized the experimental research conducted by comparative psychologist Zing-Yang Kuo(郭任远,1898–1970)and Harvey Carr,both of whom were Tsai’s supervisors at different times.
文摘This paper presents a dynamic geospatial knowledge graph as part of The World Avatar project,with an underlying ontology based on CityGML 2.0 for three-dimensional geometrical city objects.We comprehensively evaluated,repaired and refined an existing CityGML ontology to produce an improved version that could pass the necessary tests and complete unit test development.A corresponding data transformation tool,originally designed to work alongside CityGML,was extended.This allowed for the transformation of original data into a form of semantic triples.We compared various scalable technologies for this semantic data storage and chose Blazegraph™as it provided the required geospatial search functionality.We also evaluated scalable hardware data solutions and file systems using the publicly available CityGML 2.0 data of Charlottenburg in Berlin,Germany as a working example.The structural isomorphism of the CityGML schemas and the OntoCityGML Tbox allowed the data to be transformed without loss of information.Efficient geospatial search algorithms allowed us to retrieve building data from any point in a city using coordinates.The use of named graphs and namespaces for data partitioning ensured the system performance stayed well below its capacity limits.This was achieved by evaluating scalable and dedicated data storage hardware capable of hosting expansible file systems,which strengthened the architectural foundations of the target system.
基金The Major Support Project for the Emerging Cross-Discipline of Philosophy Social Science Foundation of Zhejiang Province“Neurophilosophical Basis and Experimental Research of Direct Perceive Other Minds”(21XXJC05ZD)The National Social Science Foundation(16CZX015).
文摘Yu-Chuan Tsang(臧玉洤,1901-1964),styled Botan(伯潭),was an outstanding Chinese physiological psychologist,a comparative neuroscientist,and a neuroanatomist(Fig.1).He was a member of the First Council of the Chinese Society for Anatomical Sciences,an executive member of the sec-ond,third,fourth and fifth councils,and the Chairman of the Third Council.He was one of the founders of neuroanatomy in modem China and the Beijing Medical College(now the Department of Medicine at Peking University).Neu-roanatomy is a discipline that consists of making observa-tions and making recordings.Moreover,there are different interdisciplinary subjects based on neuroscience,including cognitive science,neurobehavioral science,neuroengineer-ing,and psychology.Tsang's academic career followed an opposite direction,starting from psychology and turning to neuroanatomy,where he made remarkable achievements.
