BACKGROUND The incidence of Barrett’s esophagus(BE)in China is lower compared to the Western populations.Hence,studies conducted in the Chinese population has been limited.The current treatment options available for ...BACKGROUND The incidence of Barrett’s esophagus(BE)in China is lower compared to the Western populations.Hence,studies conducted in the Chinese population has been limited.The current treatment options available for BE treatment includes argon plasma coagulation(APC),radiofrequency ablation and cryoablation,all with varying degrees of success.AIM To determine the efficacy and safety of HybridAPC in the treatment of BE.METHODS The study cohort consisted of patients with BE who underwent HybridAPC ablation treatment.These procedures were performed by seven endoscopists from different tertiary hospitals.The duration of the procedure,curative rate,complications and recurrent rate by 1-year follow-up were recorded.RESULTS Eighty individuals were enrolled for treatment from July 2017 to June 2020,comprising of 39 males and 41 females with a median age of 54 years(range,30 to 83 years).The technical success rate of HybridAPC was 100%and the overall curative rate was 98.15%.No severe complications occurred during the operation.BE cases were classified as short-segment BE and long-segment BE.Patients with short-segment BE were all considered cured without complications.Thirty-six patients completed the one-year follow-up without recurrence.Twenty-four percent had mild dysplasia which were all resolved with one post-procedural treatment.The mean duration of the procedure was 10.94±6.52 min.CONCLUSION Treatment of BE with HybridAPC was found to be a simple and quick procedure that is safe and effective during the short-term follow-up,especially in cases of short-segment BE.This technique could be considered as a feasible alternative ablation therapy for BE.展开更多
In this paper we propose a method to model flowers of solid shape. Based on (Ijiri et al., 2005)’s method, we separate individual flower modeling and inflorescence modeling procedures into structure and geometry mode...In this paper we propose a method to model flowers of solid shape. Based on (Ijiri et al., 2005)’s method, we separate individual flower modeling and inflorescence modeling procedures into structure and geometry modeling. We incorporate interactive editing gestures to allow the user to edit structure parameters freely onto structure diagram. Furthermore, we use free-hand sketching techniques to allow users to create and edit 3D geometrical elements freely and easily. The final step is to automatically merge all independent 3D geometrical elements into a single waterproof mesh. Our experiments show that this solid modeling approach is promising. Using our approach, novice users can create vivid flower models easily and freely. The generated flower model is waterproof. It can have applications in visualization, animation, gaming, and toys and decorations if printed out on 3D rapid prototyping devices.展开更多
BACKGROUND Hypothyroidism is an endocrine disorder that has worldwide prevalence and can affect multiple organ systems.We report a case of hypothyroidism with elevated pancreatic amylase and trypsin without acute panc...BACKGROUND Hypothyroidism is an endocrine disorder that has worldwide prevalence and can affect multiple organ systems.We report a case of hypothyroidism with elevated pancreatic amylase and trypsin without acute pancreatitis.No such case has been previously reported.CASE SUMMARY A 29-year-old woman did not pay much attention to a fever 4 d prior.During this time,she experienced anorexia and only drank a small amount of water every day.She did not present with abdominal distension,postprandial nausea,vomiting,cough or expectoration.After physical and laboratory examinations,the patient was diagnosed with hypothyroidism.During the course of the disease,hypothyroidism was generally accompanied by constantly increased pancreatic amylase and trypsin.After admission,the possible etiology of the patient was excluded and the concentrations of pancreatic lipase and amylase in serum were>2000U/L(reference range 23-300 U/L)and 410 U/L(reference range 30-110 U/L),respectively.So we highly suspected that it may be acute pancreatitis.Interestingly,she never developed any complications associated with acute pancreatitis despite high levels of serum pancreatic amylase and trypsin,and she reported no symptoms of abdominal pain.Serum amylase and lipase decreased gradually after active thyroxine supplementation,and the patient was discharged from the hospital after active treatment.CONCLUSION This case suggests that clinicians should pay attention to hypothyroidism with elevated pancreatic amylase and trypsin,even if no complications of acute pancreatitis are reported.展开更多
BACKGROUND Creutzfeldt-Jakob disease(CJD)is a rare degenerative disease of the central nervous system that can be contagious or hereditary and is a rare cause of rapidly progressive dementia.It almost always results i...BACKGROUND Creutzfeldt-Jakob disease(CJD)is a rare degenerative disease of the central nervous system that can be contagious or hereditary and is a rare cause of rapidly progressive dementia.It almost always results in death within 1-2 years from symptom onset.CASE SUMMARY Here,we report the case of a 57-year-old male who initially experienced dizziness followed by a 1-mo fast decline in memory function.He presented to the local hospital and underwent magnetic resonance imaging and cerebrospinal fluid(CSF)examination,with no definitive diagnosis.However,the symptoms of progressive forgetting worsened.In addition,he exhibited progressive involuntary tremor of the limbs.Then,he came to our hospital,and according to the results of CSF examination,electroencephalography(EEG)and magnetic resonance imaging(MRI)tests and clinical manifestations of cerebellar ataxia,dementia,and myoclonus that rapidly progressed,with a short duration of illness,he was finally diagnosed with sporadic CJD(sCJD).CONCLUSION This case report aims to create awareness among physicians to emphasize auxiliary examination,CSF examination,EEG and MRI tests and recognition of cerebellar ataxia,dementia,and myoclonus that rapidly progress to prompt pursuit of an early diagnosis and identification of sCJD and to reduce complications.展开更多
文摘BACKGROUND The incidence of Barrett’s esophagus(BE)in China is lower compared to the Western populations.Hence,studies conducted in the Chinese population has been limited.The current treatment options available for BE treatment includes argon plasma coagulation(APC),radiofrequency ablation and cryoablation,all with varying degrees of success.AIM To determine the efficacy and safety of HybridAPC in the treatment of BE.METHODS The study cohort consisted of patients with BE who underwent HybridAPC ablation treatment.These procedures were performed by seven endoscopists from different tertiary hospitals.The duration of the procedure,curative rate,complications and recurrent rate by 1-year follow-up were recorded.RESULTS Eighty individuals were enrolled for treatment from July 2017 to June 2020,comprising of 39 males and 41 females with a median age of 54 years(range,30 to 83 years).The technical success rate of HybridAPC was 100%and the overall curative rate was 98.15%.No severe complications occurred during the operation.BE cases were classified as short-segment BE and long-segment BE.Patients with short-segment BE were all considered cured without complications.Thirty-six patients completed the one-year follow-up without recurrence.Twenty-four percent had mild dysplasia which were all resolved with one post-procedural treatment.The mean duration of the procedure was 10.94±6.52 min.CONCLUSION Treatment of BE with HybridAPC was found to be a simple and quick procedure that is safe and effective during the short-term follow-up,especially in cases of short-segment BE.This technique could be considered as a feasible alternative ablation therapy for BE.
基金Project supported by the Hi-Tech Research and Development Pro-gram (863) of China (Nos. 2007AA01Z311 and 2007AA04Z1A5)the Postdoctoral Science Foundation of China (No. 20070421185)the National Research Foundation for the Doctoral Program of Higher Education of China (No. 20060335114)
文摘In this paper we propose a method to model flowers of solid shape. Based on (Ijiri et al., 2005)’s method, we separate individual flower modeling and inflorescence modeling procedures into structure and geometry modeling. We incorporate interactive editing gestures to allow the user to edit structure parameters freely onto structure diagram. Furthermore, we use free-hand sketching techniques to allow users to create and edit 3D geometrical elements freely and easily. The final step is to automatically merge all independent 3D geometrical elements into a single waterproof mesh. Our experiments show that this solid modeling approach is promising. Using our approach, novice users can create vivid flower models easily and freely. The generated flower model is waterproof. It can have applications in visualization, animation, gaming, and toys and decorations if printed out on 3D rapid prototyping devices.
基金Supported by Shanghai Shenkang Hospital Development Center,No.SHDC12016109.
文摘BACKGROUND Hypothyroidism is an endocrine disorder that has worldwide prevalence and can affect multiple organ systems.We report a case of hypothyroidism with elevated pancreatic amylase and trypsin without acute pancreatitis.No such case has been previously reported.CASE SUMMARY A 29-year-old woman did not pay much attention to a fever 4 d prior.During this time,she experienced anorexia and only drank a small amount of water every day.She did not present with abdominal distension,postprandial nausea,vomiting,cough or expectoration.After physical and laboratory examinations,the patient was diagnosed with hypothyroidism.During the course of the disease,hypothyroidism was generally accompanied by constantly increased pancreatic amylase and trypsin.After admission,the possible etiology of the patient was excluded and the concentrations of pancreatic lipase and amylase in serum were>2000U/L(reference range 23-300 U/L)and 410 U/L(reference range 30-110 U/L),respectively.So we highly suspected that it may be acute pancreatitis.Interestingly,she never developed any complications associated with acute pancreatitis despite high levels of serum pancreatic amylase and trypsin,and she reported no symptoms of abdominal pain.Serum amylase and lipase decreased gradually after active thyroxine supplementation,and the patient was discharged from the hospital after active treatment.CONCLUSION This case suggests that clinicians should pay attention to hypothyroidism with elevated pancreatic amylase and trypsin,even if no complications of acute pancreatitis are reported.
基金Shanghai Shenkang Hospital Development Center,No.SHDC12016109.
文摘BACKGROUND Creutzfeldt-Jakob disease(CJD)is a rare degenerative disease of the central nervous system that can be contagious or hereditary and is a rare cause of rapidly progressive dementia.It almost always results in death within 1-2 years from symptom onset.CASE SUMMARY Here,we report the case of a 57-year-old male who initially experienced dizziness followed by a 1-mo fast decline in memory function.He presented to the local hospital and underwent magnetic resonance imaging and cerebrospinal fluid(CSF)examination,with no definitive diagnosis.However,the symptoms of progressive forgetting worsened.In addition,he exhibited progressive involuntary tremor of the limbs.Then,he came to our hospital,and according to the results of CSF examination,electroencephalography(EEG)and magnetic resonance imaging(MRI)tests and clinical manifestations of cerebellar ataxia,dementia,and myoclonus that rapidly progressed,with a short duration of illness,he was finally diagnosed with sporadic CJD(sCJD).CONCLUSION This case report aims to create awareness among physicians to emphasize auxiliary examination,CSF examination,EEG and MRI tests and recognition of cerebellar ataxia,dementia,and myoclonus that rapidly progress to prompt pursuit of an early diagnosis and identification of sCJD and to reduce complications.
