AIM:To investigate the expression and prognostic value of CCL2 in gastric cancer,as well as its relationshipwith tumor hypoxia.METHODS:Tumor tissues from 68 gastric cancer patients(GC)were analyzed,and the expression ...AIM:To investigate the expression and prognostic value of CCL2 in gastric cancer,as well as its relationshipwith tumor hypoxia.METHODS:Tumor tissues from 68 gastric cancer patients(GC)were analyzed,and the expression of CCL2and hypoxia-inducible factor 1 alpha(HIF-1α)in tumortissues was detected by immunohistochemistry.Statistical evaluations that were used included univariate logrank tests of Kaplan-Meier curves and multivariate Coxregression model analysis.RESULTS:CCL2 was highly expressed in 66.2%(45/68)of gastric cancer specimens.The distribution of CCL2expression in tumor tissue was consistent with thatof HIF-1α.Patients with high CCL2 expression in GChad a lower overall survival rate[50.6 mo(95%CI:44.44-56.93)vs 64.6 mo(95%CI:60.27-68.94),P=0.013].CONCLUSION:CCL2 expression correlates closely with HIF-1αexpression in gastric cancer.CCL2 may be an independent prognostic marker for GC.展开更多
The morphology and kinetics evolution of the γ’(Ni3 Al)phase during re-dissolution are studied in Ni-15 at% Al alloy,the changes of volume fraction and average particle radius of theγ’phase were clarified with pha...The morphology and kinetics evolution of the γ’(Ni3 Al)phase during re-dissolution are studied in Ni-15 at% Al alloy,the changes of volume fraction and average particle radius of theγ’phase were clarified with phasefield simulation.During isothermal aging,the interdistance of the neighboringγ’phase affects the interface concentration gradient of Al,which dominates the growth or redissolution of the γ’phase particle.After isothermal aging at 700 K,the alloy is continuously heated to 900 K with different heating rates,the re-dissolution lag happens,meaning the coalescence coarsening of adjacent γ’phase particles still proceeds at the initial heating stage.The predissolution of γ’phase with cubic shape is re-dissolved firstly at the edges and corners,in continuous heating to 900 K or by second-order aging from 700 to 900 K.Different from continuous heating,in the second-order aging process,the connected particles with band shape are broken initially by re-dissolving.At different heating rates,the similar dynamic relationships are abstracted for the volume fraction and the heating rates,and the average particle radius and the heating rates.展开更多
基金Supported by National Natural Science Foundation of China,No.81101739China International Medical Foundation,No.CIMF-F-H001-023
文摘AIM:To investigate the expression and prognostic value of CCL2 in gastric cancer,as well as its relationshipwith tumor hypoxia.METHODS:Tumor tissues from 68 gastric cancer patients(GC)were analyzed,and the expression of CCL2and hypoxia-inducible factor 1 alpha(HIF-1α)in tumortissues was detected by immunohistochemistry.Statistical evaluations that were used included univariate logrank tests of Kaplan-Meier curves and multivariate Coxregression model analysis.RESULTS:CCL2 was highly expressed in 66.2%(45/68)of gastric cancer specimens.The distribution of CCL2expression in tumor tissue was consistent with thatof HIF-1α.Patients with high CCL2 expression in GChad a lower overall survival rate[50.6 mo(95%CI:44.44-56.93)vs 64.6 mo(95%CI:60.27-68.94),P=0.013].CONCLUSION:CCL2 expression correlates closely with HIF-1αexpression in gastric cancer.CCL2 may be an independent prognostic marker for GC.
基金supported by the National Natural Science Foundation of China(No.51571122)the Fundamental Research Funds for the Central Universities(No 30916015107)。
文摘The morphology and kinetics evolution of the γ’(Ni3 Al)phase during re-dissolution are studied in Ni-15 at% Al alloy,the changes of volume fraction and average particle radius of theγ’phase were clarified with phasefield simulation.During isothermal aging,the interdistance of the neighboringγ’phase affects the interface concentration gradient of Al,which dominates the growth or redissolution of the γ’phase particle.After isothermal aging at 700 K,the alloy is continuously heated to 900 K with different heating rates,the re-dissolution lag happens,meaning the coalescence coarsening of adjacent γ’phase particles still proceeds at the initial heating stage.The predissolution of γ’phase with cubic shape is re-dissolved firstly at the edges and corners,in continuous heating to 900 K or by second-order aging from 700 to 900 K.Different from continuous heating,in the second-order aging process,the connected particles with band shape are broken initially by re-dissolving.At different heating rates,the similar dynamic relationships are abstracted for the volume fraction and the heating rates,and the average particle radius and the heating rates.
