Cerebral ischemia-reperfusion is a process in which the blood supply to the brain is temporarily interrupted and subsequently restored.However,it is highly likely to lead to further aggravation of pathological damage ...Cerebral ischemia-reperfusion is a process in which the blood supply to the brain is temporarily interrupted and subsequently restored.However,it is highly likely to lead to further aggravation of pathological damage to ischemic tissues or the nervous system.,and has accordingly been a focus of extensive clinical research.As a traditional Chinese medicinal formulation,Sanhua Decoction has gradually gained importance in the treatment of cerebrovascular diseases.Its main constituents include Citrus aurantium,Magnolia officinalis,rhubarb,and Qiangwu,which are primarily used to regulate qi.In the treatment of neurological diseases,the therapeutic effects of the Sanhua Decoction are mediated via different pathways,including antioxidant,anti-inflammatory,and neurotransmitter regu-latory pathways,as well as through the protection of nerve cells and a reduction in cerebral edema.Among the studies conducted to date,many have found that the application of Sanhua Decoction in the treatment of neurological diseases has clear therapeutic effects.In addition,as a natural treatment,the Sanhua Decoction has received widespread attention,given that it is safer and more effective than traditional Western medicines.Consequently,research on the mechanisms of action and efficacy of the Sanhua Decoctions in the treatment of cerebral ischemia-reperfusion injury is of considerable significance.In this paper,we describe the pathogenesis of cerebral ischemia-reperfusion injury and review the current status of its treatment to examine the therapeutic mechanisms of action of the Sanhua Decoction.We hope that the findings of the research presented herein will contribute to a better understanding of the efficacy of this formulation in the treatment of cerebral ischemia-reperfusion,and provide a scientific basis for its application in clinical practice.展开更多
Background:The prevalence of frailty among nursing home residents is high.However,in China,prevalence of frailty keeps unknown in this population.The purpose of this meta-analysis is to assess the prevalence of frailt...Background:The prevalence of frailty among nursing home residents is high.However,in China,prevalence of frailty keeps unknown in this population.The purpose of this meta-analysis is to assess the prevalence of frailty and prefrailty and find out the factors related to the prevalence of frailty among nursing home residents in China.Methods:We searched both English(PubMed,Cochrane Library,Embase,Web of Science and Scopus)and Chinese(CNKI,WanFang,SinoMed,and VIP)databases from their inception date until 15 September 2020.Two reviewers independently screened literature,extracted data,and evaluated the risk of bias included studies.Stata12.0 software was used to conduct meta-analysis.Results:A total of 16 studies were included in this review,involving 7,777 nursing home residents.The prevalence of frailty ranged from 29.2% to 66.6% in the included studies.The pooled prevalence of frailty and prefrailty were 49%(95%CI:43-55%)and 42%(95%CI:34–50%),respectively.The assessment tool(P<0.001),gender(P<0.001),self-rated health(P<0.001)and type of institution(P<0.001)were significantly associated with the prevalence of frailty among nursing home residents in China.Conclusions:The prevalence of frailty among nursing home residents in China was relatively high.Considering the adverse health outcomes of frailty,nursing home administrators should screen frailty regularly,identify the risk factors of frailty,take actions accordingly and improve the frailty status for older adults.展开更多
Objective:To understand the status of nursing students'professional attitudes,professional identity,and employment intention under the new coronary pneumonia pandemic,and to analyze the factors influencing nursing...Objective:To understand the status of nursing students'professional attitudes,professional identity,and employment intention under the new coronary pneumonia pandemic,and to analyze the factors influencing nursing students'employment intention.Methods:A cross-sectional survey was conducted on 689 nursing students using a questionnaire,and the results were analyzed by multiple unordered and ordered regressions.Results:47.17%of the nursing students chose to work in clinical nursing in the future;95.5%of the nursing students preferred to work in Grade III class hospital hospitals;0.73%of the nursing students actively chose to work in the infectious disease unit in the background of COVID-19 pandemic.In the analysis of professional attitudes,female nursing students scored higher than male nursing students;Senior students and above scored significantly higher than junior nursing students;nursing students who had internship experience scored higher than those who had not;nursing students who had someone close to them who was involved in the rescue work of the COVID-19 pandemic scored higher in professional attitudes.Regression analysis showed that the higher the professional identity score,the more likely the nursing students were to choose a nursing-related job and expect a higher salary;nursing students who chose nursing because it was easy to find a job,followed the advice of others,or had a family income of less than 3000 yuan per capita also expected a higher salary.In the context of the pandemic,nursing students with high career attitude scores were less likely to choose clinical nursing jobs;students without nursing practitioners at home were less likely to choose hospitals and health management organizations;nursing students with high career identity were more likely to choose Grade III class hospitals.Conclusion:The outbreak of COVID-19 has influenced the employment intention of nursing students,in the background of pandemic,about half of them still choose to engage in clinical nursing work;most of them recognize the outstanding contribution and professional value of nurses in the fight against epidemic.Meanwhile,through this research,it is believed that nursing students at school have insufficient awareness of infectious diseases and other public health emergencies.It is recommended that relevant colleges and universities strengthen knowledge and related courses on the prevention and control of infectious diseases and public health emergency events.展开更多
基金Supported by Key Project of Henan Provincial Administration of Traditional Chinese Medicine,No.2017ZY1020General Public Relations Project of Henan Provincial Department of Science and Technology,No.212102311123General Research Project of the National Administration of Traditional Chinese Medicine,No.GZY-KJS-2021-017.
文摘Cerebral ischemia-reperfusion is a process in which the blood supply to the brain is temporarily interrupted and subsequently restored.However,it is highly likely to lead to further aggravation of pathological damage to ischemic tissues or the nervous system.,and has accordingly been a focus of extensive clinical research.As a traditional Chinese medicinal formulation,Sanhua Decoction has gradually gained importance in the treatment of cerebrovascular diseases.Its main constituents include Citrus aurantium,Magnolia officinalis,rhubarb,and Qiangwu,which are primarily used to regulate qi.In the treatment of neurological diseases,the therapeutic effects of the Sanhua Decoction are mediated via different pathways,including antioxidant,anti-inflammatory,and neurotransmitter regu-latory pathways,as well as through the protection of nerve cells and a reduction in cerebral edema.Among the studies conducted to date,many have found that the application of Sanhua Decoction in the treatment of neurological diseases has clear therapeutic effects.In addition,as a natural treatment,the Sanhua Decoction has received widespread attention,given that it is safer and more effective than traditional Western medicines.Consequently,research on the mechanisms of action and efficacy of the Sanhua Decoctions in the treatment of cerebral ischemia-reperfusion injury is of considerable significance.In this paper,we describe the pathogenesis of cerebral ischemia-reperfusion injury and review the current status of its treatment to examine the therapeutic mechanisms of action of the Sanhua Decoction.We hope that the findings of the research presented herein will contribute to a better understanding of the efficacy of this formulation in the treatment of cerebral ischemia-reperfusion,and provide a scientific basis for its application in clinical practice.
基金funded by the Ministry of Education Humanities and Social Sciences Foundation(18YJAZH060)National Natural Science Foundation of China(No.71704133).
文摘Background:The prevalence of frailty among nursing home residents is high.However,in China,prevalence of frailty keeps unknown in this population.The purpose of this meta-analysis is to assess the prevalence of frailty and prefrailty and find out the factors related to the prevalence of frailty among nursing home residents in China.Methods:We searched both English(PubMed,Cochrane Library,Embase,Web of Science and Scopus)and Chinese(CNKI,WanFang,SinoMed,and VIP)databases from their inception date until 15 September 2020.Two reviewers independently screened literature,extracted data,and evaluated the risk of bias included studies.Stata12.0 software was used to conduct meta-analysis.Results:A total of 16 studies were included in this review,involving 7,777 nursing home residents.The prevalence of frailty ranged from 29.2% to 66.6% in the included studies.The pooled prevalence of frailty and prefrailty were 49%(95%CI:43-55%)and 42%(95%CI:34–50%),respectively.The assessment tool(P<0.001),gender(P<0.001),self-rated health(P<0.001)and type of institution(P<0.001)were significantly associated with the prevalence of frailty among nursing home residents in China.Conclusions:The prevalence of frailty among nursing home residents in China was relatively high.Considering the adverse health outcomes of frailty,nursing home administrators should screen frailty regularly,identify the risk factors of frailty,take actions accordingly and improve the frailty status for older adults.
文摘Objective:To understand the status of nursing students'professional attitudes,professional identity,and employment intention under the new coronary pneumonia pandemic,and to analyze the factors influencing nursing students'employment intention.Methods:A cross-sectional survey was conducted on 689 nursing students using a questionnaire,and the results were analyzed by multiple unordered and ordered regressions.Results:47.17%of the nursing students chose to work in clinical nursing in the future;95.5%of the nursing students preferred to work in Grade III class hospital hospitals;0.73%of the nursing students actively chose to work in the infectious disease unit in the background of COVID-19 pandemic.In the analysis of professional attitudes,female nursing students scored higher than male nursing students;Senior students and above scored significantly higher than junior nursing students;nursing students who had internship experience scored higher than those who had not;nursing students who had someone close to them who was involved in the rescue work of the COVID-19 pandemic scored higher in professional attitudes.Regression analysis showed that the higher the professional identity score,the more likely the nursing students were to choose a nursing-related job and expect a higher salary;nursing students who chose nursing because it was easy to find a job,followed the advice of others,or had a family income of less than 3000 yuan per capita also expected a higher salary.In the context of the pandemic,nursing students with high career attitude scores were less likely to choose clinical nursing jobs;students without nursing practitioners at home were less likely to choose hospitals and health management organizations;nursing students with high career identity were more likely to choose Grade III class hospitals.Conclusion:The outbreak of COVID-19 has influenced the employment intention of nursing students,in the background of pandemic,about half of them still choose to engage in clinical nursing work;most of them recognize the outstanding contribution and professional value of nurses in the fight against epidemic.Meanwhile,through this research,it is believed that nursing students at school have insufficient awareness of infectious diseases and other public health emergencies.It is recommended that relevant colleges and universities strengthen knowledge and related courses on the prevention and control of infectious diseases and public health emergency events.
