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Factors influencing spiritual wellbeing among pancreatic ductal adenocarcinoma patients receiving chemotherapy
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作者 Ling-Ling Wei shu-ting zhang +3 位作者 Yu Liao Yue zhang Yan Yu Na Mi 《World Journal of Psychiatry》 SCIE 2023年第9期675-684,共10页
BACKGROUND Spiritual wellbeing emphasizes optimistic and positive attitudes while selfregulating negative emotions when coping with stress.However,there have only been a few small studies of spiritual wellbeing of pan... BACKGROUND Spiritual wellbeing emphasizes optimistic and positive attitudes while selfregulating negative emotions when coping with stress.However,there have only been a few small studies of spiritual wellbeing of pancreatic ductal adenocarcinoma(PDAC)patients undergoing chemotherapy.The core factors influencing spiritual wellbeing in this clinical population are still unclear.AIM To identify factors influencing spiritual wellbeing among patients with PDAC receiving chemotherapy.METHODS A total of 143 PDAC patients receiving chemotherapy were enrolled from January to December 2022.Patients completed general information questionnaires including:Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being 12 Item Scale(FACIT-Sp-12),European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30(EORTC QLQ-C30)and Zung’s Self-rating Anxiety Scale(SAS).Independent sample t-test,one-way analysis of variance,Pearson’s correlation analysis,and multiple linear regression analysis were adopted for statistical analyses.P<0.05(two-tailed)was considered statistically significant for all tests.RESULTS Total spiritual wellbeing(FACIT-Sp-12)score was 32.16±10.06 points,while dimension sub-scores were 10.85±3.76 for faith,10.55±3.42 for meaning,and 10.76±4.00 for peace.Total spiritual wellbeing score was negatively correlated with SAS score for anxiety and with the symptom domain of EORTC QLC-C30.Conversely,spiritual wellbeing score was positively correlated with global health status and EORTC QLQ-C30 role functioning domain score.Multivariate regression analysis identified educational level,health insurance category,symptom domain,functional role domain,and global health status as significant independent factors influencing spiritual wellbeing among PDAC patients undergoing chemotherapy(R2=0.502,P<0.05).CONCLUSION Individualized spiritual support is needed for PDAC patients.Health,daily functioning,emotional,cognitive,and social function status should be taken into account to promote implementation of spirituality in nursing practice. 展开更多
关键词 Pancreatic ductal adenocarcinoma CHEMOTHERAPY Spiritual wellbeing Quality of life ANXIETY
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基于离子液体的超级电容在3 V及65℃老化条件下的铝碳界面效应
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作者 叶珍珍 张抒婷 +7 位作者 陈鑫祺 王瑾 金鹰 崔超婕 张磊 钱陆明 张刚 骞伟中 《电化学》 CAS CSCD 北大核心 2022年第12期50-59,共10页
相比于传统乙腈电解液体系的超级电容器,离子液体基超级电容器具有工作窗口电压高,能量密度大,不可燃等优点,适用于碳中和时代清洁但不稳定电力领域的大规模储能。然而,目前的工作主要集中在对纽扣型离子液体-超级电容器的研究上,有关... 相比于传统乙腈电解液体系的超级电容器,离子液体基超级电容器具有工作窗口电压高,能量密度大,不可燃等优点,适用于碳中和时代清洁但不稳定电力领域的大规模储能。然而,目前的工作主要集中在对纽扣型离子液体-超级电容器的研究上,有关软包式离子液体-超级电容器的长循环寿命评测的报道较少。构建可靠的超级电容器用于长时间测试或在高温下开展加速老化测试,应考虑集流体/电极界面的良好接触,以最小化电荷转移电阻。本文以包覆不同碳层的泡沫铝为集流体,研究了超级电容器新系统中的碳-铝界面效应。通过环氧树脂薄膜碳化得到的均匀无定形碳层,相比通过PVDF粘附石墨烯碳层,赋予了铝相和碳相更强的相互作用。此外,为了充分挖掘大离子尺寸的离子液体电解液的潜力,本文采用介孔碳电极实现离子在介孔间的快速扩散。因此,本工作首次制备了由介孔碳电极、离子液体电解液和覆碳三维泡沫铝集流体组成的新结构软包式超级电容器。以自制的容量为37 F的不同软包式超级电容器件,通过3 V、65℃、500 h加速老化试验,研究了其时间依赖性的电化学性能,包括CV测试、恒流充放电测试、电容值、接触电阻、电化学阻抗谱等。相比石墨烯包覆的泡沫铝基器件,无定形碳层包覆的泡沫铝基器件表现出更高的电容保持率。此外,我们还对ESR进行了等效电路拟合,并深入分析了接触电阻、电荷转移电阻、韦伯电阻,研究了C-Al界面对高能量密度超级电容器的高性能和稳定性的影响。500小时老化测试前后的极片表征证实了上述结果。高温、高压条件使粘附石墨烯碳层的泡沫铝界面结构不可靠。而泡沫铝表面原位包覆的碳层在老化过程中表现出较强的相互作用和稳定的结构。这些坚实的数据为面向高能量密度、高功率密度和长循环寿命,进一步优化高窗口电压超级电容器提供了充足的信息。 展开更多
关键词 超级电容器 老化试验 碳-铝界面 离子液体 泡沫铝
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Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion 被引量:14
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作者 Qing-zhang Tuo Yu Liu +21 位作者 Zheng Xiang Hong-Fa Yan Ting Zou Yang Shu Xu-long Ding Jin-jun Zou Shuo Xu Fei Tang Yan-qiu Gong Xiao-lan Li Yu-jie Guo Zhao-yue Zheng Ai-ping Deng zhang-zhong Yang Wen-jing Li shu-ting zhang Scott Ayton Ashley I.Bush Heng Xu Lunzhi Dai Biao Dong Peng Lei 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2022年第3期881-895,共15页
Ischemic stroke represents a significant danger to human beings,especially the elderly.Interventions are only available to remove the clot,and the mechanism of neuronal death during ischemic stroke is still in debate.... Ischemic stroke represents a significant danger to human beings,especially the elderly.Interventions are only available to remove the clot,and the mechanism of neuronal death during ischemic stroke is still in debate.Ferroptosis is increasingly appreciated as a mechanism of cell death after ischemia in various organs. 展开更多
关键词 ORGANS DEATH cerebral ISCHEMIA
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A practical synthesis of bis(indolyl)methanes catalyzed by BF_3·Et_2O 被引量:7
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作者 Xia-Fei Xu Yan Xiong +4 位作者 Xue-Ge Ling Xi-Mi Xie Jie Yuan shu-ting zhang Zhong-Rong Song 《Chinese Chemical Letters》 SCIE CAS CSCD 2014年第3期406-410,共5页
Practical BF3.Et20 catalyzed reactions between indoles and a series of carbonyl compounds at room temperature are described, which afford bis(indolyl)methanes with isolated yields up to 96%,
关键词 Bis(indolyl)methanes BF3.Et2O lndoles ALDEHYDES KETONES
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Cognitive impairment in two subtypes of a single subcortical infarction 被引量:4
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作者 Tang Yang Qiao Deng +6 位作者 Shuai Jiang Yu-Ying Yan Ye Yuan Si-Miao Wu shu-ting zhang Jia-Yu Sun Bo Wu 《Chinese Medical Journal》 SCIE CAS CSCD 2021年第24期2992-2998,共7页
Background:Single subcortical infarction(SSI)is caused by two main etiological subtypes,which are branch atheromatous disease(BAD)and cerebral small vessel disease(CSVD)-related SSI.We applied the Beijing version of t... Background:Single subcortical infarction(SSI)is caused by two main etiological subtypes,which are branch atheromatous disease(BAD)and cerebral small vessel disease(CSVD)-related SSI.We applied the Beijing version of the Montreal Cognitive Assessment(MoCA-BJ),the Shape Trail Test(STT),and the Stroop Color and Word Test(SCWT)to investigate the differences in cognitive performance between these two subtypes of SSI.Methods:Patients with acute SSIs were prospectively enrolled.The differences of MoCA-BJ,STT,and SCWT between the BAD group and CSVD-related SSI group were analyzed.A generalized linear model was used to analyze the associations between SSI patients with different etiological mechanisms and cognitive function.We investigated the correlations between MoCA-BJ,STT,and SCWT using Spearman’s correlation analysis and established cut-off scores for Shape Trail Test A(STT-A)and STT-B to identify cognitive impairment in patients with SSI.Results:This study enrolled a total of 106 patients,including 49 and 57 patients with BAD and CSVD-related SSI,respectively.The BAD group performances were worse than those of the CSVD-related SSI group for STT-A(83[60.5-120.0]vs.68[49.0-86.5],P=0.01),STT-B(204[151.5-294.5]vs.153[126.5-212.5],P=0.015),and the number of correct answers on Stroop-C(46[41-49]vs.49[45-50],P=0.035).After adjusting for age,years of education,National Institutes of Health Stroke Scale and lesion location,the performance of SSI patients with different etiological mechanisms still differed significantly for STT-A and STT-B.Conclusions:BAD patients were more likely to perform worse than CSVD-related SSI patients in the domains of language,attention,executive function,and memory.The mechanism of cognitive impairment after BAD remains unclear. 展开更多
关键词 BRAIN Cognitive impairment Cerebral small vessel disease Subcortical infarction STROKE
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Effective synthesis of benzyl halides triggered by in situ prepared hypervalent halides 被引量:3
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作者 Xue-Ge Ling Yan Xiong +2 位作者 shu-ting zhang Ruo-Feng Huang Xiao-Hui zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2013年第1期45-48,共4页
An effective approach for the direct benzylhalogenation with in situ generation of hypervalent halides has been developed. A variety of benzyl halides are produced in moderate to excellent yields (up to 99%) with hi... An effective approach for the direct benzylhalogenation with in situ generation of hypervalent halides has been developed. A variety of benzyl halides are produced in moderate to excellent yields (up to 99%) with high regioselectivities. UV absorption spectrum is employed to detect the formation of tert-butyl hypoiodite. 展开更多
关键词 Benzyl halidesBrominationHypervalentlodination
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