BACKGROUND Acute non-variceal upper gastrointestinal bleeding(ANVUGIB)constitutes a prevalent emergency within Gastroenterology,encompassing 80%-90%of all gastrointestinal hemorrhage incidents.This condition is distin...BACKGROUND Acute non-variceal upper gastrointestinal bleeding(ANVUGIB)constitutes a prevalent emergency within Gastroenterology,encompassing 80%-90%of all gastrointestinal hemorrhage incidents.This condition is distinguished by its abrupt onset,swift progression,and notably elevated mortality rate.AIM To gather clinical data from patients with ANVUGIB at our hospital in order to elucidate the clinical characteristics specific to our institution and analyze the therapeutic effectiveness of endoscopic hemostasis.METHODS We retrospectively retrieved the records of 532 patients diagnosed with ANVUGIB by endoscopy at our hospital between March 2021 and March 2023,utilizing our medical record system.Data pertaining to general patient information,etiological factors,disease outcomes,and other relevant variables were meticulously collected and analyzed.RESULTS Among the 532 patients diagnosed with ANVUGIB,the male-to-female ratio was 2.91:1,with a higher prevalence among males.Notably,43.6%of patients presented with black stool as their primary complaint,while 27.4%had hematemesis as their initial symptom.Upon admission,17%of patients exhibited both hematemesis and black stool,while most ANVUGIB patients primarily complained of overt gastrointestinal bleeding.Urgent routine blood examinations at admission revealed that 75.8%of patients had anemia,with 63.4%experiencing moderate to severe anemia,and 1.5%having extremely severe anemia(hemoglobin<30 g/L).With regard to etiology,53.2%of patients experienced bleeding without a definitive trigger,24.2%had a history of using gastric mucosa-irritating medications,24.2%developed bleeding after alcohol consumption,2.8%attributed it to improper diet,1.7%to emotional excitement,and 2.3%to fatigue preceding the bleeding episode.Drug-induced ANVUGIB was more prevalent in the elderly than middle-aged and young individuals,while bleeding due to alcohol consumption showed the opposite trend.Additionally,diet-related bleeding was more common among the young age group compared to the middle-aged group.Gastrointestinal endoscopy identified peptic ulcers as the most frequent cause of ANVUGIB(73.3%),followed by gastrointestinal malignancies(10.9%),acute gastric mucous lesions(9.8%),and androgenic upper gastrointestinal bleeding(1.5%)among inpatients with ANVUGIB.Of the 532 patients with gastrointestinal bleeding,68 underwent endoscopic hemostasis,resulting in an endoscopic treatment rate of 12.8%,with a high immediate hemostasis success rate of 94.1%.展开更多
Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheime...Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheimer’s disease affects the entire brain,further research is needed to elucidate alterations in mitochondrial metabolism in the brain as a whole.Here,we investigated the expression of several important mitochondrial biogenesis-related cytokines in multiple brain regions after treatment with neural stem cell-derived exosomes and used a combination of whole brain clearing,immunostaining,and lightsheet imaging to clarify their spatial distribution.Additionally,to clarify whether the sirtuin 1(SIRT1)-related pathway plays a regulatory role in neural stem cell-de rived exosomes interfering with mitochondrial functional changes,we generated a novel nervous system-SIRT1 conditional knoc kout AP P/PS1mouse model.Our findings demonstrate that neural stem cell-de rived exosomes significantly increase SIRT1 levels,enhance the production of mitochondrial biogenesis-related fa ctors,and inhibit astrocyte activation,but do not suppress amyloid-βproduction.Thus,neural stem cell-derived exosomes may be a useful therapeutic strategy for Alzheimer’s disease that activates the SIRT1-PGC1αsignaling pathway and increases NRF1 and COXIV synthesis to improve mitochondrial biogenesis.In addition,we showed that the spatial distribution of mitochondrial biogenesis-related factors is disrupted in Alzheimer’s disease,and that neural stem cell-derived exosome treatment can reverse this effect,indicating that neural stem cell-derived exosomes promote mitochondrial biogenesis.展开更多
We have applied strong coupling unitary transformation method combined with Bose–Einstein statistical law to investigate magnetopolaron energy level temperature effects in halogen ion crystal quantum wells.The obtain...We have applied strong coupling unitary transformation method combined with Bose–Einstein statistical law to investigate magnetopolaron energy level temperature effects in halogen ion crystal quantum wells.The obtained results showed that under magnetic field effect,magnetopolaron quasiparticle was formed through the interaction of electrons and surrounding phonons.At the same time,magnetopolaron was influenced by phonon temperature statistical law and important energy level shifts down and binding energy increases.This revealed that lattice temperature and magnetic field could easily affect magnetopolaron and the above results could play key roles in exploring thermoelectric conversion and conductivity of crystal materials.展开更多
In this editorial,we comment on Liu et al’s article published in the recent issue of the World Journal of Gastroenterology.Biochemically and pathologically,Liu et al proved that the urate-lowering activity of leech t...In this editorial,we comment on Liu et al’s article published in the recent issue of the World Journal of Gastroenterology.Biochemically and pathologically,Liu et al proved that the urate-lowering activity of leech total protein(LTP)was mainly attributed to the rectification of gut microbiota.Specifically,we noticed the change in Bacteroides and Akkermansia after LTP administration.Both bacteria have been reported to alleviate metabolic dysfunction-associated steatohepatitis and other chronic metabolic diseases.LTP was administrated through intragastric manners.Most possibly,LTP would be digested by the gut microbiota further.The anti-hyperuricemia effects should,to the most possible extent,be exerted by the peptides or their secondary metabolic products.Human gut microbiota communicates with other organs through metabolites generated by the microbes or co-metabolized with the host.Whether the anti-hyperuricemia effect could be partially ascribed to the microbiota metabolites also deserves to be discussed.Although metabolomics analysis was performed for serum samples,fecal meta-bolomics was highly advocated which could facilitate exact mechanism expla-nation.This study implied that gut microbiota contains many unexplored targets with different therapeutic potentials.It is foreseeable that utilizing these targets can avoid the impairment or side effects of directly using human targets to some extent.展开更多
Excitons have significant impacts on the properties of semiconductors.They exhibit significantly different properties when a direct semiconductor turns in to an indirect one by doping.Huybrecht variational method is a...Excitons have significant impacts on the properties of semiconductors.They exhibit significantly different properties when a direct semiconductor turns in to an indirect one by doping.Huybrecht variational method is also found to influence the study of exciton ground state energy and ground state binding energy in Al_(x)Ga_(1−x)As semiconductor spherical quantum dots.The Al_(x)Ga_(1−x)As is considered to be a direct semiconductor at AI concentration below 0.45,and an indirect one at the concentration above 0.45.With regards to the former,the ground state binding energy increases and decreases with AI concentration and eigenfrequency,respectively;however,while the ground state energy increases with AI concentration,it is marginally influenced by eigenfrequency.On the other hand,considering the latter,while the ground state binding energy increases with AI concentration,it decreases with eigenfrequency;nevertheless,the ground state energy increases both with AI concentration and eigenfrequency.Hence,for the better practical performance of the semiconductors,the properties of the excitons are suggested to vary by adjusting AI concentration and eigenfrequency.展开更多
BACKGROUND Duodenal neuroendocrine tumours(DNETs)are rare neoplasms.However,the incidence of DNETs has been increasing in recent years,especially as an incidental finding during endoscopic studies.Regrettably,there is...BACKGROUND Duodenal neuroendocrine tumours(DNETs)are rare neoplasms.However,the incidence of DNETs has been increasing in recent years,especially as an incidental finding during endoscopic studies.Regrettably,there is no consensus regarding the ideal treatment of DNETs.Even there are few studies on the clinical features and survival analysis of DNETs.AIM To analyze the clinical characteristics and prognostic factors of patients with duodenal neuroendocrine tumours.METHODS The clinical data of DNETs diagnosed in the First Affiliated Hospital of Air Force Military Medical University from June 2011 to July 2022 were collected.Neuroen-docrine tumours located in the ampulla area of the duodenum were divided into the ampullary region group;neuroendocrine tumours in any part of the duo-denum outside the ampullary area were divided into the nonampullary region group.Using a retrospective study,the clinical characteristics of the two groups and risk factors affecting the survival of DNET patients were analysed.RESULTS Twenty-nine DNET patients were screened.The male to female ratio was 1:1.9,and females comprised the majority.The ampullary region group accounted for 24.1%(7/29),while the nonampullary region group accounted for 75.9%(22/29).When diagnosed,the clinical symptoms of the ampullary region group were mainly abdominal pain(85.7%),while those of the nonampullary region groups were mainly abdominal distension(59.1%).There were differences in the composition of staging of tumours between the two groups(Fisher's exact probability method,P=0.001),with nonampullary stage II tumours(68.2%)being the main stage(P<0.05).After the diagnosis of DNETs,the survival rate of the ampullary region group was 14.3%(1/7),which was lower than that of 72.7%(16/22)in the nonampullary region group(Fisher's exact probability method,P=0.011).The survival time of the ampullary region group was shorter than that of the nonampullary region group(P<0.000).The median survival time of the ampullary region group was 10.0 months and that of the nonampullary region group was 451.0 months.Multivariate analysis showed that tumours in the ampulla region and no surgical treatment after diagnosis were independent risk factors for the survival of DNET patients(HR=0.029,95%CI 0.004-0.199,P<0.000;HR=12.609,95%CI:2.889-55.037,P=0.001).Further analysis of nonampullary DNET patients showed that the survival time of patients with a tumour diameter<2 cm was longer than that of patients with a tumour diameter≥2 cm(t=7.243,P=0.048).As of follow-up,6 patients who died of nonampullary DNETs had a tumour diameter that was≥2 cm,and 3 patients in stage IV had liver metastasis.Patients with a tumour diameter<2 cm underwent surgical treatment,and all survived after surgery.CONCLUSION Surgical treatment is a protective factor for prolonging the survival of DNET patients.Compared to DNETs in the ampullary region,patients in the nonampullary region group had a longer survival period.The liver is the organ most susceptible to distant metastasis of nonampullary DNETs.展开更多
Background:Xiaoxianxiong decoction is a classic formula in traditional Chinese medicine used to treat type 2 diabetes mellitus and proven to be effective.But the material basis and underlying mechanisms remain unclear...Background:Xiaoxianxiong decoction is a classic formula in traditional Chinese medicine used to treat type 2 diabetes mellitus and proven to be effective.But the material basis and underlying mechanisms remain unclear.The aim of the present study was to elucidate the potential effective material basis of Xiaoxianxiong decoction and molecular mechanism treating type 2 diabetes mellitus.Methods:The absorbed bioactive components were identified based on serum pharmacochemistry.Network analysis were performed to obtain effect targets for docking verification with the absorbed prototypes to determine the potential effective material basis.On the above basis,network pharmacology was conducted to explore the molecular mechanism.Results:76 compounds were identified of Xiaoxianxiong decoction and 61 absorbed bioactive compounds were investigated.Serine/threonine kinase 1 and ALB were key targets acquired by network analysis for molecular docking.Subsequently,5 compounds were considered as the potential effective material basis,namely berberine,berberrubine,lariciresinol and gingerenone A,jatrorrhizine.Further,the mechanism mainly lies in the insulin signaling pathway,HIF-1 signaling pathway,PI3K-Akt signaling pathway,FoxO signaling pathway,AGE-RAGE signaling pathway in diabetic complications,phospholipase D signaling pathway to regulate blood glucose levels on target tissues as well as organs and exhibit anti-inflammatory,promote cell differentiation and cell growth,maintain oxygen homeostasis and affect the enzymes along with key metabolites.Conclusion:This integrated research strategy to investigate the treatment of Xiaoxianxiong decoction on type 2 diabetes mellitus provides valuable insights for further study and clinical practice of Xiaoxianxiong decoction.展开更多
[Objective] This research aimed at studying the mechanism of the occurrence of epithelial cell loss in bladders of prenatal and postnatal mice. [Method] Bladder epithelia of 1-2-day-old newborn Kunming mice and mice a...[Objective] This research aimed at studying the mechanism of the occurrence of epithelial cell loss in bladders of prenatal and postnatal mice. [Method] Bladder epithelia of 1-2-day-old newborn Kunming mice and mice at later period of embryonic development were acquired, and paraffin sections of such epithelia were then made for Mallory's coloration and ordinary optical microscopic observation. The acquired bladder epithelia were made into frozen sections, which were then colored by DAPI and labeled in situ by Terminal-deoxynucleoitidyl Transferase Mediated Nick End Labeling(TUNEL) for fluorescent microscopic observation. DNA electrophoresis and TUNEL in situ labeling were conducted on the acquired urine exfoliated cells. [Result] The results showed that the complete three layers of cells occurred in 20-day-old mouse embryos, whereas no superficial cells resided in the bladder epithelia of newborn mice and no cells exfoliating were observed. Cells exfoliating from the bladder epithelia of newborn mice were observed, and they exhibited the phenomenon of apoptosis. There were apoptosis existed in the urine cells of newborn mice. [Conclusion] Therefore, the results showed that a few days before and after their birth, mice witnessed the process of cell exfoliation in their bladder epithelia and the exfoliated cells showed typical characteristics of apoptosis.展开更多
Rapid assessment of foliar chlorophyll content in tobacco is critical for assessment of growth and precise management to improve quality and yield while minimizing adverse environmental impact. Our objective is to dev...Rapid assessment of foliar chlorophyll content in tobacco is critical for assessment of growth and precise management to improve quality and yield while minimizing adverse environmental impact. Our objective is to develop a precise agricultural practice predicting tobacco-leaf chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;"> content. Reflectance experiments have been conducted on flue-cured tobacco over 3 consecutive years under different light quality. Leaf hyperspectral reflectance and chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;"> content data have been collected at 15-day intervals from 30 days after transplant until harvesting. We identified the central band that is sensitive to tobacco-leaf chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;"> content and the optimum wavelength combinations for establishing new spectral indices (simple ratio index, RVI;normalized difference vegetation index, NDVI;and simple difference vegetation index, DVI). We then established linear and BackPropagation (BP) neural network models to estimate chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;"> content. The central bands for leaf chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;"> content are concentrated in the visible range (410 - 680 nm) in combination with the shortwave infrared range (1900 - 2400 nm). The optimum spectral range for the spectral band combinations</span><span style="font-family:Verdana;"> RVI, NDVI, and DVI</span><span style="font-family:Verdana;"> are 440 and 470 nm, 440 and 470 nm, and 440 and 460 nm, respectively. The linear RVI, NDVI, and DVI models, SMLR model and the BP neural network model have respective R</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> values of 0.76, 0.77, 0.69, 0.78 and 0.86, and root mean square error values of 0.63, 1.60, 1.59, 2.04 and 0.05 mg chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;">/g (fresh weight), respectively. Our results identified chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;"> sensitive spectral regions and new indices facilitate a rapid, non-destructive field estimation of leaf chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;"> content for tobacco.展开更多
Wind power,solar power,and electrical load forecasting are essential works to ensure the safe and stable operation of the electric power system.With the increasing permeability of new energy and the rising demand resp...Wind power,solar power,and electrical load forecasting are essential works to ensure the safe and stable operation of the electric power system.With the increasing permeability of new energy and the rising demand response load,the uncertainty on the production and load sides are both increased,bringing new challenges to the forecasting work and putting forward higher requirements to the forecasting accuracy.Most review/survey papers focus on one specific forecasting object(wind,solar,or load),a few involve the above two or three objects,but the forecasting objects are surveyed separately.Some papers predict at least two kinds of objects simultaneously to cope with the increasing uncertainty at both production and load sides.However,there is no corresponding review at present.Hence,our study provides a comprehensive review of wind,solar,and electrical load forecasting methods.Furthermore,the survey of Numerical Weather Prediction wind speed/irradiance correction methods is also included in this manuscript.Challenges and future research directions are discussed at last.展开更多
With the increasing proportion of wind power integration, the volatility of wind power brings huge challenges to the safe and stable operation of the electric power system. At present, the indexes commonly used to eva...With the increasing proportion of wind power integration, the volatility of wind power brings huge challenges to the safe and stable operation of the electric power system. At present, the indexes commonly used to evaluate the volatility of wind power only consider its overall characteristics, such as the standard deviation of wind power, the average of power variables, etc., while ignoring the detailed volatility of wind power, that is, the features of the frequency distribution of power variables. However, how to accurately describe the detailed volatility of wind power is the key foundation to reduce its adverse influences. To address this, a quantitative method for evaluating the detailed volatility of wind power at multiple temporal-spatial scales is proposed. First, the volatility indexes which can evaluate the detailed fluctuation characteristics of wind power are presented, including the upper confidence limit, lower confidence limit and confidence interval of power variables under the certain confidence level. Then, the actual wind power data from a location in northern China is used to illustrate the application of the proposed indexes at multiple temporal(year–season–month–day) and spatial scales(wind turbine–wind turbines–wind farm–wind farms) using the calculation time windows of 10 min, 30 min, 1 h, and 4 h. Finally, the relationships between wind power forecasting accuracy and its corresponding detailed volatility are analyzed to further verify the effectiveness of the proposed indexes. The results show that the proposed volatility indexes can effectively characterize the detailed fluctuations of wind power at multiple temporal-spatial scales. It is anticipated that the results of this study will serve as an important reference for the reserve capacity planning and optimization dispatch in the electric power system which with a high proportion of renewable energy.展开更多
The effect of the crystal orientations and precipitates on the corrosion behavior of Al-Cu-Li single crystals was studied by scanning electron microscopy, transmission electron microscopy, optical microscopy, immersio...The effect of the crystal orientations and precipitates on the corrosion behavior of Al-Cu-Li single crystals was studied by scanning electron microscopy, transmission electron microscopy, optical microscopy, immersion testing in exfoliation corrosion solution, and electrochemical testing. The results show that the corrosion rates of different orientations of the aged Al-Cu-Li alloy increase in the order of (001) 1 phase deteriorated the corrosion resistance of the Al-Cu-Li alloy, and the degree of deterioration differed in different crystal plane orientations. The severe localized corrosion of the aged alloy propagates along the crystallography and extends along the {111}Alplane in the form of corrosion bands.展开更多
Suaeda salsa is an important local species in the intertidal beach of the Western Pacific coast. However,under the artificial cofferdam and Spartina alterniflora expansion,Suaeda marsh has degraded seriously. Therefor...Suaeda salsa is an important local species in the intertidal beach of the Western Pacific coast. However,under the artificial cofferdam and Spartina alterniflora expansion,Suaeda marsh has degraded seriously. Therefore,using Yancheng Nature Reserve as a case study area,taking ETM+images in 2000,2006 and 2011 as the basic data sources,we revealed the evolution characteristics of Salsa marsh which was impacted. The research results are as follows. From 2000 to 2011,Salsa marsh area in the artificial area tempestuously degraded,decreasing by 87. 158%,more than 22% than those in the natural area. The landscape was fragmentized. Landscape polymerization degree index dropped from 95. 780 to 65. 455,more than 16% than those in the natural area. The mean patch area fell down to 21. 429 ha from 389. 333 ha,more than 11% that in the natural area. Compared to the steady change in natural conditions,the area was reduced by 118. 167 ha/a from 2000 to 2006,while during 2006-2011,it was only 51. 500 ha/a in artificial area. As for spatial change of landscape,in artificial area,the Salsa marsh centroid moved forward to the southeast with 666. 350 m,but that in natural area moved forward to the north with 1 042. 710 m from 2000 to 2006. From 2006 to 2011,the centroid moved forward to east and north respectively. Artificial cofferdam transformed the area into freshwater ecosystem,and meanwhile the freshwater was beneficial to Reed marsh. During 2000 to 2006,in the artificial area,539 ha Salsa marsh controlled by cofferdam transferred into reed marsh and aquaculture ponds,of which the transformation rate was nearly 4% higher than that in natural area. From 2006 to 2011,178 ha Salsa marsh was transferred into reed marsh,the transformation rate was 20% higher than that in natural area. With rapid spreading and strong competition of Spartina species,the coastal wetland has formed the pattern of " Salsa – Spartina marshes". From 2000 to 2006,in artificial area,15. 24% of Salsa marsh was transferred into Spartina marsh,of which the transformation rate was13% higher than that in natural area. And from 2006 to 2011,30. 07% Salsa marsh was replaced by the Spartina marsh in artificial area,the rate was almost 10% higher than that in the natural area.展开更多
The design energy productions deviate from the actual situation, which are affected by the accuracy of two significant factors - the wind resource assessment and wind farm micro-siting. A running wind farm in northern...The design energy productions deviate from the actual situation, which are affected by the accuracy of two significant factors - the wind resource assessment and wind farm micro-siting. A running wind farm in northern China was taken as the object in this investigation. The measured data obtained in operation phase and the relevant information in design phase were integrated and a post evaluation of wind resource assessment, micro-siting and generating capacity reduction factors of the wind farm in design phase was provided. The results indicate that the representative year wind regimes of the wind farm in design phase can basically reflect the wind conditions in the wind farm without the consideration of the trends of long-term changes in wind speed;micro-siting project in design phase is superior to that in practical;generating capacity reduction factors, overall on the high side, should be further optimized considering 20-year operation period.展开更多
Objective:The aim of present meta-analysis was to evaluate the clinical efficacy of Ginkgo biloba extract combined with conventional therapy in the treatment of diabetic retinopathy(DR).Methods:The randomized controll...Objective:The aim of present meta-analysis was to evaluate the clinical efficacy of Ginkgo biloba extract combined with conventional therapy in the treatment of diabetic retinopathy(DR).Methods:The randomized controlled trials(RCTs)of Ginkgo biloba extract adjuvant conventional therapy for treating DR were searched in PubMed,the Cochrane Library,China Knowledge Network(CNKI),China Biomedical Literature Service System(SinoMed),VIP Information Chinese Journal Service Platform(VIP),and Wanfang database.Two reviewers independently extracted data and conducted methodological quality assessment.Data analysis was performed using Revised Cochrane risk-of-bias tool for randomized trials(RoB 2).Results:A total of 9 RCTs involving 798 patients were included in current research.Meta-analysis showed that Ginkgo biloba extract combined with conventional medicine can improve total effective rate[OR=0.33,95%CI=(0.23,0.46),P<0.0001],visual acuity[OR=-0.11,95%CI=(-0.14,-0.07),P<0.0001]and visual field average defect[OR=0.59,95%CI=(0.53,0.65),P<0.0001].Conclusion:The available evidence indicated that Ginkgo biloba extract combined with conventional medicine can be beneficial for treating DR.However,our findings were warranted to verify by more large-scale,multi-center clinical trials.展开更多
Traditional assessment indexes could not fully describe offshore wind resources,for the meteorological properties of offshore are more complex than onshore.As a result,the uncertainty of offshore wind power projects w...Traditional assessment indexes could not fully describe offshore wind resources,for the meteorological properties of offshore are more complex than onshore.As a result,the uncertainty of offshore wind power projects would be increased and final economic benefits would be affected.Therefore,a study on offshore wind resource assessment is carried out,including three processes of“studying data sources,conducting multidimensional indexes system and proposing an offshore wind resource assessment method based on analytic hierarchy process(AHP).First,measured wind data and two kinds of reanalysis data are used to analyze the characteristics and reliability of data sources.Second,indexes such as effective wind speed occurrence,affluent level occurrence,coefficient of variation,neutral state occurrence have been proposed to depict availability,richness,and stability of offshore wind resources,respectively.Combined with existing parameters(wind power density,dominant wind direction occurrence,water depth,distance to coast),a multidimensional indexes system has been built and on this basis,an offshore wind energy potential assessment method has been proposed.Furthermore,the proposed method is verified by the annual energy production of five offshore wind turbines and practical operating data of four offshore wind farms in China.This study also compares the ranking results of the AHP model to two multi-criteria decision making(MCDM)models including weighted aggregated sum product assessment(WASPAS)and multi-attribute ideal real comparative analysis(MAIRCA).Results show the proposed method gains well in practical engineering applications,where the economic score values have been considered based on the offshore reasonable utilization hours of the whole life cycle in China.展开更多
The polaron phenomenon is commonly observed in low-dimensional semiconductor materials and is known to have unique effects on conductive material properties.Furthermore,the phonon dragging effect,which leads to the po...The polaron phenomenon is commonly observed in low-dimensional semiconductor materials and is known to have unique effects on conductive material properties.Furthermore,the phonon dragging effect,which leads to the polaron energy level,is less than the electron energy level.A decay magnetic field also affects the polaron effect,which causes polaron energy level changes.We demonstrate the unique electron-phonon coupling properties of this polaron using numerical calculations.Our findings have strong implications for theories of polaron properties and provide compelling evidence for a semiconductor device that industrial manufacturers use for new lowdimensional materials.展开更多
Nanorod is a unique low-dimensional nanometer structure in which the Landau level arrangement of polaron is essential for understanding its quasiparticle system. However, the stability of the polaron level is suscepti...Nanorod is a unique low-dimensional nanometer structure in which the Landau level arrangement of polaron is essential for understanding its quasiparticle system. However, the stability of the polaron level is susceptible to external factors, such as changing magnetic fields.In this manuscript, the Pekar variational method is employed to calculate the external magnetic field's effect on the nanorod's polaron Landau level. It was found that different magnetic fields have different effects on the polaron energy levels of the nanorod, which demonstrated that the external environment had critical effects on the polaron energy levels. This study provides a theoretical basis for regulating the interaction between electrons and phonons in low-dimensional nanomaterials.展开更多
Exercise intervention at the early stage of type 2 diabetes mellitus(T2DM)can aid in the maintenance of blood glucose homeostasis and prevent the development of macrovascular and microvascular complications.However,th...Exercise intervention at the early stage of type 2 diabetes mellitus(T2DM)can aid in the maintenance of blood glucose homeostasis and prevent the development of macrovascular and microvascular complications.However,the exercise-regulated pathways that prevent the development of T2DM remain largely unclear.In this study,two forms of exercise intervention,treadmill training and voluntary wheel running,were conducted for high-fat diet(HFD)-induced obese mice.We observed that both forms of exercise intervention alleviated HFD-induced insulin resistance and glucose intolerance.Skeletal muscle is recognized as the primary site for postprandial glucose uptake and for responsive alteration beyond exercise training.Metabolomic profiling of the plasma and skeletal muscle in Chow,HFD,and HFD-exercise groups revealed robust alterations in metabolic pathways by exercise intervention in both cases.Overlapping analysis identified nine metabolites,including beta-alanine,leucine,valine,and tryptophan,which were reversed by exercise treatment in both the plasma and skeletal muscle.Transcriptomic analysis of gene expression profiles in the skeletal muscle revealed several key pathways involved in the beneficial effects of exercise on metabolic homeostasis.In addition,integrative transcriptomic and metabolomic analyses uncovered strong correlations between the concentrations of bioactive metabolites and the expression levels of genes involved in energy metabolism,insulin sensitivity,and immune response in the skeletal muscle.This work established two models of exercise intervention in obese mice and provided mechanistic insights into the beneficial effects of exercise intervention on systemic energy homeostasis.展开更多
基金Supported by Xi’an Health Commission Residential Training Base Construction Project,No.2023zp09.
文摘BACKGROUND Acute non-variceal upper gastrointestinal bleeding(ANVUGIB)constitutes a prevalent emergency within Gastroenterology,encompassing 80%-90%of all gastrointestinal hemorrhage incidents.This condition is distinguished by its abrupt onset,swift progression,and notably elevated mortality rate.AIM To gather clinical data from patients with ANVUGIB at our hospital in order to elucidate the clinical characteristics specific to our institution and analyze the therapeutic effectiveness of endoscopic hemostasis.METHODS We retrospectively retrieved the records of 532 patients diagnosed with ANVUGIB by endoscopy at our hospital between March 2021 and March 2023,utilizing our medical record system.Data pertaining to general patient information,etiological factors,disease outcomes,and other relevant variables were meticulously collected and analyzed.RESULTS Among the 532 patients diagnosed with ANVUGIB,the male-to-female ratio was 2.91:1,with a higher prevalence among males.Notably,43.6%of patients presented with black stool as their primary complaint,while 27.4%had hematemesis as their initial symptom.Upon admission,17%of patients exhibited both hematemesis and black stool,while most ANVUGIB patients primarily complained of overt gastrointestinal bleeding.Urgent routine blood examinations at admission revealed that 75.8%of patients had anemia,with 63.4%experiencing moderate to severe anemia,and 1.5%having extremely severe anemia(hemoglobin<30 g/L).With regard to etiology,53.2%of patients experienced bleeding without a definitive trigger,24.2%had a history of using gastric mucosa-irritating medications,24.2%developed bleeding after alcohol consumption,2.8%attributed it to improper diet,1.7%to emotional excitement,and 2.3%to fatigue preceding the bleeding episode.Drug-induced ANVUGIB was more prevalent in the elderly than middle-aged and young individuals,while bleeding due to alcohol consumption showed the opposite trend.Additionally,diet-related bleeding was more common among the young age group compared to the middle-aged group.Gastrointestinal endoscopy identified peptic ulcers as the most frequent cause of ANVUGIB(73.3%),followed by gastrointestinal malignancies(10.9%),acute gastric mucous lesions(9.8%),and androgenic upper gastrointestinal bleeding(1.5%)among inpatients with ANVUGIB.Of the 532 patients with gastrointestinal bleeding,68 underwent endoscopic hemostasis,resulting in an endoscopic treatment rate of 12.8%,with a high immediate hemostasis success rate of 94.1%.
基金supported by the National Natural Science Foundation of China,Nos.82171194 and 81974155(both to JL)the Shanghai Municipal Science and Technology Commission Medical Guide Project,No.16411969200(to WZ)Shanghai Municipal Science and Technology Commission Biomedical Science and Technology Project,No.22S31902600(to JL)。
文摘Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheimer’s disease affects the entire brain,further research is needed to elucidate alterations in mitochondrial metabolism in the brain as a whole.Here,we investigated the expression of several important mitochondrial biogenesis-related cytokines in multiple brain regions after treatment with neural stem cell-derived exosomes and used a combination of whole brain clearing,immunostaining,and lightsheet imaging to clarify their spatial distribution.Additionally,to clarify whether the sirtuin 1(SIRT1)-related pathway plays a regulatory role in neural stem cell-de rived exosomes interfering with mitochondrial functional changes,we generated a novel nervous system-SIRT1 conditional knoc kout AP P/PS1mouse model.Our findings demonstrate that neural stem cell-de rived exosomes significantly increase SIRT1 levels,enhance the production of mitochondrial biogenesis-related fa ctors,and inhibit astrocyte activation,but do not suppress amyloid-βproduction.Thus,neural stem cell-derived exosomes may be a useful therapeutic strategy for Alzheimer’s disease that activates the SIRT1-PGC1αsignaling pathway and increases NRF1 and COXIV synthesis to improve mitochondrial biogenesis.In addition,we showed that the spatial distribution of mitochondrial biogenesis-related factors is disrupted in Alzheimer’s disease,and that neural stem cell-derived exosome treatment can reverse this effect,indicating that neural stem cell-derived exosomes promote mitochondrial biogenesis.
基金the National Natural Science Foundation of China(Grant Nos.12164032,11964026,and 12364010)the Natural Science Foundation of Inner Mongolia Autonomous Region,China(Grant Nos.2019MS01010,2022MS01014,and 2020BS01009)+1 种基金the Doctor Research Start-up Fund of Inner Mongolia Minzu University(Grant Nos.BS625 and BS439)the Basic Research Funds for Universities Directly under the Inner Mongolia Autonomous Region,China(Grant No.GXKY23Z029).
文摘We have applied strong coupling unitary transformation method combined with Bose–Einstein statistical law to investigate magnetopolaron energy level temperature effects in halogen ion crystal quantum wells.The obtained results showed that under magnetic field effect,magnetopolaron quasiparticle was formed through the interaction of electrons and surrounding phonons.At the same time,magnetopolaron was influenced by phonon temperature statistical law and important energy level shifts down and binding energy increases.This revealed that lattice temperature and magnetic field could easily affect magnetopolaron and the above results could play key roles in exploring thermoelectric conversion and conductivity of crystal materials.
文摘In this editorial,we comment on Liu et al’s article published in the recent issue of the World Journal of Gastroenterology.Biochemically and pathologically,Liu et al proved that the urate-lowering activity of leech total protein(LTP)was mainly attributed to the rectification of gut microbiota.Specifically,we noticed the change in Bacteroides and Akkermansia after LTP administration.Both bacteria have been reported to alleviate metabolic dysfunction-associated steatohepatitis and other chronic metabolic diseases.LTP was administrated through intragastric manners.Most possibly,LTP would be digested by the gut microbiota further.The anti-hyperuricemia effects should,to the most possible extent,be exerted by the peptides or their secondary metabolic products.Human gut microbiota communicates with other organs through metabolites generated by the microbes or co-metabolized with the host.Whether the anti-hyperuricemia effect could be partially ascribed to the microbiota metabolites also deserves to be discussed.Although metabolomics analysis was performed for serum samples,fecal meta-bolomics was highly advocated which could facilitate exact mechanism expla-nation.This study implied that gut microbiota contains many unexplored targets with different therapeutic potentials.It is foreseeable that utilizing these targets can avoid the impairment or side effects of directly using human targets to some extent.
基金supported by the National Natural Science Foundation of China(Nos.12164032 and 11964026)the Natural Science Foundation of Inner Mongolia(No.2019MS01010)+3 种基金Scientific Research Projects in Colleges and Universities in Inner Mongolia(No.NJZZ19145)Graduate Science Innovative Research Projects(No.S20210281Z)the Natural Science Foundation of Inner Mongolia(No.2022MS01014)Doctor Research Start-up Fund of Inner Mongolia Minzu University(No.BS625).
文摘Excitons have significant impacts on the properties of semiconductors.They exhibit significantly different properties when a direct semiconductor turns in to an indirect one by doping.Huybrecht variational method is also found to influence the study of exciton ground state energy and ground state binding energy in Al_(x)Ga_(1−x)As semiconductor spherical quantum dots.The Al_(x)Ga_(1−x)As is considered to be a direct semiconductor at AI concentration below 0.45,and an indirect one at the concentration above 0.45.With regards to the former,the ground state binding energy increases and decreases with AI concentration and eigenfrequency,respectively;however,while the ground state energy increases with AI concentration,it is marginally influenced by eigenfrequency.On the other hand,considering the latter,while the ground state binding energy increases with AI concentration,it decreases with eigenfrequency;nevertheless,the ground state energy increases both with AI concentration and eigenfrequency.Hence,for the better practical performance of the semiconductors,the properties of the excitons are suggested to vary by adjusting AI concentration and eigenfrequency.
基金The study protocol was approved by the Clinical Research Ethics Committee of Honghui Hospital,Xi’an Jiaotong University(No.202401004).
文摘BACKGROUND Duodenal neuroendocrine tumours(DNETs)are rare neoplasms.However,the incidence of DNETs has been increasing in recent years,especially as an incidental finding during endoscopic studies.Regrettably,there is no consensus regarding the ideal treatment of DNETs.Even there are few studies on the clinical features and survival analysis of DNETs.AIM To analyze the clinical characteristics and prognostic factors of patients with duodenal neuroendocrine tumours.METHODS The clinical data of DNETs diagnosed in the First Affiliated Hospital of Air Force Military Medical University from June 2011 to July 2022 were collected.Neuroen-docrine tumours located in the ampulla area of the duodenum were divided into the ampullary region group;neuroendocrine tumours in any part of the duo-denum outside the ampullary area were divided into the nonampullary region group.Using a retrospective study,the clinical characteristics of the two groups and risk factors affecting the survival of DNET patients were analysed.RESULTS Twenty-nine DNET patients were screened.The male to female ratio was 1:1.9,and females comprised the majority.The ampullary region group accounted for 24.1%(7/29),while the nonampullary region group accounted for 75.9%(22/29).When diagnosed,the clinical symptoms of the ampullary region group were mainly abdominal pain(85.7%),while those of the nonampullary region groups were mainly abdominal distension(59.1%).There were differences in the composition of staging of tumours between the two groups(Fisher's exact probability method,P=0.001),with nonampullary stage II tumours(68.2%)being the main stage(P<0.05).After the diagnosis of DNETs,the survival rate of the ampullary region group was 14.3%(1/7),which was lower than that of 72.7%(16/22)in the nonampullary region group(Fisher's exact probability method,P=0.011).The survival time of the ampullary region group was shorter than that of the nonampullary region group(P<0.000).The median survival time of the ampullary region group was 10.0 months and that of the nonampullary region group was 451.0 months.Multivariate analysis showed that tumours in the ampulla region and no surgical treatment after diagnosis were independent risk factors for the survival of DNET patients(HR=0.029,95%CI 0.004-0.199,P<0.000;HR=12.609,95%CI:2.889-55.037,P=0.001).Further analysis of nonampullary DNET patients showed that the survival time of patients with a tumour diameter<2 cm was longer than that of patients with a tumour diameter≥2 cm(t=7.243,P=0.048).As of follow-up,6 patients who died of nonampullary DNETs had a tumour diameter that was≥2 cm,and 3 patients in stage IV had liver metastasis.Patients with a tumour diameter<2 cm underwent surgical treatment,and all survived after surgery.CONCLUSION Surgical treatment is a protective factor for prolonging the survival of DNET patients.Compared to DNETs in the ampullary region,patients in the nonampullary region group had a longer survival period.The liver is the organ most susceptible to distant metastasis of nonampullary DNETs.
基金National Natural Science Foundation of China(No.8177141422).
文摘Background:Xiaoxianxiong decoction is a classic formula in traditional Chinese medicine used to treat type 2 diabetes mellitus and proven to be effective.But the material basis and underlying mechanisms remain unclear.The aim of the present study was to elucidate the potential effective material basis of Xiaoxianxiong decoction and molecular mechanism treating type 2 diabetes mellitus.Methods:The absorbed bioactive components were identified based on serum pharmacochemistry.Network analysis were performed to obtain effect targets for docking verification with the absorbed prototypes to determine the potential effective material basis.On the above basis,network pharmacology was conducted to explore the molecular mechanism.Results:76 compounds were identified of Xiaoxianxiong decoction and 61 absorbed bioactive compounds were investigated.Serine/threonine kinase 1 and ALB were key targets acquired by network analysis for molecular docking.Subsequently,5 compounds were considered as the potential effective material basis,namely berberine,berberrubine,lariciresinol and gingerenone A,jatrorrhizine.Further,the mechanism mainly lies in the insulin signaling pathway,HIF-1 signaling pathway,PI3K-Akt signaling pathway,FoxO signaling pathway,AGE-RAGE signaling pathway in diabetic complications,phospholipase D signaling pathway to regulate blood glucose levels on target tissues as well as organs and exhibit anti-inflammatory,promote cell differentiation and cell growth,maintain oxygen homeostasis and affect the enzymes along with key metabolites.Conclusion:This integrated research strategy to investigate the treatment of Xiaoxianxiong decoction on type 2 diabetes mellitus provides valuable insights for further study and clinical practice of Xiaoxianxiong decoction.
基金Supported by the Key Scientific and Technological Project of Henan Province(162102110092)
文摘[Objective] This research aimed at studying the mechanism of the occurrence of epithelial cell loss in bladders of prenatal and postnatal mice. [Method] Bladder epithelia of 1-2-day-old newborn Kunming mice and mice at later period of embryonic development were acquired, and paraffin sections of such epithelia were then made for Mallory's coloration and ordinary optical microscopic observation. The acquired bladder epithelia were made into frozen sections, which were then colored by DAPI and labeled in situ by Terminal-deoxynucleoitidyl Transferase Mediated Nick End Labeling(TUNEL) for fluorescent microscopic observation. DNA electrophoresis and TUNEL in situ labeling were conducted on the acquired urine exfoliated cells. [Result] The results showed that the complete three layers of cells occurred in 20-day-old mouse embryos, whereas no superficial cells resided in the bladder epithelia of newborn mice and no cells exfoliating were observed. Cells exfoliating from the bladder epithelia of newborn mice were observed, and they exhibited the phenomenon of apoptosis. There were apoptosis existed in the urine cells of newborn mice. [Conclusion] Therefore, the results showed that a few days before and after their birth, mice witnessed the process of cell exfoliation in their bladder epithelia and the exfoliated cells showed typical characteristics of apoptosis.
文摘Rapid assessment of foliar chlorophyll content in tobacco is critical for assessment of growth and precise management to improve quality and yield while minimizing adverse environmental impact. Our objective is to develop a precise agricultural practice predicting tobacco-leaf chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;"> content. Reflectance experiments have been conducted on flue-cured tobacco over 3 consecutive years under different light quality. Leaf hyperspectral reflectance and chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;"> content data have been collected at 15-day intervals from 30 days after transplant until harvesting. We identified the central band that is sensitive to tobacco-leaf chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;"> content and the optimum wavelength combinations for establishing new spectral indices (simple ratio index, RVI;normalized difference vegetation index, NDVI;and simple difference vegetation index, DVI). We then established linear and BackPropagation (BP) neural network models to estimate chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;"> content. The central bands for leaf chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;"> content are concentrated in the visible range (410 - 680 nm) in combination with the shortwave infrared range (1900 - 2400 nm). The optimum spectral range for the spectral band combinations</span><span style="font-family:Verdana;"> RVI, NDVI, and DVI</span><span style="font-family:Verdana;"> are 440 and 470 nm, 440 and 470 nm, and 440 and 460 nm, respectively. The linear RVI, NDVI, and DVI models, SMLR model and the BP neural network model have respective R</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> values of 0.76, 0.77, 0.69, 0.78 and 0.86, and root mean square error values of 0.63, 1.60, 1.59, 2.04 and 0.05 mg chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;">/g (fresh weight), respectively. Our results identified chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;"> sensitive spectral regions and new indices facilitate a rapid, non-destructive field estimation of leaf chlorophyll-</span><i><span style="font-family:Verdana;">a</span></i><span style="font-family:Verdana;"> content for tobacco.
基金supported by China Three Gorges Corporation(Key technology research and demonstration application of large-scale source-net-load-storage integration under the vision of carbon neutrality)Fundamental Research Funds for the Central Universities(2020MS021).
文摘Wind power,solar power,and electrical load forecasting are essential works to ensure the safe and stable operation of the electric power system.With the increasing permeability of new energy and the rising demand response load,the uncertainty on the production and load sides are both increased,bringing new challenges to the forecasting work and putting forward higher requirements to the forecasting accuracy.Most review/survey papers focus on one specific forecasting object(wind,solar,or load),a few involve the above two or three objects,but the forecasting objects are surveyed separately.Some papers predict at least two kinds of objects simultaneously to cope with the increasing uncertainty at both production and load sides.However,there is no corresponding review at present.Hence,our study provides a comprehensive review of wind,solar,and electrical load forecasting methods.Furthermore,the survey of Numerical Weather Prediction wind speed/irradiance correction methods is also included in this manuscript.Challenges and future research directions are discussed at last.
基金supported in part by the National Key R&D Program of China (No.2017YFE0109000)the project of China Datang Corporation Ltd
文摘With the increasing proportion of wind power integration, the volatility of wind power brings huge challenges to the safe and stable operation of the electric power system. At present, the indexes commonly used to evaluate the volatility of wind power only consider its overall characteristics, such as the standard deviation of wind power, the average of power variables, etc., while ignoring the detailed volatility of wind power, that is, the features of the frequency distribution of power variables. However, how to accurately describe the detailed volatility of wind power is the key foundation to reduce its adverse influences. To address this, a quantitative method for evaluating the detailed volatility of wind power at multiple temporal-spatial scales is proposed. First, the volatility indexes which can evaluate the detailed fluctuation characteristics of wind power are presented, including the upper confidence limit, lower confidence limit and confidence interval of power variables under the certain confidence level. Then, the actual wind power data from a location in northern China is used to illustrate the application of the proposed indexes at multiple temporal(year–season–month–day) and spatial scales(wind turbine–wind turbines–wind farm–wind farms) using the calculation time windows of 10 min, 30 min, 1 h, and 4 h. Finally, the relationships between wind power forecasting accuracy and its corresponding detailed volatility are analyzed to further verify the effectiveness of the proposed indexes. The results show that the proposed volatility indexes can effectively characterize the detailed fluctuations of wind power at multiple temporal-spatial scales. It is anticipated that the results of this study will serve as an important reference for the reserve capacity planning and optimization dispatch in the electric power system which with a high proportion of renewable energy.
基金the financial support from the National Natural Science Foundation of China (No. 51961013)the Natural Science Foundation of Jiangxi Province, China (No. 20202ACBL214002)+2 种基金the China Postdoctoral Science Foundation (Nos. 2019M660159 and 2020T130093)the Postdoctoral Science Foundation of Jiangxi Province, China (No. 2019KY25)the Program of Qingjiang Excellent Young Talents of Jiangxi University of Science and Technology, China (No. JXUSTQJYX2020022)。
文摘The effect of the crystal orientations and precipitates on the corrosion behavior of Al-Cu-Li single crystals was studied by scanning electron microscopy, transmission electron microscopy, optical microscopy, immersion testing in exfoliation corrosion solution, and electrochemical testing. The results show that the corrosion rates of different orientations of the aged Al-Cu-Li alloy increase in the order of (001) 1 phase deteriorated the corrosion resistance of the Al-Cu-Li alloy, and the degree of deterioration differed in different crystal plane orientations. The severe localized corrosion of the aged alloy propagates along the crystallography and extends along the {111}Alplane in the form of corrosion bands.
基金Supported by National Natural Science Foundation of China(41771199)Basic Research Project of Jiangsu Province,China(BK20171277)
文摘Suaeda salsa is an important local species in the intertidal beach of the Western Pacific coast. However,under the artificial cofferdam and Spartina alterniflora expansion,Suaeda marsh has degraded seriously. Therefore,using Yancheng Nature Reserve as a case study area,taking ETM+images in 2000,2006 and 2011 as the basic data sources,we revealed the evolution characteristics of Salsa marsh which was impacted. The research results are as follows. From 2000 to 2011,Salsa marsh area in the artificial area tempestuously degraded,decreasing by 87. 158%,more than 22% than those in the natural area. The landscape was fragmentized. Landscape polymerization degree index dropped from 95. 780 to 65. 455,more than 16% than those in the natural area. The mean patch area fell down to 21. 429 ha from 389. 333 ha,more than 11% that in the natural area. Compared to the steady change in natural conditions,the area was reduced by 118. 167 ha/a from 2000 to 2006,while during 2006-2011,it was only 51. 500 ha/a in artificial area. As for spatial change of landscape,in artificial area,the Salsa marsh centroid moved forward to the southeast with 666. 350 m,but that in natural area moved forward to the north with 1 042. 710 m from 2000 to 2006. From 2006 to 2011,the centroid moved forward to east and north respectively. Artificial cofferdam transformed the area into freshwater ecosystem,and meanwhile the freshwater was beneficial to Reed marsh. During 2000 to 2006,in the artificial area,539 ha Salsa marsh controlled by cofferdam transferred into reed marsh and aquaculture ponds,of which the transformation rate was nearly 4% higher than that in natural area. From 2006 to 2011,178 ha Salsa marsh was transferred into reed marsh,the transformation rate was 20% higher than that in natural area. With rapid spreading and strong competition of Spartina species,the coastal wetland has formed the pattern of " Salsa – Spartina marshes". From 2000 to 2006,in artificial area,15. 24% of Salsa marsh was transferred into Spartina marsh,of which the transformation rate was13% higher than that in natural area. And from 2006 to 2011,30. 07% Salsa marsh was replaced by the Spartina marsh in artificial area,the rate was almost 10% higher than that in the natural area.
文摘The design energy productions deviate from the actual situation, which are affected by the accuracy of two significant factors - the wind resource assessment and wind farm micro-siting. A running wind farm in northern China was taken as the object in this investigation. The measured data obtained in operation phase and the relevant information in design phase were integrated and a post evaluation of wind resource assessment, micro-siting and generating capacity reduction factors of the wind farm in design phase was provided. The results indicate that the representative year wind regimes of the wind farm in design phase can basically reflect the wind conditions in the wind farm without the consideration of the trends of long-term changes in wind speed;micro-siting project in design phase is superior to that in practical;generating capacity reduction factors, overall on the high side, should be further optimized considering 20-year operation period.
基金This project was supported by the National Natural Science foundation of China(No.8177141422)。
文摘Objective:The aim of present meta-analysis was to evaluate the clinical efficacy of Ginkgo biloba extract combined with conventional therapy in the treatment of diabetic retinopathy(DR).Methods:The randomized controlled trials(RCTs)of Ginkgo biloba extract adjuvant conventional therapy for treating DR were searched in PubMed,the Cochrane Library,China Knowledge Network(CNKI),China Biomedical Literature Service System(SinoMed),VIP Information Chinese Journal Service Platform(VIP),and Wanfang database.Two reviewers independently extracted data and conducted methodological quality assessment.Data analysis was performed using Revised Cochrane risk-of-bias tool for randomized trials(RoB 2).Results:A total of 9 RCTs involving 798 patients were included in current research.Meta-analysis showed that Ginkgo biloba extract combined with conventional medicine can improve total effective rate[OR=0.33,95%CI=(0.23,0.46),P<0.0001],visual acuity[OR=-0.11,95%CI=(-0.14,-0.07),P<0.0001]and visual field average defect[OR=0.59,95%CI=(0.53,0.65),P<0.0001].Conclusion:The available evidence indicated that Ginkgo biloba extract combined with conventional medicine can be beneficial for treating DR.However,our findings were warranted to verify by more large-scale,multi-center clinical trials.
文摘Traditional assessment indexes could not fully describe offshore wind resources,for the meteorological properties of offshore are more complex than onshore.As a result,the uncertainty of offshore wind power projects would be increased and final economic benefits would be affected.Therefore,a study on offshore wind resource assessment is carried out,including three processes of“studying data sources,conducting multidimensional indexes system and proposing an offshore wind resource assessment method based on analytic hierarchy process(AHP).First,measured wind data and two kinds of reanalysis data are used to analyze the characteristics and reliability of data sources.Second,indexes such as effective wind speed occurrence,affluent level occurrence,coefficient of variation,neutral state occurrence have been proposed to depict availability,richness,and stability of offshore wind resources,respectively.Combined with existing parameters(wind power density,dominant wind direction occurrence,water depth,distance to coast),a multidimensional indexes system has been built and on this basis,an offshore wind energy potential assessment method has been proposed.Furthermore,the proposed method is verified by the annual energy production of five offshore wind turbines and practical operating data of four offshore wind farms in China.This study also compares the ranking results of the AHP model to two multi-criteria decision making(MCDM)models including weighted aggregated sum product assessment(WASPAS)and multi-attribute ideal real comparative analysis(MAIRCA).Results show the proposed method gains well in practical engineering applications,where the economic score values have been considered based on the offshore reasonable utilization hours of the whole life cycle in China.
基金supported by the National Natural Science Foundation of China(12164032 and 11964026)the Natural Science Foundation of Inner Mongolia(No.2019MS01010,2022MS01014)+1 种基金Doctor Research Start-up Fund of Inner Mongolia Minzu University(BS625)Scientific Research Projects in Colleges and Universities in Inner Mongolia(No.NJZZ19145)
文摘The polaron phenomenon is commonly observed in low-dimensional semiconductor materials and is known to have unique effects on conductive material properties.Furthermore,the phonon dragging effect,which leads to the polaron energy level,is less than the electron energy level.A decay magnetic field also affects the polaron effect,which causes polaron energy level changes.We demonstrate the unique electron-phonon coupling properties of this polaron using numerical calculations.Our findings have strong implications for theories of polaron properties and provide compelling evidence for a semiconductor device that industrial manufacturers use for new lowdimensional materials.
基金Natural Science Foundation of Inner Mongolia (Nos. 2020BS01001 and 2022MS01014)the Basic Scientific Research Business Projects in Colleges and Universities Directly under Inner Mongolia Autonomous Region (No.GXKY22059)the Doctoral Scientific Research Foundation of Inner Mongolia Minzu University. (Nos. BS511 and BS625)。
文摘Nanorod is a unique low-dimensional nanometer structure in which the Landau level arrangement of polaron is essential for understanding its quasiparticle system. However, the stability of the polaron level is susceptible to external factors, such as changing magnetic fields.In this manuscript, the Pekar variational method is employed to calculate the external magnetic field's effect on the nanorod's polaron Landau level. It was found that different magnetic fields have different effects on the polaron energy levels of the nanorod, which demonstrated that the external environment had critical effects on the polaron energy levels. This study provides a theoretical basis for regulating the interaction between electrons and phonons in low-dimensional nanomaterials.
基金supported by grants from the National Key Research and Development Program of China(2018YFA0800403 and 2021YFC2701903)the Training Program of the Major Research Plan of the National Natural Science Foundation of China(91857110)+5 种基金the National Natural Science Foundation of China(81670740,82100904,and 32000817)the National Natural Science Fund for Excellent Young Scholars of China(81722012)Zhejiang Provincial Natural Science Foundation of China(LZ21H070001 and LQ21C110001)the Innovative Institute of Basic Medical Sciences of Zhejiang University,the Fundamental Research Funds for the Central Universities,the Construction Fund of Medical Key Disciplines of Hangzhou,Hangzhou Science and Technology Bureau(20150733Q13 and ZD20200129)the Construction Fund of Key Medical Disciplines of Hangzhou(OO20200055)the K.C.Wong Education Foundation.
文摘Exercise intervention at the early stage of type 2 diabetes mellitus(T2DM)can aid in the maintenance of blood glucose homeostasis and prevent the development of macrovascular and microvascular complications.However,the exercise-regulated pathways that prevent the development of T2DM remain largely unclear.In this study,two forms of exercise intervention,treadmill training and voluntary wheel running,were conducted for high-fat diet(HFD)-induced obese mice.We observed that both forms of exercise intervention alleviated HFD-induced insulin resistance and glucose intolerance.Skeletal muscle is recognized as the primary site for postprandial glucose uptake and for responsive alteration beyond exercise training.Metabolomic profiling of the plasma and skeletal muscle in Chow,HFD,and HFD-exercise groups revealed robust alterations in metabolic pathways by exercise intervention in both cases.Overlapping analysis identified nine metabolites,including beta-alanine,leucine,valine,and tryptophan,which were reversed by exercise treatment in both the plasma and skeletal muscle.Transcriptomic analysis of gene expression profiles in the skeletal muscle revealed several key pathways involved in the beneficial effects of exercise on metabolic homeostasis.In addition,integrative transcriptomic and metabolomic analyses uncovered strong correlations between the concentrations of bioactive metabolites and the expression levels of genes involved in energy metabolism,insulin sensitivity,and immune response in the skeletal muscle.This work established two models of exercise intervention in obese mice and provided mechanistic insights into the beneficial effects of exercise intervention on systemic energy homeostasis.
