Cancer has been an insurmountable problem in the history of medical science.The uncontrollable proliferation of cancer cells is one of cancers main characteristics,which is closely associated with abn ormal mitosis.Ta...Cancer has been an insurmountable problem in the history of medical science.The uncontrollable proliferation of cancer cells is one of cancers main characteristics,which is closely associated with abn ormal mitosis.Targeting mitosis is an effective method for cancer treatment.This review summarizes several natural products with anti-tumor effects related to mitosis,focusing on targeting microtubulin,inducing DNA damage,and modulating mitosis-associated kinases.Furthermore,the main disadvantages of several typical compounds,including drug resistance,toxicity to non-tumor tissues,and poor aqueous solubility and pharmacokinetic properties,are also discussed,together with strategies to address them.Improved understanding of cancer cell mitosis and natural products may pave the way to drug development for the treatment of cancer.展开更多
基金This study was jointly supported by the National Key R&D Program of China(Grant No.2021YFE0203100)the National Natural Science Foundation of China(No.82274154)the Technology Project of Haihe Laboratory of Modern Chinese Medicine(HH2022X1008).
基金This work was supported by the National Key Research and Development Program of China(Grant No:2021YFE0203100)National Natural Science Foundation of China(Grant Nos:81873089,81603253 and 81973570)+1 种基金Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No:ZYYCXTD-C-202009)Innovation Team and Talents Cultivation Program ofNational Administration ofTraditional Chinese Medicine(Grant No:ZYYCXTD-D-202002).
文摘Cancer has been an insurmountable problem in the history of medical science.The uncontrollable proliferation of cancer cells is one of cancers main characteristics,which is closely associated with abn ormal mitosis.Targeting mitosis is an effective method for cancer treatment.This review summarizes several natural products with anti-tumor effects related to mitosis,focusing on targeting microtubulin,inducing DNA damage,and modulating mitosis-associated kinases.Furthermore,the main disadvantages of several typical compounds,including drug resistance,toxicity to non-tumor tissues,and poor aqueous solubility and pharmacokinetic properties,are also discussed,together with strategies to address them.Improved understanding of cancer cell mitosis and natural products may pave the way to drug development for the treatment of cancer.
