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Biointerface engineering nanoplatforms for cancer-targeted drug delivery 被引量:3
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作者 Huaiyu Zhang shujun dong +5 位作者 Zhongmin Li Xiangru Feng Weiguo Xu Catrina Mae STulinao Yang Jiang Jianxun Ding 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2020年第4期397-415,共19页
Over the past decade,nanoparticle-based therapeutic modalities have become promising strategies in cancer therapy.Selective delivery of anticancer drugs to the lesion sites is critical for elimination of the tumor and... Over the past decade,nanoparticle-based therapeutic modalities have become promising strategies in cancer therapy.Selective delivery of anticancer drugs to the lesion sites is critical for elimination of the tumor and an improved prognosis.Innovative design and advanced biointerface engineering have promoted the development of various nanocarriers for optimized drug delivery.Keeping in mind the biological framework of the tumormicroenvironment,biomembrane-camouflaged nanoplatforms have been a research focus,reflecting their superiority in cancer targeting.In this review,we summarize the development of various biomimetic cell membrane-camouflaged nanoplatforms for cancertargeted drug delivery,which are classified according to the membranes fromdifferent cells.The challenges and opportunities of the advanced biointerface engineering drug delivery nanosystems in cancer therapy are discussed. 展开更多
关键词 Cell membrane-camouflaged nanoplatform BIOFUNCTIONALIZATION Tumor microenvironment Controlled drug delivery Targeted cancer therapy
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A coating strategy on titanium implants with enhanced photodynamic therapy and CO-based gas therapy for bacterial killing and inflammation regulation
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作者 Liang Cheng Bingshuai Zhou +6 位作者 Manlin Qi Xiaolin Sun shujun dong Yue Sun Biao dong Lin Wang Yingwei Yang 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第2期386-395,共10页
Antimicrobial photodynamic therapy(aPDT)has been considered a noninvasive and effective modality against the bacterial infection of peri‑implantitis,especially the aPDT triggered by near-infrared(NIR)light due to the ... Antimicrobial photodynamic therapy(aPDT)has been considered a noninvasive and effective modality against the bacterial infection of peri‑implantitis,especially the aPDT triggered by near-infrared(NIR)light due to the large penetration depth in tissue.However,the complexity of hypoxia microenvironments and the distance of aPDT sterilization still pose challenges before realizing the aPDT clinical application.Due to the long lifespan and transmission distance of therapeutic gas molecules,we design a multi-functional gas generator that combines aPDT as well as O_(2) and CO gas release function,which can solve the problem of hypoxia(O_(2))in PDT and the problem of inflammation regulation(CO)in the distal part of peri‑implant inflammation under near-infrared(NIR)irradiation.In the composite nanoplatform that spin-coated on the surface of titanium implants,up-conversion nanoparticles(UCNPs)were involved in converting the NIR to visible,which further excites the partially oxidized stannic sulfide(SnS_(2)),realizing the therapeutic gas release.Indocyanine green(ICG)was further integrated to enhance the aPDT performance(Ti-U@SnS_(2)/I).Therefore,reactive oxygen species(ROS),CO,and O_(2) can be controllably administered via a composite nano-platform mediated by a single NIR light(808 nm).This implant surface modification strategy could achieve great self-enhancement antibacterial effectiveness and regulate the lingering questions,such as relieving the anoxic microenvironment and reaching deep infection sites,providing a viable antibiotic-free technique to combat peri‑implantitis. 展开更多
关键词 Photodynamic therapy BIOMATERIALS Dental implant Reactive oxygen species Carbon monoxide Hybrid nanoplatform
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Functional biomaterials for comprehensive periodontitis therapy
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作者 Jiayi Luan Ruotao Li +5 位作者 Weiguo Xu Huiying Sun Qiqi Li Di Wang shujun dong Jianxun Ding 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2023年第6期2310-2333,共24页
Periodontitis is an inflammatory disease caused by bacterial infection directly, and the dysregulation of host immune-inflammatory response finally destroys periodontal tissues. Current treatment strategies for period... Periodontitis is an inflammatory disease caused by bacterial infection directly, and the dysregulation of host immune-inflammatory response finally destroys periodontal tissues. Current treatment strategies for periodontitis mainly involve mechanical scaling/root planing(SRP), surgical procedures,and systemic or localized delivery of antimicrobial agents. However, SRP or surgical treatment alone has unsatisfactory long-term effects and is easy to relapse. In addition, the existing drugs for local periodontal therapy do not stay in the periodontal pocket long enough and have difficulties in maintaining a steady, effective concentration to obtain a therapeutic effect, and continuous administration always causes drug resistance. Many recent studies have shown that adding bio-functional materials and drug delivery systems upregulates the therapeutic effectiveness of periodontitis. This review focuses on the role of biomaterials in periodontitis treatment and presents an overview of antibacterial therapy, host modulatory therapy, periodontal regeneration, and multifunctional regulation of periodontitis therapy. Biomaterials provide advanced approaches for periodontal therapy, and it is foreseeable that further understanding and applications of biomaterials will promote the development of periodontal therapy. 展开更多
关键词 Biomaterial Antibacterial effect Host modulation Periodontal regeneration Periodontitis therapy ANTI-OXIDANT ANTI-INFLAMMATION Drug delivery
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Occurrence and distribution of bisphenol compounds in different categories of animal feeds used in China 被引量:2
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作者 Ruiguo Wang Tianjiao Tan +4 位作者 Haijun Liang Yuan Huang shujun dong Peilong Wang Xiaoou Su 《Emerging Contaminants》 2021年第1期179-186,共8页
Bisphenol compounds(BPs)are of concern worldwide as potential environmental contaminants,and these chemicals may migrate into animal-derived foodstuffs from animal feeds.In this study,12 BPs were analyzed in 7 varieti... Bisphenol compounds(BPs)are of concern worldwide as potential environmental contaminants,and these chemicals may migrate into animal-derived foodstuffs from animal feeds.In this study,12 BPs were analyzed in 7 varieties of animal feed groups totaling 203 samples collected from various provinces in China.6 BPs were found in these feed samples,with a total detection frequency of 75.5%.The total concentration of all BPs(S6BPs)in each type of feed ranged from below the limit of detection to 75.3 ng g^(-1),with an overall mean value of 4.52 ng g^(-1).The frequency of BPs contamination and the S6BPs values were found to be higher in animal-based feeds(P_(frequency)>0.05,P_(concentration)<0.01)than in plantbased feeds.BPA and BPS were the predominant BPs in these feed samples,accounting for(on average)63.9%and 24.6%of the total BPs,respectively.Overall,the mean concentrations of BPA in these animal feeds were much lower than the legal limits set by China and European Union,implying a low direct risk to both animal health and animal-derived food safety.However,the evident risk of the contamination of various animal-derived food items with BPs passed through the feed chain merits further investigation. 展开更多
关键词 BISPHENOL FEED OCCURRENCE Risk UPLC-MS/MS
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Short-and medium-chain chlorinated paraffins in imported commercial dry cat and dog food in China:Concentrations,distributions and risk assessment
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作者 shujun dong Su Zhang +10 位作者 Ruiguo Wang Xiaolong Xia Mengdie Fan Yaxin Wang Jie Cheng Xiaomin Li Tong Li Wei Zhang Shulin Wei Yun Zou Peilong Wang 《Emerging Contaminants》 2020年第1期268-273,共6页
Chlorinated paraffins(CPs)are produced in large amounts and used worldwide.Dietary intake is the primary pathway for the exposure of pets to CPs,but limited information is available concerning the potential contaminat... Chlorinated paraffins(CPs)are produced in large amounts and used worldwide.Dietary intake is the primary pathway for the exposure of pets to CPs,but limited information is available concerning the potential contamination of pet food by CPs.In the present study,the concentrations and congener group profiles of short-chain CPs(SCCPs)and medium-chain CPs(MCCPs)were assessed in 35 imported commercial dry cat and dog foods collected in China,and the estimated daily intakes of SCCPs and MCCPs for cats and dogs through the consumption of such foods was calculated.The concentrations of SCCPs and MCCPs in the cat and dog foods were determined to be in the ranges of 108e45,300 ng/g(median:1340 ng/g)and 3.8e52,700 ng/g(median:11 ng/g),respectively.The predominant congener groups were C10Cl6 for SCCPs and C14Cl7-8 for MCCPs.The high levels of CPs found in certain pet foods suggest the potential for adverse health effects. 展开更多
关键词 Short-chain chlorinated paraffin Medium-chain chlorinated paraffin Cat food Dog food Dietary exposure
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