Unsymmetric sulfides and selenides have great applications in the pharmaceutical field.Herein,we describe the reductive coupling reaction of xanthate esters with sulfur-containing and selenium-containing compounds(thi...Unsymmetric sulfides and selenides have great applications in the pharmaceutical field.Herein,we describe the reductive coupling reaction of xanthate esters with sulfur-containing and selenium-containing compounds(thio(seleno)sulfonates and disulfides(selenides))under the nickel-catalyzed condition.It provides a mild and effective method for the synthesis of unsymmetric sulfides and selenides which has the advantages of mild reaction conditions,high yields and a wide range of substrates.展开更多
Objective： The arrival of precision medicine plan brings new opportunities and challenges for patients undergoing precision diagnosis and treatment of malignant tumors. With the development of medical imaging, inform...Objective： The arrival of precision medicine plan brings new opportunities and challenges for patients undergoing precision diagnosis and treatment of malignant tumors. With the development of medical imaging, information on different modality imaging can be integrated and comprehensively analyzed by imaging fusion system. This review aimed to update the application of multimodality imaging fusion technology in the precise diagnosis and treatment of malignant tumors under the precision medicine plan. We introduced several multimodality imaging fusion technologies and their application to the diagnosis and treatment of malignant tumors in clinical practice. Date Sources： The data cited in this review were obtained mainly from the PubMed database from 1996 to 2016, using the keywords of ＂precision medicine＂, ＂fusion imaging＂, ＂multimodality＂, and ＂tumor diagnosis and treatment＂. Study Selection： Original articles, clinical practice, reviews, and other relevant literatures published in English were reviewed. Papers focusing on precision medicine, fusion imaging, multimodality, and tumor diagnosis and treatment were selected. Duplicated papers were excluded. Results： Multimodality imaging fusion technology plays an important role in tumor diagnosis and treatment under the precision medicine plan, such as accurate location, qualitative diagnosis, tumor staging, treatment plan design, and real-time intraoperative monitoring. Multimodality imaging fusion systems could provide more imaging information of tumors from different dimensions and angles, thereby offing strong technical support for the implementation of precision oncology. Conclusion： Under the precision medicine plan, personalized treatment of tumors is a distinct possibility. We believe that multimodality imaging fusion technology will find an increasingly wide application in clinical practice.展开更多
Fluorescent silicon nanoparticles (SiNPs) bring exciting opportunities for long-awaited silicon-based optical application, while intrinsic indirect band gap of silicon severely limits photoluminescent quantum yield (P...Fluorescent silicon nanoparticles (SiNPs) bring exciting opportunities for long-awaited silicon-based optical application, while intrinsic indirect band gap of silicon severely limits photoluminescent quantum yield (PLQY) of SiNPs. To address this critical issue, we herein demonstrate a facile and general method, Le., solvent polarity-induced photoluminescence enhancement (SPIPE)1 yielding several-fold increase in quantum yield (QY) of SiNPs. Typically, different kinds of 4-substituented-1,8-naphthalic anhydride molecules, Le., 4-Br-1,8-naphthalic anhydride (BNA)1 4-triphenylamino-1,8-naphthalic anhydride (TPNA)1 and 4-dimethylamino-1,8-naphthalic anhydride (DMNA)1 are rationally designed and synthesized, which serve as surface ligands for the production of BNA-, TPNA-, and DMNA-capped small-sized (diameter:- 3.8-5.8 nm) SiNPs with QY of^8%,~15%,~16%, respectively. Of particular significance, QY of the resultant SiNPs could be greatly enhanced from^10% to^50% through the SPlPE strategy. Taken together with the theoretical calculation and the results of time-correlated single photon counting, we reveal that actived excited-state charge transfer interactions between surface-covered ligand and silicon oxide coating would be responsible for the observed QY enhancement. Moreover, other five kinds of solvents (i.e., methanol, isopropanol, dimethyl sulfoxide, N,N-dimethylformamide, and acetonitrile) are further employed for the SiNPs treatment, and similar improvement of QY values are observed, convincingly demonstrating the universal evidence of SPIPE of the SiNPs.展开更多
In many reactions involving selenosulfonate or thiosulfonate,the sutfone group often leaves in form of benzenesutfinic acid or sodium benzenesulfinate.A one-pot two-step reaction of selenosulfonate with isocyanides an...In many reactions involving selenosulfonate or thiosulfonate,the sutfone group often leaves in form of benzenesutfinic acid or sodium benzenesulfinate.A one-pot two-step reaction of selenosulfonate with isocyanides and allyl alcohol under aqueous conditions to afford selenocarbamates and allyl sulfone compounds is reported.The sulfinic acid as the first-step side product is converted to the allyl sulfone compound by water promoted reaction with allyl alcohol.Water acts as both an oxygen source of selenocarbamates and as a promoter to drive the second step reactio n.The reactions have the advantages of mild conditions,green,environment-friendly,and high atomic economy.展开更多
A TFA promoted multi-component reaction of aryldiazonium with sodium metabisulphite and thiols to construct thiosulfonates under transition-metal free conditions is reported.The thiosulfonates were isolated in good yi...A TFA promoted multi-component reaction of aryldiazonium with sodium metabisulphite and thiols to construct thiosulfonates under transition-metal free conditions is reported.The thiosulfonates were isolated in good yields with broad tolerance of functional group.Readily available inorganic Na2S2O5 was applied as the sulfur dioxide surrogate.This strategy features easily available substrates,mild reaction conditions and free transition-metal catalyst.展开更多
A Ni(II)-catalyzed reductive cross-coupling reaction of oxalates and thiosulfonates/selenosulfonates to synthesize benzylic sulfides/selenides under mild conditions is developed.The oxalates prepared from the correspo...A Ni(II)-catalyzed reductive cross-coupling reaction of oxalates and thiosulfonates/selenosulfonates to synthesize benzylic sulfides/selenides under mild conditions is developed.The oxalates prepared from the corresponding alcohols are used as carbon radical precursors to participate in the reaction.展开更多
A manganese (Ⅲ)-promoted oxidative radical cascade reaction of easily accessible arylboronic acids with isocyanides to construct diimide derivatives was studied. This protocol provides a new way to synthesis of acety...A manganese (Ⅲ)-promoted oxidative radical cascade reaction of easily accessible arylboronic acids with isocyanides to construct diimide derivatives was studied. This protocol provides a new way to synthesis of acetyl diimide derivatives. New C-C, C-N and C=O bonds were formed in one step.展开更多
A Mn(Ⅲ) mediated radical reaction of new designed multi-functionalized 2-isocyano-6-alkenyl(alkynyl)benzonitriles with arylboronic acids has been developed.This reaction provides a method for the synthesis of pyrrolo...A Mn(Ⅲ) mediated radical reaction of new designed multi-functionalized 2-isocyano-6-alkenyl(alkynyl)benzonitriles with arylboronic acids has been developed.This reaction provides a method for the synthesis of pyrroloisoquinoline derivatives through the formation of two C-C bonds and one C-N bond via radical cascade cyclization in one step.展开更多
基金National Natural Science Foundation of China(Nos.21971174 and U2267224),PAPD,Cyrus Tang(Zhongying)Scholar,Jiangsu Qing-Lan Project for Young and Middle-aged Academic Leaders(2023)and Soochow University for financialsupport.
文摘Unsymmetric sulfides and selenides have great applications in the pharmaceutical field.Herein,we describe the reductive coupling reaction of xanthate esters with sulfur-containing and selenium-containing compounds(thio(seleno)sulfonates and disulfides(selenides))under the nickel-catalyzed condition.It provides a mild and effective method for the synthesis of unsymmetric sulfides and selenides which has the advantages of mild reaction conditions,high yields and a wide range of substrates.
文摘Objective： The arrival of precision medicine plan brings new opportunities and challenges for patients undergoing precision diagnosis and treatment of malignant tumors. With the development of medical imaging, information on different modality imaging can be integrated and comprehensively analyzed by imaging fusion system. This review aimed to update the application of multimodality imaging fusion technology in the precise diagnosis and treatment of malignant tumors under the precision medicine plan. We introduced several multimodality imaging fusion technologies and their application to the diagnosis and treatment of malignant tumors in clinical practice. Date Sources： The data cited in this review were obtained mainly from the PubMed database from 1996 to 2016, using the keywords of ＂precision medicine＂, ＂fusion imaging＂, ＂multimodality＂, and ＂tumor diagnosis and treatment＂. Study Selection： Original articles, clinical practice, reviews, and other relevant literatures published in English were reviewed. Papers focusing on precision medicine, fusion imaging, multimodality, and tumor diagnosis and treatment were selected. Duplicated papers were excluded. Results： Multimodality imaging fusion technology plays an important role in tumor diagnosis and treatment under the precision medicine plan, such as accurate location, qualitative diagnosis, tumor staging, treatment plan design, and real-time intraoperative monitoring. Multimodality imaging fusion systems could provide more imaging information of tumors from different dimensions and angles, thereby offing strong technical support for the implementation of precision oncology. Conclusion： Under the precision medicine plan, personalized treatment of tumors is a distinct possibility. We believe that multimodality imaging fusion technology will find an increasingly wide application in clinical practice.
基金the National Basic Research Program of China (973 Program)(Nos. 2013CB934400 and 2012CB932400)the National Natural Science Foundation of China (NSFC)(Nos. 21672157, 21542015, 21372174, 61361160412, and 31400860)+2 种基金the Ph.D. Programs Foundation of Ministry of Education of China (No. 20133201130004)the Project of Scientific and Technologic Infrastructure of Suzhou (No. SZS201708)Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC).
文摘Fluorescent silicon nanoparticles (SiNPs) bring exciting opportunities for long-awaited silicon-based optical application, while intrinsic indirect band gap of silicon severely limits photoluminescent quantum yield (PLQY) of SiNPs. To address this critical issue, we herein demonstrate a facile and general method, Le., solvent polarity-induced photoluminescence enhancement (SPIPE)1 yielding several-fold increase in quantum yield (QY) of SiNPs. Typically, different kinds of 4-substituented-1,8-naphthalic anhydride molecules, Le., 4-Br-1,8-naphthalic anhydride (BNA)1 4-triphenylamino-1,8-naphthalic anhydride (TPNA)1 and 4-dimethylamino-1,8-naphthalic anhydride (DMNA)1 are rationally designed and synthesized, which serve as surface ligands for the production of BNA-, TPNA-, and DMNA-capped small-sized (diameter:- 3.8-5.8 nm) SiNPs with QY of^8%,~15%,~16%, respectively. Of particular significance, QY of the resultant SiNPs could be greatly enhanced from^10% to^50% through the SPlPE strategy. Taken together with the theoretical calculation and the results of time-correlated single photon counting, we reveal that actived excited-state charge transfer interactions between surface-covered ligand and silicon oxide coating would be responsible for the observed QY enhancement. Moreover, other five kinds of solvents (i.e., methanol, isopropanol, dimethyl sulfoxide, N,N-dimethylformamide, and acetonitrile) are further employed for the SiNPs treatment, and similar improvement of QY values are observed, convincingly demonstrating the universal evidence of SPIPE of the SiNPs.
基金the National Natural Science Foundation of China (Nos.21971174,21772137,21672157)the Ph.D.Programs Foundation of PAPD+2 种基金the Project of Scientific and Technologic Infrastructure of Suzhou (No.SZS201708)the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (No. 16KJA150002)Soochow University,and State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials for financial support。
文摘In many reactions involving selenosulfonate or thiosulfonate,the sutfone group often leaves in form of benzenesutfinic acid or sodium benzenesulfinate.A one-pot two-step reaction of selenosulfonate with isocyanides and allyl alcohol under aqueous conditions to afford selenocarbamates and allyl sulfone compounds is reported.The sulfinic acid as the first-step side product is converted to the allyl sulfone compound by water promoted reaction with allyl alcohol.Water acts as both an oxygen source of selenocarbamates and as a promoter to drive the second step reactio n.The reactions have the advantages of mild conditions,green,environment-friendly,and high atomic economy.
基金the National Natural Science Foundation of China(Nos.21971174,21772137,21672157)the PhD Programs Foundation of PAPD+2 种基金the Project of Scientific and Technologic Infrastructure of Suzhou(No.SZS201708)the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions(No.16KJA150002)Soochow University,and State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials for financial support。
文摘A TFA promoted multi-component reaction of aryldiazonium with sodium metabisulphite and thiols to construct thiosulfonates under transition-metal free conditions is reported.The thiosulfonates were isolated in good yields with broad tolerance of functional group.Readily available inorganic Na2S2O5 was applied as the sulfur dioxide surrogate.This strategy features easily available substrates,mild reaction conditions and free transition-metal catalyst.
基金We gratefully acknowledge the National Natural Science Foundation of China(No.21971174,21772137)PAPD,Cyrus Tang(Zhongying)scholar and Soochow University for financial support.
文摘A Ni(II)-catalyzed reductive cross-coupling reaction of oxalates and thiosulfonates/selenosulfonates to synthesize benzylic sulfides/selenides under mild conditions is developed.The oxalates prepared from the corresponding alcohols are used as carbon radical precursors to participate in the reaction.
基金the National Natural Science Foundation of China(Nos. 21772137, 21672157, 21372174)the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (No. 16KJA150002)+2 种基金the Ph.D. Programs Foundation of PAPDthe project of scientific and technologic infrastructure of Suzhou (No. SZS201708)Soochow University for financial support
文摘A manganese (Ⅲ)-promoted oxidative radical cascade reaction of easily accessible arylboronic acids with isocyanides to construct diimide derivatives was studied. This protocol provides a new way to synthesis of acetyl diimide derivatives. New C-C, C-N and C=O bonds were formed in one step.
基金the National Natural Science Foundation of China(Nos.21971174,21772137,21542015 and 21672157)PAPD,the Project of Scientific and Technologic Infrastructure of Suzhou(No.SZS201708)+1 种基金the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions(No.16KJA150002)Soochow University for financial support。
文摘A Mn(Ⅲ) mediated radical reaction of new designed multi-functionalized 2-isocyano-6-alkenyl(alkynyl)benzonitriles with arylboronic acids has been developed.This reaction provides a method for the synthesis of pyrroloisoquinoline derivatives through the formation of two C-C bonds and one C-N bond via radical cascade cyclization in one step.
基金We gratefully acknowledge the National Natural Science Foundation of China （Nos. 21772137, 21542015 and 21672157）, PAPD, the Project of Scientific and Technologic Infrastructure of Suzhou （No. SZS201708）, and the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions （No. 16KJA150002）.
