Motivated by the recent discovery of unconventional superconductivity around a magnetic quantum critical point in pressurized CeSb_(2),here we present a high-pressure study of an isostructural antiferromagnetic(AFM) S...Motivated by the recent discovery of unconventional superconductivity around a magnetic quantum critical point in pressurized CeSb_(2),here we present a high-pressure study of an isostructural antiferromagnetic(AFM) SmSb_(2) through electrical transport and synchrotron x-ray diffraction measurements.At P_(C)~2.5 GPa,we found a pressure-induced magnetic phase transition accompanied by a Cmca→P4/nmm structural phase transition.In the pristine AFM phase below P_(C),the AFM transition temperature of SmSb_(2) is insensitive to pressure;in the emergent magnetic phase above P_(C),however,the magnetic critical temperature increases rapidly with increasing pressure.In addition,at ambient pressure,the magnetoresistivity(MR) of SmSb_(2) increases suddenly upon cooling below the AFM transition temperature and presents linear nonsaturating behavior under high field at 2 K.With increasing pressure above P_(C),the MR behavior remains similar to that observed at ambient pressure,both in terms of temperature-and field-dependent MR.This leads us to argue an AFM-like state for SmSb_(2) above P_(C).Within the investigated pressure of up to 45.3 GPa and the temperature of down to 1.8 K,we found no signature of superconductivity in SmSb_(2).展开更多
Objective:To explore the clinical and pathological characteristics of cerebral venous sinus thrombosis(CVST)with subarachnoid hemorrhage(SAH)and intracerebral hemorrhage(ICH),and to investigate the diagnosis,radiograp...Objective:To explore the clinical and pathological characteristics of cerebral venous sinus thrombosis(CVST)with subarachnoid hemorrhage(SAH)and intracerebral hemorrhage(ICH),and to investigate the diagnosis,radiographic changes,and prognosis over the course of treatment.Methods:The clinical data and radiographic findings of a young male CVST patient,who presented with initial symptoms of SAH and ICH,were collected and analyzed.The relevant literature was also reviewed.Results:The patient had no specific clinical symptoms except for headache.The brain computed tomography(CT)scan revealed SAH,a high-density shadow in the right posterior fossa and cerebellar hemisphere,and ICH in the left frontal lobe.Magnetic resonance venography(MRV)further revealed bilateral thrombosis in the transverse and sigmoid sinuses.Conclusion:CVST with SAH and ICH is rare and difficult to diagnose.Careful radiological study and clinical analysis are important for the correct and early diagnosis of this condition.Anticoagulation therapy is considered the primary treatment for CVST.展开更多
Flexible energy-storage devices play a critical role in the development of portable, flexible and wearable electronics. In addition, biological materials including plants or plant-based materials are known for their s...Flexible energy-storage devices play a critical role in the development of portable, flexible and wearable electronics. In addition, biological materials including plants or plant-based materials are known for their safety, biodegradability, biocompatibility, environmental benignancy, and low cost. With respect to these advances, a flexible alkaline zinc-manganese dioxide (Zn-MnO2) battery is fabricated with a kelp-based electrolyte in this study. To the best of our knowledge, pure kelp is utilized as a semi-solid electrolyte for flexible Zn-MnO2 alkaline batteries for the first time, with which the as-assembled battery exhibited a specific capacity of 60 mA·h and could discharge for 120 h. Furthermore, the as-assembled Zn-MnO2 battery can be bent into a ring-shape and power a light-emitting diode screen, showing promising potential for the practical application in the future flexible, portable and biodegradable electronic devices.展开更多
According to the characteristics of the road features,an Encoder-Decoder deep semantic segmentation network is designed for the road extraction of remote sensing images.Firstly,as the features of the road target are r...According to the characteristics of the road features,an Encoder-Decoder deep semantic segmentation network is designed for the road extraction of remote sensing images.Firstly,as the features of the road target are rich in local details and simple in semantic features,an Encoder-Decoder network with shallow layers and high resolution is designed to improve the ability to represent detail information.Secondly,as the road area is a small proportion in remote sensing images,the cross-entropy loss function is improved,which solves the imbalance between positive and negative samples in the training process.Experiments on large road extraction datasets show that the proposed method gets the recall rate 83.9%,precision 82.5%and F1-score 82.9%,which can extract the road targets in remote sensing images completely and accurately.The Encoder-Decoder network designed in this paper performs well in the road extraction task and needs less artificial participation,so it has a good application prospect.展开更多
van der Waals(vdW)semiconductors have gained significant attention due to their unique physical properties and promising applications,which are embedded within distinct crystallographic symmetries.Here,we report a pre...van der Waals(vdW)semiconductors have gained significant attention due to their unique physical properties and promising applications,which are embedded within distinct crystallographic symmetries.Here,we report a pressure-induced crystallineamorphization-recrystallization transition under compression in binary vdW semiconductor SiP.Upon compression to 52 GPa,bulk SiP undergoes a consecutive phase transition from pristine crystalline to amorphous phase,ultimately to recrystallized phase.By employing synchrotron X-ray diffraction experiments in conjunction with high-pressure crystal structure searching techniques,we reveal that the recrystallized Si P hosts a tetragonal structure(space group I4mm)and further transforms partially into a cubic phase(space group Fm3m).Consistently,electrical transport and alternating-current magnetic susceptibility measurements indicate the presence of three superconducting phases,which are embedded in separate crystallographic symmetries—the amorphous,tetragonal,and cubic structures.Furthermore,a high superconducting transition temperature of 12.3 K is observed in its recovered tetragonal phase during decompression.Our findings uncover a novel phase evolution path and elucidate a pressure-engineered structure-property relationship in vdW semiconductor SiP.These results not only offer a new platform to explore the transformation between different structures and functionalities,but also provide new opportunities for the design and exploration of advanced devices based on vdW materials.展开更多
Meningioma is one of the most common primary neoplasms in the central nervous system,but no specific molecularly targeted therapy has been approved for the clinical treatment of aggressive meningiomas.There is hence a...Meningioma is one of the most common primary neoplasms in the central nervous system,but no specific molecularly targeted therapy has been approved for the clinical treatment of aggressive meningiomas.There is hence an urgent demand to decrypt the biological and molecular landscape of malignant meningioma.Here,through the in-silica prescreening and 10-year follow-up studies of 445 meningioma patients,we uncovered that CBX7 expression progressively decreases with malignancy grade and neoplasia stage in meningioma,and a high CBX7 expression level predicts a favorable prognosis in meningioma patients.CBX7 restoration significantly induces cell cycle arrest and inhibits meningioma cell proliferation.iTRAQ-based proteomics analysis indicated that CBX7 restoration triggers the metabolic shift from glycolysis to oxidative phosphorylation.The mechanistic study demonstrated that CBX7 promotes the proteasome-dependent degradation of c-MYC protein by transcriptionally inhibiting the expression of a c-MYC deubiquitinase,USP44,consequently attenuates c-MYC-mediated transactivation of LDHA transcripts,and further inhibits glycolysis and subsequent cell proliferation.More importantly,the functional role of CBX7 was further confirmed in subcutaneous and orthotopic meningioma xenograft mouse models and meningioma patients.Altogether,our results shed light on the critical role of CBX7 in meningioma malignancy progression and identify the CBX7/USP44/c-MYC/LDHA axis as a promising therapeutic target against meningioma progression.展开更多
We study a kind of partial information non-zero sum differential games of mean-field backward doubly stochastic differential equations,in which the coefficient contains not only the state process but also its marginal...We study a kind of partial information non-zero sum differential games of mean-field backward doubly stochastic differential equations,in which the coefficient contains not only the state process but also its marginal distribution,and the cost functional is also of mean-field type.It is required that the control is adapted to a sub-filtration of the filtration generated by the underlying Brownian motions.We establish a necessary condition in the form of maximum principle and a verification theorem,which is a sufficient condition for Nash equilibrium point.We use the theoretical results to deal with a partial information linear-quadratic(LQ)game,and obtain the unique Nash equilibrium point for our LQ game problem by virtue of the unique solvability of mean-field forward-backward doubly stochastic differential equation.展开更多
A hydrogel can be coated on various substrates to enable multiple functions.Potential applications include biomedical devices,anti-fouling surfaces and microfluidics.In practical use,hydrogel coatings are often submer...A hydrogel can be coated on various substrates to enable multiple functions.Potential applications include biomedical devices,anti-fouling surfaces and microfluidics.In practical use,hydrogel coatings are often submerged in fluids.The swell of hydrogel coating deteriorates the interfacial bonding with the substrate.This paper presents a stress analysis of a hydrogel coating on a cylindrical metal substrate.We adopt the thermodynamic theory coupling large deformation and water migration and formulate two boundary value problems for the coating-substrate system with and without an interfacial crack.The inhomogeneous stress fields in the hydrogel coating are obtained.The influences of modulus,thickness of the hydrogel coating on the maximum radial stress at the interface are analyzed.These results may guide the design of hydrogel coating to avoid interfacial failure.展开更多
基金Project supported by the National Key Research and Development Program of China (Grant Nos. 2023YFA1406102 and 2022YFA1602603)the National Natural Science Foundation of China (Grant Nos. 12374049 and 12174395)+2 种基金the China Postdoctoral Science Foundation (Grant No. 2023M743542)Hefei Institutes of Physical Science,Chinese Academy of Sciences the Director’s Fundation of (Grant No. YZJJ2024QN41)the Basic Research Program of the Chinese Academy of Sciences Based on Major Scientific Infrastructures (Grant No. JZHKYPT-2021-08)。
文摘Motivated by the recent discovery of unconventional superconductivity around a magnetic quantum critical point in pressurized CeSb_(2),here we present a high-pressure study of an isostructural antiferromagnetic(AFM) SmSb_(2) through electrical transport and synchrotron x-ray diffraction measurements.At P_(C)~2.5 GPa,we found a pressure-induced magnetic phase transition accompanied by a Cmca→P4/nmm structural phase transition.In the pristine AFM phase below P_(C),the AFM transition temperature of SmSb_(2) is insensitive to pressure;in the emergent magnetic phase above P_(C),however,the magnetic critical temperature increases rapidly with increasing pressure.In addition,at ambient pressure,the magnetoresistivity(MR) of SmSb_(2) increases suddenly upon cooling below the AFM transition temperature and presents linear nonsaturating behavior under high field at 2 K.With increasing pressure above P_(C),the MR behavior remains similar to that observed at ambient pressure,both in terms of temperature-and field-dependent MR.This leads us to argue an AFM-like state for SmSb_(2) above P_(C).Within the investigated pressure of up to 45.3 GPa and the temperature of down to 1.8 K,we found no signature of superconductivity in SmSb_(2).
文摘Objective:To explore the clinical and pathological characteristics of cerebral venous sinus thrombosis(CVST)with subarachnoid hemorrhage(SAH)and intracerebral hemorrhage(ICH),and to investigate the diagnosis,radiographic changes,and prognosis over the course of treatment.Methods:The clinical data and radiographic findings of a young male CVST patient,who presented with initial symptoms of SAH and ICH,were collected and analyzed.The relevant literature was also reviewed.Results:The patient had no specific clinical symptoms except for headache.The brain computed tomography(CT)scan revealed SAH,a high-density shadow in the right posterior fossa and cerebellar hemisphere,and ICH in the left frontal lobe.Magnetic resonance venography(MRV)further revealed bilateral thrombosis in the transverse and sigmoid sinuses.Conclusion:CVST with SAH and ICH is rare and difficult to diagnose.Careful radiological study and clinical analysis are important for the correct and early diagnosis of this condition.Anticoagulation therapy is considered the primary treatment for CVST.
文摘Flexible energy-storage devices play a critical role in the development of portable, flexible and wearable electronics. In addition, biological materials including plants or plant-based materials are known for their safety, biodegradability, biocompatibility, environmental benignancy, and low cost. With respect to these advances, a flexible alkaline zinc-manganese dioxide (Zn-MnO2) battery is fabricated with a kelp-based electrolyte in this study. To the best of our knowledge, pure kelp is utilized as a semi-solid electrolyte for flexible Zn-MnO2 alkaline batteries for the first time, with which the as-assembled battery exhibited a specific capacity of 60 mA·h and could discharge for 120 h. Furthermore, the as-assembled Zn-MnO2 battery can be bent into a ring-shape and power a light-emitting diode screen, showing promising potential for the practical application in the future flexible, portable and biodegradable electronic devices.
基金National Natural Science Foundation of China(Nos.61673017,61403398)and Natural Science Foundation of Shaanxi Province(Nos.2017JM6077,2018ZDXM-GY-039)。
文摘According to the characteristics of the road features,an Encoder-Decoder deep semantic segmentation network is designed for the road extraction of remote sensing images.Firstly,as the features of the road target are rich in local details and simple in semantic features,an Encoder-Decoder network with shallow layers and high resolution is designed to improve the ability to represent detail information.Secondly,as the road area is a small proportion in remote sensing images,the cross-entropy loss function is improved,which solves the imbalance between positive and negative samples in the training process.Experiments on large road extraction datasets show that the proposed method gets the recall rate 83.9%,precision 82.5%and F1-score 82.9%,which can extract the road targets in remote sensing images completely and accurately.The Encoder-Decoder network designed in this paper performs well in the road extraction task and needs less artificial participation,so it has a good application prospect.
基金supported by the National Key Research and Development Program of China(Grant Nos.2023YFA1406102,and 2022YFA1602603)the National Natural Science Foundation of China(Grant Nos.12374049,12174397,12204420,12204004,12174395,U19A2093,and 12004004)+3 种基金the Natural Science Foundation of Anhui Province(Grant Nos.2308085MA16,and 2308085QA18)the Basic Research Program of the Chinese Academy of Sciences Based on Major Scientific Infrastructures(Grant No.JZHKYPT-2021-08)supported by the Youth Innovation Promotion Association CAS(Grant No.2020443)supported by the High Magnetic Field Laboratory of Anhui Province under Contract No.AHHM-FX-2021-03。
文摘van der Waals(vdW)semiconductors have gained significant attention due to their unique physical properties and promising applications,which are embedded within distinct crystallographic symmetries.Here,we report a pressure-induced crystallineamorphization-recrystallization transition under compression in binary vdW semiconductor SiP.Upon compression to 52 GPa,bulk SiP undergoes a consecutive phase transition from pristine crystalline to amorphous phase,ultimately to recrystallized phase.By employing synchrotron X-ray diffraction experiments in conjunction with high-pressure crystal structure searching techniques,we reveal that the recrystallized Si P hosts a tetragonal structure(space group I4mm)and further transforms partially into a cubic phase(space group Fm3m).Consistently,electrical transport and alternating-current magnetic susceptibility measurements indicate the presence of three superconducting phases,which are embedded in separate crystallographic symmetries—the amorphous,tetragonal,and cubic structures.Furthermore,a high superconducting transition temperature of 12.3 K is observed in its recovered tetragonal phase during decompression.Our findings uncover a novel phase evolution path and elucidate a pressure-engineered structure-property relationship in vdW semiconductor SiP.These results not only offer a new platform to explore the transformation between different structures and functionalities,but also provide new opportunities for the design and exploration of advanced devices based on vdW materials.
基金supported by grants from the National Natural Science Foundation of China(82072788 and 81772674 to Y.G.,82271595 to X.W.,and 81900287 to Z.J.).
文摘Meningioma is one of the most common primary neoplasms in the central nervous system,but no specific molecularly targeted therapy has been approved for the clinical treatment of aggressive meningiomas.There is hence an urgent demand to decrypt the biological and molecular landscape of malignant meningioma.Here,through the in-silica prescreening and 10-year follow-up studies of 445 meningioma patients,we uncovered that CBX7 expression progressively decreases with malignancy grade and neoplasia stage in meningioma,and a high CBX7 expression level predicts a favorable prognosis in meningioma patients.CBX7 restoration significantly induces cell cycle arrest and inhibits meningioma cell proliferation.iTRAQ-based proteomics analysis indicated that CBX7 restoration triggers the metabolic shift from glycolysis to oxidative phosphorylation.The mechanistic study demonstrated that CBX7 promotes the proteasome-dependent degradation of c-MYC protein by transcriptionally inhibiting the expression of a c-MYC deubiquitinase,USP44,consequently attenuates c-MYC-mediated transactivation of LDHA transcripts,and further inhibits glycolysis and subsequent cell proliferation.More importantly,the functional role of CBX7 was further confirmed in subcutaneous and orthotopic meningioma xenograft mouse models and meningioma patients.Altogether,our results shed light on the critical role of CBX7 in meningioma malignancy progression and identify the CBX7/USP44/c-MYC/LDHA axis as a promising therapeutic target against meningioma progression.
基金supported in part by the National Natural Science Foundation of China(Grant Nos.11871309,11671229,71871129,11371226,11301298)the National Key R&D Program of China(Grant No.2018 YFA0703900)+2 种基金the Natural Science Foundation of Shandong Province(No.ZR2019MA013)the Special Funds of Taishan Scholar Project(No.tsqn20161041)the Fostering Project of Dominant Discipline and Talent Team of Shandong Province Higher Education Institutions.
文摘We study a kind of partial information non-zero sum differential games of mean-field backward doubly stochastic differential equations,in which the coefficient contains not only the state process but also its marginal distribution,and the cost functional is also of mean-field type.It is required that the control is adapted to a sub-filtration of the filtration generated by the underlying Brownian motions.We establish a necessary condition in the form of maximum principle and a verification theorem,which is a sufficient condition for Nash equilibrium point.We use the theoretical results to deal with a partial information linear-quadratic(LQ)game,and obtain the unique Nash equilibrium point for our LQ game problem by virtue of the unique solvability of mean-field forward-backward doubly stochastic differential equation.
基金the support of the National Natural Foundation of China(Grants 11922210 and 11772249)the support of the National Natural Foundation of China(Grant 12002255).
文摘A hydrogel can be coated on various substrates to enable multiple functions.Potential applications include biomedical devices,anti-fouling surfaces and microfluidics.In practical use,hydrogel coatings are often submerged in fluids.The swell of hydrogel coating deteriorates the interfacial bonding with the substrate.This paper presents a stress analysis of a hydrogel coating on a cylindrical metal substrate.We adopt the thermodynamic theory coupling large deformation and water migration and formulate two boundary value problems for the coating-substrate system with and without an interfacial crack.The inhomogeneous stress fields in the hydrogel coating are obtained.The influences of modulus,thickness of the hydrogel coating on the maximum radial stress at the interface are analyzed.These results may guide the design of hydrogel coating to avoid interfacial failure.
