In recent years,mobile Internet technology and location based services have wide application.Application providers and users have accumulated huge amount of trajectory data.While publishing and analyzing user trajecto...In recent years,mobile Internet technology and location based services have wide application.Application providers and users have accumulated huge amount of trajectory data.While publishing and analyzing user trajectory data have brought great convenience for people,the disclosure risks of user privacy caused by the trajectory data publishing are also becoming more and more prominent.Traditional k-anonymous trajectory data publishing technologies cannot effectively protect user privacy against attackers with strong background knowledge.For privacy preserving trajectory data publishing,we propose a differential privacy based(k-Ψ)-anonymity method to defend against re-identification and probabilistic inference attack.The proposed method is divided into two phases:in the first phase,a dummy-based(k-Ψ)-anonymous trajectory data publishing algorithm is given,which improves(k-δ)-anonymity by considering changes of thresholdδon different road segments and constructing an adaptive threshold setΨthat takes into account road network information.In the second phase,Laplace noise regarding distance of anonymous locations under differential privacy is used for trajectory perturbation of the anonymous trajectory dataset outputted by the first phase.Experiments on real road network dataset are performed and the results show that the proposed method improves the trajectory indistinguishability and achieves good data utility in condition of preserving user privacy.展开更多
The northeastern part of the Tibetan Plateau is a region where different tectonic blocks collide and intersect,and large earthquakes are frequent.Global Navigation Satellite System(GNSS)observations show that tectonic...The northeastern part of the Tibetan Plateau is a region where different tectonic blocks collide and intersect,and large earthquakes are frequent.Global Navigation Satellite System(GNSS)observations show that tectonic deformation in this region is strong and manifests as non-uniform deformation associated with tectonic features.S-wave splitting studies of near-field seismic data show that seismic anisotropy parameters can also reveal the upper crustal medium deformation beneath the reporting station.In this paper,we summarize the surface deformation from GNSS observations and crustal deformation from seismic anisotropy data in the northeastern Tibetan Plateau.By comparing the principal compressive strain direction with the fast S-wave polarization direction of near-field S-wave splitting,we analyzed deformation and its differences in surface and upper crustal media in the northeastern Tibetan Plateau and adjacent areas.The principal compressive strain direction derived from GNSS is generally consistent with the polarization direction of fast S-waves,but there are also local tectonic regions with large differences between them,which reflect the different deformation mechanisms of regional upper crustal media.The combination of GNSS and seismic anisotropy data can reveal the depth variation characteristics of crustal deformation and deepen understanding of three-dimensional crustal deformation and the deep dynamical mechanisms underlying it.it.展开更多
Atherosclerotic cardiovascular disease and its complications are a high-incidence disease worldwide.Numerous studies have shown that blood flow shear has a huge impact on the function of vascular endothelial cells,and...Atherosclerotic cardiovascular disease and its complications are a high-incidence disease worldwide.Numerous studies have shown that blood flow shear has a huge impact on the function of vascular endothelial cells,and it plays an important role in gene regulation of pro-inflammatory,pro-thrombotic,pro-oxidative stress,and cell permeability.Many impor-tant endothelial cell mechanosensitive genes have been discovered,including KLK10,CCN gene family,NRP2,YAP,TAZ,HIF-1α,NF-kB,FOS,JUN,TFEB,KLF2/KLF4,NRF2,and ID1.Some of them have been intensively studied,whereas the relevant regulatory mechanism of other genes remains unclear.Focusing on these mechanosensitive genes will provide new strategies for therapeutic intervention in atherosclerotic vascular disease.Thus,this article reviews the mechanosensitive genes affecting vascular endothelial cells,including classical pathways and some newly screened genes,and summarizes the latest research progress on their roles in the pathogenesis of atherosclerosis to reveal effective therapeutic targets of drugs and provide new insights foranti-atherosclerosis.展开更多
The development of n-type semiconductor is still far behind that of p-type semiconductor on account of the challenges in enhancing carrier mobility and environmental stability.Herein,by blending with the polymers,n-ty...The development of n-type semiconductor is still far behind that of p-type semiconductor on account of the challenges in enhancing carrier mobility and environmental stability.Herein,by blending with the polymers,n-type ultrathin crystalline thin film was successfully prepared by the method of meniscus-guided coating.Remarkably,the n-type crystalline films exhibit ultrathin thickness as low as 5 nm and excellent mobility of 1.58 cm^(2) V^(-1) s^(-1),which is outstanding in currently reported organic n-type transistors.Moreover,the PS layer provides a high-quality interface with ultralow defect which has strong resistance to external interference with excellent long-term stability,paving the way for the application of n-type transistors in logic circuits.展开更多
This paper constructs coefficients of the integral and the internal structure upgrading in the secondary and tertiary industries, selects per capita real gross domestic product as a threshold variable and build panel ...This paper constructs coefficients of the integral and the internal structure upgrading in the secondary and tertiary industries, selects per capita real gross domestic product as a threshold variable and build panel threshold model according to inter-provincial panel data of China from 1998 to 2016. Results indicated that population aging has a double threshold effect on the integral industrial structure upgrading, whose influence increases first and then decreases, significantly promoting the upgrading process. As for internal structure, population aging has no significant threshold effect on the upgrading in the secondary industry, but exerts a single negative threshold effect in the tertiary industry. When economic development is under the threshold, its negative impact is greater. Further analysis also suggests that regional differences exist significantly in the threshold effect of population aging on the industrial structure upgrading.展开更多
In recent years,hyperthyroid heart disease has become a condition with high incidence rate and high mortality rate.This paper discusses the pathogenesis,treatment,and influencing factors of hyperthyroid heart disease ...In recent years,hyperthyroid heart disease has become a condition with high incidence rate and high mortality rate.This paper discusses the pathogenesis,treatment,and influencing factors of hyperthyroid heart disease from two different angles-traditional Chinese medicine and western medicine-in hope to provide a reference basis for the treatment of hyperthyroid heart disease.展开更多
With the popularity of sensor-rich mobile devices,mobile crowdsensing(MCS)has emerged as an effective method for data collection and processing.However,MCS platform usually need workers’precise locations for optimal ...With the popularity of sensor-rich mobile devices,mobile crowdsensing(MCS)has emerged as an effective method for data collection and processing.However,MCS platform usually need workers’precise locations for optimal task execution and collect sensing data from workers,which raises severe concerns of privacy leakage.Trying to preserve workers’location and sensing data from the untrusted MCS platform,a differentially private data aggregation method based on worker partition and location obfuscation(DP-DAWL method)is proposed in the paper.DP-DAWL method firstly use an improved K-means algorithm to divide workers into groups and assign different privacy budget to the group according to group size(the number of workers).Then each worker’s location is obfuscated and his/her sensing data is perturbed by adding Laplace noise before uploading to the platform.In the stage of data aggregation,DP-DAWL method adopts an improved Kalman filter algorithm to filter out the added noise(including both added noise of sensing data and the system noise in the sensing process).Through using optimal estimation of noisy aggregated sensing data,the platform can finally gain better utility of aggregated data while preserving workers’privacy.Extensive experiments on the synthetic datasets demonstrate the effectiveness of the proposed method.展开更多
[Objective] This study analyzed the differences in DDX3 Y gene sequences among male horse,male donkey,male mule,male hinny and male foal to investigate the relationship between DDX3 Y gene structure and the mechanism ...[Objective] This study analyzed the differences in DDX3 Y gene sequences among male horse,male donkey,male mule,male hinny and male foal to investigate the relationship between DDX3 Y gene structure and the mechanism of infertility in male Equus ferus × asinus. [Method] Partial sequences of DDX3 Y gene in male horse,male donkey,male mule,male hinny and male foal were obtained by genome comparison,sequencing and cloning,and compared by bioinformatics methods. [Result] The CDS regions varied in 5 base pairs and two amino acids. DDX3 Y protein was predicted to be an unstable protein. In addition,the results also showed that DDX3 Y gene in male horse displayed a closer phylogenetic relationship to male mule and male foal; DDX3 Y gene in male donkey displayed a closer phylogenetic relationship to male hinny. [Conclusion]This study provided scientific basis for further exploring the function of DDX3 Y gene and the mechanism of reproductive regulation in male Equus ferus × asinus.展开更多
Objective:It has been documented that ezrin/radixin/moesin(ERM)phosphorylation by the p38 mitogen-activated protein kinase(MAPK),Rho/ROCK,and protein kinase C(PKC)pathways leads to filamentous actin(F-actin)reorganiza...Objective:It has been documented that ezrin/radixin/moesin(ERM)phosphorylation by the p38 mitogen-activated protein kinase(MAPK),Rho/ROCK,and protein kinase C(PKC)pathways leads to filamentous actin(F-actin)reorganization and microvascular endothelial cell hyperpermeability.In this study,we investigated the effects of Xijiao Dihuang Decoction combined with Yinqiao Powder(XDY)on influenza virus(IV)-induced F-actin restructuring and ERM phosphorylation regulated by the Rho/Rho kinase 1(ROCK),p38 MAPK,and PKC signaling pathways in pulmonary microvascular endothelial cells(PMVECs).Methods:Serum containing XDY(XDY-CS;13.8 g/kg)was acquired using standard protocols for serum pharmacology.Primary PMVECs were obtained from male Wistar rats and cultured.After adsorption of IV A(multiplicity of infection,0.01)for 1 h,medium with 20%XDY-CS was added to the PMVECs.The distributions of F-actin and phosphorylated ERM were determined by confocal microscopy,and F-actin expression was measured by flow cytometry.The expression levels of ROCK1,phosphorylated myosin phosphatase target-subunit(p-MYPT),phosphorylated MAPK kinase,phosphorylated p38(p-p38),phosphorylated PKC(p-PKC),and phosphorylated ERM(p-ERM)were determined by western blotting.Results:F-actin reorganization in IV-infected PMVECs was reversed by XDY-CS treatment,which was accompanied by reduced p-ERM production.The p-ERM protein accumulated at plasma membrane of PMVECs infected with IV,which was also inhibited by XDY-CS treatment.展开更多
Brassinosteroids(BRs)are plant-specific steroid hormones which regulate plant growth,development,and adaptation.Transcriptional regulation plays key roles in plant hormone signaling.A mediator can serve as a bridge be...Brassinosteroids(BRs)are plant-specific steroid hormones which regulate plant growth,development,and adaptation.Transcriptional regulation plays key roles in plant hormone signaling.A mediator can serve as a bridge between gene-specific transcription factors and the RNA polymerase machinery,functioning as an essential component in regulating the transcriptional process.However,whether a mediator is involved in BR signaling is unknown.Here,we discovered that Oryza sativa mediator subunit 25(Os MED25)is an important regulator of rice BR signaling.Phenotypic analyses showed that the Os MED25-RNAi and osmed25 mutant presented erect leaves,as observed in BR-deficient mutants.In addition,the Os MED25-RNAi and osmed25 mutant exhibited decreased BR sensitivity.Genetic analysis indicated that Os MED25-RNAi could suppress the enhanced BR signaling phenotype of Osbzr1-D.Further biochemical analysis showed that Os MED25 interacts with Os BZR1 in vivo,and Os MED25 is enriched on the promoter of Os BZR1 target genes.RNA sequencing analysis indicated that Os MED25 affects the expression of approximately 45%of Os BZR1-regulated genes and mainly functions as a corepressor of Os BZR1.Together,these findings revealed that Os MED25 regulates rice BR signaling by interacting with Os BZR1 and modulating the expression of Os BZR1 target genes,thus expanding our understanding of the roles of mediators in plant hormone signaling.展开更多
Near-infrared organic phototransistors have wide application prospects in many fields.The active materials with the high mobility and near-infrared response are critical to building high-performance near-infrared orga...Near-infrared organic phototransistors have wide application prospects in many fields.The active materials with the high mobility and near-infrared response are critical to building high-performance near-infrared organic phototransistors,which are scarce at present.Herein,a new charge transfer cocrystal using 5,7-dihydroindolo[2,3-b]carbazole(5,7-ICZ)as the donor and 2,2’-(benzo[1,2-b:4,5-b’]dithiophene-4,8-diylidene)dimalononitrile(DTTCNQ)as the acceptor is properly designed and prepared in a stoichiometric ratio(D:A=1:1),which not only displays a high electron mobility of 0.15 cm^(2)V^(-1)s^(-1) and very low dark current,but also can serve as the active layer materials in the region of near-infrared detection due to the narrowed band gap and good charge transport properties.A high photosensitivity of 1.8×10^(4),the ultrahigh photoresponsivity of 2,923 A W-1and the high detectivity of 4.26×10^(11)Jones of the organic near-infrared phototransistors are obtained.展开更多
On December 18,2023,an M_(s)6.2 earthquake occurred in Jishishan,Gansu Province,China.This earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of t...On December 18,2023,an M_(s)6.2 earthquake occurred in Jishishan,Gansu Province,China.This earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of the Tibetan Plateau(i.e.,Qinghai-Tibet Plateau),encompassing a rhombic-shaped area that intersects the Qilian-Qaidam Basin,Alxa Block,Ordos Block,and South China Block.In this study,we analyzed the deep tectonic pattern of the Jishishan earthquake by incorporating data on the crustal thickness,velocity structure,global navigation satellite system(GNSS)strain field,and anisotropy.We discovered that the location of the earthquake was related to changes in the crustal structure.The results showed that the Jishishan M_(s)6.2 earthquake occurred in a unique position,with rapid changes in the crustal thickness,Vp/Vs,phase velocity,and S-wave velocity.The epicenter of the earthquake was situated at the transition zone between high and low velocities and was in proximity to a low-velocity region.Additionally,the source area is flanked by two high-velocity anomalies from the east and west.The principal compressive strain orientation near the Lajishan Fault is primarily in the NNE and NE directions,which align with the principal compressive stress direction in this region.In some areas of the Lajishan Fault,the principal compressive strain orientations show the NNW direction,consistent with the direction of the upper crustal fast-wave polarization from local earthquakes and the phase velocity azimuthal anisotropy.These features underscore the relationship between the occurrence of the Jishishan M_(s)6.2 earthquake and the deep inhomogeneous structure and deep tectonic characteristics.The NE margin of the Tibetan Plateau was thickened by crustal extension in the process of northeastward expansion,and the middle and lower crustal materials underwent structural deformation and may have been filled with salt-containing fluids during the extension process.The presence of this weak layer makes it easier for strong earthquakes to occur through the release of overlying rigid crustal stresses.However,it is unlikely that an earthquake of comparable or larger magnitude would occur in the short term(e.g.,in one year)at the Jishishan east margin fault.展开更多
Grain number is a flexible trait and contributes significantly to grain yield.In rice,the zinc finger transcription factor DROUGHT AND SALT TOLERANCE(DST)controls grain number by directly regulating cytokinin oxidase!...Grain number is a flexible trait and contributes significantly to grain yield.In rice,the zinc finger transcription factor DROUGHT AND SALT TOLERANCE(DST)controls grain number by directly regulating cytokinin oxidase!dehydrogenase 2(OsCKX2)expression.Although specific upstream regulators of the DST-OsCKX2 module have been identified,the mechanism employed by DST to regulate the expression of OsCKX2 remains unclear.Here,we demonstrate that DST-interacting protein 1(DIP1),known as Mediator subunit OsMED25,acts as an interacting coactivator of DST.Phenotypic analyses revealed that OsMED25-RNAi and the osmed25 mutant plants exhibited enlarged panicles,with enhanced branching and spikelet number,similar to the dst mutant.Genetic analysis indicated that OsMED25 acts in the same pathway as the DST-OsCKX2 module to regulate spikelet number per panicle.Further biochemical analysis showed that OsMED25 physically interacts with DST at the promoter region of OsCKX2,and then recruits RNA polymerase II(Pol II)to activate OsCKX2 transcription.Thus,OsMED25 was involved in the communication between DST and Pol II general transcriptional machinery to regulate spikelet number.In general,our findings reveal a novel function of OsMED25 in DST-OsCKX2 modulated transcriptional regulation,thus enhancing our un derstanding of the regulatory mechanism underlying DST-OsCKX2-mediated spikelet number.展开更多
In this research,the tribocorrosion behavior of 316L stainless steel in simulated seawater was investigated under continuous and intermittent sliding at open circuit potential.The tribocorrosion mechanism was discusse...In this research,the tribocorrosion behavior of 316L stainless steel in simulated seawater was investigated under continuous and intermittent sliding at open circuit potential.The tribocorrosion mechanism was discussed in terms of wear morphologies,mechanical property as well as chemical composition.Meanwhile,microstructure evolution inside the wear track and open circuit potential recorded after sliding were analyzed to quantify the repassivation kinetics and evaluate the impact of the regenerated passive film on wear.The results showed that the wear rate increased under intermittent sliding when the pause time is long enough to repassivate after sliding.Repeated sliding promoted the refinement of the grain inside the sliding area,which was beneficial to the generation of the thicker and more compact passive film inside the wear track.The ruptured passive film often acted as abrasives during subsequent sliding.Therefore,the accelerated material loss under intermittent sliding was attributed to the periodic mechanical removal of the thickened passive film and the enhanced abrasive wear inside the wear track.展开更多
Current tribocorrosion research of metallic materials and their surface protective coatings mainly focuses on their short-term properties,with test time of 0.5‒2.0 h and a sliding distance 50‒500 m,which may significa...Current tribocorrosion research of metallic materials and their surface protective coatings mainly focuses on their short-term properties,with test time of 0.5‒2.0 h and a sliding distance 50‒500 m,which may significantly deviate from the practical long-term service condition and thus cause a catastrophe of marine equipments.In this study,three carbon-based multilayer coatings(Ti/DLC,TiC_(x)/DLC,and Ti‒TiC_(x)/DLC)were deposited on S32750 substrates,and both short-term and long-term tribocorrosion behaviors were investigated.The experimental results indicate that the coatings substantially improve the tribocorrosion resistance of the S32750 stainless steel.During the short-term tribocorrosion test,TiC_(x)/DLC exhibited the best tribocorrosion resistance owing to its high hardness.During the long-term tribocorrosion test,however,Ti‒TiC_(x)/DLC coating indicated the best anti-tribocorrosion performance owing to its excellent fracture toughness together with high hardness.Moreover,under 5 N,Ti‒TiC_(x)/DLC can withstand a long-term test of more than 24 h.Additionally,under a higher load of 20 N,the Ti‒TiC_(x)/DLC with a corresponding sliding distance of approximately 1,728 m maintained a low friction coefficient of approximately 0.06.However,the coating was completely worn out;this is attributable to the formation of tribocorrosion products consisting of graphitized carbon and nanocrystalline Fe_(x)O_(y).展开更多
Simultaneously realizing the optical and electrical properties of organic materials is always challenging.Herein,a convenient and promising strategy for designing organic materials with integrated optoelectronic prope...Simultaneously realizing the optical and electrical properties of organic materials is always challenging.Herein,a convenient and promising strategy for designing organic materials with integrated optoelectronic properties based on cocrystal engineering has been put forward.By selecting the fluorene(Flu)and the 7,7′,8,8′-tetracyanoquinodimethane(TCNQ)as functional constituents,the Flu-TCNQ cocrystal prepared shows deep red emission at 702 nm,which is comparable to the commercialized red quantum dot.The highest electron mobility of organic field-effect transistor(OFET)based on Flu-TCNQ is 0.32 cm^(2)V^(−1)s^(−1).Spectroscopic analysis indicates that the intermolecular driving force contributing to the co-assembly of Flu-TCNQ is mainly charge transfer(CT)interaction,which leads to its different optoelectronic properties from constituents.展开更多
基金supported by the Fundamental Research Funds for the Central Universities(No.GK201906009)CERNET Innovation Project(No.NGII20190704)Science and Technology Program of Xi’an City(No.2019216914GXRC005CG006-GXYD5.2).
文摘In recent years,mobile Internet technology and location based services have wide application.Application providers and users have accumulated huge amount of trajectory data.While publishing and analyzing user trajectory data have brought great convenience for people,the disclosure risks of user privacy caused by the trajectory data publishing are also becoming more and more prominent.Traditional k-anonymous trajectory data publishing technologies cannot effectively protect user privacy against attackers with strong background knowledge.For privacy preserving trajectory data publishing,we propose a differential privacy based(k-Ψ)-anonymity method to defend against re-identification and probabilistic inference attack.The proposed method is divided into two phases:in the first phase,a dummy-based(k-Ψ)-anonymous trajectory data publishing algorithm is given,which improves(k-δ)-anonymity by considering changes of thresholdδon different road segments and constructing an adaptive threshold setΨthat takes into account road network information.In the second phase,Laplace noise regarding distance of anonymous locations under differential privacy is used for trajectory perturbation of the anonymous trajectory dataset outputted by the first phase.Experiments on real road network dataset are performed and the results show that the proposed method improves the trajectory indistinguishability and achieves good data utility in condition of preserving user privacy.
基金supported by the National Natural Science Foundation of China(No.42074065)the basic research project of Institute of Earthquake Forecasting China Earthquake Administration(No.2021IEF0601)。
文摘The northeastern part of the Tibetan Plateau is a region where different tectonic blocks collide and intersect,and large earthquakes are frequent.Global Navigation Satellite System(GNSS)observations show that tectonic deformation in this region is strong and manifests as non-uniform deformation associated with tectonic features.S-wave splitting studies of near-field seismic data show that seismic anisotropy parameters can also reveal the upper crustal medium deformation beneath the reporting station.In this paper,we summarize the surface deformation from GNSS observations and crustal deformation from seismic anisotropy data in the northeastern Tibetan Plateau.By comparing the principal compressive strain direction with the fast S-wave polarization direction of near-field S-wave splitting,we analyzed deformation and its differences in surface and upper crustal media in the northeastern Tibetan Plateau and adjacent areas.The principal compressive strain direction derived from GNSS is generally consistent with the polarization direction of fast S-waves,but there are also local tectonic regions with large differences between them,which reflect the different deformation mechanisms of regional upper crustal media.The combination of GNSS and seismic anisotropy data can reveal the depth variation characteristics of crustal deformation and deepen understanding of three-dimensional crustal deformation and the deep dynamical mechanisms underlying it.it.
基金supported in part by the National Natural Science Foundation of China(No.31971242,12032007)the Chongqing Science and Technology Bureau(China)(No.cstc2021jsyj-yzysbA0057)the Joint Medical Research Project of Chongqing Science and Technology Bureau and Chongqing Health Commission(China)(No.2018ZDXM032).
文摘Atherosclerotic cardiovascular disease and its complications are a high-incidence disease worldwide.Numerous studies have shown that blood flow shear has a huge impact on the function of vascular endothelial cells,and it plays an important role in gene regulation of pro-inflammatory,pro-thrombotic,pro-oxidative stress,and cell permeability.Many impor-tant endothelial cell mechanosensitive genes have been discovered,including KLK10,CCN gene family,NRP2,YAP,TAZ,HIF-1α,NF-kB,FOS,JUN,TFEB,KLF2/KLF4,NRF2,and ID1.Some of them have been intensively studied,whereas the relevant regulatory mechanism of other genes remains unclear.Focusing on these mechanosensitive genes will provide new strategies for therapeutic intervention in atherosclerotic vascular disease.Thus,this article reviews the mechanosensitive genes affecting vascular endothelial cells,including classical pathways and some newly screened genes,and summarizes the latest research progress on their roles in the pathogenesis of atherosclerosis to reveal effective therapeutic targets of drugs and provide new insights foranti-atherosclerosis.
基金the financial support of the National Key Research and Development Program(No.2022YFF1202700)National Natural Science Foundation of China(No.52121002)the Haihe Laboratory of Sustainable Chemical Transformations.
文摘The development of n-type semiconductor is still far behind that of p-type semiconductor on account of the challenges in enhancing carrier mobility and environmental stability.Herein,by blending with the polymers,n-type ultrathin crystalline thin film was successfully prepared by the method of meniscus-guided coating.Remarkably,the n-type crystalline films exhibit ultrathin thickness as low as 5 nm and excellent mobility of 1.58 cm^(2) V^(-1) s^(-1),which is outstanding in currently reported organic n-type transistors.Moreover,the PS layer provides a high-quality interface with ultralow defect which has strong resistance to external interference with excellent long-term stability,paving the way for the application of n-type transistors in logic circuits.
基金This study is supported by funds of National Natural Science Foundation of China’s project “China’s population aging process and labor productivity: inspection, forecasting and policy options”[Grant number: 71573093]National Natural Science Foundation of China’s project [Grant number:71573093].
文摘This paper constructs coefficients of the integral and the internal structure upgrading in the secondary and tertiary industries, selects per capita real gross domestic product as a threshold variable and build panel threshold model according to inter-provincial panel data of China from 1998 to 2016. Results indicated that population aging has a double threshold effect on the integral industrial structure upgrading, whose influence increases first and then decreases, significantly promoting the upgrading process. As for internal structure, population aging has no significant threshold effect on the upgrading in the secondary industry, but exerts a single negative threshold effect in the tertiary industry. When economic development is under the threshold, its negative impact is greater. Further analysis also suggests that regional differences exist significantly in the threshold effect of population aging on the industrial structure upgrading.
文摘In recent years,hyperthyroid heart disease has become a condition with high incidence rate and high mortality rate.This paper discusses the pathogenesis,treatment,and influencing factors of hyperthyroid heart disease from two different angles-traditional Chinese medicine and western medicine-in hope to provide a reference basis for the treatment of hyperthyroid heart disease.
基金This research was funded by Key Research and Development Program of Shaanxi Province(No.2017GY-064)the National Key R&D Program of China(No.2017YFB1402102).
文摘With the popularity of sensor-rich mobile devices,mobile crowdsensing(MCS)has emerged as an effective method for data collection and processing.However,MCS platform usually need workers’precise locations for optimal task execution and collect sensing data from workers,which raises severe concerns of privacy leakage.Trying to preserve workers’location and sensing data from the untrusted MCS platform,a differentially private data aggregation method based on worker partition and location obfuscation(DP-DAWL method)is proposed in the paper.DP-DAWL method firstly use an improved K-means algorithm to divide workers into groups and assign different privacy budget to the group according to group size(the number of workers).Then each worker’s location is obfuscated and his/her sensing data is perturbed by adding Laplace noise before uploading to the platform.In the stage of data aggregation,DP-DAWL method adopts an improved Kalman filter algorithm to filter out the added noise(including both added noise of sensing data and the system noise in the sensing process).Through using optimal estimation of noisy aggregated sensing data,the platform can finally gain better utility of aggregated data while preserving workers’privacy.Extensive experiments on the synthetic datasets demonstrate the effectiveness of the proposed method.
基金Supported by Project of Science and Technology Department of Inner Mongolia Autonomous Region
文摘[Objective] This study analyzed the differences in DDX3 Y gene sequences among male horse,male donkey,male mule,male hinny and male foal to investigate the relationship between DDX3 Y gene structure and the mechanism of infertility in male Equus ferus × asinus. [Method] Partial sequences of DDX3 Y gene in male horse,male donkey,male mule,male hinny and male foal were obtained by genome comparison,sequencing and cloning,and compared by bioinformatics methods. [Result] The CDS regions varied in 5 base pairs and two amino acids. DDX3 Y protein was predicted to be an unstable protein. In addition,the results also showed that DDX3 Y gene in male horse displayed a closer phylogenetic relationship to male mule and male foal; DDX3 Y gene in male donkey displayed a closer phylogenetic relationship to male hinny. [Conclusion]This study provided scientific basis for further exploring the function of DDX3 Y gene and the mechanism of reproductive regulation in male Equus ferus × asinus.
基金This work was supported by funding from the National Natural Science Foundation of China(Grant Nos.81473520 and 81102697).
文摘Objective:It has been documented that ezrin/radixin/moesin(ERM)phosphorylation by the p38 mitogen-activated protein kinase(MAPK),Rho/ROCK,and protein kinase C(PKC)pathways leads to filamentous actin(F-actin)reorganization and microvascular endothelial cell hyperpermeability.In this study,we investigated the effects of Xijiao Dihuang Decoction combined with Yinqiao Powder(XDY)on influenza virus(IV)-induced F-actin restructuring and ERM phosphorylation regulated by the Rho/Rho kinase 1(ROCK),p38 MAPK,and PKC signaling pathways in pulmonary microvascular endothelial cells(PMVECs).Methods:Serum containing XDY(XDY-CS;13.8 g/kg)was acquired using standard protocols for serum pharmacology.Primary PMVECs were obtained from male Wistar rats and cultured.After adsorption of IV A(multiplicity of infection,0.01)for 1 h,medium with 20%XDY-CS was added to the PMVECs.The distributions of F-actin and phosphorylated ERM were determined by confocal microscopy,and F-actin expression was measured by flow cytometry.The expression levels of ROCK1,phosphorylated myosin phosphatase target-subunit(p-MYPT),phosphorylated MAPK kinase,phosphorylated p38(p-p38),phosphorylated PKC(p-PKC),and phosphorylated ERM(p-ERM)were determined by western blotting.Results:F-actin reorganization in IV-infected PMVECs was reversed by XDY-CS treatment,which was accompanied by reduced p-ERM production.The p-ERM protein accumulated at plasma membrane of PMVECs infected with IV,which was also inhibited by XDY-CS treatment.
基金National Natural Science Foundation of China(31671653,31801017,31871591)National Transgenic Science and Technology Program(2018ZX0800102B)+1 种基金National Key Research and Development Program of China(2017YFD0100501)Natural Science Foundation of Heilongjiang Province(C2018064)。
文摘Brassinosteroids(BRs)are plant-specific steroid hormones which regulate plant growth,development,and adaptation.Transcriptional regulation plays key roles in plant hormone signaling.A mediator can serve as a bridge between gene-specific transcription factors and the RNA polymerase machinery,functioning as an essential component in regulating the transcriptional process.However,whether a mediator is involved in BR signaling is unknown.Here,we discovered that Oryza sativa mediator subunit 25(Os MED25)is an important regulator of rice BR signaling.Phenotypic analyses showed that the Os MED25-RNAi and osmed25 mutant presented erect leaves,as observed in BR-deficient mutants.In addition,the Os MED25-RNAi and osmed25 mutant exhibited decreased BR sensitivity.Genetic analysis indicated that Os MED25-RNAi could suppress the enhanced BR signaling phenotype of Osbzr1-D.Further biochemical analysis showed that Os MED25 interacts with Os BZR1 in vivo,and Os MED25 is enriched on the promoter of Os BZR1 target genes.RNA sequencing analysis indicated that Os MED25 affects the expression of approximately 45%of Os BZR1-regulated genes and mainly functions as a corepressor of Os BZR1.Together,these findings revealed that Os MED25 regulates rice BR signaling by interacting with Os BZR1 and modulating the expression of Os BZR1 target genes,thus expanding our understanding of the roles of mediators in plant hormone signaling.
基金supported by the Ministry of Science and Technology of China(2018YFA0703200 and 2017YFA0204503)the National Natural Science Foundation of China(52121002,51733004,U21A6002,51725304 and 21875158)+1 种基金Tianjin Natural Science Foundation(20JCJQJC00300)China Postdoctoral Science Foundation(2021M692381)。
文摘Near-infrared organic phototransistors have wide application prospects in many fields.The active materials with the high mobility and near-infrared response are critical to building high-performance near-infrared organic phototransistors,which are scarce at present.Herein,a new charge transfer cocrystal using 5,7-dihydroindolo[2,3-b]carbazole(5,7-ICZ)as the donor and 2,2’-(benzo[1,2-b:4,5-b’]dithiophene-4,8-diylidene)dimalononitrile(DTTCNQ)as the acceptor is properly designed and prepared in a stoichiometric ratio(D:A=1:1),which not only displays a high electron mobility of 0.15 cm^(2)V^(-1)s^(-1) and very low dark current,but also can serve as the active layer materials in the region of near-infrared detection due to the narrowed band gap and good charge transport properties.A high photosensitivity of 1.8×10^(4),the ultrahigh photoresponsivity of 2,923 A W-1and the high detectivity of 4.26×10^(11)Jones of the organic near-infrared phototransistors are obtained.
基金the National Natural Science Foundation of China(Project Nos.41804046 and 41974050)the Special Fund of the Key Laboratory of Earthquake Prediction,China Earthquake Administration(No.CEAIEF2022010100).
文摘On December 18,2023,an M_(s)6.2 earthquake occurred in Jishishan,Gansu Province,China.This earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of the Tibetan Plateau(i.e.,Qinghai-Tibet Plateau),encompassing a rhombic-shaped area that intersects the Qilian-Qaidam Basin,Alxa Block,Ordos Block,and South China Block.In this study,we analyzed the deep tectonic pattern of the Jishishan earthquake by incorporating data on the crustal thickness,velocity structure,global navigation satellite system(GNSS)strain field,and anisotropy.We discovered that the location of the earthquake was related to changes in the crustal structure.The results showed that the Jishishan M_(s)6.2 earthquake occurred in a unique position,with rapid changes in the crustal thickness,Vp/Vs,phase velocity,and S-wave velocity.The epicenter of the earthquake was situated at the transition zone between high and low velocities and was in proximity to a low-velocity region.Additionally,the source area is flanked by two high-velocity anomalies from the east and west.The principal compressive strain orientation near the Lajishan Fault is primarily in the NNE and NE directions,which align with the principal compressive stress direction in this region.In some areas of the Lajishan Fault,the principal compressive strain orientations show the NNW direction,consistent with the direction of the upper crustal fast-wave polarization from local earthquakes and the phase velocity azimuthal anisotropy.These features underscore the relationship between the occurrence of the Jishishan M_(s)6.2 earthquake and the deep inhomogeneous structure and deep tectonic characteristics.The NE margin of the Tibetan Plateau was thickened by crustal extension in the process of northeastward expansion,and the middle and lower crustal materials underwent structural deformation and may have been filled with salt-containing fluids during the extension process.The presence of this weak layer makes it easier for strong earthquakes to occur through the release of overlying rigid crustal stresses.However,it is unlikely that an earthquake of comparable or larger magnitude would occur in the short term(e.g.,in one year)at the Jishishan east margin fault.
基金supported by the National Key Research and Development Program of China (Grant No. 2019YFD1000300)Agricultural Seed Project of Shandong Province (Grant Nos 2020LZGC005, 2021LZGC0017)+1 种基金the Tai-Shan Scholar Program from Shandong Province (Grant No. tsxk20150901)the K. C. Wong Education Foundation.
文摘Grain number is a flexible trait and contributes significantly to grain yield.In rice,the zinc finger transcription factor DROUGHT AND SALT TOLERANCE(DST)controls grain number by directly regulating cytokinin oxidase!dehydrogenase 2(OsCKX2)expression.Although specific upstream regulators of the DST-OsCKX2 module have been identified,the mechanism employed by DST to regulate the expression of OsCKX2 remains unclear.Here,we demonstrate that DST-interacting protein 1(DIP1),known as Mediator subunit OsMED25,acts as an interacting coactivator of DST.Phenotypic analyses revealed that OsMED25-RNAi and the osmed25 mutant plants exhibited enlarged panicles,with enhanced branching and spikelet number,similar to the dst mutant.Genetic analysis indicated that OsMED25 acts in the same pathway as the DST-OsCKX2 module to regulate spikelet number per panicle.Further biochemical analysis showed that OsMED25 physically interacts with DST at the promoter region of OsCKX2,and then recruits RNA polymerase II(Pol II)to activate OsCKX2 transcription.Thus,OsMED25 was involved in the communication between DST and Pol II general transcriptional machinery to regulate spikelet number.In general,our findings reveal a novel function of OsMED25 in DST-OsCKX2 modulated transcriptional regulation,thus enhancing our un derstanding of the regulatory mechanism underlying DST-OsCKX2-mediated spikelet number.
基金A-class pilot of the Chinese Academy of Sciences(No.XDA22010303)National Science Fund for Distinguished Young Scholars of China(No.52025014)+3 种基金CAS Interdisciplinary Innovation Team(No.292020000008)CASNST Joint Research Project(No.174433KYSB20200021)National Natural Science Foundation of China(No.51801226)K.C.Wong Education Foundation(No.GJTD-2019–13)。
文摘In this research,the tribocorrosion behavior of 316L stainless steel in simulated seawater was investigated under continuous and intermittent sliding at open circuit potential.The tribocorrosion mechanism was discussed in terms of wear morphologies,mechanical property as well as chemical composition.Meanwhile,microstructure evolution inside the wear track and open circuit potential recorded after sliding were analyzed to quantify the repassivation kinetics and evaluate the impact of the regenerated passive film on wear.The results showed that the wear rate increased under intermittent sliding when the pause time is long enough to repassivate after sliding.Repeated sliding promoted the refinement of the grain inside the sliding area,which was beneficial to the generation of the thicker and more compact passive film inside the wear track.The ruptured passive film often acted as abrasives during subsequent sliding.Therefore,the accelerated material loss under intermittent sliding was attributed to the periodic mechanical removal of the thickened passive film and the enhanced abrasive wear inside the wear track.
基金This work was supported by the National Natural Science Foundation of China(Nos.52025014 and 51801226)A-class pilot of the Chinese Academy of Sciences(No.XDA22010303)+2 种基金K.C.Wong Education Foundation(No.GJTD-2019-13)CAS-NST Joint Research Project(No.174433KYSB20200021)CAS Interdisciplinary Innovation Team(No.292020000008).
文摘Current tribocorrosion research of metallic materials and their surface protective coatings mainly focuses on their short-term properties,with test time of 0.5‒2.0 h and a sliding distance 50‒500 m,which may significantly deviate from the practical long-term service condition and thus cause a catastrophe of marine equipments.In this study,three carbon-based multilayer coatings(Ti/DLC,TiC_(x)/DLC,and Ti‒TiC_(x)/DLC)were deposited on S32750 substrates,and both short-term and long-term tribocorrosion behaviors were investigated.The experimental results indicate that the coatings substantially improve the tribocorrosion resistance of the S32750 stainless steel.During the short-term tribocorrosion test,TiC_(x)/DLC exhibited the best tribocorrosion resistance owing to its high hardness.During the long-term tribocorrosion test,however,Ti‒TiC_(x)/DLC coating indicated the best anti-tribocorrosion performance owing to its excellent fracture toughness together with high hardness.Moreover,under 5 N,Ti‒TiC_(x)/DLC can withstand a long-term test of more than 24 h.Additionally,under a higher load of 20 N,the Ti‒TiC_(x)/DLC with a corresponding sliding distance of approximately 1,728 m maintained a low friction coefficient of approximately 0.06.However,the coating was completely worn out;this is attributable to the formation of tribocorrosion products consisting of graphitized carbon and nanocrystalline Fe_(x)O_(y).
基金The authors acknowledge financial support from the National Key R&D Program(No.2017YFA0204503)the National Natural Science Foundation of China(Grant Nos.21875158,51733004,and 91833306)the Natural Science Foundation of Tianjin City(No.20JCJQJC00300).
文摘Simultaneously realizing the optical and electrical properties of organic materials is always challenging.Herein,a convenient and promising strategy for designing organic materials with integrated optoelectronic properties based on cocrystal engineering has been put forward.By selecting the fluorene(Flu)and the 7,7′,8,8′-tetracyanoquinodimethane(TCNQ)as functional constituents,the Flu-TCNQ cocrystal prepared shows deep red emission at 702 nm,which is comparable to the commercialized red quantum dot.The highest electron mobility of organic field-effect transistor(OFET)based on Flu-TCNQ is 0.32 cm^(2)V^(−1)s^(−1).Spectroscopic analysis indicates that the intermolecular driving force contributing to the co-assembly of Flu-TCNQ is mainly charge transfer(CT)interaction,which leads to its different optoelectronic properties from constituents.
基金supported by the National Key R&D Program (2017YFA0204503)the National Natural Science Foundation of China (91833306, 51903186, 21875158, 51633006, and 51733004)China Postdoctoral Science Foundation (2019T120183 and 2021M692381)。
