To identify the roles of serum IL-18, IL- 10, TNF-α and sIL-2R in the pathogenisis of chronic hepatitis C and the effects of interferon on the men- tioned serum cytokines. Methods: The levels of IL-18, IL-10, TNF-α ...To identify the roles of serum IL-18, IL- 10, TNF-α and sIL-2R in the pathogenisis of chronic hepatitis C and the effects of interferon on the men- tioned serum cytokines. Methods: The levels of IL-18, IL-10, TNF-α and sIL-2R were detected in 10 healthy controls, 24 a- symptomatic HCV carriers, and 27 patients with chronic hepatitis C (before and after IFN treatment) by enzyme linked immunosorbent assay (ELISA). Results: The levels of IL-18, IL-10, TNF-α and sIL- 2R in the patients of chronic hepatitis C were higher than those in the healthy controls (P<0.05) and in asymptomatic HCV carriers (P<0. 05). The values of the mentioned cytokines showed a significant posi- tive correlation to GPT. The levels of the mentioned cytokines decreased obviously after IFN treatment (P <0. 05), while the serum levels of IL-10 and sIL-2R reduced in sequence in no-response group, partial- response group and complete-response group. Conclusions: IL-18, IL-10, TNF-α and sIL-2R co- participate in the pathogenisis of chronic hepatitis C, and are used to evaluate the effect of IFN on the im- mune state of organisms, and IL-10 and sIL-2R are important for predicting the anti-viral efficacy of IFN.展开更多
文摘To identify the roles of serum IL-18, IL- 10, TNF-α and sIL-2R in the pathogenisis of chronic hepatitis C and the effects of interferon on the men- tioned serum cytokines. Methods: The levels of IL-18, IL-10, TNF-α and sIL-2R were detected in 10 healthy controls, 24 a- symptomatic HCV carriers, and 27 patients with chronic hepatitis C (before and after IFN treatment) by enzyme linked immunosorbent assay (ELISA). Results: The levels of IL-18, IL-10, TNF-α and sIL- 2R in the patients of chronic hepatitis C were higher than those in the healthy controls (P<0.05) and in asymptomatic HCV carriers (P<0. 05). The values of the mentioned cytokines showed a significant posi- tive correlation to GPT. The levels of the mentioned cytokines decreased obviously after IFN treatment (P <0. 05), while the serum levels of IL-10 and sIL-2R reduced in sequence in no-response group, partial- response group and complete-response group. Conclusions: IL-18, IL-10, TNF-α and sIL-2R co- participate in the pathogenisis of chronic hepatitis C, and are used to evaluate the effect of IFN on the im- mune state of organisms, and IL-10 and sIL-2R are important for predicting the anti-viral efficacy of IFN.
