BACKGROUND The understanding of bile acid(BA)and unsaturated fatty acid(UFA)profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2DM)coexisting with non-alcoholic fatty...BACKGROUND The understanding of bile acid(BA)and unsaturated fatty acid(UFA)profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2DM)coexisting with non-alcoholic fatty liver disease(NAFLD).Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in T2DM.AIM To identify potential metabolite biomarkers capable of distinguishing between NAFLD and T2DM.METHODS A training model was developed involving 399 participants,comprising 113 healthy controls(HCs),134 individuals with T2DM without NAFLD,and 152 individuals with T2DM and NAFLD.External validation encompassed 172 participants.NAFLD patients were divided based on liver fibrosis scores.The analytical approach employed univariate testing,orthogonal partial least squares-discriminant analysis,logistic regression,receiver operating characteristic curve analysis,and decision curve analysis to pinpoint and assess the diagnostic value of serum biomarkers.RESULTS Compared to HCs,both T2DM and NAFLD groups exhibited diminished levels of specific BAs.In UFAs,particular acids exhibited a positive correlation with NAFLD risk in T2DM,while theω-6:ω-3 UFA ratio demonstrated a negative correlation.Levels ofα-linolenic acid andγ-linolenic acid were linked to significant liver fibrosis in NAFLD.The validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM patients.CONCLUSION This study underscores the connection between altered BA and UFA profiles and the presence of NAFLD in individuals with T2DM,proposing their potential as biomarkers in the pathogenesis of NAFLD.展开更多
An instrumented drilling system can be applied for the acquisition of drilling process parameters. The system can provide continuous and huge data for geotechnical engineering. However, due to the complexity of ground...An instrumented drilling system can be applied for the acquisition of drilling process parameters. The system can provide continuous and huge data for geotechnical engineering. However, due to the complexity of ground strata, the variation in the drilling parameters with stratigraphical characteristics is great and the correlation between likely comparable parameters is not high, which limits the use of conventional correlation approaches in this field. How to use the data for engineering and how to get a reasonable interpretation for the relationships among the drilling parameters, as well as between a drilling parameter and formational characteristics, become a technical choke point for the development and application of the instrumented drilling system. Based on similarity criteria, the extraction of sample data and characteristics, the pretreatment of data and feature matching algorithms have been analyzed and an approach of slope coefficient searching identification has been established. A case study was carried out for the similarity between the rotational speed of the drill bit, flushing pressure, and effective thrust force graphics in general weathered granite. The result shows that the similarity coefficients between the rotational speed of the drill bit, flushing pressure, and effective thrust force are 0.72 and 0.83, respectively. Although there are differences between the distances of the graphics, the curves of both rotational speed and flushing pressure agree with the effective thrust curve in shape, which provides a possible method for the identification of various formations by use of the similarity between feature drilling parameters.展开更多
Objective: Pulmonary nodules(PNs) are one of the imaging manifestations of early lung cancer screening,which should receive more attention. Traditional Chinese medicine believes that voice changes occur in patients wi...Objective: Pulmonary nodules(PNs) are one of the imaging manifestations of early lung cancer screening,which should receive more attention. Traditional Chinese medicine believes that voice changes occur in patients with pulmonary diseases. The purpose of this study is to explore the differences in phonetic characteristics between patients with PNs and able-bodied persons.Methods: This study explores the phonetic characteristics of patients with PNs in order to provide a simpler and cheaper method for PN screening. It is a case-control study to explore the differences in phonetic characteristics between individuals with and without PNs. This study performed non-parametric statistics on acoustic parameters of vocalizations, collected from January 2017 to March 2018 in Shanghai,China, from these two groups;it explores the differences in third and fourth acoustic parameters between patients with PNs and a normal control group. At the same time, computed tomography(CT) scans,course of disease, combined disease and other risk factors of the patients were collected in the form of questionnaire. According to the grouping of risk factors, the phonetic characteristics of the patients with PNs were analyzed.Results: This study was comprised of 200 patients with PNs, as confirmed by CT, and 86 healthy people that served as a control group. Among patients with PNs, 43% had ground glass opacity, 32% had nodules with a diameter ≥ 8 mm, 19% had a history of smoking and 31% had hyperlipidemia. Compared with the normal group, there were statistically significant differences in pitch, intensity and shimmer in patients with PNs. Among patients with PNs, patients with diameters ≥ 8 mm had a significantly higher third formant. There was a significant difference in intensity, fourth formant and harmonics-to-noise ratio(HNR)between smoking and non-smoking patients. Compared with non-hyperlipidemia patients, the pitch, jitter and shimmer of patients with PNs and hyperlipidemia were higher and the HNR was lower;these differences were statistically significant.Conclusion: This measurable changes in vocalizations can be in patients with PNs. Patients with PNs had lower and weaker voices. The size of PNs had an effect on the phonetic formant. Smoking may contribute to damage to the voice and formant changes. Voice damage is more pronounced in individuals who have PNs accompanied by hyperlipidemia.展开更多
基金Supported by the Scientific Research Projects of Jiangsu Provincial Health and Health Commission,No.ZDB2020034 and No.M2021056.
文摘BACKGROUND The understanding of bile acid(BA)and unsaturated fatty acid(UFA)profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2DM)coexisting with non-alcoholic fatty liver disease(NAFLD).Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in T2DM.AIM To identify potential metabolite biomarkers capable of distinguishing between NAFLD and T2DM.METHODS A training model was developed involving 399 participants,comprising 113 healthy controls(HCs),134 individuals with T2DM without NAFLD,and 152 individuals with T2DM and NAFLD.External validation encompassed 172 participants.NAFLD patients were divided based on liver fibrosis scores.The analytical approach employed univariate testing,orthogonal partial least squares-discriminant analysis,logistic regression,receiver operating characteristic curve analysis,and decision curve analysis to pinpoint and assess the diagnostic value of serum biomarkers.RESULTS Compared to HCs,both T2DM and NAFLD groups exhibited diminished levels of specific BAs.In UFAs,particular acids exhibited a positive correlation with NAFLD risk in T2DM,while theω-6:ω-3 UFA ratio demonstrated a negative correlation.Levels ofα-linolenic acid andγ-linolenic acid were linked to significant liver fibrosis in NAFLD.The validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM patients.CONCLUSION This study underscores the connection between altered BA and UFA profiles and the presence of NAFLD in individuals with T2DM,proposing their potential as biomarkers in the pathogenesis of NAFLD.
基金the Research Grant Council of HKSAP Government and Hong Kong Jockey Club Charities Trust (No.HKU7005/01E)the National Key Technologies R&D Program of China (No.2006BAB02A17)
文摘An instrumented drilling system can be applied for the acquisition of drilling process parameters. The system can provide continuous and huge data for geotechnical engineering. However, due to the complexity of ground strata, the variation in the drilling parameters with stratigraphical characteristics is great and the correlation between likely comparable parameters is not high, which limits the use of conventional correlation approaches in this field. How to use the data for engineering and how to get a reasonable interpretation for the relationships among the drilling parameters, as well as between a drilling parameter and formational characteristics, become a technical choke point for the development and application of the instrumented drilling system. Based on similarity criteria, the extraction of sample data and characteristics, the pretreatment of data and feature matching algorithms have been analyzed and an approach of slope coefficient searching identification has been established. A case study was carried out for the similarity between the rotational speed of the drill bit, flushing pressure, and effective thrust force graphics in general weathered granite. The result shows that the similarity coefficients between the rotational speed of the drill bit, flushing pressure, and effective thrust force are 0.72 and 0.83, respectively. Although there are differences between the distances of the graphics, the curves of both rotational speed and flushing pressure agree with the effective thrust curve in shape, which provides a possible method for the identification of various formations by use of the similarity between feature drilling parameters.
基金supported by the TCM Diagnosis Key Discipline of Administration of TCM of ChinaKey Laboratory of Health Identification and Assessment in Shanghai (No. 13DZ2261000)+1 种基金TCM Diagnosis Leading Academic Discipline Project of State Administration of TCM of ChinaSpecial Fund of Technical Standards by Science and Technology Commission of Shanghai (No.14DZ0500400)。
文摘Objective: Pulmonary nodules(PNs) are one of the imaging manifestations of early lung cancer screening,which should receive more attention. Traditional Chinese medicine believes that voice changes occur in patients with pulmonary diseases. The purpose of this study is to explore the differences in phonetic characteristics between patients with PNs and able-bodied persons.Methods: This study explores the phonetic characteristics of patients with PNs in order to provide a simpler and cheaper method for PN screening. It is a case-control study to explore the differences in phonetic characteristics between individuals with and without PNs. This study performed non-parametric statistics on acoustic parameters of vocalizations, collected from January 2017 to March 2018 in Shanghai,China, from these two groups;it explores the differences in third and fourth acoustic parameters between patients with PNs and a normal control group. At the same time, computed tomography(CT) scans,course of disease, combined disease and other risk factors of the patients were collected in the form of questionnaire. According to the grouping of risk factors, the phonetic characteristics of the patients with PNs were analyzed.Results: This study was comprised of 200 patients with PNs, as confirmed by CT, and 86 healthy people that served as a control group. Among patients with PNs, 43% had ground glass opacity, 32% had nodules with a diameter ≥ 8 mm, 19% had a history of smoking and 31% had hyperlipidemia. Compared with the normal group, there were statistically significant differences in pitch, intensity and shimmer in patients with PNs. Among patients with PNs, patients with diameters ≥ 8 mm had a significantly higher third formant. There was a significant difference in intensity, fourth formant and harmonics-to-noise ratio(HNR)between smoking and non-smoking patients. Compared with non-hyperlipidemia patients, the pitch, jitter and shimmer of patients with PNs and hyperlipidemia were higher and the HNR was lower;these differences were statistically significant.Conclusion: This measurable changes in vocalizations can be in patients with PNs. Patients with PNs had lower and weaker voices. The size of PNs had an effect on the phonetic formant. Smoking may contribute to damage to the voice and formant changes. Voice damage is more pronounced in individuals who have PNs accompanied by hyperlipidemia.
