Soil erosion is one of the most serious environmental issues,especially in vulnerable areas such as the Pisha sandstone regions located in the Loess Plateau(China).In these types of reliefs,long-term studies monitorin...Soil erosion is one of the most serious environmental issues,especially in vulnerable areas such as the Pisha sandstone regions located in the Loess Plateau(China).In these types of reliefs,long-term studies monitoring runoff and soil loss are scarce,and even more considering the efficiency of different soil management techniques applied to reduce land degradation.In this study,seven years(2014-2020)of in-situ measurements of surface runoff and soil loss for different land uses(forestland,shrubland,grassland,farmland,and bare land)in a Pisha Sandstone environment at the Loess Plateau were con-ducted.We applied the Water Erosion Prediction Project(WEPP)model combining the large database with the precipitation regimes.Our results showed that runoff volume coming from observed and simulated data exhibited significant differences among them depending on the different vegetation types.Runoff and soil loss were different among diverse land use types as follows:farmland>grassland>shrubland>forestland.After conducting a calibration,we found satisfactorily simulated surface runoff and sediment yield based on precipitation regimes and land uses at sandstone reliefs.Simulation performance of surface runoff was better than sediment yield.The range of standard error of the model simulation for event and annual values of runoff were 4.71 mm and 12.19 mm,respectively.The standard error for event and annual values of soil loss were 4.19 t/hm^(2)and 21.86 t/hm^(2).In the calibration group,R2 of runoff and soil loss were 0.92 and 0.86 respectively,while Nash-Sutcliffe coefficient(E)reached 0.90 and 0.85,respectively.In the validation group,the R2 for both runoff and soil loss were 0.82 and 0.56,respectively.Nash-Sutcliffe coefficient(E)were 0.77 and 0.54 for the runoff and sediment yield.We concluded that using a detailed monitoring dataset,the WEPP model could accu-rately simulate and predict water erosion in the hillslopes of Pisha sandstone area.展开更多
Importance:Pediatric palliative care(PPC)is an interdisciplinary collaboration that focuses on the prevention and relief of patient suffering.PPC has emerged as a critical field of medical expertise and practice.Howev...Importance:Pediatric palliative care(PPC)is an interdisciplinary collaboration that focuses on the prevention and relief of patient suffering.PPC has emerged as a critical field of medical expertise and practice.However,no information is available regarding the progress of PPC in the Chinese mainland.Objective:This study investigated the geographic distribution,team structure,and services of PPC teams in the Chinese mainland.It also investigated the level of understanding and implementation among pediatric oncologists regarding PPC.Methods:The PPC subspecialty group of the Pediatrics Society of the Chinese Medical Association included 45 PPC teams.The team structure and services were investigated using questionnaires mailed to the team leader of each PPC team.In addition,we sent questionnaires regarding the level of PPC understanding and implementation of PPC practices to 170 pediatric oncologists in 11 hospitals.Results:The geographical distribution of PPC teams is uneven in China.Most PPC teams are concentrated in the eastern provincial capital of China.Most PPC teams had limited staff and services.The level of PPC understanding was considerably limited across all demographics;most pediatric oncologists reported“some understanding”(n=71,41.8%)or“poor understanding”(n=50,29.4%).Only 62.9%of pediatric oncologists had experience providing advice to family members regarding PPC matters.Interpretation:China is currently experiencing a critical shortage of PPC resources.Most pediatric oncologists had a limited understanding of PPC and reported limited practical implementation of PPC,which leads to underutilization of PPC resources.展开更多
Our aim is to examine the impact of DICER1 mutations on the pathogenesis of pleuropulmonary blastoma(PPB) by evaluating the mutation frequency and investigating the family history of Chinese patients with PPB. The fam...Our aim is to examine the impact of DICER1 mutations on the pathogenesis of pleuropulmonary blastoma(PPB) by evaluating the mutation frequency and investigating the family history of Chinese patients with PPB. The family histories of 12 children with PPB recruited consecutively were surveyed. Blood samples from patients and their first-degree relatives were tested for DICER1 mutations. Whole-genome sequencing of blood samples and formalin-fixed and paraffin-embedded(FFPE) tumor tissue was performed in one family with twins. Twelve patients with PPB included six type II and six type III cases. Seven of the12 patients harbored DICER1 mutations, six of which were frameshift or nonsense mutations. Another case carried a germline DICER1 mutation affecting the splice site. FFPE sample had a nonsense mutation in TDG and missense mutations in DICER1.In addition, two cases with DICER1 mutations were found to have lung cysts preceding the diagnosis of PPB. Furthermore, one patient had a family history remarkable for thyroid diseases. Our results indicate that the germline mutation frequency in Chinese patients with PPB is similar to the ones reported for patients from USA, UK, and Japan. Moreover, our study strongly suggests that investigating the family history and detecting germline DICER1 mutations might be of benefit to increasing awareness and improving the accuracy of the differential diagnosis of PPB from non-malignant lung cysts.展开更多
Importance:Childhood solid tumors account for the highest proportion of childhood cancers and are one of the leading causes of death in childhood.However,their pathogenesis is unclear.Objective:To explore prenatal and...Importance:Childhood solid tumors account for the highest proportion of childhood cancers and are one of the leading causes of death in childhood.However,their pathogenesis is unclear.Objective:To explore prenatal and perinatal risk factors for solid malignancies in children.Methods:We enrolled 71 consecutive pediatric patients (44 boys and 27 girls;median age,30 months) with solid tumors who were diagnosed and treated at our center from January 2013 to December 2016 as the case group.We also enrolled 211 age-and residence-matched healthy children (ratio of approximately 3:1 with the case group) as the control group.We conducted a questionnaire-based survey with the parents of these 282 children.Univariate and multivariate conditional logistic regression analyses of the collected data were performed.Results:Confirmed solid malignancies included neuroblastoma (n =32),rhabdomyosarcoma (n =18),retinoblastoma (n =7),renal tumors (n =3),and other tumors (n =11).Risk factors for solid childhood tumors in the univariate analysis were the parents' age,gravidity,parity,abortion history,vaginal bleeding,family history of malignancy,and prenatal use of folic acid or hematinics/iron supplements (P ＜ 0.05),and those in the multivariate analysis were higher parity (odds ratio [OR],2.482;95％ confidence interval [CI],1.521-4.048),family history of malignancy (OR,3.667;95％ CI,1.679-8.009),and prenatal use of hematinics/iron supplements (OR,2.882;95％ CI,1.440-5.767).In contrast,use of prenatal folic acid was protective (OR,0.334;95％ CI,0.160-0.694).Interpretation:A family history of malignancy,use of prenatal hematinics/iron supplements,and higher parity are risk factors for solid childhood tumors,whereas use of prenatal folic acid is a protective factor.展开更多
基金supported by the National Key Research and Development Program(2022YFF1300803)National Natural Science Foundation of China(42177310)the Water Conservancy Development Project of the Inner Mongolia Autonomous Region(Research on Classification and Evaluation System for Construction Objectives of Huangfuchuan Eco-clean Watershed,NSK2022-03).
文摘Soil erosion is one of the most serious environmental issues,especially in vulnerable areas such as the Pisha sandstone regions located in the Loess Plateau(China).In these types of reliefs,long-term studies monitoring runoff and soil loss are scarce,and even more considering the efficiency of different soil management techniques applied to reduce land degradation.In this study,seven years(2014-2020)of in-situ measurements of surface runoff and soil loss for different land uses(forestland,shrubland,grassland,farmland,and bare land)in a Pisha Sandstone environment at the Loess Plateau were con-ducted.We applied the Water Erosion Prediction Project(WEPP)model combining the large database with the precipitation regimes.Our results showed that runoff volume coming from observed and simulated data exhibited significant differences among them depending on the different vegetation types.Runoff and soil loss were different among diverse land use types as follows:farmland>grassland>shrubland>forestland.After conducting a calibration,we found satisfactorily simulated surface runoff and sediment yield based on precipitation regimes and land uses at sandstone reliefs.Simulation performance of surface runoff was better than sediment yield.The range of standard error of the model simulation for event and annual values of runoff were 4.71 mm and 12.19 mm,respectively.The standard error for event and annual values of soil loss were 4.19 t/hm^(2)and 21.86 t/hm^(2).In the calibration group,R2 of runoff and soil loss were 0.92 and 0.86 respectively,while Nash-Sutcliffe coefficient(E)reached 0.90 and 0.85,respectively.In the validation group,the R2 for both runoff and soil loss were 0.82 and 0.56,respectively.Nash-Sutcliffe coefficient(E)were 0.77 and 0.54 for the runoff and sediment yield.We concluded that using a detailed monitoring dataset,the WEPP model could accu-rately simulate and predict water erosion in the hillslopes of Pisha sandstone area.
基金The Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Municipal Administration of Hospitals(No.XTCX201812)Management Research Project of Beijing Children’s Hospital,Capital Medical University(No.YGLQ202001)。
文摘Importance:Pediatric palliative care(PPC)is an interdisciplinary collaboration that focuses on the prevention and relief of patient suffering.PPC has emerged as a critical field of medical expertise and practice.However,no information is available regarding the progress of PPC in the Chinese mainland.Objective:This study investigated the geographic distribution,team structure,and services of PPC teams in the Chinese mainland.It also investigated the level of understanding and implementation among pediatric oncologists regarding PPC.Methods:The PPC subspecialty group of the Pediatrics Society of the Chinese Medical Association included 45 PPC teams.The team structure and services were investigated using questionnaires mailed to the team leader of each PPC team.In addition,we sent questionnaires regarding the level of PPC understanding and implementation of PPC practices to 170 pediatric oncologists in 11 hospitals.Results:The geographical distribution of PPC teams is uneven in China.Most PPC teams are concentrated in the eastern provincial capital of China.Most PPC teams had limited staff and services.The level of PPC understanding was considerably limited across all demographics;most pediatric oncologists reported“some understanding”(n=71,41.8%)or“poor understanding”(n=50,29.4%).Only 62.9%of pediatric oncologists had experience providing advice to family members regarding PPC matters.Interpretation:China is currently experiencing a critical shortage of PPC resources.Most pediatric oncologists had a limited understanding of PPC and reported limited practical implementation of PPC,which leads to underutilization of PPC resources.
基金supported by the Beijing Training Plan of TOP-notch Personnel (CIT&TCD201304189)
文摘Our aim is to examine the impact of DICER1 mutations on the pathogenesis of pleuropulmonary blastoma(PPB) by evaluating the mutation frequency and investigating the family history of Chinese patients with PPB. The family histories of 12 children with PPB recruited consecutively were surveyed. Blood samples from patients and their first-degree relatives were tested for DICER1 mutations. Whole-genome sequencing of blood samples and formalin-fixed and paraffin-embedded(FFPE) tumor tissue was performed in one family with twins. Twelve patients with PPB included six type II and six type III cases. Seven of the12 patients harbored DICER1 mutations, six of which were frameshift or nonsense mutations. Another case carried a germline DICER1 mutation affecting the splice site. FFPE sample had a nonsense mutation in TDG and missense mutations in DICER1.In addition, two cases with DICER1 mutations were found to have lung cysts preceding the diagnosis of PPB. Furthermore, one patient had a family history remarkable for thyroid diseases. Our results indicate that the germline mutation frequency in Chinese patients with PPB is similar to the ones reported for patients from USA, UK, and Japan. Moreover, our study strongly suggests that investigating the family history and detecting germline DICER1 mutations might be of benefit to increasing awareness and improving the accuracy of the differential diagnosis of PPB from non-malignant lung cysts.
文摘Importance:Childhood solid tumors account for the highest proportion of childhood cancers and are one of the leading causes of death in childhood.However,their pathogenesis is unclear.Objective:To explore prenatal and perinatal risk factors for solid malignancies in children.Methods:We enrolled 71 consecutive pediatric patients (44 boys and 27 girls;median age,30 months) with solid tumors who were diagnosed and treated at our center from January 2013 to December 2016 as the case group.We also enrolled 211 age-and residence-matched healthy children (ratio of approximately 3:1 with the case group) as the control group.We conducted a questionnaire-based survey with the parents of these 282 children.Univariate and multivariate conditional logistic regression analyses of the collected data were performed.Results:Confirmed solid malignancies included neuroblastoma (n =32),rhabdomyosarcoma (n =18),retinoblastoma (n =7),renal tumors (n =3),and other tumors (n =11).Risk factors for solid childhood tumors in the univariate analysis were the parents' age,gravidity,parity,abortion history,vaginal bleeding,family history of malignancy,and prenatal use of folic acid or hematinics/iron supplements (P ＜ 0.05),and those in the multivariate analysis were higher parity (odds ratio [OR],2.482;95％ confidence interval [CI],1.521-4.048),family history of malignancy (OR,3.667;95％ CI,1.679-8.009),and prenatal use of hematinics/iron supplements (OR,2.882;95％ CI,1.440-5.767).In contrast,use of prenatal folic acid was protective (OR,0.334;95％ CI,0.160-0.694).Interpretation:A family history of malignancy,use of prenatal hematinics/iron supplements,and higher parity are risk factors for solid childhood tumors,whereas use of prenatal folic acid is a protective factor.
