The energy spectrum of energetic electrons is a key factor representing the dynamic variations of Earth’s Van Allen radiation belts.Increased measurements have indicated that the commonly used Maxwellian and Kappa di...The energy spectrum of energetic electrons is a key factor representing the dynamic variations of Earth’s Van Allen radiation belts.Increased measurements have indicated that the commonly used Maxwellian and Kappa distributions are inadequate for capturing the realistic spectral distributions of radiation belt electrons.Here we adopt the Kappa-type(KT)distribution as the fitting function and perform a statistical analysis to investigate the radiation belt electron flux spectra observed by the Van Allen Probes.By calculating the optimal values of the key KT distribution parameters(i.e.,κandθ2)from the observed spectral shapes,we fit the radiation belt electron fluxes at different L-shells under different geomagnetic conditions.In this manner,we obtain typical values of the KT distribution parameters,which are statistically feasible for modeling the radiation belt electron flux profiles during either geomagnetically quiet or active periods.A comparison of the KT distribution model results with those using the Maxwellian or Kappa distribution reveals the advantage of the KT distribution for studying the overall properties of the radiation belt electron spectral distribution,which has important implications for deepening the current understanding of the radiation belt electron dynamics under evolving geomagnetic conditions.展开更多
Objective To investigate the association between preoperative,operative,and postoperative factors and persistent pleural effusion after the extracardiac Fontan procedure. Methods Ninety-five consecutive patients diagn...Objective To investigate the association between preoperative,operative,and postoperative factors and persistent pleural effusion after the extracardiac Fontan procedure. Methods Ninety-five consecutive patients diagnosed with univentricular heart underwent extracardiac connection using Gore-Tax conduits at the Department of Children’s Heart Centre,Justus-Liebig-University Giessen in Germany from June 1996 to July 2007. The outcome measures were duration and volume of chest tube drainage after surgical intervention. The investigated factors included age and weight at the time of operation,anatomical diagnosis,preoperative oxygen saturation,mean pulmonary artery pressure,ventricular end-diastolic pressure,fenestration,cardiopulmonary bypass time,conduit size,postoperative pulmonary artery pressure,administration of angiotensin-converting enzyme inhibitors,and postoperative infection. Associations between these factors and persistent pleural effusion after the extracardiac Fontan procedure were analyzed. Results Every patient suffered postoperative effusion. The median duration of postoperative chest tube drainage was 9 days (range,3-69 days),and the median volume was 12 mL·kg-1·d-1 (range,2.0-37.5 mL·kg-1·d-1). Thirty-seven (38.9%) patients had pleural drainage for more than 15 days,and the volume in 35 (36.8%) patients exceeded 25 mL·kg-1·d-1. Nineteen (20%) patients required placement of additional chest tubes for re-accumulation of pleural effusion after removal of previous chest tubes. Fifteen (17.8%) patients were hospitalized again due to pleural effusion after discharge. The median length of hospital stay after the operation was 14 days (range,4-78 days). Multivariate analysis results showed that non-fenestration,low preoperative oxygen saturation,and postoperative infections were independent risk factors for prolonged duration of pleural drainage (P<0.05). Long cardiopulmonary bypass time,non-fenestration,small conduit size,and low preoperative oxygen saturation were independent risk factors for excessive volume of pleural drainage (P<0.05).Conclusions For reduing postoperative duration and volume of pleural drainage following Fontan procedure,it seems to be important to improve the preoperative oxygen saturation,use large size of conduit,shorten cardiopulmonary bypass time,and make fenestration during the operation,as well as avoid postoperative infections.展开更多
Because radiation belt electrons can pose a potential threat to the safety of satellites orbiting in space,it is of great importance to develop a reliable model that can predict the highly dynamic variations in outer ...Because radiation belt electrons can pose a potential threat to the safety of satellites orbiting in space,it is of great importance to develop a reliable model that can predict the highly dynamic variations in outer radiation belt electron fluxes.In the present study,we develop a forecast model of radiation belt electron fluxes based on the data assimilation method,in terms of Van Allen Probe measurements combined with three-dimensional radiation belt numerical simulations.Our forecast model can cover the entire outer radiation belt with a high temporal resolution(1 hour)and a spatial resolution of 0.25 L over a wide range of both electron energy(0.1-5.0 MeV)and pitch angle(5°-90°).On the basis of this model,we forecast hourly electron fluxes for the next 1,2,and 3 days during an intense geomagnetic storm and evaluate the corresponding prediction performance.Our model can reasonably predict the stormtime evolution of radiation belt electrons with high prediction efficiency(up to~0.8-1).The best prediction performance is found for~0.3-3 MeV electrons at L=~3.25-4.5,which extends to higher L and lower energies with increasing pitch angle.Our results demonstrate that the forecast model developed can be a powerful tool to predict the spatiotemporal changes in outer radiation belt electron fluxes,and the model has both scientific significance and practical implications.展开更多
The pitch angle distributions of ions and electrons can be affected by various processes;thus,they can serve as an important indicator of the physical mechanisms driving the dynamics of space plasmas.From observations...The pitch angle distributions of ions and electrons can be affected by various processes;thus,they can serve as an important indicator of the physical mechanisms driving the dynamics of space plasmas.From observations from the Mars Ion and Neutral Particle Analyzer onboard the Tianwen-1 orbiter,we calculated the pitch angle distributions of protons in the Martian induced magnetosphere by using information from the magnetohydrodynamically simulated magnetic field,and we statistically analyzed the spatial occurrence pattern of different types of pitch angle distributions.Even though no symmetrical features were seen in the dataset,we found the dominance of the field-aligned distribution type over the energy range from 188 to 6232 eV.Maps of the occurrence rate showed the preferential presence of a trapped-like distribution at the lower altitudes of the surveyed nightside region.Although our results are more or less restricted by the adopted magnetic field,they indicate the complexity of the near-Mars proton pitch angle distributions and infer the possibility of wave–particle interactions in the Martian induced magnetosphere.展开更多
The Macao Science Satellite-1(MSS-1),designed by the Macao University of Science and Technology and the National Space Science Center(NSSC)of China,is equipped to detect the fine structure of the magnetic field over t...The Macao Science Satellite-1(MSS-1),designed by the Macao University of Science and Technology and the National Space Science Center(NSSC)of China,is equipped to detect the fine structure of the magnetic field over the South Atlantic Anomaly(SAA)region,monitoring geomagnetic field variations,and obtaining the energetic electron spectrum distributions in the Earth’s inner radiation belt.In this study,we simulate the distributions of trapped,quasi-trapped,and untrapped electrons along the orbit of MSS-1 based on a drift-source model.The simulation results show that the particle detector with 90°looking direction can observe trapped electrons in the SAA region,untrapped electrons in the regions conjugated with the SAA region at the north hemisphere,and quasitrapped electrons in all other regions.In contrast,the detectors with<60°looking directions can measure only untrapped electrons.Generally,quasi-trapped electron fluxes accumulate along the drift trajectory and are due primarily to CRAND,until reaching the SAA region where quasi-trapped electrons are all lost into the atmosphere.展开更多
Non-traumatic osteonecrosis of the femoral head(NONFH)is one of the most common orthopedic diseases,influenced by multiple signaling pathways and inflammatory factors.The PI3K/AKT signaling pathway is closely related ...Non-traumatic osteonecrosis of the femoral head(NONFH)is one of the most common orthopedic diseases,influenced by multiple signaling pathways and inflammatory factors.The PI3K/AKT signaling pathway is closely related to various biological processes such as apoptosis,autophagy,and metabolism in cells.Increasing evidence suggests that it plays an important role in the development of femoral head necrosis.This paper aims to explore the mechanism of the PI3K/AKT signaling pathway in the pathogenesis of NONFH by analyzing its regulation of lipid metabolism,cell apoptosis and autophagy,and intravascular coagulation.This study provides new insights for the research of NONFH.展开更多
为了研究变循环发动机(Variable Cycle Engine,VCE)多维度仿真模型中整机零维仿真模型与核心机驱动风扇级(Core Driven Fan Stage,CDFS)三维仿真模型之间边界参数传递处理方式对计算结果的影响,建立了CDFS和前可变面积涵道引射器(Forwar...为了研究变循环发动机(Variable Cycle Engine,VCE)多维度仿真模型中整机零维仿真模型与核心机驱动风扇级(Core Driven Fan Stage,CDFS)三维仿真模型之间边界参数传递处理方式对计算结果的影响,建立了CDFS和前可变面积涵道引射器(Forward Variable Area Bypass Injector,FVABI)耦合三维仿真模型及CDFS单部件三维仿真模型,对比了CDFS工作特性及出口区域静压分布的差异,并采用迭代耦合方法将CDFS工作特性耦合于循环参数分析,研究了CDFS出口静压分布差异对VCE多维度仿真模型计算结果的影响。结果表明,耦合仿真模型中CDFS稳定工作范围随着内涵出口静压变化而变化,其数值喘振点的换算流量与CDFS单部件仿真模型存在明显的差异。FVABI部件的存在降低了内涵出口及FVABI出口的平均静压边界条件对CDFS出口区域静压分布的影响,而且CDFS内、外涵流量分配会显著影响CDFS出口区域的静压分布。因此,由耦合仿真模型得到的CDFS出口区域静压分布更为真实、合理。超声速巡航工况下,相较于在CDFS出口使用平均静压边界条件,VCE多维度仿真模型在使用真实静压分布之后,CDFS内涵压比和等熵效率基本不变,CDFS外涵压比和等熵效率分别降低了0.86%和2.27%,导致VCE推力升高了0.41%,且迭代次数大幅降低。展开更多
Radiation belt electron dropouts indicate electron flux decay to the background level during geomagnetic storms,which is commonly attributed to the effects of wave-induced pitch angle scattering and magnetopause shado...Radiation belt electron dropouts indicate electron flux decay to the background level during geomagnetic storms,which is commonly attributed to the effects of wave-induced pitch angle scattering and magnetopause shadowing.To investigate the loss mechanisms of radiation belt electron dropouts triggered by a solar wind dynamic pressure pulse event on 12 September 2014,we comprehensively analyzed the particle and wave measurements from Van Allen Probes.The dropout event was divided into three periods:before the storm,the initial phase of the storm,and the main phase of the storm.The electron pitch angle distributions(PADs)and electron flux dropouts during the initial and main phases of this storm were investigated,and the evolution of the radial profile of electron phase space density(PSD)and the(μ,K)dependence of electron PSD dropouts(whereμ,K,and L^*are the three adiabatic invariants)were analyzed.The energy-independent decay of electrons at L>4.5 was accompanied by butterfly PADs,suggesting that the magnetopause shadowing process may be the major loss mechanism during the initial phase of the storm at L>4.5.The features of electron dropouts and 90°-peaked PADs were observed only for>1 MeV electrons at L<4,indicating that the wave-induced scattering effect may dominate the electron loss processes at the lower L-shell during the main phase of the storm.Evaluations of the(μ,K)dependence of electron PSD drops and calculations of the minimum electron resonant energies of H+-band electromagnetic ion cyclotron(EMIC)waves support the scenario that the observed PSD drop peaks around L^*=3.9 may be caused mainly by the scattering of EMIC waves,whereas the drop peaks around L^*=4.6 may result from a combination of EMIC wave scattering and outward radial diffusion.展开更多
基金the National Natural Science Foundation of China(Grant Nos.42188101,42025404,41974186,42174188,and 42204160)the National Key R&D Program of China(Grant No.2022YFF0503700)+2 种基金the B-type Strategic Priority Program of the Chinese Academy of Sciences(Grant No.XDB41000000)the Fundamental Research Funds for the Central Universities(Grant Nos.2042022kf1016 and 2042023kf1025)the China Postdoctoral Science Foundation(Grant No.2022M722447)。
文摘The energy spectrum of energetic electrons is a key factor representing the dynamic variations of Earth’s Van Allen radiation belts.Increased measurements have indicated that the commonly used Maxwellian and Kappa distributions are inadequate for capturing the realistic spectral distributions of radiation belt electrons.Here we adopt the Kappa-type(KT)distribution as the fitting function and perform a statistical analysis to investigate the radiation belt electron flux spectra observed by the Van Allen Probes.By calculating the optimal values of the key KT distribution parameters(i.e.,κandθ2)from the observed spectral shapes,we fit the radiation belt electron fluxes at different L-shells under different geomagnetic conditions.In this manner,we obtain typical values of the KT distribution parameters,which are statistically feasible for modeling the radiation belt electron flux profiles during either geomagnetically quiet or active periods.A comparison of the KT distribution model results with those using the Maxwellian or Kappa distribution reveals the advantage of the KT distribution for studying the overall properties of the radiation belt electron spectral distribution,which has important implications for deepening the current understanding of the radiation belt electron dynamics under evolving geomagnetic conditions.
文摘Objective To investigate the association between preoperative,operative,and postoperative factors and persistent pleural effusion after the extracardiac Fontan procedure. Methods Ninety-five consecutive patients diagnosed with univentricular heart underwent extracardiac connection using Gore-Tax conduits at the Department of Children’s Heart Centre,Justus-Liebig-University Giessen in Germany from June 1996 to July 2007. The outcome measures were duration and volume of chest tube drainage after surgical intervention. The investigated factors included age and weight at the time of operation,anatomical diagnosis,preoperative oxygen saturation,mean pulmonary artery pressure,ventricular end-diastolic pressure,fenestration,cardiopulmonary bypass time,conduit size,postoperative pulmonary artery pressure,administration of angiotensin-converting enzyme inhibitors,and postoperative infection. Associations between these factors and persistent pleural effusion after the extracardiac Fontan procedure were analyzed. Results Every patient suffered postoperative effusion. The median duration of postoperative chest tube drainage was 9 days (range,3-69 days),and the median volume was 12 mL·kg-1·d-1 (range,2.0-37.5 mL·kg-1·d-1). Thirty-seven (38.9%) patients had pleural drainage for more than 15 days,and the volume in 35 (36.8%) patients exceeded 25 mL·kg-1·d-1. Nineteen (20%) patients required placement of additional chest tubes for re-accumulation of pleural effusion after removal of previous chest tubes. Fifteen (17.8%) patients were hospitalized again due to pleural effusion after discharge. The median length of hospital stay after the operation was 14 days (range,4-78 days). Multivariate analysis results showed that non-fenestration,low preoperative oxygen saturation,and postoperative infections were independent risk factors for prolonged duration of pleural drainage (P<0.05). Long cardiopulmonary bypass time,non-fenestration,small conduit size,and low preoperative oxygen saturation were independent risk factors for excessive volume of pleural drainage (P<0.05).Conclusions For reduing postoperative duration and volume of pleural drainage following Fontan procedure,it seems to be important to improve the preoperative oxygen saturation,use large size of conduit,shorten cardiopulmonary bypass time,and make fenestration during the operation,as well as avoid postoperative infections.
基金supported by the National Natural Science Foundation of China (Grant Nos. 42025404, 42188101, and 42241143)the National Key R&D Program of China (Grant Nos. 2022YFF0503700 and 2022YFF0503900)+1 种基金the B-type Strategic Priority Program of the Chinese Academy of Sciences (Grant No. XDB41000000)the Fundamental Research Funds for the Central Universities (Grant No. 2042022kf1012)
文摘Because radiation belt electrons can pose a potential threat to the safety of satellites orbiting in space,it is of great importance to develop a reliable model that can predict the highly dynamic variations in outer radiation belt electron fluxes.In the present study,we develop a forecast model of radiation belt electron fluxes based on the data assimilation method,in terms of Van Allen Probe measurements combined with three-dimensional radiation belt numerical simulations.Our forecast model can cover the entire outer radiation belt with a high temporal resolution(1 hour)and a spatial resolution of 0.25 L over a wide range of both electron energy(0.1-5.0 MeV)and pitch angle(5°-90°).On the basis of this model,we forecast hourly electron fluxes for the next 1,2,and 3 days during an intense geomagnetic storm and evaluate the corresponding prediction performance.Our model can reasonably predict the stormtime evolution of radiation belt electrons with high prediction efficiency(up to~0.8-1).The best prediction performance is found for~0.3-3 MeV electrons at L=~3.25-4.5,which extends to higher L and lower energies with increasing pitch angle.Our results demonstrate that the forecast model developed can be a powerful tool to predict the spatiotemporal changes in outer radiation belt electron fluxes,and the model has both scientific significance and practical implications.
基金supported by the National Natural Science Foundation of China(Grant No.42241143)the pre-research projects on Civil Aerospace Technologies(No.D020104)funded by the China National Space Administration.
文摘The pitch angle distributions of ions and electrons can be affected by various processes;thus,they can serve as an important indicator of the physical mechanisms driving the dynamics of space plasmas.From observations from the Mars Ion and Neutral Particle Analyzer onboard the Tianwen-1 orbiter,we calculated the pitch angle distributions of protons in the Martian induced magnetosphere by using information from the magnetohydrodynamically simulated magnetic field,and we statistically analyzed the spatial occurrence pattern of different types of pitch angle distributions.Even though no symmetrical features were seen in the dataset,we found the dominance of the field-aligned distribution type over the energy range from 188 to 6232 eV.Maps of the occurrence rate showed the preferential presence of a trapped-like distribution at the lower altitudes of the surveyed nightside region.Although our results are more or less restricted by the adopted magnetic field,they indicate the complexity of the near-Mars proton pitch angle distributions and infer the possibility of wave–particle interactions in the Martian induced magnetosphere.
基金supported by the National Natural Science Foundation of China(Grant Nos.42188101,42174190,42025404,41904143,41974186,and 41904144)the Fundamental Research Funds for the Central Universities(2042021kf0016)+2 种基金the B-type Strategic Priority Program of the Chinese Academy of Sciences(Grant No.XDB41000000)the pre-research projects on Civil Aerospace Technologies funded by the China National Space Administration(Grant Nos.D020303,D020308,D020104)the China Postdoctoral Science Foundation Project(Grant No.2019M662700,2020M672405)。
文摘The Macao Science Satellite-1(MSS-1),designed by the Macao University of Science and Technology and the National Space Science Center(NSSC)of China,is equipped to detect the fine structure of the magnetic field over the South Atlantic Anomaly(SAA)region,monitoring geomagnetic field variations,and obtaining the energetic electron spectrum distributions in the Earth’s inner radiation belt.In this study,we simulate the distributions of trapped,quasi-trapped,and untrapped electrons along the orbit of MSS-1 based on a drift-source model.The simulation results show that the particle detector with 90°looking direction can observe trapped electrons in the SAA region,untrapped electrons in the regions conjugated with the SAA region at the north hemisphere,and quasitrapped electrons in all other regions.In contrast,the detectors with<60°looking directions can measure only untrapped electrons.Generally,quasi-trapped electron fluxes accumulate along the drift trajectory and are due primarily to CRAND,until reaching the SAA region where quasi-trapped electrons are all lost into the atmosphere.
文摘Non-traumatic osteonecrosis of the femoral head(NONFH)is one of the most common orthopedic diseases,influenced by multiple signaling pathways and inflammatory factors.The PI3K/AKT signaling pathway is closely related to various biological processes such as apoptosis,autophagy,and metabolism in cells.Increasing evidence suggests that it plays an important role in the development of femoral head necrosis.This paper aims to explore the mechanism of the PI3K/AKT signaling pathway in the pathogenesis of NONFH by analyzing its regulation of lipid metabolism,cell apoptosis and autophagy,and intravascular coagulation.This study provides new insights for the research of NONFH.
文摘为了研究变循环发动机(Variable Cycle Engine,VCE)多维度仿真模型中整机零维仿真模型与核心机驱动风扇级(Core Driven Fan Stage,CDFS)三维仿真模型之间边界参数传递处理方式对计算结果的影响,建立了CDFS和前可变面积涵道引射器(Forward Variable Area Bypass Injector,FVABI)耦合三维仿真模型及CDFS单部件三维仿真模型,对比了CDFS工作特性及出口区域静压分布的差异,并采用迭代耦合方法将CDFS工作特性耦合于循环参数分析,研究了CDFS出口静压分布差异对VCE多维度仿真模型计算结果的影响。结果表明,耦合仿真模型中CDFS稳定工作范围随着内涵出口静压变化而变化,其数值喘振点的换算流量与CDFS单部件仿真模型存在明显的差异。FVABI部件的存在降低了内涵出口及FVABI出口的平均静压边界条件对CDFS出口区域静压分布的影响,而且CDFS内、外涵流量分配会显著影响CDFS出口区域的静压分布。因此,由耦合仿真模型得到的CDFS出口区域静压分布更为真实、合理。超声速巡航工况下,相较于在CDFS出口使用平均静压边界条件,VCE多维度仿真模型在使用真实静压分布之后,CDFS内涵压比和等熵效率基本不变,CDFS外涵压比和等熵效率分别降低了0.86%和2.27%,导致VCE推力升高了0.41%,且迭代次数大幅降低。
基金This work was supported by the B-type Strategic Priority Program of the Chinese Academy of Sciences(grant no.XDB41000000)the National Natural Science Foundation of China(grant nos.42025404,41704162,41974186,41674163,41904144,41904143)+1 种基金the pre-research projects on Civil Aerospace Technologies(grant nos.D020303,D020308,D020104)the China National Space Administration,and the China Postdoctoral Science Foundation Project(grant no.2019M662700).We also acknowledge the Van Allen Probes mission,particularly the ECT and EMFISIS team,for providing particle and wave data.The electron flux data were obtained from http://www.rbsp-ect.lanl.gov/data_pub/.The wave data from the EMFISIS instrument were obtained from http://emfisis.physics.uiowa.edu/data/index.The solar wind parameters and geomagnetic indices were obtained from the online OMNIWeb(http://omniweb.gsfc.nasa.gov/).
文摘Radiation belt electron dropouts indicate electron flux decay to the background level during geomagnetic storms,which is commonly attributed to the effects of wave-induced pitch angle scattering and magnetopause shadowing.To investigate the loss mechanisms of radiation belt electron dropouts triggered by a solar wind dynamic pressure pulse event on 12 September 2014,we comprehensively analyzed the particle and wave measurements from Van Allen Probes.The dropout event was divided into three periods:before the storm,the initial phase of the storm,and the main phase of the storm.The electron pitch angle distributions(PADs)and electron flux dropouts during the initial and main phases of this storm were investigated,and the evolution of the radial profile of electron phase space density(PSD)and the(μ,K)dependence of electron PSD dropouts(whereμ,K,and L^*are the three adiabatic invariants)were analyzed.The energy-independent decay of electrons at L>4.5 was accompanied by butterfly PADs,suggesting that the magnetopause shadowing process may be the major loss mechanism during the initial phase of the storm at L>4.5.The features of electron dropouts and 90°-peaked PADs were observed only for>1 MeV electrons at L<4,indicating that the wave-induced scattering effect may dominate the electron loss processes at the lower L-shell during the main phase of the storm.Evaluations of the(μ,K)dependence of electron PSD drops and calculations of the minimum electron resonant energies of H+-band electromagnetic ion cyclotron(EMIC)waves support the scenario that the observed PSD drop peaks around L^*=3.9 may be caused mainly by the scattering of EMIC waves,whereas the drop peaks around L^*=4.6 may result from a combination of EMIC wave scattering and outward radial diffusion.
