目的:观察翼状胬肉切除联合自体带角膜缘上皮的球结膜移植术治疗翼状胬肉患者的疗效观察。方法:前瞻性对照研究。选取2015-10/2019-10于我院接受治疗的翼状胬肉患者102例102眼,按随机数字表法分为两组:对照组行翼状胬肉切除联合羊膜移...目的:观察翼状胬肉切除联合自体带角膜缘上皮的球结膜移植术治疗翼状胬肉患者的疗效观察。方法:前瞻性对照研究。选取2015-10/2019-10于我院接受治疗的翼状胬肉患者102例102眼,按随机数字表法分为两组:对照组行翼状胬肉切除联合羊膜移植术治疗51眼,观察组行翼状胬肉切除联合自体带角膜缘上皮的球结膜移植术治疗51眼。比较两组患者术中失血量、手术时间、角膜上皮修复时间及术后3mo临床疗效,并记录手术前后泪膜破裂时间(BUT)、裸眼视力(UCVA)、泪液分泌试验(SⅠt)、角膜散光度(CAD)变化情况,以及术后治疗美学量表评分比较和随访过程中的复发情况。结果:观察组患者角膜上皮修复时间短于对照组(4.14±1.35 vs 4.72±1.37d,P<0.05),手术时间长于对照组(32.24±6.69 vs 29.67±5.21min,P<0.05),而两组术中失血量比较无差异(P>0.05);术后3mo,两组患者治疗有效率比较无差异(86.3%vs 78.4%,P>0.05),BUT、UCVA、SⅠt较术前均显著上升(均P<0.05),且观察组UCVA、SⅠt显著高于对照组(均P<0.05),两组BUT比较无差异(P>0.05),两组CAD较术前均显著下降(均P<0.05),但组间比较无差异(P>0.05);术后3mo,观察组翼状胬肉治疗美学量表中眼部恢复、自觉症状评分均显著高于对照组(均P<0.05),而两组间术区清洁及充血情况评分比较无差异(均P>0.05);两组随访期间的复发率比较无差异(P>0.05)。结论:翼状胬肉切除联合自体带角膜缘上皮的球结膜移植术可有效治疗翼状胬肉,防止复发,相比于翼状胬肉切除联合羊膜移植术,患者术后恢复更快,美观度更佳。展开更多
Curcumae Longae Rhizoma(CLR)is the rhizome of Curcuma longa L.Pharmacological studies show that CLR can be used to treat cervical cancer,lung cancer,lupus nephritis,and other conditions.In this paper,we review botany,...Curcumae Longae Rhizoma(CLR)is the rhizome of Curcuma longa L.Pharmacological studies show that CLR can be used to treat cervical cancer,lung cancer,lupus nephritis,and other conditions.In this paper,we review botany,traditional application,phytochemistry,pharmacological activity,and pharmacokinetics of CLR.The literature from 1981 to date was entirely collected from online databases,such as Web of Science,Google Scholar,China Academic Journals full-text database(CNKI),Wiley,Springer,PubMed,and ScienceDirect.The data were also obtained from ancient books,theses and dissertations,and Flora Reipublicae Popularis Sinicae.There are a total of 275 compounds that have been isolated from CLR,including phenolic compounds,volatile oils,and others.The therapeutic effect of turmeric has been expanded from breaking blood and activating qi in the traditional sense to antitumor,anti-inflammatory,antioxidation,neuroprotection,antibacterial,hypolipidemic effects,and other benefits.However,the active ingredients and mechanisms of action related to relieving disease remain ill defined,which requires more in-depth research and verification at a clinical level.展开更多
Paridis Rhizoma(PR) is also known as the flower with seven leaves and one branch, PR with golden thread, etc. It tastes bitter, numb, and slightly cold and has little poison. It is often used for the treatment of exte...Paridis Rhizoma(PR) is also known as the flower with seven leaves and one branch, PR with golden thread, etc. It tastes bitter, numb, and slightly cold and has little poison. It is often used for the treatment of external skin infection, sore throat, snake bite, fall pain, frightening convulsion, and other diseases. PR has analgesic, sedative, anti-inflammatory, hemostatic, antitumor, antibacterial, antiviral, and renal and liver protective effects;inhibition of angiogenesis;immune regulation;and antioxidant and cardiovascular effects, and antifertility and anti-early pregnancy sperm killing effects. Steroidal saponins, β-ecdysone, polysaccharides, microelements, flavonoid glycosides, and amino acids were isolated from PR. In this paper, its pharmacology, application, ethnopharmacology, phytochemistry, quality control, toxicology, and pharmacokinetics were reviewed. This information suggests that we should focus on the development of new drugs related to PR, including specific ingredients, so as to make PR play a greater therapeutic potential. At the same time, attention should be paid to the rational use of PR resources to avoid excessive using, resulting in resource shortage. Therefore, we can carry out the research on the substitutes of PR, a large-scale planting of(Paridis Rhizoma) PR, and develop the same genus of PR and other resources. So far, great progress has been made in pharmacology and phytochemistry, especially in antitumor research, and many traditional uses have been confirmed and clarified by modern pharmacological research. However, there are few studies on the mechanism of its pharmacological action and few studies on processing. To develop new drugs in the future, more studies and experiments are still needed to prove the effect of PR and explore more new effects.展开更多
A novel polydopamine-graft-poly（2-methyl-2-oxazoline） （PDA-g-PMOXA） coating was prepared by immobilizing poly（2-methyl-2-oxazoline） （PMOXA） onto material surfaces through polydopamine （PDA） anchored coating ...A novel polydopamine-graft-poly（2-methyl-2-oxazoline） （PDA-g-PMOXA） coating was prepared by immobilizing poly（2-methyl-2-oxazoline） （PMOXA） onto material surfaces through polydopamine （PDA） anchored coating for the first time. And then, the chemical composition, hydrophilicity, and protein-resistant properties of the PDA-g-PMOXA coating were studied using X-ray photoelectron spectroscopy （XPS）, contact angel （CA） test, surface plasmon resonance （SPR）, and quartz crystal microbalance with dissipation （QCM-D） measurement. Finally, the coating was applied to the capillary inner surface for protein separation by capillary electrophoresis （CE）.展开更多
文摘目的:观察翼状胬肉切除联合自体带角膜缘上皮的球结膜移植术治疗翼状胬肉患者的疗效观察。方法:前瞻性对照研究。选取2015-10/2019-10于我院接受治疗的翼状胬肉患者102例102眼,按随机数字表法分为两组:对照组行翼状胬肉切除联合羊膜移植术治疗51眼,观察组行翼状胬肉切除联合自体带角膜缘上皮的球结膜移植术治疗51眼。比较两组患者术中失血量、手术时间、角膜上皮修复时间及术后3mo临床疗效,并记录手术前后泪膜破裂时间(BUT)、裸眼视力(UCVA)、泪液分泌试验(SⅠt)、角膜散光度(CAD)变化情况,以及术后治疗美学量表评分比较和随访过程中的复发情况。结果:观察组患者角膜上皮修复时间短于对照组(4.14±1.35 vs 4.72±1.37d,P<0.05),手术时间长于对照组(32.24±6.69 vs 29.67±5.21min,P<0.05),而两组术中失血量比较无差异(P>0.05);术后3mo,两组患者治疗有效率比较无差异(86.3%vs 78.4%,P>0.05),BUT、UCVA、SⅠt较术前均显著上升(均P<0.05),且观察组UCVA、SⅠt显著高于对照组(均P<0.05),两组BUT比较无差异(P>0.05),两组CAD较术前均显著下降(均P<0.05),但组间比较无差异(P>0.05);术后3mo,观察组翼状胬肉治疗美学量表中眼部恢复、自觉症状评分均显著高于对照组(均P<0.05),而两组间术区清洁及充血情况评分比较无差异(均P>0.05);两组随访期间的复发率比较无差异(P>0.05)。结论:翼状胬肉切除联合自体带角膜缘上皮的球结膜移植术可有效治疗翼状胬肉,防止复发,相比于翼状胬肉切除联合羊膜移植术,患者术后恢复更快,美观度更佳。
基金supported by the Graduate Innovative Research Project Foundation of Heilongjiang University of Chinese Medicine(No.2022yjscx059)the Natural Science Foundation of Heilongjiang Province[No.LH2021H097]+3 种基金the National Natural Science Foundation Matching Project(No.2018PT02)the National Natural Science Foundation of China(No.81703684,81803690,and 81973604)The Special Funds from the Central Finance to Support the Development of Local Universitiesthe scientific research project of Heilongjiang Provincial Health Commission(No.20211313050171)。
文摘Curcumae Longae Rhizoma(CLR)is the rhizome of Curcuma longa L.Pharmacological studies show that CLR can be used to treat cervical cancer,lung cancer,lupus nephritis,and other conditions.In this paper,we review botany,traditional application,phytochemistry,pharmacological activity,and pharmacokinetics of CLR.The literature from 1981 to date was entirely collected from online databases,such as Web of Science,Google Scholar,China Academic Journals full-text database(CNKI),Wiley,Springer,PubMed,and ScienceDirect.The data were also obtained from ancient books,theses and dissertations,and Flora Reipublicae Popularis Sinicae.There are a total of 275 compounds that have been isolated from CLR,including phenolic compounds,volatile oils,and others.The therapeutic effect of turmeric has been expanded from breaking blood and activating qi in the traditional sense to antitumor,anti-inflammatory,antioxidation,neuroprotection,antibacterial,hypolipidemic effects,and other benefits.However,the active ingredients and mechanisms of action related to relieving disease remain ill defined,which requires more in-depth research and verification at a clinical level.
基金supported by the Innovative Talents Funding of The Heilongjiang University of Chinese Medicine Doctoral Innovation Foundation [No. 2014bs05]the Graduate Innovative Research Project Foundation of Heilongjiang University of Chinese Medicine [No. 2019yjscx013]+7 种基金the Application Technology Research and Development Projects of Harbin Technology Bureau [No. 2014RFQXJ149]the Natural Science Foundation of Heilongjiang Province [No. H2015037]Heilongjiang University of Chinese Medicine [No. 2018RCD25]the National Natural Science Foundation Matching Project [No. 2018PT02]the National Natural Science Foundation Matching Project [No. 2017PT01]Heilongjiang Postdoctoral Scientific Research Developmental Fund [No. LBH Q16210 and LBH-Q17161]the National Natural Science Foundation of China [No. 81703684, 81803690, 81973604]the Postdoctoral Initial Fund of Heilongjiang Province, the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province [No. UNPYSCT 2017219 and UNPYSCT 2017215]。
文摘Paridis Rhizoma(PR) is also known as the flower with seven leaves and one branch, PR with golden thread, etc. It tastes bitter, numb, and slightly cold and has little poison. It is often used for the treatment of external skin infection, sore throat, snake bite, fall pain, frightening convulsion, and other diseases. PR has analgesic, sedative, anti-inflammatory, hemostatic, antitumor, antibacterial, antiviral, and renal and liver protective effects;inhibition of angiogenesis;immune regulation;and antioxidant and cardiovascular effects, and antifertility and anti-early pregnancy sperm killing effects. Steroidal saponins, β-ecdysone, polysaccharides, microelements, flavonoid glycosides, and amino acids were isolated from PR. In this paper, its pharmacology, application, ethnopharmacology, phytochemistry, quality control, toxicology, and pharmacokinetics were reviewed. This information suggests that we should focus on the development of new drugs related to PR, including specific ingredients, so as to make PR play a greater therapeutic potential. At the same time, attention should be paid to the rational use of PR resources to avoid excessive using, resulting in resource shortage. Therefore, we can carry out the research on the substitutes of PR, a large-scale planting of(Paridis Rhizoma) PR, and develop the same genus of PR and other resources. So far, great progress has been made in pharmacology and phytochemistry, especially in antitumor research, and many traditional uses have been confirmed and clarified by modern pharmacological research. However, there are few studies on the mechanism of its pharmacological action and few studies on processing. To develop new drugs in the future, more studies and experiments are still needed to prove the effect of PR and explore more new effects.
基金support of the Ministry of Science and Technology of China(No.2012CB933802)
文摘A novel polydopamine-graft-poly（2-methyl-2-oxazoline） （PDA-g-PMOXA） coating was prepared by immobilizing poly（2-methyl-2-oxazoline） （PMOXA） onto material surfaces through polydopamine （PDA） anchored coating for the first time. And then, the chemical composition, hydrophilicity, and protein-resistant properties of the PDA-g-PMOXA coating were studied using X-ray photoelectron spectroscopy （XPS）, contact angel （CA） test, surface plasmon resonance （SPR）, and quartz crystal microbalance with dissipation （QCM-D） measurement. Finally, the coating was applied to the capillary inner surface for protein separation by capillary electrophoresis （CE）.
