Transdermal drug delivery refers to a means of delivering drugs through the surface of the skin for local or systemic treatment. The drug functions after absorption through the skin into the systemic circulation via c...Transdermal drug delivery refers to a means of delivering drugs through the surface of the skin for local or systemic treatment. The drug functions after absorption through the skin into the systemic circulation via capillary action at a certain rate. Use of traditional physical and chemical enhancers to improve the transdermal permeation rate by increasing drug solubility, diffusion coefficient, and reservoir effect is not feasible owing to the toxic side effects of the overuse of chemical penetration enhancers. Nanoformulations generally vary in size and range from 10 nm to 100 nm. The smaller particle size leads to increased drug permeability, stability, retention, and targeting, making nano-formulations suitable for transdermal drug delivery. The different applications of nano-formulations(vesicles or nanoparticles and nanoemulsions) have been widely studied. Here, the classification, characteristics, transdermal mechanism, and application of the most popular nano-formulations in transdermal drug delivery system are reviewed.展开更多
To the Editor:Sebaceous carcinoma(SC)is a rare cutaneous malignant tumor differentiated from the epithelium lining and arising from the sebaceous gland.[1]Consequently,nevus sebaceous(NS)tends to develop into a benign...To the Editor:Sebaceous carcinoma(SC)is a rare cutaneous malignant tumor differentiated from the epithelium lining and arising from the sebaceous gland.[1]Consequently,nevus sebaceous(NS)tends to develop into a benign or malignant neoplasm.[2]Herein,we report dermoscopic findings in a rare case of SC arising in NS with protruding nodule in erosive erythematous surface rapidly arising from yellow pigment plaque resulting in no recurrence.Dermoscopy is a powerful diagnostic tool to generate a preoperative diagnosis.展开更多
Introduction:Nail psoriasis is a type of psoriasis involving nail lesions characterized by pitting,onycholysis,longitudinal ridges,and subungual hyperkeratosis.We herein describe a 9-year-old girl with nail psoriasis ...Introduction:Nail psoriasis is a type of psoriasis involving nail lesions characterized by pitting,onycholysis,longitudinal ridges,and subungual hyperkeratosis.We herein describe a 9-year-old girl with nail psoriasis who presented with nail crumbling and was treated with topical cream containing 45μg/g mouse monoclonal antibody to human interleukin-8.Case presentation:A 9-year-old Chinese girl presented with a 6-month history of a rough,thickened fingernail and toenails.Nail plate crumbling,onycholysis,and fissured periungual folds were observed under dermoscopy and ultraviolet dermoscopy.The nails were soaked in warm water,then topical wrapped with Abcream cream overnight.After about 4 months of treatment,the nails significantly improved by both dermoscopy and ultraviolet-dermoscopy evaluattion.Discussion:Due to the different wavelengths of light emitted by polarized light dermatoscope and ultraviolet-dermatoscope,the characteristics of observation will be different.Abcream acts by antagonizing human interleukin-8,inhibiting leukocyte chemotaxis and neovascularization,and regulating the abnormal proliferation and differentiation of keratinocytes.Conclusion:Ultraviolet-dermoscopy is pivotal in evaluating the severity and potency of nail psoriasis.And Abcream can be regarded as a new drug for the treatment of nail psoriasis in children.展开更多
To the Editor:Malassezia located in the skin of patients with atopic dermatitis(AD)might be related to its pathogenesis,consisting of Malassezia globosa and Malassezia restricta as the dominant species.[1]However,the ...To the Editor:Malassezia located in the skin of patients with atopic dermatitis(AD)might be related to its pathogenesis,consisting of Malassezia globosa and Malassezia restricta as the dominant species.[1]However,the specific molecular mechanisms of Malassezia on host immune cells from AD patients are still unclear.In our study,the Affymetrix Human Prime View array was used to detect the effect of M.globosa on the gene expression of peripheral blood mononuclear cells(PBMCs)from AD patients,which was favorable to further understand the role of Malassezia colonization in the pathogenesis of AD.展开更多
To the Editor:Bowen disease(BD)is a squamous cell carcinoma in situ that can progress into invasive carcinoma.[1]Pigmented BDis a rare variant of squamous cell carcinoma in situ that can be diagnosed pathologically.It...To the Editor:Bowen disease(BD)is a squamous cell carcinoma in situ that can progress into invasive carcinoma.[1]Pigmented BDis a rare variant of squamous cell carcinoma in situ that can be diagnosed pathologically.It is usually characterized by slow-growing,welldefined,and non-uniform hyperpigmented plaque.[2]It is also characterized by the increased melanin pigment in the epidermis or papillary dermis in addition to the alteration of BD.In a study,7(1.67%)of 420 BD cases were pigmented.[1]Although the exact underlying mechanism of pigmented BD is unclear,pigmentation is due to the presence of an increased number of melanocytic hyperplasia by hypertrophic dendritic processes dispersed through the tumor.[3]Pigmented BD with no scaling and keratosis indicates well-differentiated stages of atypical keratinocytes developing melanin.[3]Later atypical keratinocytes result in loss of pigmentation,keratosis,and scaling.Herein,we present a rare case of pigmented BD on the proximal nail fold.展开更多
基金supported by the Postdoctoral Innovation Talents Support Program(No.BX20180207)the National Nature Science Foundation of China(No.81502722)
文摘Transdermal drug delivery refers to a means of delivering drugs through the surface of the skin for local or systemic treatment. The drug functions after absorption through the skin into the systemic circulation via capillary action at a certain rate. Use of traditional physical and chemical enhancers to improve the transdermal permeation rate by increasing drug solubility, diffusion coefficient, and reservoir effect is not feasible owing to the toxic side effects of the overuse of chemical penetration enhancers. Nanoformulations generally vary in size and range from 10 nm to 100 nm. The smaller particle size leads to increased drug permeability, stability, retention, and targeting, making nano-formulations suitable for transdermal drug delivery. The different applications of nano-formulations(vesicles or nanoparticles and nanoemulsions) have been widely studied. Here, the classification, characteristics, transdermal mechanism, and application of the most popular nano-formulations in transdermal drug delivery system are reviewed.
文摘To the Editor:Sebaceous carcinoma(SC)is a rare cutaneous malignant tumor differentiated from the epithelium lining and arising from the sebaceous gland.[1]Consequently,nevus sebaceous(NS)tends to develop into a benign or malignant neoplasm.[2]Herein,we report dermoscopic findings in a rare case of SC arising in NS with protruding nodule in erosive erythematous surface rapidly arising from yellow pigment plaque resulting in no recurrence.Dermoscopy is a powerful diagnostic tool to generate a preoperative diagnosis.
基金This research was supported by the Project for Disciplines of Excellence(No.ZYJC18033)the HX-Academician Project(No.HXYS19003)of West China Hospital,Sichuan University China.
文摘Introduction:Nail psoriasis is a type of psoriasis involving nail lesions characterized by pitting,onycholysis,longitudinal ridges,and subungual hyperkeratosis.We herein describe a 9-year-old girl with nail psoriasis who presented with nail crumbling and was treated with topical cream containing 45μg/g mouse monoclonal antibody to human interleukin-8.Case presentation:A 9-year-old Chinese girl presented with a 6-month history of a rough,thickened fingernail and toenails.Nail plate crumbling,onycholysis,and fissured periungual folds were observed under dermoscopy and ultraviolet dermoscopy.The nails were soaked in warm water,then topical wrapped with Abcream cream overnight.After about 4 months of treatment,the nails significantly improved by both dermoscopy and ultraviolet-dermoscopy evaluattion.Discussion:Due to the different wavelengths of light emitted by polarized light dermatoscope and ultraviolet-dermatoscope,the characteristics of observation will be different.Abcream acts by antagonizing human interleukin-8,inhibiting leukocyte chemotaxis and neovascularization,and regulating the abnormal proliferation and differentiation of keratinocytes.Conclusion:Ultraviolet-dermoscopy is pivotal in evaluating the severity and potency of nail psoriasis.And Abcream can be regarded as a new drug for the treatment of nail psoriasis in children.
基金the Research Project of Sichuan Provincial Education Department(No.17ZA0127)the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University,and the HX-Academician Project,West China Hospital,Sichuan University.
文摘To the Editor:Malassezia located in the skin of patients with atopic dermatitis(AD)might be related to its pathogenesis,consisting of Malassezia globosa and Malassezia restricta as the dominant species.[1]However,the specific molecular mechanisms of Malassezia on host immune cells from AD patients are still unclear.In our study,the Affymetrix Human Prime View array was used to detect the effect of M.globosa on the gene expression of peripheral blood mononuclear cells(PBMCs)from AD patients,which was favorable to further understand the role of Malassezia colonization in the pathogenesis of AD.
文摘To the Editor:Bowen disease(BD)is a squamous cell carcinoma in situ that can progress into invasive carcinoma.[1]Pigmented BDis a rare variant of squamous cell carcinoma in situ that can be diagnosed pathologically.It is usually characterized by slow-growing,welldefined,and non-uniform hyperpigmented plaque.[2]It is also characterized by the increased melanin pigment in the epidermis or papillary dermis in addition to the alteration of BD.In a study,7(1.67%)of 420 BD cases were pigmented.[1]Although the exact underlying mechanism of pigmented BD is unclear,pigmentation is due to the presence of an increased number of melanocytic hyperplasia by hypertrophic dendritic processes dispersed through the tumor.[3]Pigmented BD with no scaling and keratosis indicates well-differentiated stages of atypical keratinocytes developing melanin.[3]Later atypical keratinocytes result in loss of pigmentation,keratosis,and scaling.Herein,we present a rare case of pigmented BD on the proximal nail fold.
