Li2FeSiO4 is deemed to be a potential candidate for large-scale applications because of its abundance,low cost and high safety,etc.Unfortunately,its low conductivity,resulting in poor rate performance,has become a mai...Li2FeSiO4 is deemed to be a potential candidate for large-scale applications because of its abundance,low cost and high safety,etc.Unfortunately,its low conductivity,resulting in poor rate performance,has become a main obstacle to its applications in power battery and energy storage system.In this work,C-Ag coated Li2FeSiO4 is introduced to improve the innate electronic conductivity and Li-ion diffusion ability.The results demonstrate that Li2FeSiO4/C/Ag composite exhibits better electrochemical performance.It possesses a specific discharge capacity of 152,121,108 mA.h/g at 0.2C,5C and 10C,respectively.At the same time,the Li2FeSiO4/C/Ag composite shows good cycle stability and a capacity retention ratio of 97.9%after 100 cycles at 1C.展开更多
Even though the precipitation is abundant in the Karst region of Guizhou Province, remote villages in this area frequently suffer severe droughts. This paper studied the causes of droughts in this region through field...Even though the precipitation is abundant in the Karst region of Guizhou Province, remote villages in this area frequently suffer severe droughts. This paper studied the causes of droughts in this region through field investigation and references collection. Based on the cause analysis, some suggestions were provided for hazard prevention and control from an engineering perspective. Besides occasional extreme weathers, the drought in this area is primarily caused by its unique geological structures of Karst plateau and underdeveloped agricultural techniques. Meanwhile, the vicious cycle between drought and poverty, which causes the deficiency of water conservancy facilities and hazard prevention awareness, is an important reason for the frequent occurrence of agricultural and socioeconomic drought. Considering the social and economic conditions of remote villages, the long-term control of drought can only be realized if current measures are capable of bring immediate effects and benefits. Therefore, the construction of well-planned and designed water conservancy system based on each village's natural and social conditions are the priority for current hazard prevention. Generally, the exploitation of subterranean river should be considered as the first choice to stabilize the water supply for remote villages. Meanwhile, the construction and improvement of micro water conservancy facilities, such as small water tank, small pond and so on, can effectively support the water providence during droughts as well.展开更多
The present study was designed to determine the effects of Guanfu base A(GFA) on the late sodium current(INa.L),transient sodium current(INa.T),HERG current(IHERG),and Kv1.5 current(IKv1.5).The values of INa.L,INa.T,I...The present study was designed to determine the effects of Guanfu base A(GFA) on the late sodium current(INa.L),transient sodium current(INa.T),HERG current(IHERG),and Kv1.5 current(IKv1.5).The values of INa.L,INa.T,IHERG and IKv1.5 were recorded using the whole-cell patch clamp technique.Compared with other channels,GFA showed selective blocking activity in late sodium channel.It inhibited INa.L in a concentration-dependent manner with an IC50 of(1.57 ± 0.14) μmol·L-1,which was significantly lower than its IC50 values of(21.17 ± 4.51) μmol·L-1 for the INa.T.The inhibitory effect of GFA on INa,L was not affected by 200μmol·L-1 H2O2.It inhibited IHERG with an IC50 of(273 ± 34) μmol·L-1 and has slight blocking effect on IKv1.5,decreasing IKv1.5 by only 20.6% at 200 μmol·L-1.In summary,GFA inhibited INa.L selectively and remained similar inhibition in presence of reactive oxygen species..These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders.展开更多
基金Project(21771062)supported by the National Natural Science Foundation of ChinaProject(2016JJ2092)supported by the Hunan Provincial Natural Science Foundation,ChinaProject(2019013)supported by the Open Project Program of Key Laboratory of Preparation and Application of Environmental Friendly Materials,Ministry of Education,Jilin Normal University,China
文摘Li2FeSiO4 is deemed to be a potential candidate for large-scale applications because of its abundance,low cost and high safety,etc.Unfortunately,its low conductivity,resulting in poor rate performance,has become a main obstacle to its applications in power battery and energy storage system.In this work,C-Ag coated Li2FeSiO4 is introduced to improve the innate electronic conductivity and Li-ion diffusion ability.The results demonstrate that Li2FeSiO4/C/Ag composite exhibits better electrochemical performance.It possesses a specific discharge capacity of 152,121,108 mA.h/g at 0.2C,5C and 10C,respectively.At the same time,the Li2FeSiO4/C/Ag composite shows good cycle stability and a capacity retention ratio of 97.9%after 100 cycles at 1C.
基金supported by the National Natural Science Foundation of China (Grant No.41572285)
文摘Even though the precipitation is abundant in the Karst region of Guizhou Province, remote villages in this area frequently suffer severe droughts. This paper studied the causes of droughts in this region through field investigation and references collection. Based on the cause analysis, some suggestions were provided for hazard prevention and control from an engineering perspective. Besides occasional extreme weathers, the drought in this area is primarily caused by its unique geological structures of Karst plateau and underdeveloped agricultural techniques. Meanwhile, the vicious cycle between drought and poverty, which causes the deficiency of water conservancy facilities and hazard prevention awareness, is an important reason for the frequent occurrence of agricultural and socioeconomic drought. Considering the social and economic conditions of remote villages, the long-term control of drought can only be realized if current measures are capable of bring immediate effects and benefits. Therefore, the construction of well-planned and designed water conservancy system based on each village's natural and social conditions are the priority for current hazard prevention. Generally, the exploitation of subterranean river should be considered as the first choice to stabilize the water supply for remote villages. Meanwhile, the construction and improvement of micro water conservancy facilities, such as small water tank, small pond and so on, can effectively support the water providence during droughts as well.
基金supported by the Fundamental Research Funds for the Central Universities(No.JKZ2011007)the National "Key Program for New Drug Research Development"(No.2009 ZX09103-345)
文摘The present study was designed to determine the effects of Guanfu base A(GFA) on the late sodium current(INa.L),transient sodium current(INa.T),HERG current(IHERG),and Kv1.5 current(IKv1.5).The values of INa.L,INa.T,IHERG and IKv1.5 were recorded using the whole-cell patch clamp technique.Compared with other channels,GFA showed selective blocking activity in late sodium channel.It inhibited INa.L in a concentration-dependent manner with an IC50 of(1.57 ± 0.14) μmol·L-1,which was significantly lower than its IC50 values of(21.17 ± 4.51) μmol·L-1 for the INa.T.The inhibitory effect of GFA on INa,L was not affected by 200μmol·L-1 H2O2.It inhibited IHERG with an IC50 of(273 ± 34) μmol·L-1 and has slight blocking effect on IKv1.5,decreasing IKv1.5 by only 20.6% at 200 μmol·L-1.In summary,GFA inhibited INa.L selectively and remained similar inhibition in presence of reactive oxygen species..These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders.
