Objective:To explore the curative effect of nano-Kuiyangye on radiation esophagitis in Wistar rats,and to explore its possible mechanism.Methods:Wistar rats were irradiated locally with 30Gy rays to establish an anima...Objective:To explore the curative effect of nano-Kuiyangye on radiation esophagitis in Wistar rats,and to explore its possible mechanism.Methods:Wistar rats were irradiated locally with 30Gy rays to establish an animal model of radiation esophagitis in rats.After irradiation,nano-Kuiyangye,traditional Chinese medicine ulcer solution,Kangfuxin solution,nano-hydrotalcite matrix,and distilled water were used to intervene continuously for 7 d,during which the body weight and food intake of the rats were recorded.On day 7,blood was collected from the abdominal aorta under anesthesia,and the serum was obtained by centrifugation.The expression levels of pain-related factors prostaglandin-2(PGE-2),substance P(SP),and calcitonin gene-related peptide(CGRP)were detected by ELISA.Rats were sacrificed after blood collection,and full-length esophageal tissues were taken.Hematoxylin-eosin(HE)staining was performed to analyze the pathological changes of the rat esophagus,and Western Blotting was used to detect the expression of nuclear factor-κB(NF-κB)inflammatory protein.Results:Compared with the control group,the total food intake and body weight of the rats within 7 d after modeling were significantly decreased(P<0.05),and the expressions of pain-related factors PGE-2,SP,and CGRP were higher than those of the control group(P<0.05).,the esophageal pathological damage score increased(P<0.05),and the expression of NF-κB inflammatory protein increased(P<0.05);after treatment,the total food intake of the rats in the nano-Kuiyangye intervention group within 7 days after modeling was higher than that in other groups(P<0.05),the expressions of pain-related factors PGE-2,SP,and CGRP were lower than those in the model group(P<0.05),the esophageal pathological damage score was lower(P<0.05),and the expression of NF-κB inflammatory proteins was lower(P<0.05).Conclusion:Nano-Kuiyangye increases the food intake of rats with radiation esophagitis,reduces esophageal tissue damage,and reduces the concentration of serum pain factors;the anti-inflammatory effect of nano-Kuiyangye may be related to the reduction of NF-κB inflammatory factor levels.展开更多
Half-wavelength AC transmission(HWACT) is an ultra-long distance AC transmission technology, whose electrical distance is close to half-wavelength at the system power frequency. It is very important for the constructi...Half-wavelength AC transmission(HWACT) is an ultra-long distance AC transmission technology, whose electrical distance is close to half-wavelength at the system power frequency. It is very important for the construction and operation of HWACT to analyze its fault features and corresponding protection technology. In this paper, the steady-state voltage and current characteristics of the bus bar and fault point and the steady-state overvoltage distribution along the line will be analyzed when a three-phase symmetrical short-circuit fault occurs on an HWACT line. On this basis, the threephase fault characteristics for longer transmission lines are also studied.展开更多
The advantages of the all-fiber optical current transformer include but are not limited to being small in size,having no magnetic saturation,exhibiting high measurement accuracy,and boasting strong electromagnetic int...The advantages of the all-fiber optical current transformer include but are not limited to being small in size,having no magnetic saturation,exhibiting high measurement accuracy,and boasting strong electromagnetic interference resistance.However,the high cost of the all-fiber optical transformer limits its promotion and application in engineering.This paper proposes a design scheme of an independent double acquisition loop for the all-fiber optical current transformer based on the single optical path.Firstly,based on the closed-loop control mode and open-loop control mode,the twochannel sampling signal demand for relay protection,and the independent dual-acquisition loop design scheme of the all-fiber optical current transformer are proposed.Secondly,the reliability and economic feasibility of the scheme are demonstrated by an analysis of system failure and cost.The results show that the scheme can actualize the acquisition function of two independent all-fiber optical current transformer products on a single all-fiber current transformer in an integrated manner,which greatly reduces the cost of the all-fiber optical current transformer in engineering applications.展开更多
基金Beijing Administration of Traditional Chinese Medicine Major Difficult Diseases Clinical Collaboration Project of Traditional Chinese and Western Medicine (No.2019-ZX-005)。
文摘Objective:To explore the curative effect of nano-Kuiyangye on radiation esophagitis in Wistar rats,and to explore its possible mechanism.Methods:Wistar rats were irradiated locally with 30Gy rays to establish an animal model of radiation esophagitis in rats.After irradiation,nano-Kuiyangye,traditional Chinese medicine ulcer solution,Kangfuxin solution,nano-hydrotalcite matrix,and distilled water were used to intervene continuously for 7 d,during which the body weight and food intake of the rats were recorded.On day 7,blood was collected from the abdominal aorta under anesthesia,and the serum was obtained by centrifugation.The expression levels of pain-related factors prostaglandin-2(PGE-2),substance P(SP),and calcitonin gene-related peptide(CGRP)were detected by ELISA.Rats were sacrificed after blood collection,and full-length esophageal tissues were taken.Hematoxylin-eosin(HE)staining was performed to analyze the pathological changes of the rat esophagus,and Western Blotting was used to detect the expression of nuclear factor-κB(NF-κB)inflammatory protein.Results:Compared with the control group,the total food intake and body weight of the rats within 7 d after modeling were significantly decreased(P<0.05),and the expressions of pain-related factors PGE-2,SP,and CGRP were higher than those of the control group(P<0.05).,the esophageal pathological damage score increased(P<0.05),and the expression of NF-κB inflammatory protein increased(P<0.05);after treatment,the total food intake of the rats in the nano-Kuiyangye intervention group within 7 days after modeling was higher than that in other groups(P<0.05),the expressions of pain-related factors PGE-2,SP,and CGRP were lower than those in the model group(P<0.05),the esophageal pathological damage score was lower(P<0.05),and the expression of NF-κB inflammatory proteins was lower(P<0.05).Conclusion:Nano-Kuiyangye increases the food intake of rats with radiation esophagitis,reduces esophageal tissue damage,and reduces the concentration of serum pain factors;the anti-inflammatory effect of nano-Kuiyangye may be related to the reduction of NF-κB inflammatory factor levels.
基金supported by the Scientific Research Fund of Beijing Jiaotong University(KSRC12006536)the National Natural Science Foundation of China(61674011,61735004)~~
基金supported by National Key Research and Development Program of China(2016YFB0900100)
文摘Half-wavelength AC transmission(HWACT) is an ultra-long distance AC transmission technology, whose electrical distance is close to half-wavelength at the system power frequency. It is very important for the construction and operation of HWACT to analyze its fault features and corresponding protection technology. In this paper, the steady-state voltage and current characteristics of the bus bar and fault point and the steady-state overvoltage distribution along the line will be analyzed when a three-phase symmetrical short-circuit fault occurs on an HWACT line. On this basis, the threephase fault characteristics for longer transmission lines are also studied.
基金supported by the National Natural Science Foundation of China (No. U1866203)
文摘The advantages of the all-fiber optical current transformer include but are not limited to being small in size,having no magnetic saturation,exhibiting high measurement accuracy,and boasting strong electromagnetic interference resistance.However,the high cost of the all-fiber optical transformer limits its promotion and application in engineering.This paper proposes a design scheme of an independent double acquisition loop for the all-fiber optical current transformer based on the single optical path.Firstly,based on the closed-loop control mode and open-loop control mode,the twochannel sampling signal demand for relay protection,and the independent dual-acquisition loop design scheme of the all-fiber optical current transformer are proposed.Secondly,the reliability and economic feasibility of the scheme are demonstrated by an analysis of system failure and cost.The results show that the scheme can actualize the acquisition function of two independent all-fiber optical current transformer products on a single all-fiber current transformer in an integrated manner,which greatly reduces the cost of the all-fiber optical current transformer in engineering applications.
