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Isolation, characterization and modulatory potentials of β-stigmasterol, ergosterol and xylopic acid from Anchomanes difformis on mitochondrial permeability transition pore in vitro 被引量:2
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作者 Kehinde Oluseun Sodeinde Akinwunmi Oluwaseun Adeoye +7 位作者 Adedeji Adesipo Adebayo AAdeniyi John Adeolu Falode tajudeen olabisi obafemi Samuel Olalekan Olusanya Linette Twigge Jeanet Conradie Timothy O.Mosaku 《Chinese Herbal Medicines》 CAS 2023年第4期533-541,共9页
Objective: Secondary metabolites and polyphenolic compounds from medicinal plants have been demonstrated to have multiple biological functions with promising research and development prospects. This study examined the... Objective: Secondary metabolites and polyphenolic compounds from medicinal plants have been demonstrated to have multiple biological functions with promising research and development prospects. This study examined the effect of β-stigmasterol(with ergosterol) and xylopic acid isolated from Anchomanes difformis on liver mitochondrial permeability transition pore(mPTP).Methods: The compounds were isolated by vacuum liquid chromatography. Mitochondrial swelling was assessed as changes in absorbance under succinate-energized conditions.Results:1H and13C NMR spectroscopic elucidation of the isolates affirmed the presence of β-stigmasterol with ergosterol(1:0.3) and xylopic acid. The isolates reversed the increase in lipid peroxidation and inhibited the opening of mitochondrial permeability transition pores caused by calcium and glucose.Pharmacological inhibition of m PTP offers a promising therapeutic target for the treatment of mitochondrial-associated disorders.Conclusion: Reduction in the activity of calcium ATPase and the expression of Caspase-3 and-9 were observed, suggesting that they could play a role in protecting physicochemical properties of membrane bilayers from free radical-induced severe cellular damage and be useful in the management of diseases where much apoptosis occurs. 展开更多
关键词 Anchomanes difformis(Blume)Engl ERGOSTEROL mitochondrial membrane MODULATION β-stigmasterol transition pore xylopic acid
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