β-Sitosterol is a type of phytosterol that occurs naturally in plants.Previous studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unkno...β-Sitosterol is a type of phytosterol that occurs naturally in plants.Previous studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic stroke.Here we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced apoptosis.Further investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic stroke.In addition,β-sitosterol showed high affinity for NPC1L1,a key transporter of cholesterol,and antagonized its activity.In conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways.展开更多
为研究由装配整体式高延性混凝土(HDC)、带肋叠合板(PK板)、冷弯薄壁型钢组成的T型肋叠合楼板(HTPKG板)底板受力性能,通过HTPKG预制底板试件的重物均布加载静载试验,研究了HTPKG板的刚度、承载力等力学性能。分析跨度、上翼缘宽度、腹...为研究由装配整体式高延性混凝土(HDC)、带肋叠合板(PK板)、冷弯薄壁型钢组成的T型肋叠合楼板(HTPKG板)底板受力性能,通过HTPKG预制底板试件的重物均布加载静载试验,研究了HTPKG板的刚度、承载力等力学性能。分析跨度、上翼缘宽度、腹板宽度等因素对HTPKG板受压性能和承载力影响规律,选出最优板型。试验结果表明:在加载至4.4~4.5 k N时板底跨中位置均出现了裂缝,极限荷载下未出现脆断现象,说明HTPKG板具有较好的承载力和延性特征,HTPKG-4板的受力性能最佳。展开更多
基金supported by the National Natural Science Foundation of China,Nos.82104158(to XT),31800887(to LY),31972902(to LY),82001422(to YL)China Postdoctoral Science Foundation,No.2020M683750(to LY)partially by Young Talent Fund of University Association for Science and Technology in Shaanxi Province of China,No.20200307(to LY).
文摘β-Sitosterol is a type of phytosterol that occurs naturally in plants.Previous studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic stroke.Here we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced apoptosis.Further investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic stroke.In addition,β-sitosterol showed high affinity for NPC1L1,a key transporter of cholesterol,and antagonized its activity.In conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways.
文摘为研究由装配整体式高延性混凝土(HDC)、带肋叠合板(PK板)、冷弯薄壁型钢组成的T型肋叠合楼板(HTPKG板)底板受力性能,通过HTPKG预制底板试件的重物均布加载静载试验,研究了HTPKG板的刚度、承载力等力学性能。分析跨度、上翼缘宽度、腹板宽度等因素对HTPKG板受压性能和承载力影响规律,选出最优板型。试验结果表明:在加载至4.4~4.5 k N时板底跨中位置均出现了裂缝,极限荷载下未出现脆断现象,说明HTPKG板具有较好的承载力和延性特征,HTPKG-4板的受力性能最佳。
