Background:The availability of various types of COVID-19 vaccines and diverse characteristics of the vaccines pre‑sent a dilemma in vaccination choices,which may result in individuals refusing a particular COVID-19 va...Background:The availability of various types of COVID-19 vaccines and diverse characteristics of the vaccines pre‑sent a dilemma in vaccination choices,which may result in individuals refusing a particular COVID-19 vaccine ofered,hence presenting a threat to immunisation coverage and reaching herd immunity.The study aimed to assess global COVID-19 vaccination intention,vaccine characteristics infuencing vaccination acceptance and desirable vaccine characteristics infuencing the choice of vaccines.Methods:An anonymous cross-sectional survey was conducted between 4 January and 5 March 2021 in 17 coun‑tries worldwide.Proportions and the corresponding 95%confdence intervals(CI)of COVID-19 vaccine acceptance and vaccine characteristics infuencing vaccination acceptance were generated and compared across countries and regions.Multivariable logistic regression analysis was used to determine the factors associated with COVID-19 vaccine hesitancy.Results:Of the 19,714 responses received,90.4%(95%CI 81.8–95.3)reported likely or extremely likely to receive COVID-19 vaccine.A high proportion of likely or extremely likely to receive the COVID-19 vaccine was reported in Australia(96.4%),China(95.3%)and Norway(95.3%),while a high proportion reported being unlikely or extremely unlikely to receive the vaccine in Japan(34.6%),the U.S.(29.4%)and Iran(27.9%).Males,those with a lower educational level and those of older age expressed a higher level of COVID-19 vaccine hesitancy.Less than two-thirds(59.7%;95%CI 58.4–61.0)reported only being willing to accept a vaccine with an efectiveness of more than 90%,and 74.5%(95%CI 73.4–75.5)said they would accept a COVID-19 vaccine with minor adverse reactions.A total of 21.0%(95%CI 20.0–22.0)reported not accepting an mRNA vaccine and 51.8%(95%CI 50.3–53.1)reported that they would only accept a COVID-19 vaccine from a specifc country‐of‐origin.Countries from the Southeast Asia region reported the highest proportion of not accepting mRNA technology.The highest proportion from Europe and the Americas would only accept a vaccine produced by certain countries.The foremost important vaccine characteristic infuencing vaccine choice is adverse reactions(40.6%;95%CI 39.3–41.9)of a vaccine and efectiveness threshold(35.1%;95%CI 33.9–36.4).Conclusions:The inter-regional and individual country disparities in COVID-19 vaccine hesitancy highlight the importance of designing an efcient plan for the delivery of interventions dynamically tailored to the local population.展开更多
文摘Background:The availability of various types of COVID-19 vaccines and diverse characteristics of the vaccines pre‑sent a dilemma in vaccination choices,which may result in individuals refusing a particular COVID-19 vaccine ofered,hence presenting a threat to immunisation coverage and reaching herd immunity.The study aimed to assess global COVID-19 vaccination intention,vaccine characteristics infuencing vaccination acceptance and desirable vaccine characteristics infuencing the choice of vaccines.Methods:An anonymous cross-sectional survey was conducted between 4 January and 5 March 2021 in 17 coun‑tries worldwide.Proportions and the corresponding 95%confdence intervals(CI)of COVID-19 vaccine acceptance and vaccine characteristics infuencing vaccination acceptance were generated and compared across countries and regions.Multivariable logistic regression analysis was used to determine the factors associated with COVID-19 vaccine hesitancy.Results:Of the 19,714 responses received,90.4%(95%CI 81.8–95.3)reported likely or extremely likely to receive COVID-19 vaccine.A high proportion of likely or extremely likely to receive the COVID-19 vaccine was reported in Australia(96.4%),China(95.3%)and Norway(95.3%),while a high proportion reported being unlikely or extremely unlikely to receive the vaccine in Japan(34.6%),the U.S.(29.4%)and Iran(27.9%).Males,those with a lower educational level and those of older age expressed a higher level of COVID-19 vaccine hesitancy.Less than two-thirds(59.7%;95%CI 58.4–61.0)reported only being willing to accept a vaccine with an efectiveness of more than 90%,and 74.5%(95%CI 73.4–75.5)said they would accept a COVID-19 vaccine with minor adverse reactions.A total of 21.0%(95%CI 20.0–22.0)reported not accepting an mRNA vaccine and 51.8%(95%CI 50.3–53.1)reported that they would only accept a COVID-19 vaccine from a specifc country‐of‐origin.Countries from the Southeast Asia region reported the highest proportion of not accepting mRNA technology.The highest proportion from Europe and the Americas would only accept a vaccine produced by certain countries.The foremost important vaccine characteristic infuencing vaccine choice is adverse reactions(40.6%;95%CI 39.3–41.9)of a vaccine and efectiveness threshold(35.1%;95%CI 33.9–36.4).Conclusions:The inter-regional and individual country disparities in COVID-19 vaccine hesitancy highlight the importance of designing an efcient plan for the delivery of interventions dynamically tailored to the local population.
