Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties.In this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the an...Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties.In this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the antioxidative and anti-aging effects of naringin and explore the underlying mechanisms.The results showed that naringin inhibited H_(2)O_(2)-induced decline in cell viability and decreased,the content of reactive oxygen species in cells.Meanwhile,naringin prolonged the lifespan of flies,enhanced the abilities of climbing and the resistance to stress,improved the activities of antioxidant enzymes,and decreased malondialdehyde content.Naringin also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem cells.Moreover,naringin down-regulated the mRNA expressions of inr,chico,pi 3k,and akt-1,and up-regulated the mRNA expressions of dilp2,dilp3,dilp5,and foxo,thereby activating autophagy-related genes and increasing the number of lysosomes.Furthermore,the mutant stocks assays and computer molecular simulation results further indicated that naringin delayed aging by inhibiting the insulin signaling(IIS)pathway and activating the autophagy pathway,which was consistent with the result of network pharmacological predictions.展开更多
According to the application scenarios of the size of the humanflow in different consumption places,to solve the problem of crowd detection,distance estimation between crowds and the inability to monitor and calculate ...According to the application scenarios of the size of the humanflow in different consumption places,to solve the problem of crowd detection,distance estimation between crowds and the inability to monitor and calculate the humanflow in real time,this paper designs a real-time crowd detection scheme for appli-cation scenarios where consumers pay attention to the size of the humanflow in consumption places.The main use of the YOLO algorithm with the Darknet53 net-work as the main network is to separate pedestrians from the background.Pedes-trians’central two-dimensional coordinates are converted into three-dimensional coordinates,realizing crowd detection and apart from the distance estimation of crowds,real-time monitoring of current regional traffic andflow density,and solv-ing the problem of being unable to monitor and calculate people in real time.It can be applied to many aspects,such as shop rating,traffic control andflow control of scenic spots.Existing monitors are affected by different lights and cannot provide accurate data.In addition,the processing algorithm of this scheme is stable and accurate,and preprocessing is performed before judging the humanflow and the position of the human body to reduce the interference of light.This scheme has the performance of real-time monitoring and calculation through experimental verification.展开更多
Removing hydrogen sulfide(H_(2)S)via the selective oxidation has been considered an effective way to further purify the indusial sulfurcontaining due to it can completely transform residual H_(2)S into elemental sulfu...Removing hydrogen sulfide(H_(2)S)via the selective oxidation has been considered an effective way to further purify the indusial sulfurcontaining due to it can completely transform residual H_(2)S into elemental sulfur.While N-doped porous carbon was applied to H_(2)S selective oxidation,a sustainable methodology for the synthesis of efficient and stable N-doped carbon catalysts remains a difficulty,limiting its future development in large-scale applications.Herein,we present porous,honeycomb-like N-doped carbon catalysts with large specific surface areas,high pyridinic N content,and numerous structural defects for H_(2)S selective oxidation prepared using reusable NaCl as the template.The asprepared NC-10-800 catalyst exhibits excellent catalytic performance(sulfur formation rate of 784 g_(sulfur) kg_(cat.)^(-1) h^(-1)),outstanding stability(>100 h),and excellent anti-water vapor,anti-CO_(2) and anti-oxidation properties,suggesting significant potential for practical industrial application.The characterization results and kinetic study demonstrate that the large surface areas and structural defects created by the molten salt at high temperature enhance the exposure of pyridinic N sites and thus accelerate the catalytic activity.Importantly,the water-soluble NaCl template could be easily washed from the carbon nanomaterials,and thus the downstream salt-containing wastewater could be subsequently reused for the dissolution of carbon precursors.This environment-friendly,low-cost,reusable salt-template strategy has significant implications for the development of N-doped carbon catalysts for practical applications.展开更多
Nonlinear holography has recently emerged as a novel tool to reconstruct the encoded information at a new wavelength,which has important applications in optical display and optical encryption.However,this scheme still...Nonlinear holography has recently emerged as a novel tool to reconstruct the encoded information at a new wavelength,which has important applications in optical display and optical encryption.However,this scheme still struggles with low conversion efficiency and ineffective multiplexing.In this work,we demonstrate a quasi-phasematching(QPM)-division multiplexing holography in a three-dimensional(3D)nonlinear photonic crystal(NPC).3D NPC works as a nonlinear hologram,in which multiple images are distributed into different Ewald spheres in reciprocal space.The reciprocal vectors locating in a given Ewald sphere are capable of fulfilling the complete QPM conditions for the high-efficiency reconstruction of the target image at the second-harmonic(SH)wave.One can easily switch the reconstructed SH images by changing the QPM condition.The multiplexing capacity is scalable with the period number of 3D NPC.Our work provides a promising strategy to achieve highly efficient nonlinear multiplexing holography for high-security and high-density storage of optical information.展开更多
Nonlinear holography has been identified as a vital platform for optical multiplexing holography because of the appearance of new optical frequencies.However,due to nonlinear wave coupling in nonlinear optical process...Nonlinear holography has been identified as a vital platform for optical multiplexing holography because of the appearance of new optical frequencies.However,due to nonlinear wave coupling in nonlinear optical processes,the nonlinear harmonic field is coupled with the input field,laying a fundamental barrier to independent control of the interacting fields for holography.We propose and experimentally demonstrate high-dimensional orbital angular momentum(OAM)multiplexing nonlinear holography to overcome this problem.By dividing the wavefront of the fundamental wave into different orthogonal OAM channels,multiple OAM and polarization-dependent holographic images in both the fundamental wave and second-harmonic wave have been reconstructed independently in the spatial frequency domain through a type-II second harmonic generation process.Moreover,this method can be easily extended to cascadedχ2 nonlinear optical processes for multiplexing in more wavelength channels,leading to potential applications in multicasting in optical communications,multiwavelength display,multidimensional optical storage,anticounterfeiting,and optical encryption.展开更多
Xylitol,a five-carbon sugar alcohol,is a valuable sugar substitute,and widely used in the pharmaceutical,odontological and food industry due to its interesting properties.In the past decades,the xylitol industry has g...Xylitol,a five-carbon sugar alcohol,is a valuable sugar substitute,and widely used in the pharmaceutical,odontological and food industry due to its interesting properties.In the past decades,the xylitol industry has grown rapidly and more attention has been focused on xylitol purification,which possesses an important proportion of the whole industry.In our paper,the purification and crystallization of xylitol fermentation broth by biotechnology using corncob hydrolysates as substance were studied.An initial xylitol fermentation broth was decolored with activated carbon(1%M-1,60℃,165 rpm),desalted with a combination of two ionexchange resins(732 and D301),and residual sugars were separated with UBK-555(Ca^(2+)).Then the solution was vacuum-concentrated up to supersaturation(750 g/L xylitol).After adding 1%xylitol crystal seeds,the supersaturated solution was cooled to-20℃for 48 h.The crystalline xylitol of a regular tetrahedral shape with purity 95%and crystallization yield 60.2%was obtained from the clarified xylitol fermentation broth.An intact,economical and environmental-friendly route of purification and crystallization of xylitol from fermentation of corncob hydrolysates was obtained,and its experimental procedure and data provided a sound basis for large-scale industrial production.展开更多
This research was conducted to develop an effective approach to sort off-ground harvested almonds for efficient drying based on their physical and aerodynamic properties.Three popular varieties were studied,including ...This research was conducted to develop an effective approach to sort off-ground harvested almonds for efficient drying based on their physical and aerodynamic properties.Three popular varieties were studied,including Nonpareil,Monterey,and Fritz.The insect damage,axial dimensions,weight ratio,moisture content,bulk density and terminal velocity of in-hull almonds,in-shell almonds and loose hull at harvest were measured.The results indicated that the insect infestation percentage in the off-ground harvested almonds ranged from 2.5%to 6.3%,which was about half of those in the conventional on-ground dried almonds.Loose hulls and in-hull almonds had higher moisture content and wider moisture distribution than those of in-shell almonds,suggesting that sorting of the almonds and drying them separately are necessary for efficient handling and processing.Thickness was the smallest axial dimension of an almond,and thus could be used for sorting.The cut-off sizes of 16.5 mm,21.3 mm and 21.1 mm could separate 100%of the in-shell almonds from the rest for Nonpareil,Monterey and Fritz varieties,respectively,as the first step.In the second step,applying terminal velocities of 12.3 m/s,11.8 m/s and 12.2 m/s could efficiently separate the in-hull almonds and loose hulls for Nonpareil,Monterey and Fritz varieties,respectively.Overall,up to 76.7%of the loose hulls could be removed,and up to 3.3%in-hull almonds may be lost during the sorting process.The experimental results provided important information for developing efficient sorting and drying methods with improved throughput,energy efficiency,better quality and safety of off-ground harvested almonds.展开更多
基金supported by the open project of the Key Laboratory of Environmental Pollution Monitoring and Disease Control,Ministry of Education,Guizhou Medical University,China (GMU-2022-HJZ-06)。
文摘Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties.In this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the antioxidative and anti-aging effects of naringin and explore the underlying mechanisms.The results showed that naringin inhibited H_(2)O_(2)-induced decline in cell viability and decreased,the content of reactive oxygen species in cells.Meanwhile,naringin prolonged the lifespan of flies,enhanced the abilities of climbing and the resistance to stress,improved the activities of antioxidant enzymes,and decreased malondialdehyde content.Naringin also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem cells.Moreover,naringin down-regulated the mRNA expressions of inr,chico,pi 3k,and akt-1,and up-regulated the mRNA expressions of dilp2,dilp3,dilp5,and foxo,thereby activating autophagy-related genes and increasing the number of lysosomes.Furthermore,the mutant stocks assays and computer molecular simulation results further indicated that naringin delayed aging by inhibiting the insulin signaling(IIS)pathway and activating the autophagy pathway,which was consistent with the result of network pharmacological predictions.
文摘According to the application scenarios of the size of the humanflow in different consumption places,to solve the problem of crowd detection,distance estimation between crowds and the inability to monitor and calculate the humanflow in real time,this paper designs a real-time crowd detection scheme for appli-cation scenarios where consumers pay attention to the size of the humanflow in consumption places.The main use of the YOLO algorithm with the Darknet53 net-work as the main network is to separate pedestrians from the background.Pedes-trians’central two-dimensional coordinates are converted into three-dimensional coordinates,realizing crowd detection and apart from the distance estimation of crowds,real-time monitoring of current regional traffic andflow density,and solv-ing the problem of being unable to monitor and calculate people in real time.It can be applied to many aspects,such as shop rating,traffic control andflow control of scenic spots.Existing monitors are affected by different lights and cannot provide accurate data.In addition,the processing algorithm of this scheme is stable and accurate,and preprocessing is performed before judging the humanflow and the position of the human body to reduce the interference of light.This scheme has the performance of real-time monitoring and calculation through experimental verification.
基金financially supported by the National Key R&D Program of China(No.2022YFC3701900)National Natural Science Foundation of China(Nos.21606243)+1 种基金LiaoNing Revitalization Talents Program(XLYC1907053)Dalian National Laboratory for Clean Energy(DNL202021).
文摘Removing hydrogen sulfide(H_(2)S)via the selective oxidation has been considered an effective way to further purify the indusial sulfurcontaining due to it can completely transform residual H_(2)S into elemental sulfur.While N-doped porous carbon was applied to H_(2)S selective oxidation,a sustainable methodology for the synthesis of efficient and stable N-doped carbon catalysts remains a difficulty,limiting its future development in large-scale applications.Herein,we present porous,honeycomb-like N-doped carbon catalysts with large specific surface areas,high pyridinic N content,and numerous structural defects for H_(2)S selective oxidation prepared using reusable NaCl as the template.The asprepared NC-10-800 catalyst exhibits excellent catalytic performance(sulfur formation rate of 784 g_(sulfur) kg_(cat.)^(-1) h^(-1)),outstanding stability(>100 h),and excellent anti-water vapor,anti-CO_(2) and anti-oxidation properties,suggesting significant potential for practical industrial application.The characterization results and kinetic study demonstrate that the large surface areas and structural defects created by the molten salt at high temperature enhance the exposure of pyridinic N sites and thus accelerate the catalytic activity.Importantly,the water-soluble NaCl template could be easily washed from the carbon nanomaterials,and thus the downstream salt-containing wastewater could be subsequently reused for the dissolution of carbon precursors.This environment-friendly,low-cost,reusable salt-template strategy has significant implications for the development of N-doped carbon catalysts for practical applications.
基金the National Key R&D Program of China(2017YFA0303703,2018YFB1105400,and 2016YFA0302500)the National Natural Science Foundation of China(NSFC)(91950206,11874213,51875544,91963127,51675503,and 62005262)+5 种基金National Key Scientific Instrument and Equipment Development Project(61927814)Youth Innovation Promotion Association of the Chinese Academy of Sciences(2017495)Foundation of Equipment Development Department(6220914010901)Anhui Province Science and Technology Major Project(201903a05020005)Fundamental Research Funds for the Central Universities(021314380105)The China Postdoctoral Science Foundation(2020M671838 and 2021T14069)。
文摘Nonlinear holography has recently emerged as a novel tool to reconstruct the encoded information at a new wavelength,which has important applications in optical display and optical encryption.However,this scheme still struggles with low conversion efficiency and ineffective multiplexing.In this work,we demonstrate a quasi-phasematching(QPM)-division multiplexing holography in a three-dimensional(3D)nonlinear photonic crystal(NPC).3D NPC works as a nonlinear hologram,in which multiple images are distributed into different Ewald spheres in reciprocal space.The reciprocal vectors locating in a given Ewald sphere are capable of fulfilling the complete QPM conditions for the high-efficiency reconstruction of the target image at the second-harmonic(SH)wave.One can easily switch the reconstructed SH images by changing the QPM condition.The multiplexing capacity is scalable with the period number of 3D NPC.Our work provides a promising strategy to achieve highly efficient nonlinear multiplexing holography for high-security and high-density storage of optical information.
基金This work was supported by the National Key R&D Program of China(2016YFA0302500 , 2017YFA0303703)the National Natural Science Foundation of China(NSFC)(91950206 , 11874213)+2 种基金the Fundamental Research Funds for the Central Universities(1480605201)M.G.acknowledges the funding support from the Zhangjiang National Innovation Demonstration Zone(ZJ2019-ZD-005)X.F.acknowledges the funding support by Shanghai Science and Technology Development Funds(20QA1404100).
文摘Nonlinear holography has been identified as a vital platform for optical multiplexing holography because of the appearance of new optical frequencies.However,due to nonlinear wave coupling in nonlinear optical processes,the nonlinear harmonic field is coupled with the input field,laying a fundamental barrier to independent control of the interacting fields for holography.We propose and experimentally demonstrate high-dimensional orbital angular momentum(OAM)multiplexing nonlinear holography to overcome this problem.By dividing the wavefront of the fundamental wave into different orthogonal OAM channels,multiple OAM and polarization-dependent holographic images in both the fundamental wave and second-harmonic wave have been reconstructed independently in the spatial frequency domain through a type-II second harmonic generation process.Moreover,this method can be easily extended to cascadedχ2 nonlinear optical processes for multiplexing in more wavelength channels,leading to potential applications in multicasting in optical communications,multiwavelength display,multidimensional optical storage,anticounterfeiting,and optical encryption.
基金supported by a grant from the National High Technology Research and Development Program of China(863 Program).
文摘Xylitol,a five-carbon sugar alcohol,is a valuable sugar substitute,and widely used in the pharmaceutical,odontological and food industry due to its interesting properties.In the past decades,the xylitol industry has grown rapidly and more attention has been focused on xylitol purification,which possesses an important proportion of the whole industry.In our paper,the purification and crystallization of xylitol fermentation broth by biotechnology using corncob hydrolysates as substance were studied.An initial xylitol fermentation broth was decolored with activated carbon(1%M-1,60℃,165 rpm),desalted with a combination of two ionexchange resins(732 and D301),and residual sugars were separated with UBK-555(Ca^(2+)).Then the solution was vacuum-concentrated up to supersaturation(750 g/L xylitol).After adding 1%xylitol crystal seeds,the supersaturated solution was cooled to-20℃for 48 h.The crystalline xylitol of a regular tetrahedral shape with purity 95%and crystallization yield 60.2%was obtained from the clarified xylitol fermentation broth.An intact,economical and environmental-friendly route of purification and crystallization of xylitol from fermentation of corncob hydrolysates was obtained,and its experimental procedure and data provided a sound basis for large-scale industrial production.
文摘This research was conducted to develop an effective approach to sort off-ground harvested almonds for efficient drying based on their physical and aerodynamic properties.Three popular varieties were studied,including Nonpareil,Monterey,and Fritz.The insect damage,axial dimensions,weight ratio,moisture content,bulk density and terminal velocity of in-hull almonds,in-shell almonds and loose hull at harvest were measured.The results indicated that the insect infestation percentage in the off-ground harvested almonds ranged from 2.5%to 6.3%,which was about half of those in the conventional on-ground dried almonds.Loose hulls and in-hull almonds had higher moisture content and wider moisture distribution than those of in-shell almonds,suggesting that sorting of the almonds and drying them separately are necessary for efficient handling and processing.Thickness was the smallest axial dimension of an almond,and thus could be used for sorting.The cut-off sizes of 16.5 mm,21.3 mm and 21.1 mm could separate 100%of the in-shell almonds from the rest for Nonpareil,Monterey and Fritz varieties,respectively,as the first step.In the second step,applying terminal velocities of 12.3 m/s,11.8 m/s and 12.2 m/s could efficiently separate the in-hull almonds and loose hulls for Nonpareil,Monterey and Fritz varieties,respectively.Overall,up to 76.7%of the loose hulls could be removed,and up to 3.3%in-hull almonds may be lost during the sorting process.The experimental results provided important information for developing efficient sorting and drying methods with improved throughput,energy efficiency,better quality and safety of off-ground harvested almonds.
