miRNAs are endogenous 19-to 25-nt noncoding RNAs that can negatively regulate gene expression by directly cleaving target mRNA or by inhibiting its translation.Recent studies have revealed that miRNA plays a significa...miRNAs are endogenous 19-to 25-nt noncoding RNAs that can negatively regulate gene expression by directly cleaving target mRNA or by inhibiting its translation.Recent studies have revealed that miRNA plays a significant role in gastric cancer development either as a tumor suppressor gene or oncogene.miRNA-singlenucleotide polymorphisms(SNPs),as a novel class of functional SNPs/polymorphisms,have been identified as candidate biomarkers for gastric cancer susceptibility.On the basis of recent data,the present review summarizes current knowledge of the functional effects of miRNA-SNPs and their importance as candidate gastric cancer biomarkers.Additionally,this review also includes a meta-analysis of the most frequently studied miRNA-SNPs in gastric cancer.展开更多
Diamond anvil cells combined with Raman spectroscopy and angle-dispersive x-ray diffraction(ADXRD) were used to investigate the compression behavior of cinchomeronic acid(C_7H_5NO_4, CA), a hydrogen-bonded polymorphs....Diamond anvil cells combined with Raman spectroscopy and angle-dispersive x-ray diffraction(ADXRD) were used to investigate the compression behavior of cinchomeronic acid(C_7H_5NO_4, CA), a hydrogen-bonded polymorphs. The compression of form-I at approximately 6.5 GPa caused an irreversible phase transition that produced the new polymorph form-III. Lattice and internal modes in the Raman spectra were analyzed to determine the modifications in the local environment of CA form-I molecules. The form-III was indexed and refined to a low-symmetry triclinic structure with space group P1. The mechanism for the phase transition involved the reconstructions in the hydrogen-bonded networks in CA form-I.展开更多
For students in the third year of junior high school,it is their first time learning the subject of chemistry.Their future learning will be largely related to the first introduction lesson taught by the teacher,so thi...For students in the third year of junior high school,it is their first time learning the subject of chemistry.Their future learning will be largely related to the first introduction lesson taught by the teacher,so this article takes the third year chemistry introduction lesson as an example,through the combination of STSE and HPS theories applied to teaching in the process of teaching design,which plays a critical role in cultivating students'core literacy in chemistry.展开更多
基金Supported by National Natural Science Foundation of China,No.81001444Science and Technology Development Project of Nanjing,China,No.201201055 and No.2012YX001Natural Science Research in Colleges and Universities of Jiangsu Province,No.11KJD360002
文摘miRNAs are endogenous 19-to 25-nt noncoding RNAs that can negatively regulate gene expression by directly cleaving target mRNA or by inhibiting its translation.Recent studies have revealed that miRNA plays a significant role in gastric cancer development either as a tumor suppressor gene or oncogene.miRNA-singlenucleotide polymorphisms(SNPs),as a novel class of functional SNPs/polymorphisms,have been identified as candidate biomarkers for gastric cancer susceptibility.On the basis of recent data,the present review summarizes current knowledge of the functional effects of miRNA-SNPs and their importance as candidate gastric cancer biomarkers.Additionally,this review also includes a meta-analysis of the most frequently studied miRNA-SNPs in gastric cancer.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11604224,51805336,and 11774120)the Open Project of State Key Laboratory of Superhard Materials of Jilin University,China(Grant No.201708)+2 种基金the Natural Science Foundation of Liaoning Province,China(Grant No.20180550861)the Education Department of Liaoning Province,China(Grant Nos.LJZ2016031 and LJZ2016030)Shenyang Jianzhu University Discipline Content Education,China(Grant Nos.XKHY2-105 and XKHY2-101)
文摘Diamond anvil cells combined with Raman spectroscopy and angle-dispersive x-ray diffraction(ADXRD) were used to investigate the compression behavior of cinchomeronic acid(C_7H_5NO_4, CA), a hydrogen-bonded polymorphs. The compression of form-I at approximately 6.5 GPa caused an irreversible phase transition that produced the new polymorph form-III. Lattice and internal modes in the Raman spectra were analyzed to determine the modifications in the local environment of CA form-I molecules. The form-III was indexed and refined to a low-symmetry triclinic structure with space group P1. The mechanism for the phase transition involved the reconstructions in the hydrogen-bonded networks in CA form-I.
文摘For students in the third year of junior high school,it is their first time learning the subject of chemistry.Their future learning will be largely related to the first introduction lesson taught by the teacher,so this article takes the third year chemistry introduction lesson as an example,through the combination of STSE and HPS theories applied to teaching in the process of teaching design,which plays a critical role in cultivating students'core literacy in chemistry.
基金This work was financially supported by the National Basic Research Program of China （Project No. 2013 CB 127604） and the National Natural Science Foundation of China （Project No. 31390421）.
