Arson presents a challenging crime scene for fire investigators worldwide. Key to the investigation of suspected arson cases is the analysis of fire debris for the presence of accelerants or ignitable liquids. This st...Arson presents a challenging crime scene for fire investigators worldwide. Key to the investigation of suspected arson cases is the analysis of fire debris for the presence of accelerants or ignitable liquids. This study has investigated the application and method development of vapor phase mid-Infrared (mid-IR) spectroscopy using a field portable quantum cascade laser (QCL) based system for the detection and identification of accelerant residues such as gasoline, diesel, and ethanol in fire debris. A searchable spectral library of various ignitable fluids and fuel components measured in the vapor phase was constructed that allowed for real-time identification of accelerants present in samples using software developed in-house. Measurement of vapors collected from paper material that had been doused with an accelerant followed by controlled burning and then extinguished with water showed that positive identification could be achieved for gasoline, diesel, and ethanol. This vapor phase mid-IR QCL method is rapid, easy to use, and has the sensitivity and discrimination capability that make it well suited for non-destructive crime scene sample analysis. Sampling and measurement can be performed in minutes with this 7.5 kg instrument. This vibrational spectroscopic method required no time-consuming sample pretreatment or complicated solvent extraction procedure. The results of this initial feasibility study demonstrate that this portable fire debris analyzer would greatly benefit arson investigators performing analysis on-site.展开更多
It is an important issue to numerically solve the time fractional Schrödinger equation on unbounded domains, which models the dynamics of optical solitons propagating via optical fibers. The perfectly matched lay...It is an important issue to numerically solve the time fractional Schrödinger equation on unbounded domains, which models the dynamics of optical solitons propagating via optical fibers. The perfectly matched layer approach is applied to truncate the unbounded physical domain, and obtain an initial boundary value problem on a bounded computational domain, which can be efficiently solved by the finite difference method. The stability of the reduced initial boundary value problem is rigorously analyzed. Some numerical results are presented to illustrate the accuracy and feasibility of the perfectly matched layer approach. According to these examples, the absorption parameters and the width of the absorption layer will affect the absorption effect. The larger the absorption width, the better the absorption effect. There is an optimal absorption parameter, the absorption effect is the best.展开更多
Diabetes mellitus(DM)is a common multifactorial disease,causing various complications,such as chronic metabolism.The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite s...Diabetes mellitus(DM)is a common multifactorial disease,causing various complications,such as chronic metabolism.The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite side effect.However,polysaccharides mainly extracted from natural resources,have advantages of safety,accessibility,and anti-diabetic potential.We have summarized recent research of natural polysaccharides with hypoglycemic activities,focusing on different pharmacological mechanisms in various cell and animal models.The relationships of structure-hypoglycemic effect are also discussed in detail.This review could provide a comprehensive perspective for better understanding on development and mechanism of natural polysaccharides against diabetes mellitus,which have been required by clinical studies yet.展开更多
The change in the ecological environment in the arid core area is a critical issue in the context of global warming.To study the paleoclimate evolution,precise identification of minerals deposited in Asia’s arid hint...The change in the ecological environment in the arid core area is a critical issue in the context of global warming.To study the paleoclimate evolution,precise identification of minerals deposited in Asia’s arid hinterland,Lop Nur Salt Lake,NW China was conducted.The hyperspectral data of the salt crust was sampled to identify the species and content of sedimentary minerals,and the multispectral photos were used to reconstruct the salt crust morphology using the unmanned aerial vehicles platform.The SUnSAL(sparse unmixing by variable splitting and augmented Lagrangian)method was employed to inverse the sedimentary mineral components along the shoreline.The heterogeneity of salt and clay minerals in bright and dark ear-shaped strips was evaluated.The paleoclimatic environment associated with salt lake extinction was reconstructed by analyzing paleoclimate records of sediments,spectral reflectance and morphology of the salt crust.Results show that:(1)the variations in the micro-geomorphology of the salt crust are obviously the reason for the formation of bright and dark ear-shaped strips and the differences in the species and relative content of the sedimentary minerals are the microscopic reason.The high ratio of sedimentary salt minerals to clay minerals(RS/C)contributes to the high reflectivity,and the salt crust presents a bright texture.The low RS/C results in the low reflectivity,salt crust presents a dark texture;(2)the bright and dark ear-shaped strips represent warm-arid and cold-humid climates.The shape of the Lop Nur Lake shoreline evolved due to alternating warm-dry and cold-humid paleoclimate changes.展开更多
Orthogonal Time Frequency Space(OTFS)signaling with index modulation(IM)is a promising transmission scheme characterized by high transmission efficiency for high mobility scenarios.In this paper,we study the receiver ...Orthogonal Time Frequency Space(OTFS)signaling with index modulation(IM)is a promising transmission scheme characterized by high transmission efficiency for high mobility scenarios.In this paper,we study the receiver for coded OTFS-IM system.First,we construct the corresponding factor graph,on which the structured prior incorporating activation pattern constraint and channel coding is devised.Then we develop a iterative receiver via structured prior-based hybrid belief propagation(BP)and expectation propagation(EP)algorithm,named as StrBP-EP,for the coded OTFS-IM system.To reduce the computational complexity of discrete distribution introduced by structured prior,Gaussian approximation conducted by EP is adopted.To further reduce the complexity,we derive two variations of the proposed algorithm by using some approximations.Simulation results validate the superior performance of the proposed algorithm.展开更多
A preliminary miRNA screening showed that expression levels of rno-miRNA-27a-3p were significantly increased in the serum and brain tissues of rats undergoing cerebral ischemia.In recent years,there is evidence of the...A preliminary miRNA screening showed that expression levels of rno-miRNA-27a-3p were significantly increased in the serum and brain tissues of rats undergoing cerebral ischemia.In recent years,there is evidence of the protective capacity of the saponins extracted from panax ginseng and its primary active ingredient ginsenosideRg1oncerebral ischemic injury.Methods:Fetal rat neurons(FRNs)were cultured in glucose-and-serumfree medium and exposed to hypoxia to establish a cerebral ischemia model in vitro(oxygen and glucose deprivation model,OGD).Antioxidant indexes(CAT,SOD),inflammatory markers(MPO,TNF-αand IL-6),and the expression of apoptosis and proliferation associated proteins(NF kB-p65,Caspase 3-cleaved,BCL-2)were examined.Results:Pre-treatment of Rg1(30–100μg/mL)could effectively inhibit the decline of antioxidant indexes(CAT,SOD)and increase in inflammatory markers(MPO,TNF-αand IL-6),and effectively inhibited the apoptosis in FRNs induced by OGD in a gradient-dependent manner.The mechanism analysis showed that the role of Rg1 in protecting against ischemia-induced neuron damage depends on its indirect up-regulation of PPAR protein via suppression of rnomiRNA-27a-3p.Moreover,these effects of Rg1 could be reversed by exogenous rno-miRNA-27a-3p and PPAR gene silencing in FRNs exposed to OGD.Conclusion:To summarize,our study demonstrates that Rg1 could effectively attenuate neuronal damage caused by cerebral ischemia via the rno-miRNA-27a-3p/PPARγpathway.Further,clarification of the novel mechanism will certainly improve our previous understanding of the role of Rg1 and enhancing its level in treatments for alleviating ischemic brain injury.展开更多
Massive neutrinos are expected to affect the large-scale structure formation,including the major component of solid substances,dark matter halos.How halos are influenced by neutrinos is vital and interesting,and angul...Massive neutrinos are expected to affect the large-scale structure formation,including the major component of solid substances,dark matter halos.How halos are influenced by neutrinos is vital and interesting,and angular momentum(AM)as a significant feature provides a statistical perspective for this issue.Exploring halos from TianNu N-body cosmological simulation with the co-evolving neutrino particles,we obtain some concrete conclusions.First,by comparing the same halos with and without neutrinos,in contrast to the neutrino-free case,over 89.71%of halos have smaller halo moduli,over 71.06%have smaller particle-mass-reduced(PMR)AM moduli,and over 95.44%change their orientations of less than 0°.65.Moreover,the relative variation of PMR modulus is more visible for low-mass halos.Second,to explore the PMR moduli of halos in dense or sparse areas,we divide the whole box into big cubes,and search for halos within a small spherical cell in a single cube.From the two-level divisions,we discover that in denser cubes,the variation of PMR moduli with massive neutrinos decreases more significantly.This distinction suggests that neutrinos exert heavier influence on halos'moduli in compact regions.With massive neutrinos,most halos(86.60%)have lower masses than without neutrinos.展开更多
In this study,we developed a novel on-line solid phase extraction(SPE)-ultra-high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)-based analytical method for simultaneously quantifying 12 illic...In this study,we developed a novel on-line solid phase extraction(SPE)-ultra-high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)-based analytical method for simultaneously quantifying 12 illicit drugs and metabolites(methamphetamine,amphetamine,morphine,codeine,6-monoacetylmorphine,benzoylecgonine,3,4-methylenedioxymethamphetamine,3,4-methylenedioxyamphetamine,cocaine,ketamine,norketamine,and methcathinone)and cotinine(COT)in wastewater samples.The analysis was performed by loading 2 m L of the sample onto an Oasis hydrophilic-lipophilic balance cartridge and using a cleanup step(5%methanol)to eliminate interference with a total run time of 13 min.The isotope-labeled internal standard method was used to quantify the target substances and correct for unavoidable losses and matrix effects during the on-line SPE process.Typical analytical characteristics used for method validation were sensitivity,linearity,precision,repeatability,recovery,and matrix effects.The limit of detection(LOD)and limit of quantification(LOQ)of each target were set at 0.20 ng/L and 0.50 ng/L,respectively.The linearity was between 0.5 ng/L and250 ng/L,except for that of COT.The intra-and inter-day precisions were<10.45%and 25.64%,respectively,and the relative recovery ranged from 83.74%to 162.26%.The method was used to analyze various wastewater samples from 33 cities in China,and the results were compared with the experimental results of identical samples analyzed using off-line SPE.The difference rate was between 19.91%and-20.44%,and the error range could be considered acceptable.These findings showed that on-line SPE is a suitable alternative to off-line SPE for the analysis of illicit drugs in samples.展开更多
It is a challenge in the field sampling to face conflict between the statistical requirements and the logistical constraints when explicitly estimating the macrobenthos species richness in the heterogeneous intertidal...It is a challenge in the field sampling to face conflict between the statistical requirements and the logistical constraints when explicitly estimating the macrobenthos species richness in the heterogeneous intertidal wetlands. To solve this problem, this study tried to design an optimal, efficient and practical sampling strategy by comprehensively focusing on the three main parts of the entire process(to optimize the sampling method, to determine the minimum sampling effort and to explore the proper sampling interval) in a typical intertidal wetland of the Changjiang(Yangtze) Estuary, China. Transect sampling was selected and optimized by stratification based on pronounced habitat types(tidal flat, tidal creek, salt marsh vegetation). This type of sampling is also termed within-transect stratification sampling. The optimal sampling intervals and the minimum sample effort were determined by two beneficial numerical methods: Monte Carlo simulations and accumulative species curves. The results show that the within-transect stratification sampling with typical habitat types was effective for encompassing 81% of the species, suggesting that this type of sampling design can largely reduce the sampling effort and labor. The optimal sampling intervals and minimum sampling efforts for three habitats were determined: sampling effort must exceed 1.8 m^2 by 10 m intervals in the salt marsh vegetation, 2 m^2 by 10 m intervals in the tidal flat, and 3 m^2 by 1 m intervals in the tidal creek habitat. It was suggested that the differences were influenced by the mobility range of the dominant species and the habitats' physical differences(e.g., tidal water, substrate, vegetation cover). The optimized sampling strategy could provide good precision in the richness estimation of macrobenthos and balance the sampling effort. Moreover, the conclusions presented here provide a reference for recommendations to consider before macrobenthic surveys take place in estuarine wetlands. The sampling strategy, focusing on the three key parts of the sampling design, had a good operational effect and could be used as a guide for field sampling for habitat management or ecosystem assessment.展开更多
弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphpma,DLBCL)是非霍奇金淋巴瘤中最常见的类型,在分子遗传学、免疫表型等方面具有高度异质性,患者临床预后也截然不同。R-CHOP方案为DLBCL标准治疗方案,如何进一步提高DLBCL疗效是近年来...弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphpma,DLBCL)是非霍奇金淋巴瘤中最常见的类型,在分子遗传学、免疫表型等方面具有高度异质性,患者临床预后也截然不同。R-CHOP方案为DLBCL标准治疗方案,如何进一步提高DLBCL疗效是近年来的研究热点。2015年美国临床肿瘤学会(ASCO)提出基于细胞起源分型进行R-CHOP+X方案治疗的策略,但这些方案相继失败。基于更加精准的分层方法,筛选出不同DLBCL亚组并进行针对性治疗,是未来DLBCL治疗的方向。此外,抗体-药物偶联物、双特异性抗体和嵌合抗原受体T细胞(chimeric antigen receptor T-cell,CAR-T)等免疫治疗近年来取得突破性进展,为DLBCL患者带来新的希望。本文针对基于精准分层的DLBCL靶向治疗、免疫治疗的最新进展及遗传学检测方法予以综述。展开更多
Interfacial structure greatly affects the mechanical properties of laminated plates.However,the critical material properties that impact the interfacial morphology,appearance,and associated bonding mechanism of explos...Interfacial structure greatly affects the mechanical properties of laminated plates.However,the critical material properties that impact the interfacial morphology,appearance,and associated bonding mechanism of explosive welded plates are still unknown.In this paper,the same base plate(AZ31B alloy)and different flyer metals(aluminum alloy,copper,and stainless steel)were used to investigate interfacial morphology and structure.SEM and TEM results showed that typical sine wave,wave-like,and half-wave-like interfaces were found at the bonding interfaces of Al/Mg,Cu/Mg and SS/Mg clad plates,respectively.The different interfacial morphologies were mainly due to the differences in hardness and yield strength between the flyer and base metals.The results of the microstructural distribution at the bonding interface indicated metallurgical bonding,instead of the commonly believed solid-state bonding,in the explosive welded clad plate.In addition,the shear strength of the bonding interface of the explosive welded Al/Mg,Cu/Mg and SS/Mg clad plates can reach up to 201.2 MPa,147.8 MPa,and 128.4 MPa,respectively.The proposed research provides the design basis for laminated composite metal plates fabrication by explosive welding technology.展开更多
In this study, an ionic liquid(IL), 1-butyl-2,3-dimmmethylimidazolium hexafluorophosphate([Bmmim][PF6]),was used in combination with a composite solvent of methyl acetate and n-heptane to enhance the oil extraction fr...In this study, an ionic liquid(IL), 1-butyl-2,3-dimmmethylimidazolium hexafluorophosphate([Bmmim][PF6]),was used in combination with a composite solvent of methyl acetate and n-heptane to enhance the oil extraction from oily sludge. The oil recovery increased by approximately 15% compared with that of solvent extraction without [Bmmim][PF6] at the optimal ratios of IL to sludge and solvents to sludge, which were at 2:5(M/M) and 4:1(V/M), respectively. The saturate, aromatic, resin and asphaltene(SARA) analysis revealed that the recovery of resins and asphaltenes was increased by 14% and 38%, respectively, in the solvent extraction with the addition of [Bmmim][PF6]. [Bmmim][PF6] maintained a good performance after its reuse four times. The addition of[Bmmim][PF6] changed the adhesion forces between oil and soil. The IL-assisted solvent extraction procedure followed the pseudo second-order kinetic model, while the unassisted solvent extraction procedure followed the pseudo first-order kinetic model. The results also demonstrated that [Bmmim][PF6] decreased the solvent consumption by approximately 60% each time. Additionally, [Bmmim][PF6] can be easily separated. The results suggested that enhancing the solvent extraction with this IL is a promising way to recover oil from oily sludge with a higher oil recovery rate and lower organic solvent consumption than those with the unassisted solvent extraction method.展开更多
Coal and gas outburst is a dynamic phenomenon in underground mining engineering that is often accompanied by the throwing and breakage of large amounts of coal.To study the crushing effect and its evolution during out...Coal and gas outburst is a dynamic phenomenon in underground mining engineering that is often accompanied by the throwing and breakage of large amounts of coal.To study the crushing effect and its evolution during outbursts,coal samples with different initial particle sizes were evaluated using a coal and gas outburst testing device.Three basic particle sizes,5–10 mesh,10–40 mesh,and 40–80 mesh,as well as some mixed particle size coal samples were used in tests.The coal particles were pre-compacted at a pressure of 4 MPa before the tests.The vertical ground stress(4 MPa)and the horizontal ground stress(2.4 MPa)were initially simulated by the hydraulic system and maintained throughout.During the tests,the samples were first placed in a vacuum for 3 h,and the coal was filled with gas(CH4)for an adsorption time of approximately 5 h.Finally,the gas valve was shut off and the coal and gas outburst was induced by quickly opening the outburst hole.The coal particles that were thrown out by the outburst test device were collected and screened based on the particle size.The results show the following.(1)Smaller particle sizes have a worse crushing effect than larger sizes.Furthermore,the well-graded coal particles are weakly broken during the outburst process.(2)As the number of repeated tests increases,the relative breakage index grows;however,the increment of growth decreases after each test,showing that further fragmentation becomes increasingly difficult.展开更多
The ultrasonic technique has been demonstrated to be a promising method for the disposal of hazardous oily sludge.However,the separation of oil from the surfaces of the solid particles is still difficult due to the st...The ultrasonic technique has been demonstrated to be a promising method for the disposal of hazardous oily sludge.However,the separation of oil from the surfaces of the solid particles is still difficult due to the strong interaction between the oil and solid particle.In this study,three types of surfactants were used to assist the ultrasonic treatment of oily sludge.The oil component,surface composition,and structure of the solid particle were determined.The results showed that different surfactants had different oil removal abilities.In the three surfactant-assisted sonication systems,the oil removal rate increased during the starting reaction period and then decreased with longer sonication time.The results of four components analysis suggested that surfactant easy to be ionized in water posed a better removal effect on resins,while the amphiphilic surfactant preferred saturates,aromatics and asphaltenes.The morphology analysis indicated that particle size was shattered into smaller ones by the ultrasonic process,and the wettability of the solid surface also changed during this treatment.The characterization of the oil component and solid particle during surfactant-assisted ultrasonication treatment will help to better understand the separation of oil from oily sludge and improve the oil recovery efficiency from oily sludge.展开更多
Objective The aim of the study was to evaluate the long-term efficacy and safety of percutaneous microwave ablation(MWA) for small hepatic cancers adjacent to large vessels and to investigate the treatment strategies....Objective The aim of the study was to evaluate the long-term efficacy and safety of percutaneous microwave ablation(MWA) for small hepatic cancers adjacent to large vessels and to investigate the treatment strategies.Methods From March 2009 to July 2015,a total of 86 patients with 94 tumors underwent ultrasound(US)-guided percutaneous MWA,with pathologically proven or clinically diagnosed liver cancers measuring ≤ 3 cm in diameter and located ≤ 10 mm from a major vessel(n = 94).Regular follow-up after MWA was performed to assess treatment efficacy and perioperative complications.Results The complete ablation rate at 1 month after MWA was 93.3%(84/90).The 6-,9-,12-,24-,36-,48-,60-,72-,and 84-month local recurrence rates were 2.4%,2.4%,3.7%,6.6%,8.4%,8.4%,8.4%,8.4%,and 8.4%,respectively.There were no major complications.The perioperative special complication rate was 5.32%(5/94),including 3 cases of moderate liver function damage and 2 cases of limited sub-capsular hematoma.Conclusion Percutaneous MWA for small hepatic cancers adjacent to large vessels is feasible,effective,and safe with an acceptable rate of complications.The key point is to strictly follow operative indications and adopt proper treatment strategies.展开更多
文摘Arson presents a challenging crime scene for fire investigators worldwide. Key to the investigation of suspected arson cases is the analysis of fire debris for the presence of accelerants or ignitable liquids. This study has investigated the application and method development of vapor phase mid-Infrared (mid-IR) spectroscopy using a field portable quantum cascade laser (QCL) based system for the detection and identification of accelerant residues such as gasoline, diesel, and ethanol in fire debris. A searchable spectral library of various ignitable fluids and fuel components measured in the vapor phase was constructed that allowed for real-time identification of accelerants present in samples using software developed in-house. Measurement of vapors collected from paper material that had been doused with an accelerant followed by controlled burning and then extinguished with water showed that positive identification could be achieved for gasoline, diesel, and ethanol. This vapor phase mid-IR QCL method is rapid, easy to use, and has the sensitivity and discrimination capability that make it well suited for non-destructive crime scene sample analysis. Sampling and measurement can be performed in minutes with this 7.5 kg instrument. This vibrational spectroscopic method required no time-consuming sample pretreatment or complicated solvent extraction procedure. The results of this initial feasibility study demonstrate that this portable fire debris analyzer would greatly benefit arson investigators performing analysis on-site.
文摘It is an important issue to numerically solve the time fractional Schrödinger equation on unbounded domains, which models the dynamics of optical solitons propagating via optical fibers. The perfectly matched layer approach is applied to truncate the unbounded physical domain, and obtain an initial boundary value problem on a bounded computational domain, which can be efficiently solved by the finite difference method. The stability of the reduced initial boundary value problem is rigorously analyzed. Some numerical results are presented to illustrate the accuracy and feasibility of the perfectly matched layer approach. According to these examples, the absorption parameters and the width of the absorption layer will affect the absorption effect. The larger the absorption width, the better the absorption effect. There is an optimal absorption parameter, the absorption effect is the best.
基金financially supported by the National Natural Science Foundation of China(32201969)Natural Science Foundation of Henan Province(212300410297)+3 种基金Basic Research Plan of Higher Education School Key Scientific Research Project of Henan Province(21A550014)Doctoral Research Foundation of Zhengzhou University of Light Industry(2020BSJJ015)Program for Science and Technology Innovation Talents in Universities of Henan Province(20HASTIT037)Youth Talents Project of Henan Province(2020HYTP046).
文摘Diabetes mellitus(DM)is a common multifactorial disease,causing various complications,such as chronic metabolism.The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite side effect.However,polysaccharides mainly extracted from natural resources,have advantages of safety,accessibility,and anti-diabetic potential.We have summarized recent research of natural polysaccharides with hypoglycemic activities,focusing on different pharmacological mechanisms in various cell and animal models.The relationships of structure-hypoglycemic effect are also discussed in detail.This review could provide a comprehensive perspective for better understanding on development and mechanism of natural polysaccharides against diabetes mellitus,which have been required by clinical studies yet.
基金Supported by the National Natural Science Foundation of China(Nos.42071313,41571363)the Science and Technology Project for Black Soil Granary(No.XDA28080500)the Scientific Investigation of Natural and Cultural Heritage of Lop Nur Region(No.2014FY210500)。
文摘The change in the ecological environment in the arid core area is a critical issue in the context of global warming.To study the paleoclimate evolution,precise identification of minerals deposited in Asia’s arid hinterland,Lop Nur Salt Lake,NW China was conducted.The hyperspectral data of the salt crust was sampled to identify the species and content of sedimentary minerals,and the multispectral photos were used to reconstruct the salt crust morphology using the unmanned aerial vehicles platform.The SUnSAL(sparse unmixing by variable splitting and augmented Lagrangian)method was employed to inverse the sedimentary mineral components along the shoreline.The heterogeneity of salt and clay minerals in bright and dark ear-shaped strips was evaluated.The paleoclimatic environment associated with salt lake extinction was reconstructed by analyzing paleoclimate records of sediments,spectral reflectance and morphology of the salt crust.Results show that:(1)the variations in the micro-geomorphology of the salt crust are obviously the reason for the formation of bright and dark ear-shaped strips and the differences in the species and relative content of the sedimentary minerals are the microscopic reason.The high ratio of sedimentary salt minerals to clay minerals(RS/C)contributes to the high reflectivity,and the salt crust presents a bright texture.The low RS/C results in the low reflectivity,salt crust presents a dark texture;(2)the bright and dark ear-shaped strips represent warm-arid and cold-humid climates.The shape of the Lop Nur Lake shoreline evolved due to alternating warm-dry and cold-humid paleoclimate changes.
基金supported in part by the National Key Research and Development Program of China(No.2021YFB2900600)in part by the National Natural Science Foundation of China under Grant 61971041 and Grant 62001027。
文摘Orthogonal Time Frequency Space(OTFS)signaling with index modulation(IM)is a promising transmission scheme characterized by high transmission efficiency for high mobility scenarios.In this paper,we study the receiver for coded OTFS-IM system.First,we construct the corresponding factor graph,on which the structured prior incorporating activation pattern constraint and channel coding is devised.Then we develop a iterative receiver via structured prior-based hybrid belief propagation(BP)and expectation propagation(EP)algorithm,named as StrBP-EP,for the coded OTFS-IM system.To reduce the computational complexity of discrete distribution introduced by structured prior,Gaussian approximation conducted by EP is adopted.To further reduce the complexity,we derive two variations of the proposed algorithm by using some approximations.Simulation results validate the superior performance of the proposed algorithm.
基金supported by the National Natural Science Foundation of China,Nos.81973317,81374007,81870977the Natural Science Foundation of Heilongjiang Province,HL2019H062+1 种基金the Projects of Basic Scientific Research Business Expenses in Higher Education Institutions of Heilongjiang Province,No.2018-KYYWF-MY-005the Students Innovative and the Entrepreneurship Training Scientific Research Foundation of Heilongjiang Province,No.102292017001.
文摘A preliminary miRNA screening showed that expression levels of rno-miRNA-27a-3p were significantly increased in the serum and brain tissues of rats undergoing cerebral ischemia.In recent years,there is evidence of the protective capacity of the saponins extracted from panax ginseng and its primary active ingredient ginsenosideRg1oncerebral ischemic injury.Methods:Fetal rat neurons(FRNs)were cultured in glucose-and-serumfree medium and exposed to hypoxia to establish a cerebral ischemia model in vitro(oxygen and glucose deprivation model,OGD).Antioxidant indexes(CAT,SOD),inflammatory markers(MPO,TNF-αand IL-6),and the expression of apoptosis and proliferation associated proteins(NF kB-p65,Caspase 3-cleaved,BCL-2)were examined.Results:Pre-treatment of Rg1(30–100μg/mL)could effectively inhibit the decline of antioxidant indexes(CAT,SOD)and increase in inflammatory markers(MPO,TNF-αand IL-6),and effectively inhibited the apoptosis in FRNs induced by OGD in a gradient-dependent manner.The mechanism analysis showed that the role of Rg1 in protecting against ischemia-induced neuron damage depends on its indirect up-regulation of PPAR protein via suppression of rnomiRNA-27a-3p.Moreover,these effects of Rg1 could be reversed by exogenous rno-miRNA-27a-3p and PPAR gene silencing in FRNs exposed to OGD.Conclusion:To summarize,our study demonstrates that Rg1 could effectively attenuate neuronal damage caused by cerebral ischemia via the rno-miRNA-27a-3p/PPARγpathway.Further,clarification of the novel mechanism will certainly improve our previous understanding of the role of Rg1 and enhancing its level in treatments for alleviating ischemic brain injury.
基金supported by the National Natural Science Foundation of China(grant Nos.11929301 and 61802428)。
文摘Massive neutrinos are expected to affect the large-scale structure formation,including the major component of solid substances,dark matter halos.How halos are influenced by neutrinos is vital and interesting,and angular momentum(AM)as a significant feature provides a statistical perspective for this issue.Exploring halos from TianNu N-body cosmological simulation with the co-evolving neutrino particles,we obtain some concrete conclusions.First,by comparing the same halos with and without neutrinos,in contrast to the neutrino-free case,over 89.71%of halos have smaller halo moduli,over 71.06%have smaller particle-mass-reduced(PMR)AM moduli,and over 95.44%change their orientations of less than 0°.65.Moreover,the relative variation of PMR modulus is more visible for low-mass halos.Second,to explore the PMR moduli of halos in dense or sparse areas,we divide the whole box into big cubes,and search for halos within a small spherical cell in a single cube.From the two-level divisions,we discover that in denser cubes,the variation of PMR moduli with massive neutrinos decreases more significantly.This distinction suggests that neutrinos exert heavier influence on halos'moduli in compact regions.With massive neutrinos,most halos(86.60%)have lower masses than without neutrinos.
基金supported by the National Key Research and Development Program of China(Grant No.:2018YFC0807402)the National Natural Science Foundation of China(Grant No.:82073810)。
文摘In this study,we developed a novel on-line solid phase extraction(SPE)-ultra-high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)-based analytical method for simultaneously quantifying 12 illicit drugs and metabolites(methamphetamine,amphetamine,morphine,codeine,6-monoacetylmorphine,benzoylecgonine,3,4-methylenedioxymethamphetamine,3,4-methylenedioxyamphetamine,cocaine,ketamine,norketamine,and methcathinone)and cotinine(COT)in wastewater samples.The analysis was performed by loading 2 m L of the sample onto an Oasis hydrophilic-lipophilic balance cartridge and using a cleanup step(5%methanol)to eliminate interference with a total run time of 13 min.The isotope-labeled internal standard method was used to quantify the target substances and correct for unavoidable losses and matrix effects during the on-line SPE process.Typical analytical characteristics used for method validation were sensitivity,linearity,precision,repeatability,recovery,and matrix effects.The limit of detection(LOD)and limit of quantification(LOQ)of each target were set at 0.20 ng/L and 0.50 ng/L,respectively.The linearity was between 0.5 ng/L and250 ng/L,except for that of COT.The intra-and inter-day precisions were<10.45%and 25.64%,respectively,and the relative recovery ranged from 83.74%to 162.26%.The method was used to analyze various wastewater samples from 33 cities in China,and the results were compared with the experimental results of identical samples analyzed using off-line SPE.The difference rate was between 19.91%and-20.44%,and the error range could be considered acceptable.These findings showed that on-line SPE is a suitable alternative to off-line SPE for the analysis of illicit drugs in samples.
基金The Special Scientific Research Funds for Central Non-profit Institutes(East China Sea Fisheries Research Institute)under contract No.2016T08the National Natural Science Foundation of China under contract No.31400410
文摘It is a challenge in the field sampling to face conflict between the statistical requirements and the logistical constraints when explicitly estimating the macrobenthos species richness in the heterogeneous intertidal wetlands. To solve this problem, this study tried to design an optimal, efficient and practical sampling strategy by comprehensively focusing on the three main parts of the entire process(to optimize the sampling method, to determine the minimum sampling effort and to explore the proper sampling interval) in a typical intertidal wetland of the Changjiang(Yangtze) Estuary, China. Transect sampling was selected and optimized by stratification based on pronounced habitat types(tidal flat, tidal creek, salt marsh vegetation). This type of sampling is also termed within-transect stratification sampling. The optimal sampling intervals and the minimum sample effort were determined by two beneficial numerical methods: Monte Carlo simulations and accumulative species curves. The results show that the within-transect stratification sampling with typical habitat types was effective for encompassing 81% of the species, suggesting that this type of sampling design can largely reduce the sampling effort and labor. The optimal sampling intervals and minimum sampling efforts for three habitats were determined: sampling effort must exceed 1.8 m^2 by 10 m intervals in the salt marsh vegetation, 2 m^2 by 10 m intervals in the tidal flat, and 3 m^2 by 1 m intervals in the tidal creek habitat. It was suggested that the differences were influenced by the mobility range of the dominant species and the habitats' physical differences(e.g., tidal water, substrate, vegetation cover). The optimized sampling strategy could provide good precision in the richness estimation of macrobenthos and balance the sampling effort. Moreover, the conclusions presented here provide a reference for recommendations to consider before macrobenthic surveys take place in estuarine wetlands. The sampling strategy, focusing on the three key parts of the sampling design, had a good operational effect and could be used as a guide for field sampling for habitat management or ecosystem assessment.
基金Supported by National Natural Science Foundation of China(Grant Nos.51805359,51904206,51375328)Major program of national natural science foundation of China(U1710254),China Postdoctoral Science Foundation(Grant No.2018M631772)+2 种基金Shanxi Provincial Natural Science Foundation of China(Grant No.201901D211015)Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province(STIP)(Grant No.2019L0333)Central Special Fund for Guiding Local Science and Technology Development(YDZX20191400002149).
文摘Interfacial structure greatly affects the mechanical properties of laminated plates.However,the critical material properties that impact the interfacial morphology,appearance,and associated bonding mechanism of explosive welded plates are still unknown.In this paper,the same base plate(AZ31B alloy)and different flyer metals(aluminum alloy,copper,and stainless steel)were used to investigate interfacial morphology and structure.SEM and TEM results showed that typical sine wave,wave-like,and half-wave-like interfaces were found at the bonding interfaces of Al/Mg,Cu/Mg and SS/Mg clad plates,respectively.The different interfacial morphologies were mainly due to the differences in hardness and yield strength between the flyer and base metals.The results of the microstructural distribution at the bonding interface indicated metallurgical bonding,instead of the commonly believed solid-state bonding,in the explosive welded clad plate.In addition,the shear strength of the bonding interface of the explosive welded Al/Mg,Cu/Mg and SS/Mg clad plates can reach up to 201.2 MPa,147.8 MPa,and 128.4 MPa,respectively.The proposed research provides the design basis for laminated composite metal plates fabrication by explosive welding technology.
基金financial support from the National Natural Science Foundation of China(Nos.41807133 and 41977142)the special fund of State Key Joint Laboratory of Environment Simulation and Pollution Control(No.18K05ESPCT)the Fundamental Research Funds for the Central Universities(PT1915)。
文摘In this study, an ionic liquid(IL), 1-butyl-2,3-dimmmethylimidazolium hexafluorophosphate([Bmmim][PF6]),was used in combination with a composite solvent of methyl acetate and n-heptane to enhance the oil extraction from oily sludge. The oil recovery increased by approximately 15% compared with that of solvent extraction without [Bmmim][PF6] at the optimal ratios of IL to sludge and solvents to sludge, which were at 2:5(M/M) and 4:1(V/M), respectively. The saturate, aromatic, resin and asphaltene(SARA) analysis revealed that the recovery of resins and asphaltenes was increased by 14% and 38%, respectively, in the solvent extraction with the addition of [Bmmim][PF6]. [Bmmim][PF6] maintained a good performance after its reuse four times. The addition of[Bmmim][PF6] changed the adhesion forces between oil and soil. The IL-assisted solvent extraction procedure followed the pseudo second-order kinetic model, while the unassisted solvent extraction procedure followed the pseudo first-order kinetic model. The results also demonstrated that [Bmmim][PF6] decreased the solvent consumption by approximately 60% each time. Additionally, [Bmmim][PF6] can be easily separated. The results suggested that enhancing the solvent extraction with this IL is a promising way to recover oil from oily sludge with a higher oil recovery rate and lower organic solvent consumption than those with the unassisted solvent extraction method.
基金This research was financially supported by the National Natural Science Foundation of China(No.51434003)the Project of the Ministry of Emergency Management of the People's Republic of China(sichuan-0011-2018AQ)the Department of Science and Technology of Sichuan Province(19YYJC2854).
文摘Coal and gas outburst is a dynamic phenomenon in underground mining engineering that is often accompanied by the throwing and breakage of large amounts of coal.To study the crushing effect and its evolution during outbursts,coal samples with different initial particle sizes were evaluated using a coal and gas outburst testing device.Three basic particle sizes,5–10 mesh,10–40 mesh,and 40–80 mesh,as well as some mixed particle size coal samples were used in tests.The coal particles were pre-compacted at a pressure of 4 MPa before the tests.The vertical ground stress(4 MPa)and the horizontal ground stress(2.4 MPa)were initially simulated by the hydraulic system and maintained throughout.During the tests,the samples were first placed in a vacuum for 3 h,and the coal was filled with gas(CH4)for an adsorption time of approximately 5 h.Finally,the gas valve was shut off and the coal and gas outburst was induced by quickly opening the outburst hole.The coal particles that were thrown out by the outburst test device were collected and screened based on the particle size.The results show the following.(1)Smaller particle sizes have a worse crushing effect than larger sizes.Furthermore,the well-graded coal particles are weakly broken during the outburst process.(2)As the number of repeated tests increases,the relative breakage index grows;however,the increment of growth decreases after each test,showing that further fragmentation becomes increasingly difficult.
基金financial support from the National Natural Science Foundation of China(Nos.41977142 and 41807133)the special fund of State Key Joint Laboratory of Environment Simulation and Pollution Control(No.18K05ESPCT)。
文摘The ultrasonic technique has been demonstrated to be a promising method for the disposal of hazardous oily sludge.However,the separation of oil from the surfaces of the solid particles is still difficult due to the strong interaction between the oil and solid particle.In this study,three types of surfactants were used to assist the ultrasonic treatment of oily sludge.The oil component,surface composition,and structure of the solid particle were determined.The results showed that different surfactants had different oil removal abilities.In the three surfactant-assisted sonication systems,the oil removal rate increased during the starting reaction period and then decreased with longer sonication time.The results of four components analysis suggested that surfactant easy to be ionized in water posed a better removal effect on resins,while the amphiphilic surfactant preferred saturates,aromatics and asphaltenes.The morphology analysis indicated that particle size was shattered into smaller ones by the ultrasonic process,and the wettability of the solid surface also changed during this treatment.The characterization of the oil component and solid particle during surfactant-assisted ultrasonication treatment will help to better understand the separation of oil from oily sludge and improve the oil recovery efficiency from oily sludge.
文摘Objective The aim of the study was to evaluate the long-term efficacy and safety of percutaneous microwave ablation(MWA) for small hepatic cancers adjacent to large vessels and to investigate the treatment strategies.Methods From March 2009 to July 2015,a total of 86 patients with 94 tumors underwent ultrasound(US)-guided percutaneous MWA,with pathologically proven or clinically diagnosed liver cancers measuring ≤ 3 cm in diameter and located ≤ 10 mm from a major vessel(n = 94).Regular follow-up after MWA was performed to assess treatment efficacy and perioperative complications.Results The complete ablation rate at 1 month after MWA was 93.3%(84/90).The 6-,9-,12-,24-,36-,48-,60-,72-,and 84-month local recurrence rates were 2.4%,2.4%,3.7%,6.6%,8.4%,8.4%,8.4%,8.4%,and 8.4%,respectively.There were no major complications.The perioperative special complication rate was 5.32%(5/94),including 3 cases of moderate liver function damage and 2 cases of limited sub-capsular hematoma.Conclusion Percutaneous MWA for small hepatic cancers adjacent to large vessels is feasible,effective,and safe with an acceptable rate of complications.The key point is to strictly follow operative indications and adopt proper treatment strategies.
