Pancreatic cancer is one of the deadliest cancers,ranking fourth among cancer-related deaths. Despite all the major molecular advances and treatment breakthroughs, mainly targeted therapies, the cornerstone treatment ...Pancreatic cancer is one of the deadliest cancers,ranking fourth among cancer-related deaths. Despite all the major molecular advances and treatment breakthroughs, mainly targeted therapies, the cornerstone treatment of metastatic pancreatic cancer(m PC) remains cytotoxic chemotherapy. In 2016, more than 40 years after the introduction of gemcitabine in the management of m PC, the best choice for first-line treatment has not yet been fully elucidated. Two main strategies have been adopted to enhance treatment efficacy. The first strategy is based on combining non-cross resistant drugs, while the second option includes the development of newer generations of chemotherapy. More recently, two new regimens, FOLFIRINOX and gemcitabine/nab-paclitaxel(GNP), have both been shown to improve overall survival in comparison with gemcitabine alone, at the cost of increased toxicity. Therefore, the best choice for first line therapy is a matter of debate. For some authors, FOLFIRINOX should be the first choice in patients with an Eastern Cooperative Oncology Group score(0-1) given its lower hazard ratio. However, others do not share this opinion. In this paper, we review the main comparison points between FOLFIRINOX and GNP. We analyze the two pivotal trials to determine the similarities and differences in study design. In addition, we compare the toxicity profile of the two regimens as well as the impact on quality of life. Finally, we present studies revealing real life experiences and review the advantages and disadvantages of possible second-line therapies including their cost effectiveness.展开更多
MicroRNAs(miRNAs)are highly deregulated in cancer and play a role in the initiation of tumorigenesis.Recently,miRNAs have attracted attention in gastrointestinal(GI)cancers.Single nucleotide polymorphisms(SNPs)could a...MicroRNAs(miRNAs)are highly deregulated in cancer and play a role in the initiation of tumorigenesis.Recently,miRNAs have attracted attention in gastrointestinal(GI)cancers.Single nucleotide polymorphisms(SNPs)could affect the genes involved in each step of miRNA biosynthesis.Several metaanalyses of case-control studies have assessed the association between miRNA“pathway”gene-SNPs(including biosynthesis regulators and binding sites)and susceptibility to GI cancers.We present in this mini-review the current knowledge on the association between miRNAs“pathway”genes and GI cancer predisposition.The interaction between miRNA/regulators/binding site-SNPs and environmental as well as genomic factors is an interesting field that should be exploited in future studies.展开更多
文摘Pancreatic cancer is one of the deadliest cancers,ranking fourth among cancer-related deaths. Despite all the major molecular advances and treatment breakthroughs, mainly targeted therapies, the cornerstone treatment of metastatic pancreatic cancer(m PC) remains cytotoxic chemotherapy. In 2016, more than 40 years after the introduction of gemcitabine in the management of m PC, the best choice for first-line treatment has not yet been fully elucidated. Two main strategies have been adopted to enhance treatment efficacy. The first strategy is based on combining non-cross resistant drugs, while the second option includes the development of newer generations of chemotherapy. More recently, two new regimens, FOLFIRINOX and gemcitabine/nab-paclitaxel(GNP), have both been shown to improve overall survival in comparison with gemcitabine alone, at the cost of increased toxicity. Therefore, the best choice for first line therapy is a matter of debate. For some authors, FOLFIRINOX should be the first choice in patients with an Eastern Cooperative Oncology Group score(0-1) given its lower hazard ratio. However, others do not share this opinion. In this paper, we review the main comparison points between FOLFIRINOX and GNP. We analyze the two pivotal trials to determine the similarities and differences in study design. In addition, we compare the toxicity profile of the two regimens as well as the impact on quality of life. Finally, we present studies revealing real life experiences and review the advantages and disadvantages of possible second-line therapies including their cost effectiveness.
文摘MicroRNAs(miRNAs)are highly deregulated in cancer and play a role in the initiation of tumorigenesis.Recently,miRNAs have attracted attention in gastrointestinal(GI)cancers.Single nucleotide polymorphisms(SNPs)could affect the genes involved in each step of miRNA biosynthesis.Several metaanalyses of case-control studies have assessed the association between miRNA“pathway”gene-SNPs(including biosynthesis regulators and binding sites)and susceptibility to GI cancers.We present in this mini-review the current knowledge on the association between miRNAs“pathway”genes and GI cancer predisposition.The interaction between miRNA/regulators/binding site-SNPs and environmental as well as genomic factors is an interesting field that should be exploited in future studies.
