Synthetic biology is a crucial component of the“cyber‐biological revolution”in this new industrial revolution.Owing to breakthroughs in synthetic biology,deoxyribonucleic acid(DNA),the storehouse of hereditary mate...Synthetic biology is a crucial component of the“cyber‐biological revolution”in this new industrial revolution.Owing to breakthroughs in synthetic biology,deoxyribonucleic acid(DNA),the storehouse of hereditary material in biological systems,can now be used as a medium for storage(synthesis)and reading(sequencing)of information.However,integrating synthetic biology with computerization has also caused cyberbiosecurity concerns,encompassing biosecurity and information security issues.Malicious codes intended to attack computer systems can be stored as artificially synthesized DNA fragments,which can be released during DNA sequencing and decoding and attack computer and network systems.As these cyberbiosecurity threats become increasingly realistic,spreading awareness and information about how they can be prevented and controlled is crucial.This review aims to address this need by offering crucial theoretical backing for cyberbiosecurity research and raising awareness of risk mitigation and control measures in information security,biosecurity,and national security。展开更多
Neuromorphic computing has the potential to achieve the requirements of the next-generation artificial intelligence(AI)systems,due to its advantages of adaptive learning and parallel computing.Meanwhile,biocomputing h...Neuromorphic computing has the potential to achieve the requirements of the next-generation artificial intelligence(AI)systems,due to its advantages of adaptive learning and parallel computing.Meanwhile,biocomputing has seen ongoing development with the rise of synthetic biology,becoming the driving force for new generation semiconductor synthetic biology(SemiSynBio)technologies.DNA-based biomolecules could potentially perform the functions of Boolean operators as logic gates and be used to construct artificial neural networks(ANNs),providing the possibility of executing neuromorphic computing at the molecular level.Herein,we briefly outline the principles of neuromorphic computing,describe the advances in DNA computing with a focus on synthetic neuromorphic computing,and summarize the major challenges and prospects for synthetic neuromorphic computing.We believe that constructing such synthetic neuromorphic circuits will be an important step toward realizing neuromorphic computing,which would be of widespread use in biocomputing,DNA storage,information security,and national defense.展开更多
In eukaryotic genomes, the fundamental unit of chromatin is the nucleosome, which is composed of a histone octamer that contains two copies of each histone, H3, H2A, H2B, and H4 (Bell et al., 2011).Chromatin is wrappe...In eukaryotic genomes, the fundamental unit of chromatin is the nucleosome, which is composed of a histone octamer that contains two copies of each histone, H3, H2A, H2B, and H4 (Bell et al., 2011).Chromatin is wrapped in the nucleus in a highly helical state to play an essential role in gene regulation (Li et al., 2007).展开更多
Dear Editor,Synthetic DNA is emerging as a new data storage medium with high density and durable preservation capability potential(Ceze et al., 2019;Yazdi et al., 2015), thus enhancing the security of data stored in D...Dear Editor,Synthetic DNA is emerging as a new data storage medium with high density and durable preservation capability potential(Ceze et al., 2019;Yazdi et al., 2015), thus enhancing the security of data stored in DNA is particularly important(Cherian et al., 2013;El-Zoghabi et al., 2013;Kalsi et al.,2018).展开更多
文摘Synthetic biology is a crucial component of the“cyber‐biological revolution”in this new industrial revolution.Owing to breakthroughs in synthetic biology,deoxyribonucleic acid(DNA),the storehouse of hereditary material in biological systems,can now be used as a medium for storage(synthesis)and reading(sequencing)of information.However,integrating synthetic biology with computerization has also caused cyberbiosecurity concerns,encompassing biosecurity and information security issues.Malicious codes intended to attack computer systems can be stored as artificially synthesized DNA fragments,which can be released during DNA sequencing and decoding and attack computer and network systems.As these cyberbiosecurity threats become increasingly realistic,spreading awareness and information about how they can be prevented and controlled is crucial.This review aims to address this need by offering crucial theoretical backing for cyberbiosecurity research and raising awareness of risk mitigation and control measures in information security,biosecurity,and national security。
文摘Neuromorphic computing has the potential to achieve the requirements of the next-generation artificial intelligence(AI)systems,due to its advantages of adaptive learning and parallel computing.Meanwhile,biocomputing has seen ongoing development with the rise of synthetic biology,becoming the driving force for new generation semiconductor synthetic biology(SemiSynBio)technologies.DNA-based biomolecules could potentially perform the functions of Boolean operators as logic gates and be used to construct artificial neural networks(ANNs),providing the possibility of executing neuromorphic computing at the molecular level.Herein,we briefly outline the principles of neuromorphic computing,describe the advances in DNA computing with a focus on synthetic neuromorphic computing,and summarize the major challenges and prospects for synthetic neuromorphic computing.We believe that constructing such synthetic neuromorphic circuits will be an important step toward realizing neuromorphic computing,which would be of widespread use in biocomputing,DNA storage,information security,and national defense.
基金supported by the National Key R&D Program of China(2022YFC2105501)the National Natural Science Foundation of China(32202720)+2 种基金the Agricultural Science and Technology Innovation Program(CAAS-ZDRW202304 and CAAS-ASTIPG2022-IFST-07)the Central Public-interest Scientific Institution Basal Research Fund(1610392020001)the Agricultural Science and Technology Innovation Program(ASTIP)。
基金supported by grants from the National Natural Science Foundation of China (32130080)the Central Public-interest Scientific Institution Basal Research Fund (Y2020YJ09)+2 种基金the Agricultural Science and Technology Innovation Program (CAASZDRW202109)Agricultural Science and Technology Innovation Program (ASTIP-CAASZDRW202009)the Project of Hainan Yazhou Bay Seed Lab (B21HJ0223)
文摘In eukaryotic genomes, the fundamental unit of chromatin is the nucleosome, which is composed of a histone octamer that contains two copies of each histone, H3, H2A, H2B, and H4 (Bell et al., 2011).Chromatin is wrapped in the nucleus in a highly helical state to play an essential role in gene regulation (Li et al., 2007).
文摘Dear Editor,Synthetic DNA is emerging as a new data storage medium with high density and durable preservation capability potential(Ceze et al., 2019;Yazdi et al., 2015), thus enhancing the security of data stored in DNA is particularly important(Cherian et al., 2013;El-Zoghabi et al., 2013;Kalsi et al.,2018).
