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Oxidative Metabolism of Estrone Modified by Genistein and Bisphenol A in Rat Liver Microsomes 被引量:1
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作者 GHELDIU Ana-Maria POPA Daniela-Saveta +1 位作者 LOGHIN Felicia vlase laurian 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2015年第11期834-838,共5页
Genistein, the main isoflavone from soy, and bisphenol A (BPA), a food contaminant, are considered ubiquitous xenoestrogens. Here we investigated the influence of genistein and BPA on estrone (El) metabolism in ra... Genistein, the main isoflavone from soy, and bisphenol A (BPA), a food contaminant, are considered ubiquitous xenoestrogens. Here we investigated the influence of genistein and BPA on estrone (El) metabolism in rat liver microsomes. Both substances inhibited the 2-hydroxylation and 16a-hydroxylation of E1, but in different degrees, thereby reducing the 2-OH-E1/16a-OH-E1 ratio, 展开更多
关键词 BPA Oxidative Metabolism of Estrone Modified by Genistein and Bisphenol A in Rat Liver Microsomes
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